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Aliases for NUP88 Gene

Aliases for NUP88 Gene

  • Nucleoporin 88 2 3 5
  • Nucleoporin Nup88 3 4
  • Nucleoporin 88kDa 2 3
  • Nuclear Pore Complex Protein Nup88 3
  • Nuclear Pore Complex Protein 88 3
  • 88 KDa Nucleoporin 4
  • Nucleoporin 88kD 2
  • Karyoporin 3

External Ids for NUP88 Gene

Previous GeneCards Identifiers for NUP88 Gene

  • GC17M005674
  • GC17M005233
  • GC17M005489
  • GC17M005230
  • GC17M005180
  • GC17M005361
  • GC17M005363

Summaries for NUP88 Gene

Entrez Gene Summary for NUP88 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for NUP88 Gene

NUP88 (Nucleoporin 88) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include transporter activity.

UniProtKB/Swiss-Prot for NUP88 Gene

  • Essential component of nuclear pore complex.

Gene Wiki entry for NUP88 Gene

Additional gene information for NUP88 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP88 Gene

Genomics for NUP88 Gene

GeneHancer (GH) Regulatory Elements for NUP88 Gene

Promoters and enhancers for NUP88 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J005416 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 658.8 +1.2 1209 4.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B IRF4 YY1 RPAIN NUP88 RABEP1 ENSG00000263272 C1QBP DHX33 LOC101927979 DERL2 GC17P005414 GC17M005386
GH17J005386 Promoter 0.5 EPDnew 661.7 +33.9 33873 0.1 NUP88 RABEP1 RPAIN MIS12 DERL2 PIR48672 ENSG00000263220
GH17J004965 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 35.3 +451.5 451544 5.4 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 SPAG7 PIR49988 MIR6865 MIR6864 ENSG00000262429 ZNF232 NUP88 MIS12 INCA1 CHRNE
GH17J004996 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 32.6 +421.3 421313 4.2 HDGF MLX ARID4B SIN3A DMAP1 YBX1 YY1 ZNF766 ZNF207 ZNF143 INCA1 KIF1C NUP88 CHRNE ZNF232 MIS12 ZZEF1 CAMTA2 DERL2 ENSG00000234203
GH17J005466 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.8 -48.1 -48063 3 HDGF CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 LOC105371506 DHX33 RPAIN NUP88 DERL2 ZNF594 RABEP1 MIS12 LOC105371508 LOC100130950
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUP88 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUP88 gene promoter:
  • SRF (504 AA)
  • SRF
  • CUTL1
  • Pax-3
  • Arnt
  • HEN1
  • POU2F1
  • POU2F1a
  • AhR
  • FOXF2

Genomic Locations for NUP88 Gene

Genomic Locations for NUP88 Gene
59,198 bases
Minus strand
59,223 bases
Minus strand

Genomic View for NUP88 Gene

Genes around NUP88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP88 Gene

Proteins for NUP88 Gene

  • Protein details for NUP88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex protein Nup88
    Protein Accession:
    Secondary Accessions:
    • D3DTM2
    • Q9BWE5

    Protein attributes for NUP88 Gene

    741 amino acids
    Molecular mass:
    83542 Da
    Quaternary structure:
    • Interacts with NUP214/CAN.

neXtProt entry for NUP88 Gene

Post-translational modifications for NUP88 Gene

  • Ubiquitination at Lys552, Lys531, isoforms=226, and isoforms=150
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUP88 Gene

Domains & Families for NUP88 Gene

Gene Families for NUP88 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for NUP88 Gene


Suggested Antigen Peptide Sequences for NUP88 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUP88: view

No data available for UniProtKB/Swiss-Prot for NUP88 Gene

Function for NUP88 Gene

Molecular function for NUP88 Gene

UniProtKB/Swiss-Prot Function:
Essential component of nuclear pore complex.
GENATLAS Biochemistry:
CAN/NUP214 interacting protein 88

Phenotypes From GWAS Catalog for NUP88 Gene

Gene Ontology (GO) - Molecular Function for NUP88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9049309
GO:0005515 protein binding IEA --
GO:0017056 structural constituent of nuclear pore IEA --
genes like me logo Genes that share ontologies with NUP88: view
genes like me logo Genes that share phenotypes with NUP88: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP88

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUP88 Gene

Localization for NUP88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP88 Gene

Nucleus, nuclear pore complex.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP88 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUP88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IDA 23777819
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUP88: view

Pathways & Interactions for NUP88 Gene

SuperPathways for NUP88 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP88: view

