Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUP210L Gene

Aliases for NUP210L Gene

  • Nucleoporin 210 Like 2 3 5
  • Nuclear Pore Membrane Glycoprotein 210-Like 3 4
  • Nucleoporin Nup210-Like 3 4
  • Nucleoporin 210kDa Like 2 3
  • Nuclear Pore Membrane Glycoprotein 210-Like (LOC91181) 3
  • Nucleoporin 210 KDa-Like 4

External Ids for NUP210L Gene

Previous GeneCards Identifiers for NUP210L Gene

  • GC01M150780
  • GC01M152231
  • GC01M153965
  • GC01M125327

Summaries for NUP210L Gene

GeneCards Summary for NUP210L Gene

NUP210L (Nucleoporin 210 Like) is a Protein Coding gene. Among its related pathways are RNA transport. An important paralog of this gene is NUP210.

Additional gene information for NUP210L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP210L Gene

Genomics for NUP210L Gene

GeneHancer (GH) Regulatory Elements for NUP210L Gene

Promoters and enhancers for NUP210L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J154154 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 624.7 -1.9 -1851 6 ZFX CC2D1A CBFA2T2 ZNF148 MLLT1 GTF2F1 ZSCAN21 BACH1 TRIM24 CREM NUP210L CREB3L4 CHTOP CRTC2 SHC1 UBAP2L INTS3 RPS27 SLC27A3 ENSG00000238279
GH01J154153 Enhancer 0.5 ENCODE 600.7 +1.3 1296 0.2 PRDM1 CEBPB ZBTB17 ZNF335 ADNP CEBPG NUP210L MIR5698
GH01J153955 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.4 +196.8 196816 5.1 SP1 CC2D1A ZFX ELF3 SIX5 ZNF148 NKRF ZNF121 ZNF687 ZSCAN21 CRTC2 NUP210L UBAP2L CREB3L4 SLC27A3 ILF2 INTS3 SLC39A1 RPS27 ENSG00000272030
GH01J154177 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.3 -25.8 -25764 6.8 HDGF SP1 ZFX ELF3 MNT ZNF148 NKRF POLR2A ZNF121 CEBPG TPM3 PYGO2 UBAP2L ENSG00000272654 LOC101928120 NUP210L C1orf189 SNORA58B HAX1 ATP8B2
GH01J154324 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.1 -172.5 -172485 6.8 ZNF652 SP1 CC2D1A ZFX CTCF ZNF148 NKRF ZNF121 GTF2F1 ZNF687 ATP8B2 UBAP2L CLK2 CHTOP LOC101928120 CRTC2 ILF2 INTS3 FLAD1 PYGO2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUP210L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUP210L gene promoter:
  • AhR
  • AML1a
  • Arnt
  • ATF6
  • CUTL1
  • GATA-1
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)

Genomic Locations for NUP210L Gene

Genomic Locations for NUP210L Gene
chr1:153,992,685-154,155,116
(GRCh38/hg38)
Size:
162,432 bases
Orientation:
Minus strand
chr1:153,965,161-154,127,592
(GRCh37/hg19)
Size:
162,432 bases
Orientation:
Minus strand

Genomic View for NUP210L Gene

Genes around NUP210L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP210L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP210L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP210L Gene

Proteins for NUP210L Gene

  • Protein details for NUP210L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VU65-P210L_HUMAN
    Recommended name:
    Nuclear pore membrane glycoprotein 210-like
    Protein Accession:
    Q5VU65
    Secondary Accessions:
    • E7EP56
    • Q5T4L7
    • Q6ZRN1
    • Q6ZRT4
    • Q6ZU81
    • Q8NDI6
    • Q9UF31

    Protein attributes for NUP210L Gene

    Size:
    1888 amino acids
    Molecular mass:
    210605 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86345.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC87279.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB63757.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP210L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP210L Gene

Post-translational modifications for NUP210L Gene

  • Glycosylation at posLast=812812, isoforms=2304, posLast=18591859, isoforms=2931, posLast=495495, isoforms=2348, posLast=14451445, isoforms=284, and posLast=522522
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUP210L Gene

Domains & Families for NUP210L Gene

Gene Families for NUP210L Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Protein Domains for NUP210L Gene

Suggested Antigen Peptide Sequences for NUP210L Gene

GenScript: Design optimal peptide antigens:
  • Nucleoporin Nup210-like (P210L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VU65

UniProtKB/Swiss-Prot:

P210L_HUMAN :
  • Belongs to the NUP210 family.
Family:
  • Belongs to the NUP210 family.
genes like me logo Genes that share domains with NUP210L: view

Function for NUP210L Gene

Phenotypes From GWAS Catalog for NUP210L Gene

genes like me logo Genes that share phenotypes with NUP210L: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NUP210L - Now 50% OFF >
  • * NUP210L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NUP210L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUP210L Gene

