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Aliases for NUP210 Gene

Aliases for NUP210 Gene

  • Nucleoporin 210 2 3 5
  • Nuclear Envelope Pore Membrane Protein POM 210 3 4
  • Nuclear Pore Membrane Glycoprotein 210 3 4
  • Pore Membrane Protein Of 210 KDa 3 4
  • Nuclear Pore Protein Gp210 3 4
  • Nucleoporin Nup210 3 4
  • Nucleoporin 210kDa 2 3
  • POM210 3 4
  • KIAA0906 4
  • GP210 3

External Ids for NUP210 Gene

Previous GeneCards Identifiers for NUP210 Gene

  • GC03U990118
  • GC03M013297
  • GC03M013332
  • GC03M013420
  • GC03M013548
  • GC03M013607
  • GC03M013634
  • GC03M014743
  • GC03M013756
  • GC03M013880
  • GC03M013994
  • GC03M014114
  • GC03M014241
  • GC03M014362
  • GC03M014483
  • GC03M014612

Summaries for NUP210 Gene

Entrez Gene Summary for NUP210 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]

GeneCards Summary for NUP210 Gene

NUP210 (Nucleoporin 210) is a Protein Coding gene. Diseases associated with NUP210 include Autoimmune Disease Of Urogenital Tract and Primary Biliary Cirrhosis. Among its related pathways are Interferon gamma signaling and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein dimerization activity. An important paralog of this gene is NUP210L.

UniProtKB/Swiss-Prot for NUP210 Gene

  • Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

Additional gene information for NUP210 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP210 Gene

Genomics for NUP210 Gene

GeneHancer (GH) Regulatory Elements for NUP210 Gene

Promoters and enhancers for NUP210 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J013412 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 612.5 +2.7 2651 10 ZNF652 ZFX SP1 ELF3 ZKSCAN8 CBFA2T2 ZNF148 NKRF MLLT1 ZNF121 NUP210 IQSEC1 GC03M014974
GH03J013351 Enhancer 1.3 Ensembl ENCODE dbSUPER 20.6 +67.1 67148 2.4 CTCF ZNF148 MLLT1 GTF2F1 BACH1 TRIM24 ZNF639 EGR1 SMARCA4 MTA1 NUP210 HDAC11-AS1 HDAC11 IQSEC1 GC03M014974
GH03J013331 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.9 +87.8 87821 2.6 SP1 NKRF ZNF687 IKZF1 BACH1 IKZF2 RELA ZIC2 TRIM22 PKNOX1 NUP210 IQSEC1 GC03M014974
GH03J013450 Enhancer 1.6 FANTOM5 ENCODE dbSUPER 8.9 -31.7 -31659 2.1 SP1 ELF3 CTCF MNT NKRF POLR2A MLLT1 ZNF121 GTF2F1 CSDE1 XPC TMEM43 RPL32 ENSG00000228242 NUP210 GC03P013444 ENSG00000238138 GC03M014974
GH03J013254 Enhancer 0.9 Ensembl 15.2 +165.8 165822 0.6 CEBPG RERE TFE3 SP1 SP5 ZNF644 RXRA SOX13 CEBPA GATAD2A NUP210 IQSEC1 GC03P013212 GC03P013098
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUP210 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUP210 gene promoter:
  • AREB6
  • E47
  • GATA-1
  • HEN1
  • HSF1 (long)
  • HSF1short
  • Lmo2
  • Nkx5-1
  • RP58

Genomic Locations for NUP210 Gene

Genomic Locations for NUP210 Gene
chr3:13,316,230-13,420,322
(GRCh38/hg38)
Size:
104,093 bases
Orientation:
Minus strand
chr3:13,357,737-13,461,809
(GRCh37/hg19)
Size:
104,073 bases
Orientation:
Minus strand

Genomic View for NUP210 Gene

Genes around NUP210 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP210 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP210 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP210 Gene

Proteins for NUP210 Gene

  • Protein details for NUP210 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEM1-PO210_HUMAN
    Recommended name:
    Nuclear pore membrane glycoprotein 210
    Protein Accession:
    Q8TEM1
    Secondary Accessions:
    • A6NN56
    • O94980
    • Q6NXG6
    • Q8NBJ1
    • Q9H6C8
    • Q9UFP3

    Protein attributes for NUP210 Gene

    Size:
    1887 amino acids
    Molecular mass:
    205111 Da
    Quaternary structure:
    • Forms dimers and possibly higher-order oligomers.
    Miscellaneous:
    • Recognized by antinuclear autoantibodies in primary biliary cirrhosis.
    • Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions.
    SequenceCaution:
    • Sequence=BAB15332.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11688.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP210 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP210 Gene

Post-translational modifications for NUP210 Gene

  • N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity).
  • Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase.
  • Glycosylation at posLast=10391039, isoforms=1116, posLast=11351135, isoforms=1362, isoforms=2484, isoforms=2681, isoforms=2337, isoforms=2405, posLast=801801, isoforms=1441, posLast=926926, and isoforms=244
  • Ubiquitination at posLast=12581258, isoforms=2212, isoforms=1063, posLast=10201020, posLast=15761576, posLast=3232, isoforms=2774, posLast=228228, posLast=17241724, posLast=201201, and isoforms=279
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • PO210_HUMAN (1579)

No data available for DME Specific Peptides for NUP210 Gene

Domains & Families for NUP210 Gene

Gene Families for NUP210 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for NUP210 Gene

Suggested Antigen Peptide Sequences for NUP210 Gene

GenScript: Design optimal peptide antigens:
  • Pore membrane protein of 210 kDa (PO210_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TEM1

UniProtKB/Swiss-Prot:

PO210_HUMAN :
  • Belongs to the NUP210 family.
Family:
  • Belongs to the NUP210 family.
genes like me logo Genes that share domains with NUP210: view

Function for NUP210 Gene

Molecular function for NUP210 Gene

UniProtKB/Swiss-Prot Function:
Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.

