Aliases for NUMB Gene
Aliases for NUMB Gene
External Ids for NUMB Gene
- HGNC: 8060
- Entrez Gene: 8650
- Ensembl: ENSG00000133961
- OMIM: 603728
- UniProtKB: P49757
Previous HGNC Symbols for NUMB Gene
- C14orf41
Previous GeneCards Identifiers for NUMB Gene
- GC14M071246
- GC14M067537
- GC14M071731
- GC14M072811
- GC14M073741
- GC14M053907
Summaries for NUMB Gene
-
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for NUMB Gene
NUMB (NUMB, Endocytic Adaptor Protein) is a Protein Coding gene. Diseases associated with NUMB include Melanoma, Uveal and Maxillary Sinus Adenoid Cystic Carcinoma. Among its related pathways are Notch signaling pathway (KEGG) and ERK Signaling. Gene Ontology (GO) annotations related to this gene include beta-catenin binding and alpha-catenin binding. An important paralog of this gene is NUMBL.
UniProtKB/Swiss-Prot for NUMB Gene
-
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Additional gene information for NUMB Gene
- Monarch Initiative
- Search for NUMB at DataMed
- Search for NUMB at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUMB Gene
Genomics for NUMB Gene
GeneHancer (GH) Regulatory Elements for NUMB Gene
Promoters and enhancers for NUMB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NUMB on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NUMB gene promoter:
-
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alphaA
- AP-2alpha isoform 3
Regulatory Element Products
Genomic Locations for NUMB Gene
Genomic Locations for NUMB Gene
- chr14:73,275,107-73,458,617
- (GRCh38/hg38)
- Size:
- 183,511 bases
- Orientation:
- Minus strand
- chr14:73,741,815-73,930,348
- (GRCh37/hg19)
- Size:
- 188,534 bases
- Orientation:
- Minus strand
Genomic View for NUMB Gene
Genes around NUMB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q24.2-q24.3 by Entrez Gene
- 14q24.3 by HGNC
- 14q24.3 by Ensembl
NUMB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NUMB Gene
Proteins for NUMB Gene
-
Protein details for NUMB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49757-NUMB_HUMAN
- Recommended name:
- Protein numb homolog
- Protein Accession:
- P49757
- B1P2N5
- B1P2N6
- B1P2N7
- B1P2N8
- B1P2N9
- B4E2B1
- Q6NUQ7
- Q86SY1
- Q8WW73
- Q9UBG1
- Q9UEQ4
- Q9UKE8
- Q9UKE9
- Q9UKF0
- Q9UQJ4
Protein attributes for NUMB Gene
- Size:
- 651 amino acids
- Molecular mass:
- 70804 Da
- Quaternary structure:
-
- Interacts with CDH1 and TFAP2B (By similarity). Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.
- SequenceCaution:
-
- Sequence=AAH20788.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
Protein Expression for NUMB Gene
Post-translational modifications for NUMB Gene
- Phosphorylated on Ser-276 and Ser-295 by CaMK1.
- Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for NUMB Gene
- ENSEMBL proteins:
-
- ENSP00000352563
- ENSP00000452416
- ENSP00000451513
- ENSP00000451117
- ENSP00000453209
- ENSP00000452357
- ENSP00000451559
- ENSP00000451959
- ENSP00000441258
- ENSP00000451625
- ENSP00000451326
- ENSP00000347169
- ENSP00000452888
- ENSP00000450817
- ENSP00000446001
- ENSP00000452069
- ENSP00000451300
- ENSP00000451374
- ENSP00000348644
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NUMB (Numb)
-
Custom Antibody ServicesOriGene Antibodies for NUMB
- AP05298PU-N
- AP05298SU-N
- AP52967PU-N
- CF501518
- CF501561
- CF501613
- CF501614
- CF502168
- CF802131
- CF802132
- CF802138
- CF802140
- CF802143
- CF802157
- CF802160
- CF802161
- CF802162
- CF802163
- CF802164
- CF802169
- CF802174
- CF802212
- CF802221
- CF802316
- TA302758
- TA319756
- TA336652
- TA350244
- TA501518
- TA501561
- TA501561S
- TA501613
- TA501614
- TA502168
- TA802131
- TA802132
- TA802138
- TA802140
- TA802143
- TA802157
- TA802160
- TA802161
- TA802162
- TA802163
- TA802164
- TA802169
- TA802174
- TA802212
- TA802221
- TA802316
- Novus Biologicals Antibodies for NUMB
-
Abcam antibodies for NUMB
- Invitrogen Antibodies for NUMB (AFLGC-NUMB)
- GeneTex NUMB Antibody for NUMB
-
Custom Antibody ServicesProSci Antibodies for NUMB
-
Santa Cruz Biotechnology (SCBT) Antibodies for NUMB
- Sino Biological Antibodies for NUMB
