Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUP133 Gene

Aliases for NUP133 Gene

  • Nucleoporin 133 2 3 5
  • 133 KDa Nucleoporin 3 4
  • Nucleoporin Nup133 3 4
  • Nucleoporin 133kDa 2 3
  • Nuclear Pore Complex Protein Nup133 3
  • Nucleoporin 133kD 3
  • HNUP133 3

External Ids for NUP133 Gene

Previous GeneCards Identifiers for NUP133 Gene

  • GC01M228024
  • GC01M225271
  • GC01M225976
  • GC01M226538
  • GC01M225883
  • GC01M227643
  • GC01M229580
  • GC01M200067

Summaries for NUP133 Gene

Entrez Gene Summary for NUP133 Gene

  • The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUP133 Gene

NUP133 (Nucleoporin 133) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Transport of the SLBP independent Mature mRNA.

UniProtKB/Swiss-Prot for NUP133 Gene

  • Involved in poly(A)+ RNA transport.

Gene Wiki entry for NUP133 Gene

Additional gene information for NUP133 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP133 Gene

Genomics for NUP133 Gene

GeneHancer (GH) Regulatory Elements for NUP133 Gene

Promoters and enhancers for NUP133 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J229507 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.1 -145 2.8 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B LOC101927478 NUP133 HMGN2P19 GC01M229537 RNU4-21P
GH01J228781 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 129.6 +725.3 725278 3.7 FEZF1 ZNF2 YY1 ZNF213 ZNF416 FOS KLF13 REST KAT8 MIER3 NUP133 CICP26 C1orf35 ENSG00000269890 HMGN2P19 HIST3H3 PRSS38 ABCB10 TAF5L URB2
GH01J229219 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 110.4 +286.4 286395 4.5 CLOCK YBX1 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF548 SP3 ZNF610 NUP133 ENSG00000269890 URB2 HMGN2P19 LOC105373158 HIST3H3 ENSG00000233920 ENSG00000226920 LOC100421842 HMGB1P26
GH01J229267 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 71 +237.7 237689 5.4 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 RAB4A LOC105373159 NUP133 URB2 ENSG00000269890 HIST3H3 CCSAP TAF5L TMEM78 ABCB10
GH01J230142 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 57.6 -637.2 -637171 5.8 HDGF PKNOX1 SMAD1 ARNT FEZF1 YY1 ZNF766 ZNF263 REST ZNF662 NUP133 URB2 LOC105373159 COG2 HMGN2P19 GC01P230113 GALNT2 GC01M230200
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUP133 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUP133 gene promoter:
  • C/EBPbeta
  • AML1a
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • TGIF
  • POU2F1a
  • POU2F1
  • Ik-1

Genomic Locations for NUP133 Gene

Genomic Locations for NUP133 Gene
68,082 bases
Minus strand
67,060 bases
Minus strand

Genomic View for NUP133 Gene

Genes around NUP133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP133 Gene

Proteins for NUP133 Gene

  • Protein details for NUP133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear pore complex protein Nup133
    Protein Accession:
    Secondary Accessions:
    • B2RAZ8
    • Q5T8N0
    • Q9H9W2
    • Q9NV71
    • Q9NVC4

    Protein attributes for NUP133 Gene

    1156 amino acids
    Molecular mass:
    128979 Da
    Quaternary structure:
    • Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.
    • Sequence=BAA91885.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP133 Gene

neXtProt entry for NUP133 Gene

Post-translational modifications for NUP133 Gene

  • Ubiquitination at Lys1110, isoforms=842, isoforms=787, isoforms=674, and Lys523
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP133 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP133 Gene

Domains & Families for NUP133 Gene

Gene Families for NUP133 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for NUP133 Gene

Suggested Antigen Peptide Sequences for NUP133 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleoporin Nup133 family.
  • Belongs to the nucleoporin Nup133 family.
genes like me logo Genes that share domains with NUP133: view

Function for NUP133 Gene

Molecular function for NUP133 Gene

UniProtKB/Swiss-Prot Function:
Involved in poly(A)+ RNA transport.

