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Aliases for NUP35 Gene

Aliases for NUP35 Gene

  • Nucleoporin 35 2 3 5
  • Mitotic Phosphoprotein 44 2 3 4
  • Nuclear Pore Complex Protein Nup53 3 4
  • Nucleoporin NUP53 3 4
  • Nucleoporin 35kDa 2 3
  • MP-44 3 4
  • NUP53 3 4
  • MP44 3 4
  • 35 KDa Nucleoporin 4
  • Nucleoporin NUP35 3
  • NP44 3

External Ids for NUP35 Gene

Previous GeneCards Identifiers for NUP35 Gene

  • GC02P184192
  • GC02P183814
  • GC02P183697
  • GC02P183982
  • GC02P175847

Summaries for NUP35 Gene

Entrez Gene Summary for NUP35 Gene

  • This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]

GeneCards Summary for NUP35 Gene

NUP35 (Nucleoporin 35) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Transport of the SLBP independent Mature mRNA.

UniProtKB/Swiss-Prot for NUP35 Gene

  • Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.

Gene Wiki entry for NUP35 Gene

Additional gene information for NUP35 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP35 Gene

Genomics for NUP35 Gene

GeneHancer (GH) Regulatory Elements for NUP35 Gene

Promoters and enhancers for NUP35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J183123 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 663.7 +7.5 7505 3.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 NUP35 DUSP19 LOC105373774 GC02P183146
GH02J183117 Promoter 0.7 EPDnew 650.7 +0.0 5 0.1 FOXA2 CREB1 ATF2 NUP35 GC02P183146
GH02J183034 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 34.7 -80.3 -80322 4.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A IRF4 YY1 POLR2B ZNF766 ZNF143 NCKAP1 NUP35 DNAJC10 FRZB ENSG00000202141 GC02M183023
GH02J183078 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 -38.5 -38465 2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 FOS DUSP19 NCKAP1 NUP35 ENSG00000224643 FRZB
GH02J182714 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -400.8 -400822 3.9 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B DNAJC10 NCKAP1 NUP35 PDE1A FRZB GC02P182762
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUP35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUP35 gene promoter:
  • SRY
  • FOXL1
  • AML1a
  • oct-B2
  • Oct-B1
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)

Genomic Locations for NUP35 Gene

Genomic Locations for NUP35 Gene
chr2:183,117,490-183,161,684
(GRCh38/hg38)
Size:
44,195 bases
Orientation:
Plus strand
chr2:183,982,241-184,026,408
(GRCh37/hg19)
Size:
44,168 bases
Orientation:
Plus strand

Genomic View for NUP35 Gene

Genes around NUP35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP35 Gene

Proteins for NUP35 Gene

  • Protein details for NUP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFH5-NUP35_HUMAN
    Recommended name:
    Nucleoporin NUP35
    Protein Accession:
    Q8NFH5
    Secondary Accessions:
    • B4DP57
    • B4DYB4
    • Q4ZFZ9
    • Q53S95
    • Q8TDJ1

    Protein attributes for NUP35 Gene

    Size:
    326 amino acids
    Molecular mass:
    34774 Da
    Quaternary structure:
    • Interacts with TMEM48/NDC1. Forms a complex with NUP93, NUP155, NUP205 and lamin B; the interaction with NUP93 is direct.

    Three dimensional structures from OCA and Proteopedia for NUP35 Gene

    Alternative splice isoforms for NUP35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP35 Gene

Post-translational modifications for NUP35 Gene

  • Ubiquitination at isoforms=2, 3294 and isoforms=2, 3269
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUP35 Gene

Domains & Families for NUP35 Gene

Gene Families for NUP35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for NUP35 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFH5

UniProtKB/Swiss-Prot:

NUP35_HUMAN :
  • Belongs to the Nup35 family.
Family:
  • Belongs to the Nup35 family.
genes like me logo Genes that share domains with NUP35: view

Function for NUP35 Gene

Molecular function for NUP35 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC.