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for NUMB
- Origene Custom Protein Services for NUMB
- Search GeneTex for Proteins for NUMB
-
Abcam proteins for NUMB
Assay Products
- antibodies-online: Search results for 1 available NUMB Elisa Kits ranked by validation data
- Compare Top NUMB Elisa Kits
-
Recommended
-
Abcam assays for NUMB
No data available for DME Specific Peptides for NUMB Gene
Domains & Families for NUMB Gene
Gene Families for NUMB Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for NUMB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NUMB Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for NUMB Gene
Function for NUMB Gene
Molecular function for NUMB Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
- GENATLAS Biochemistry:
- Drosophila numb homolog,signal transducer Eps15 of yeast,nematode homolog
Phenotypes From GWAS Catalog for NUMB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9303539 |
| GO:0008013 | beta-catenin binding | IEA | -- |
| GO:0045294 | alpha-catenin binding | IEA | -- |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for NUMB Gene
- MGI mutant phenotypes for NUMB:
-
inferred from 4 alleles
- cardiovascular system phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- mortality/aging
- cellular phenotype
- reproductive system phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for NUMB:
-
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with Ras
- Decreased hepcidin::fluc mRNA expression
Animal Model Products
-
Taconic Biosciences Mouse Models for NUMB
- Cyagen custom Knockout/knockin (KOKI) mouse models for NUMB
-
CRISPR Products
-
OriGene CRISPR knockouts for NUMB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUMB
- genomics-online: gRNA clones - Search results for 132 available NUMB gene related products
- Overview of 132 available NUMB gene related products
-
Recommended
- Applied Biological Materials CRISPR for NUMB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUMB
- GenScript: Design CRISPR guide RNA sequences for NUMB
miRNA for NUMB Gene
- miRTarBase miRNAs that target NUMB
-
- hsa-mir-31-5p (MIRT004970)
- hsa-mir-335-5p (MIRT019211)
- hsa-mir-375 (MIRT020047)
- hsa-mir-29c-3p (MIRT020360)
- hsa-mir-103a-3p (MIRT027189)
- hsa-mir-146a-5p (MIRT054669)
- hsa-mir-1277-5p (MIRT071145)
- hsa-mir-4684-5p (MIRT547256)
- hsa-mir-107 (MIRT547257)
- hsa-mir-4738-3p (MIRT547258)
- hsa-mir-1184 (MIRT547259)
- hsa-mir-6074 (MIRT547260)
- hsa-mir-4496 (MIRT547261)
- hsa-mir-3163 (MIRT547262)
- hsa-mir-4703-5p (MIRT547263)
- hsa-mir-3942-5p (MIRT547264)
- hsa-mir-509-5p (MIRT547265)
- hsa-mir-4418 (MIRT547266)
- hsa-mir-509-3-5p (MIRT547267)
- hsa-mir-548av-3p (MIRT547268)
- hsa-let-7c-5p (MIRT731260)
- hsa-mir-34a-5p (MIRT731352)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUMB
- Browse OriGene Inhibitory RNA Products For NUMB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUMB
- genomics-online: shRNA clones - Search results for 132 available NUMB gene related products
- Overview of 132 available NUMB gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for NUMB
- RC209744
- RC209744L1
- RC209744L2
- RC209744L3
- RC209744L4
- RC216230
- RC216230L1
- RC216230L2
- RC216230L3
- RC216230L4
- RC220960
- RC220960L1
- RC220960L2
- RC220960L3
- RC220960L4
- RC221018
- RC221018L1
- RC221018L2
- RC221018L3
- RC221018L4
- RC520960
- RG209744
- RG216230
- RG220960
- RG221018
- RC209744L1V
- RC209744L2V
- RC209744L3V
- RC209744L4V
- RC216230L1V
- RC216230L2V
- RC216230L3V
- RC216230L4V
- RC220960L1V
- RC220960L2V
- RC220960L3V
- RC220960L4V
- RC221018L1V
- RC221018L2V
- RC221018L3V
- RC221018L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for NUMB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUMB
- genomics-online: cdna clones - Search results for 132 available NUMB gene related products
- Overview of 132 available NUMB gene related products
-
Recommended
- orf clones - Search results for 132 available NUMB gene related products
- Overview of 132 available NUMB gene related products
-
Recommended
- Applied Biological Materials Clones for NUMB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUMB Gene