Phenotypes From GWAS Catalog for NUP133 Gene

Gene Ontology (GO) - Molecular Function for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11564755
GO:0017056 structural constituent of nuclear pore IDA 11684705
genes like me logo Genes that share ontologies with NUP133: view
genes like me logo Genes that share phenotypes with NUP133: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP133

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP133 Gene

Localization for NUP133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP133 Gene

Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). {ECO:0000269 PubMed:11564755, ECO:0000269 PubMed:11684705}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP133 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 colocalizes_with condensed chromosome kinetochore IDA,IEA 17098863
GO:0000940 colocalizes_with condensed chromosome outer kinetochore IDA 17363900
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope TAS --
genes like me logo Genes that share ontologies with NUP133: view

Pathways & Interactions for NUP133 Gene

SuperPathways for NUP133 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
3 Cell Cycle, Mitotic
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP133: view

Pathways by source for NUP133 Gene

Gene Ontology (GO) - Biological Process for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA --
GO:0006110 regulation of glycolytic process TAS --
GO:0006325 chromatin organization IBA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006405 RNA export from nucleus IBA --
genes like me logo Genes that share ontologies with NUP133: view

No data available for SIGNOR curated interactions for NUP133 Gene

Drugs & Compounds for NUP133 Gene

No Compound Related Data Available

Transcripts for NUP133 Gene

mRNA/cDNA for NUP133 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(303) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUP133 Gene

Nucleoporin 133kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP133

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP133 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
SP1: - - - - -
SP2: - - - - -
SP4: -
SP7: -

ExUns: 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: -
SP2: - - - -
SP5: -

Relevant External Links for NUP133 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUP133 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP133 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUP133 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.6) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUP133 Gene

Protein tissue co-expression partners for NUP133 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP133 Gene:


SOURCE GeneReport for Unigene cluster for NUP133 Gene:


Evidence on tissue expression from TISSUES for NUP133 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with NUP133: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP133 Gene

Orthologs for NUP133 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP133 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUP133 34 33
  • 99.48 (n)
(Canis familiaris)
Mammalia NUP133 34 33
  • 90.43 (n)
(Bos Taurus)
Mammalia NUP133 34 33
  • 89.07 (n)
(Monodelphis domestica)
Mammalia NUP133 34
  • 81 (a)
(Mus musculus)
Mammalia Nup133 16 34 33
  • 80.38 (n)
(Rattus norvegicus)
Mammalia Nup133 33
  • 78.48 (n)
(Ornithorhynchus anatinus)
Mammalia NUP133 34
  • 71 (a)
(Gallus gallus)
Aves NUP133 34 33
  • 74.32 (n)
(Anolis carolinensis)
Reptilia NUP133 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nup133 33
  • 66.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9485 33
(Danio rerio)
Actinopterygii nup133 34 33
  • 60.82 (n)
wufa04e09 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12743 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003503 33
  • 42.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nup133 34 33
  • 42.05 (n)
CG6958 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1223 34
  • 32 (a)
Species where no ortholog for NUP133 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP133 Gene

Gene Tree for NUP133 (if available)
Gene Tree for NUP133 (if available)
Evolutionary constrained regions (ECRs) for NUP133: view image

Paralogs for NUP133 Gene

No data available for Paralogs for NUP133 Gene

Variants for NUP133 Gene

Sequence variations from dbSNP and Humsavar for NUP133 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035854 A breast cancer sample p.Gly326Val
VAR_035855 A breast cancer sample p.Gly448Arg
rs483352747 uncertain-significance, not provided 229,441,943(-) C/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000047624 -- 229,453,454(-) T/A intron_variant
rs1000053350 -- 229,495,903(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NUP133 Gene

Variant ID Type Subtype PubMed ID
dgv299e59 CNV tandem duplication 20981092
esv3379471 CNV duplication 20981092

Variation tolerance for NUP133 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.98; 89.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUP133 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP133 Gene

Disorders for NUP133 Gene

Additional Disease Information for NUP133

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUP133 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP133 Gene

Publications for NUP133 Gene

  1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PMID: 11684705) Vasu S … Forbes DJ (The Journal of cell biology 2001) 2 3 4 22 58
  2. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. (PMID: 11564755) Belgareh N … Doye V (The Journal of cell biology 2001) 3 4 22 58
  3. Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome. (PMID: 26411495) Miyake N … Matsumoto N (American journal of human genetics 2015) 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element. (PMID: 19674973) Whittle JR … Schwartz TU (The Journal of biological chemistry 2009) 3 22 58

Products for NUP133 Gene

Sources for NUP133 Gene

Loading form....