Localization for NUP210L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP210L Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP210L gene
Compartment Confidence
nucleus 3
plasma membrane 2
lysosome 1
extracellular 0
mitochondrion 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUP210L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NUP210L: view

Pathways & Interactions for NUP210L Gene

PathCards logo

SuperPathways for NUP210L Gene

SuperPathway Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with NUP210L: view

Pathways by source for NUP210L Gene

1 KEGG pathway for NUP210L Gene

Interacting Proteins for NUP210L Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 15)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357547%0d9606.ENSP00000254508%0d9606.ENSP00000253792%0d9606.ENSP00000252999%0d9606.ENSP00000324532%0d9606.ENSP00000262265%0d
Selected Interacting proteins: ENSP00000357547 Q5VU65-P210L_HUMAN for NUP210L Gene via STRING IID

Gene Ontology (GO) - Biological Process for NUP210L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
GO:0060009 Sertoli cell development IEA --
genes like me logo Genes that share ontologies with NUP210L: view

No data available for SIGNOR curated interactions for NUP210L Gene

Drugs & Compounds for NUP210L Gene

No Compound Related Data Available

Transcripts for NUP210L Gene

mRNA/cDNA for NUP210L Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1845) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NUP210L Gene

Nucleoporin 210kDa-like:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NUP210L - Now 50% OFF >
  • * NUP210L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NUP210L tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NUP210L Gene

No ASD Table

Relevant External Links for NUP210L Gene

GeneLoc Exon Structure for
NUP210L
ECgene alternative splicing isoforms for
NUP210L

Expression for NUP210L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP210L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP210L Gene

This gene is overexpressed in Testis (x37.6).

Protein differential expression in normal tissues from HIPED for NUP210L Gene

This gene is overexpressed in Ovary (40.4) and Testis (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUP210L Gene



Protein tissue co-expression partners for NUP210L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP210L Gene:

NUP210L

SOURCE GeneReport for Unigene cluster for NUP210L Gene:

Hs.67639

Evidence on tissue expression from TISSUES for NUP210L Gene

  • Blood(2.8)
  • Lymph node(2.7)
  • Adrenal gland(2.6)
  • Intestine(2.6)
  • Lung(2.6)
  • Spleen(2.6)
  • Thyroid gland(2.6)
  • Bone marrow(2.5)
  • Eye(2.5)
  • Kidney(2.4)
  • Pancreas(2.4)
  • Skin(2.4)
  • Heart(2.3)
  • Liver(2.3)
  • Nervous system(2.3)
  • Muscle(2)
genes like me logo Genes that share expression patterns with NUP210L: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP210L Gene

Orthologs for NUP210L Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP210L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP210L 35 34
  • 99.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUP210L 35 34
  • 89.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUP210L 35 34
  • 89.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nup210l 17 35 34
  • 83.43 (n)
rat
(Rattus norvegicus)
Mammalia Nup210l 34
  • 83.07 (n)
oppossum
(Monodelphis domestica)
Mammalia NUP210L 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
chicken
(Gallus gallus)
Aves NUP210L 35 34
  • 64.47 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP210L 35
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gp210 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npp-12 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for NUP210L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NUP210L Gene

ENSEMBL:
Gene Tree for NUP210L (if available)
TreeFam:
Gene Tree for NUP210L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUP210L: view image

Paralogs for NUP210L Gene

Paralogs for NUP210L Gene

(1) SIMAP similar genes for NUP210L Gene using alignment to 1 proteins:

  • P210L_HUMAN
genes like me logo Genes that share paralogs with NUP210L: view

Variants for NUP210L Gene

Sequence variations from dbSNP and Humsavar for NUP210L Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000040094 -- 154,090,028(-) G/A intron_variant
rs1000079794 -- 154,141,909(-) C/A/T intron_variant
rs1000102785 -- 154,108,145(-) G/C intron_variant
rs1000112073 -- 154,010,705(-) T/C intron_variant
rs1000116325 -- 154,003,328(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUP210L Gene

Variant ID Type Subtype PubMed ID
esv2063006 CNV deletion 18987734
esv2586978 CNV deletion 19546169
esv2648729 CNV loss 19546169
esv2660112 CNV deletion 23128226
esv2718306 CNV deletion 23290073
esv3310079 CNV mobile element insertion 20981092
esv3383476 CNV insertion 20981092
esv3417021 CNV insertion 20981092
esv3578197 CNV loss 25503493
esv3587597 CNV loss 21293372
esv3587598 CNV loss 21293372
nsv1000153 CNV gain 25217958
nsv520398 CNV gain+loss 19592680
nsv946401 CNV duplication 23825009

Variation tolerance for NUP210L Gene

Residual Variation Intolerance Score: 3.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.46; 92.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUP210L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP210L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP210L Gene

Disorders for NUP210L Gene

Additional Disease Information for NUP210L

No disorders were found for NUP210L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP210L Gene

Publications for NUP210L Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for NUP210L Gene

Sources for NUP210L Gene

Content
Loading form....