Pathways by source for NUP88 Gene

1 Cell Signaling Technology pathway for NUP88 Gene

Gene Ontology (GO) - Biological Process for NUP88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IBA --
GO:0000056 ribosomal small subunit export from nucleus IEA,IBA --
GO:0000278 mitotic cell cycle IEA --
GO:0006110 regulation of glycolytic process TAS --
GO:0006406 mRNA export from nucleus TAS,IBA --
genes like me logo Genes that share ontologies with NUP88: view

No data available for SIGNOR curated interactions for NUP88 Gene

Drugs & Compounds for NUP88 Gene

(1) Additional Compounds for NUP88 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUP88: view

Transcripts for NUP88 Gene

mRNA/cDNA for NUP88 Gene

Unigene Clusters for NUP88 Gene

Nucleoporin 88kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP88

Alternative Splicing Database (ASD) splice patterns (SP) for NUP88 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - -
SP3: - -
SP4: -
SP6: - - - -
SP8: -

Relevant External Links for NUP88 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP88 Gene

Protein differential expression in normal tissues from HIPED for NUP88 Gene

This gene is overexpressed in Lymph node (10.5), Peripheral blood mononuclear cells (8.2), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUP88 Gene

Protein tissue co-expression partners for NUP88 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP88 Gene:


SOURCE GeneReport for Unigene cluster for NUP88 Gene:


mRNA Expression by UniProt/SwissProt for NUP88 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for NUP88 Gene

  • Liver(4.3)
  • Lung(4.3)
  • Nervous system(4.3)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with NUP88: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP88 Gene

Orthologs for NUP88 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP88 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUP88 34 33
  • 99.46 (n)
(Bos Taurus)
Mammalia NUP88 34 33
  • 90.1 (n)
(Mus musculus)
Mammalia Nup88 16 34 33
  • 87.07 (n)
(Rattus norvegicus)
Mammalia Nup88 33
  • 86.22 (n)
(Canis familiaris)
Mammalia NUP88 34 33
  • 82.09 (n)
(Ornithorhynchus anatinus)
Mammalia NUP88 34
  • 71 (a)
(Gallus gallus)
Aves NUP88 34 33
  • 72.77 (n)
(Anolis carolinensis)
Reptilia NUP88 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nup88 33
  • 65.66 (n)
Str.10700 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24356 33
(Danio rerio)
Actinopterygii nup88 34 33
  • 63.44 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001179 33
  • 43.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta mbo 34 35 33
  • 41.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for NUP88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP88 Gene

Gene Tree for NUP88 (if available)
Gene Tree for NUP88 (if available)
Evolutionary constrained regions (ECRs) for NUP88: view image

Paralogs for NUP88 Gene

(14) SIMAP similar genes for NUP88 Gene using alignment to 5 proteins:

  • I3L245_HUMAN
  • I3L2W3_HUMAN
  • I3L4K7_HUMAN
genes like me logo Genes that share paralogs with NUP88: view

No data available for Paralogs for NUP88 Gene

Variants for NUP88 Gene

Sequence variations from dbSNP and Humsavar for NUP88 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000002315 -- 5,390,875(-) T/C intron_variant
rs1000036659 -- 5,393,683(-) A/G intron_variant
rs1000044100 -- 5,388,483(-) T/C intron_variant
rs1000112313 -- 5,396,308(-) C/T intron_variant
rs1000189693 -- 5,397,605(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUP88 Gene

Variant ID Type Subtype PubMed ID
esv3582500 CNV loss 25503493
nsv574273 CNV gain 21841781
nsv819032 CNV loss 19587683
nsv819549 CNV loss 19587683

Variation tolerance for NUP88 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUP88 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP88 Gene

Disorders for NUP88 Gene

Additional Disease Information for NUP88

No disorders were found for NUP88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP88 Gene

Publications for NUP88 Gene

  1. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88. (PMID: 9049309) Fornerod M … Grosveld G (The EMBO journal 1997) 2 3 4 58
  2. Nuclear pore complex component MOS7/Nup88 is required for innate immunity and nuclear accumulation of defense regulators in Arabidopsis. (PMID: 19700630) Cheng YT … Li X (The Plant cell 2009) 3 22 58
  3. Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus. (PMID: 18606815) Andres-Hernando A … Berl T (The Journal of biological chemistry 2008) 3 22 58
  4. Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes. (PMID: 18068677) Kodiha M … Stochaj U (Biochimica et biophysica acta 2008) 3 22 58
  5. Effects of gambogic acid on the regulation of nucleoporin Nup88 in U937 cells. (PMID: 17828493) Shu W … Cui G (Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2007) 3 22 58

Products for NUP88 Gene

Sources for NUP88 Gene

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