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The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] See more...
Aliases for NUMB Gene
Aliases for NUMB Gene
External Ids for NUMB Gene
- HGNC: 8060
- Entrez Gene: 8650
- Ensembl: ENSG00000133961
- OMIM: 603728
- UniProtKB: P49757
Previous HGNC Symbols for NUMB Gene
- C14orf41
Previous GeneCards Identifiers for NUMB Gene
- GC14M071246
- GC14M067537
- GC14M071731
- GC14M072811
- GC14M073741
- GC14M053907
Summaries for NUMB Gene
-
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for NUMB Gene
NUMB (NUMB Endocytic Adaptor Protein) is a Protein Coding gene. Diseases associated with NUMB include Melanoma, Uveal and Maxillary Sinus Adenoid Cystic Carcinoma. Among its related pathways are Neuroscience and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include beta-catenin binding and alpha-catenin binding. An important paralog of this gene is NUMBL.
UniProtKB/Swiss-Prot Summary for NUMB Gene
-
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Additional gene information for NUMB Gene
- HGNC(8060)
- Entrez Gene(8650)
- Ensembl(ENSG00000133961)
- OMIM(603728)
- UniProtKB(P49757)
- Open Targets Platform(ENSG00000133961)
- Monarch Initiative
- Search for NUMB at DataMed
- Search for NUMB at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUMB Gene
Genomics for NUMB Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NUMB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NUMB on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUMB
- Top Transcription factor binding sites by QIAGEN in the NUMB gene promoter:
-
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alphaA
Genomic Locations for NUMB Gene
Genomic Locations for NUMB Gene
- chr14:73,275,107-73,458,617
- (GRCh38/hg38)
- Size:
- 183,511 bases
- Orientation:
- Minus strand
- chr14:73,741,815-73,930,348
- (GRCh37/hg19)
- Size:
- 188,534 bases
- Orientation:
- Minus strand
Genomic View for NUMB Gene
Genes around NUMB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q24.3 by HGNC
- 14q24.2-q24.3 by Entrez Gene
- 14q24.3 by Ensembl
NUMB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NUMB Gene
Proteins for NUMB Gene
-
Protein details for NUMB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49757-NUMB_HUMAN
- Recommended name:
- Protein numb homolog
- Protein Accession:
- P49757
- B1P2N5
- B1P2N6
- B1P2N7
- B1P2N8
- B1P2N9
- B4E2B1
- Q6NUQ7
- Q86SY1
- Q8WW73
- Q9UBG1
- Q9UEQ4
- Q9UKE8
- Q9UKE9
- Q9UKF0
- Q9UQJ4
Protein attributes for NUMB Gene
- Size:
- 651 amino acids
- Molecular mass:
- 70804 Da
- Quaternary structure:
-
- Interacts with CDH1 and TFAP2B (By similarity). Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.
- SequenceCaution:
-
- Sequence=AAH20788.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
Protein Expression for NUMB Gene
Post-translational modifications for NUMB Gene
- Phosphorylated on Ser-276 and Ser-295 by CaMK1.
- Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
-
Ubiquitination at Lys286
- NX_P49757 (NX_P49757-1)
- Modification sites at PhosphoSitePlus
Other Protein References for NUMB Gene
- ENSEMBL proteins:
-
- ENSP00000452416
- ENSP00000348644
- ENSP00000451117
- ENSP00000451300
- ENSP00000451513
- ENSP00000451625
- ENSP00000452888
- ENSP00000453209
- ENSP00000452069
- ENSP00000450817
- ENSP00000451326
- ENSP00000452357
- ENSP00000451374
- ENSP00000451559
- ENSP00000451959
- ENSP00000441258
- ENSP00000352563
- ENSP00000347169
- ENSP00000446001
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences NUMB Antibody (LS-B4857) and NUMB Antibody (LS-B265)
- G Biosciences Immunotag™ NUMB Antibody
- NSJ Bioreagents NUMB Antibody
-
Custom Antibody ServicesOriGene Antibodies for NUMB
- AP05298PU-N
- AP05298SU-N
- AP52967PU-N
- CF501518
- CF501561
- CF501613
- CF501614
- CF502168
- CF802131
- CF802132
- CF802138
- CF802140
- CF802143
- CF802157
- CF802160
- CF802161
- CF802162
- CF802163
- CF802164
- CF802169
- CF802174
- CF802212
- CF802221
- CF802316
- TA302758
- TA319756
- TA336652
- TA350244
- TA501518
- TA501518S
- TA501561
- TA501561S
- TA501613
- TA501613S
- TA501614
- TA501614S
- TA502168
- TA502168S
- TA802131
- TA802131S
- TA802132
- TA802132S
- TA802138
- TA802138S
- TA802140
- TA802140S
- TA802143
- TA802143S
- TA802157
- TA802157S
- TA802160
- TA802160S
- TA802161
- TA802161S
- TA802162
- TA802162S
- TA802163
- TA802163S
- TA802164
- TA802164S
- TA802169
- TA802169S
- TA802174