Localization for NUMB Gene
Subcellular locations from UniProtKB/Swiss-Prot for NUMB Gene
- Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 4 |
| cytosol | 4 |
| endosome | 3 |
| cytoskeleton | 2 |
| lysosome | 1 |
- Cell Junctions (4)
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005769 | early endosome | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005925 | focal adhesion | HDA | 21423176 |
Pathways & Interactions for NUMB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Notch signaling pathway (KEGG) | ||
| 2 | Signaling by Hedgehog | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Signaling by NOTCH1 | ||
| 5 | Neuroscience | ||
Pathways by source for NUMB Gene
1 GeneTex pathway for NUMB Gene
4 BioSystems pathways for NUMB Gene
12 Reactome pathways for NUMB Gene
1 KEGG pathway for NUMB Gene
1 R&D Systems pathway for NUMB Gene
1 Qiagen pathway for NUMB Gene
2 Cell Signaling Technology pathways for NUMB Gene
Interacting Proteins for NUMB Gene
Selected Interacting proteins:
P49757-NUMB_HUMAN
ENSP00000347169
for NUMB Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NUMB
SIGNOR curated interactions for NUMB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007405 | neuroblast proliferation | IEA | -- |
| GO:0007409 | axonogenesis | IEA | -- |
| GO:0021670 | lateral ventricle development | ISS | -- |
Transcripts for NUMB Gene
mRNA/cDNA for NUMB Gene
- (5) REFSEQ mRNAs :
- (27) Additional mRNA sequences :
- (281) Selected AceView cDNA sequences:
- (28) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000554546 3607 bps (uc001xob.2)
- ENST00000356296 3453 bps (uc001xod.2)
- ENST00000557597 3547 bps (uc001xnz.2)
- ENST00000555238 3588 bps (uc001xny.2)
- ENST00000556772 5172 bps (uc032bfw.2)
Unigene Clusters for NUMB Gene
CRISPR Products
-
OriGene CRISPR knockouts for NUMB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUMB
- genomics-online: gRNA clones - Search results for 132 available NUMB gene related products
- Overview of 132 available NUMB gene related products
-
Recommended
- Applied Biological Materials CRISPR for NUMB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUMB
- GenScript: Design CRISPR guide RNA sequences for NUMB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUMB
- Browse OriGene Inhibitory RNA Products For NUMB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUMB
- genomics-online: shRNA clones - Search results for 132 available NUMB gene related products
- Overview of 132 available NUMB gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for NUMB
- RC209744
- RC209744L1
- RC209744L2
- RC209744L3
- RC209744L4
- RC216230
- RC216230L1
- RC216230L2
- RC216230L3
- RC216230L4
- RC220960
- RC220960L1
- RC220960L2
- RC220960L3
- RC220960L4
- RC221018
- RC221018L1
- RC221018L2
- RC221018L3
- RC221018L4
- RC520960
- RG209744
- RG216230
- RG220960
- RG221018
- RC209744L1V
- RC209744L2V
- RC209744L3V
- RC209744L4V
- RC216230L1V
- RC216230L2V
- RC216230L3V
- RC216230L4V
- RC220960L1V
- RC220960L2V
- RC220960L3V
- RC220960L4V
- RC221018L1V
- RC221018L2V
- RC221018L3V
- RC221018L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for NUMB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUMB
- genomics-online: cdna clones - Search results for 132 available NUMB gene related products
- Overview of 132 available NUMB gene related products
-
Recommended
- orf clones - Search results for 132 available NUMB gene related products
- Overview of 132 available NUMB gene related products
-
Recommended
- Applied Biological Materials Clones for NUMB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 14a | · | 14b | · | 14c | · | 14d | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | · | 17c | · | 17d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | ||||||||||||||
| SP14: | |||||||||||||||||||||
| SP15: | |||||||||||||||||||||
| SP16: |
Expression for NUMB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Intestine (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for NUMB Gene
This gene is overexpressed in Whole Blood (x6.1).