Gene Ontology (GO) - Molecular Function for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0005543 phospholipid binding IBA --
genes like me logo Genes that share ontologies with NUP35: view
genes like me logo Genes that share phenotypes with NUP35: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP35

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP35 Gene

Localization for NUP35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP35 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein. Note=Tightly associated with the nuclear membrane and lamina. {ECO:0000269 PubMed:15703211}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP35 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0005652 nuclear lamina IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NUP35: view

Pathways & Interactions for NUP35 Gene

SuperPathways for NUP35 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP35: view

Pathways by source for NUP35 Gene

Gene Ontology (GO) - Biological Process for NUP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006607 NLS-bearing protein import into nucleus IBA --
genes like me logo Genes that share ontologies with NUP35: view

No data available for SIGNOR curated interactions for NUP35 Gene

Drugs & Compounds for NUP35 Gene

No Compound Related Data Available

Transcripts for NUP35 Gene

Unigene Clusters for NUP35 Gene

Nucleoporin 35kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP35

Alternative Splicing Database (ASD) splice patterns (SP) for NUP35 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - -
SP6: -
SP7:

Relevant External Links for NUP35 Gene

GeneLoc Exon Structure for
NUP35
ECgene alternative splicing isoforms for
NUP35

Expression for NUP35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUP35 Gene

This gene is overexpressed in Testis (10.4), Peripheral blood mononuclear cells (9.8), and Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUP35 Gene



Protein tissue co-expression partners for NUP35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP35 Gene:

NUP35

SOURCE GeneReport for Unigene cluster for NUP35 Gene:

Hs.180591

Evidence on tissue expression from TISSUES for NUP35 Gene

  • Skin(4.2)
  • Bone marrow(4.1)
  • Liver(4.1)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with NUP35: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP35 Gene

Orthologs for NUP35 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP35 34 33
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUP35 34 33
  • 94.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm4353 34
  • 93 (a)
OneToMany
Nup35 16 34 33
  • 88.31 (n)
cow
(Bos Taurus)
Mammalia NUP35 34 33
  • 92.84 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUP35 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup35 33
  • 89.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
chicken
(Gallus gallus)
Aves NUP35 34 33
  • 77.06 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP35 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup35 33
  • 74.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64281 33
zebrafish
(Danio rerio)
Actinopterygii nup35 34 33
  • 70.43 (n)
OneToOne
wufj68d11 33
fruit fly
(Drosophila melanogaster)
Insecta CG6540 34 33
  • 40.37 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008619 33
  • 39.96 (n)
worm
(Caenorhabditis elegans)
Secernentea npp-19 34
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10509 34
  • 42 (a)
OneToOne
Species where no ortholog for NUP35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP35 Gene

ENSEMBL:
Gene Tree for NUP35 (if available)
TreeFam:
Gene Tree for NUP35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUP35: view image

Paralogs for NUP35 Gene

Pseudogenes.org Pseudogenes for NUP35 Gene

genes like me logo Genes that share paralogs with NUP35: view

No data available for Paralogs for NUP35 Gene

Variants for NUP35 Gene

Sequence variations from dbSNP and Humsavar for NUP35 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000016510 -- 183,157,917(+) C/A intron_variant
rs1000028737 -- 183,118,935(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000122871 -- 183,152,690(+) A/G intron_variant
rs1000244981 -- 183,117,537(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000275859 -- 183,146,721(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUP35 Gene

Variant ID Type Subtype PubMed ID
esv2668397 CNV deletion 23128226
esv26746 CNV loss 19812545
esv2763287 CNV gain+loss 21179565
esv3593580 CNV gain 21293372
esv3593582 CNV loss 21293372
esv3593583 CNV loss 21293372
esv3893517 CNV gain+loss 25118596
nsv1009882 CNV gain 25217958
nsv1109318 CNV deletion 24896259
nsv1138873 CNV deletion 24896259

Variation tolerance for NUP35 Gene

Residual Variation Intolerance Score: 30.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUP35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP35

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP35 Gene

Disorders for NUP35 Gene

Additional Disease Information for NUP35

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUP35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP35 Gene

Publications for NUP35 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. (PMID: 16600873) Mansfeld J … Antonin W (Molecular cell 2006) 3 4 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PMID: 15703211) Hawryluk-Gara LA … Wozniak RW (Molecular biology of the cell 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for NUP35 Gene

Sources for NUP35 Gene

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