Phenotypes From GWAS Catalog for NUP210 Gene

Gene Ontology (GO) - Molecular Function for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with NUP210: view
genes like me logo Genes that share phenotypes with NUP210: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NUP210 - Now 50% OFF >
  • * NUP210 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NUP210 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP210 Gene

Localization for NUP210 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP210 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP210 gene
Compartment Confidence
nucleus 4
plasma membrane 3
endoplasmic reticulum 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS,IEA --
GO:0005643 nuclear pore IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with NUP210: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NUP210 Gene

Pathways & Interactions for NUP210 Gene

PathCards logo

SuperPathways for NUP210 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP210: view

Pathways by source for NUP210 Gene

Gene Ontology (GO) - Biological Process for NUP210 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0015031 protein transport IEA --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with NUP210: view

No data available for SIGNOR curated interactions for NUP210 Gene

Drugs & Compounds for NUP210 Gene

No Compound Related Data Available

Transcripts for NUP210 Gene

mRNA/cDNA for NUP210 Gene

Unigene Clusters for NUP210 Gene

Nucleoporin 210kDa:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NUP210 - Now 50% OFF >
  • * NUP210 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NUP210 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NUP210 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - - -
SP2:
SP3:
SP4:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for NUP210 Gene

GeneLoc Exon Structure for
NUP210
ECgene alternative splicing isoforms for
NUP210

Expression for NUP210 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP210 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUP210 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for NUP210 Gene

This gene is overexpressed in Nasal epithelium (24.5), Peripheral blood mononuclear cells (9.4), and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUP210 Gene



Protein tissue co-expression partners for NUP210 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUP210 Gene:

NUP210

SOURCE GeneReport for Unigene cluster for NUP210 Gene:

Hs.475525

mRNA Expression by UniProt/SwissProt for NUP210 Gene:

Q8TEM1-PO210_HUMAN
Tissue specificity: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for NUP210 Gene

  • Liver(4.6)
  • Nervous system(4.6)
  • Lung(4.3)
  • Spleen(4.2)
  • Intestine(2.8)
  • Eye(2)
genes like me logo Genes that share expression patterns with NUP210: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP210 Gene

Orthologs for NUP210 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP210 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP210 35 34
  • 99.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUP210 35 34
  • 86.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUP210 35 34
  • 84.38 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nup210 17 35 34
  • 83.15 (n)
rat
(Rattus norvegicus)
Mammalia Nup210 34
  • 82.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NUP210 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP210 35 34
  • 68.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP210 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup210 34
  • 64.62 (n)
zebrafish
(Danio rerio)
Actinopterygii nup210 35 34
  • 63.61 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gp210 35 34
  • 43.12 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006280 34
  • 42.61 (n)
worm
(Caenorhabditis elegans)
Secernentea npp-12 35 34
  • 40.08 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for NUP210 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP210 Gene

ENSEMBL:
Gene Tree for NUP210 (if available)
TreeFam:
Gene Tree for NUP210 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUP210: view image

Paralogs for NUP210 Gene

Paralogs for NUP210 Gene

(1) SIMAP similar genes for NUP210 Gene using alignment to 1 proteins:

  • PO210_HUMAN
genes like me logo Genes that share paralogs with NUP210: view

Variants for NUP210 Gene

Sequence variations from dbSNP and Humsavar for NUP210 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000046014 -- 13,387,690(-) T/C/G genic_upstream_transcript_variant, intron_variant
rs1000054 -- 13,390,641(-) G/A/C genic_upstream_transcript_variant, intron_variant
rs1000110635 -- 13,351,068(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000143795 -- 13,413,471(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000160024 -- 13,330,316(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUP210 Gene

Variant ID Type Subtype PubMed ID
esv2724941 CNV deletion 23290073
esv3366661 CNV insertion 20981092
esv3425589 CNV duplication 20981092
nsv3706 CNV insertion 18451855
nsv589740 CNV loss 21841781
nsv955315 CNV deletion 24416366

Variation tolerance for NUP210 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUP210 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP210
Human Gene Mutation Database (HGMD)
NUP210

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP210 Gene

Disorders for NUP210 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NUP210 Gene - From: HGMD, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUP210

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NUP210: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUP210 Gene

Publications for NUP210 Gene

  1. A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail. (PMID: 2184032) Greber UF … Gerace L (The EMBO journal 1990) 2 3 23 58
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 58
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 58

Products for NUP210 Gene

Sources for NUP210 Gene

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