This gene is overexpressed in Monocytes (13.7), Peripheral blood mononuclear cells (12.4), and Lung (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUMB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NUMB Gene:
NUMBSOURCE GeneReport for Unigene cluster for NUMB Gene:
Hs.525443Evidence on tissue expression from TISSUES for NUMB Gene
- Nervous system(4.9)
- Liver(4.4)
- Lung(2.8)
- Intestine(2.2)
- Kidney(2.1)
- Muscle(2.1)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for NUMB
-
OriGene qPCR primer pairs and template standards for NUMB
- genomics-online: primer clones - Search results for 132 available NUMB gene related products
- Overview of 132 available NUMB gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUMB Gene
Orthologs for NUMB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NUMB 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NUMB 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NUMB 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | NUMB 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Numb 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Numb 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | NUMB 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NUMB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | numb 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | numb 34 33 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | numb 34 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | num-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.9113 34 |
|
OneToMany | |
| Cin.4612 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4612 33 |
|
- Species where no ortholog for NUMB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NUMB Gene
- ENSEMBL:
- Gene Tree for NUMB (if available)
- TreeFam:
- Gene Tree for NUMB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NUMB: view image
Paralogs for NUMB Gene
Variants for NUMB Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000007981 | -- | 73,374,886(-) | A/G | intron_variant | |
| rs1000008500 | -- | 73,323,018(-) | T/C | intron_variant | |
| rs1000041711 | -- | 73,369,043(-) | T/C | intron_variant | |
| rs1000062392 | -- | 73,278,153(-) | G/A | intron_variant | |
| rs1000092657 | -- | 73,413,147(-) | T/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1933n100 | CNV | gain | 25217958 |
| dgv1934n100 | CNV | loss | 25217958 |
| esv1057343 | CNV | insertion | 17803354 |
| esv2651254 | CNV | insertion | 19546169 |
| esv2659371 | CNV | deletion | 23128226 |
| esv2671759 | CNV | deletion | 23128226 |
| esv3551763 | CNV | deletion | 23714750 |
| esv3634902 | CNV | gain | 21293372 |
| esv3634903 | CNV | loss | 21293372 |
| esv3634905 | CNV | gain | 21293372 |
| esv3634906 | CNV | loss | 21293372 |
| esv3634907 | CNV | loss | 21293372 |
| esv3892561 | CNV | gain | 25118596 |
| nsv1035460 | CNV | gain | 25217958 |
| nsv1042100 | CNV | loss | 25217958 |
| nsv1113660 | CNV | deletion | 24896259 |
| nsv1125358 | OTHER | inversion | 24896259 |
| nsv477096 | CNV | novel sequence insertion | 20440878 |
| nsv513411 | CNV | insertion | 21212237 |
| nsv513412 | CNV | insertion | 21212237 |
| nsv826974 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
7.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.47;
43.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NUMB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUMB Gene
Disorders for NUMB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma, uveal |
|
|
| maxillary sinus adenoid cystic carcinoma |
|
|
| tactile agnosia |
|
|
| early-onset familial alzheimer disease |
|
|
| lymphoid interstitial pneumonia |
|
|
Search NUMB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NUMB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NUMB Gene
Publications for NUMB Gene
- Numb is an endocytic protein. (PMID: 11121447) Santolini E … Di Fiore PP (The Journal of cell biology 2000) 2 3 22 58
- Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. (PMID: 9303539) Salcini AE … Di Fiore PP (Genes & development 1997) 3 4 22 58
- Characterization and role of NUMB in the human extravillous trophopblast. (PMID: 21486681) Haider M … Gruslin A (Placenta 2011) 3 4 58
- Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PMID: 17903303) O'Donnell CJ … Demissie S (BMC medical genetics 2007) 3 44 58
- Impaired expression of Notch signaling genes in aged human skeletal muscle. (PMID: 17301032) Carey KA … Cameron-Smith D (The journals of gerontology. Series A, Biological sciences and medical sciences 2007) 3 22 58
Products for NUMB Gene
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Sources for NUMB Gene
- (1)