- TA802174S
- TA802212
- TA802212S
- TA802221
- TA802221S
- TA802316
- TA802316S
- Novus Biologicals Antibodies for NUMB
-
Abcam antibodies for NUMB
- Invitrogen Antibodies for NUMB (AFLGC-Numb)
-
Custom Antibody ServicesProSci Antibodies for NUMB
-
Santa Cruz Biotechnology (SCBT) Antibodies for NUMB
- Sino Biological Antibodies for NUMB
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for NUMB
- Origene Custom Protein Services for NUMB
-
Signalway Proteins for NUMB
-
Abcam proteins for NUMB
Assay Products
- RayBiotech Custom Human Numb ELISA
- antibodies-online: Show 3 available NUMB Elisa Kits ranked by validation data
- Compare Top NUMB Elisa Kits
-
Quality Products:
-
Abcam assays for NUMB
No data available for DME Specific Peptides for NUMB Gene
Domains & Families for NUMB Gene
Gene Families for NUMB Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for NUMB Gene
- InterPro:
- Blocks:
-
- Phosphotyrosine interaction domain
- NUMB phenylalanine-rich
- ProtoNet:
Suggested Antigen Peptide Sequences for NUMB Gene
- GenScript: Design optimal peptide antigens:
-
- Numb isoform 6 (B1P2N6_HUMAN)
- Numb isoform 8 (B1P2N8_HUMAN)
- cDNA FLJ53981, highly similar to Homo sapiens numb homolog (NUMB), transcript variant 4, mRNA (B1P2N9_HUMAN)
- Protein S171 (NUMB_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NUMB Gene
Function for NUMB Gene
Molecular function for NUMB Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
- GENATLAS Biochemistry:
- Drosophila numb homolog,signal transducer Eps15 of yeast,nematode homolog
Phenotypes From GWAS Catalog for NUMB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 18172499 |
| GO:0008013 | beta-catenin binding | IEA | -- |
| GO:0045294 | alpha-catenin binding | IEA | -- |
| GO:0045296 | cadherin binding | IBA | 21873635 |
Phenotypes for NUMB Gene
- MGI mutant phenotypes for NUMB:
-
inferred from 4 alleles
- nervous system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for NUMB:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between BLM-/- and BLM+/+
- Synthetic lethal with Ras
- Decreased viability in ovarian lineage
Animal Model Products
-
Taconic Biosciences Mouse Models for NUMB
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NUMB - Select products 50% OFF >
- * NUMB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NUMB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUMB
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUMB
miRNA for NUMB Gene
- miRTarBase miRNAs that target NUMB
-
- hsa-miR-31-5p (MIRT004970)
- hsa-miR-335-5p (MIRT019211)
- hsa-miR-375 (MIRT020047)
- hsa-miR-29c-3p (MIRT020360)
- hsa-miR-103a-3p (MIRT027189)
- hsa-miR-146a-5p (MIRT054669)
- hsa-miR-1277-5p (MIRT071145)
- hsa-miR-4684-5p (MIRT547256)
- hsa-miR-107 (MIRT547257)
- hsa-miR-4738-3p (MIRT547258)
- hsa-miR-1184 (MIRT547259)
- hsa-miR-6074 (MIRT547260)
- hsa-miR-4496 (MIRT547261)
- hsa-miR-3163 (MIRT547262)
- hsa-miR-4703-5p (MIRT547263)
- hsa-miR-3942-5p (MIRT547264)
- hsa-miR-509-5p (MIRT547265)
- hsa-miR-4418 (MIRT547266)
- hsa-miR-509-3-5p (MIRT547267)
- hsa-miR-548av-3p (MIRT547268)
- hsa-let-7c-5p (MIRT731260)
- hsa-miR-34a-5p (MIRT731352)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUMB
- Browse OriGene Inhibitory RNA Products For NUMB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUMB
Clone Products
- Applied Biological Materials (abm): Clones for NUMB - Select products 50% OFF >
- * NUMB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MR225927L4
- MR230616
- MR230770
- RC209744
- RC209744L3
- RC209744L4
- RC216230
- RC216230L1
- RC216230L2
- RC216230L3
- RC216230L4
- RC220960
- RC220960L1
- RC220960L2
- RC220960L3
- RC220960L4
- RC221018
- RC221018L3
- RC221018L4
- RG209744
- RG216230
- RG220960
- RG221018
- RR207545
- RR207545L3
- RR207545L4
- MR209237L3V
- MR209237L4V
- MR225820L3V
- MR225820L4V
- MR225927L3V
- MR225927L4V
- RC209744L3V
- RC209744L4V
- RC216230L1V
- RC216230L2V
- RC216230L3V
- RC216230L4V
- RC220960L1V
- RC220960L2V
- RC220960L3V
- RC220960L4V
- RC221018L3V
- RC221018L4V
- RR207545L3V
- RR207545L4V
- MG209237
- MG225820
- MG225927
- MR209237
- MR209237L4
- MR225820
- MR209237L3
- MR225820L3
- MR225820L4
- MR225927
- MR225927L3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for NUMB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUMB
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUMB Gene
Localization for NUMB Gene
Subcellular locations from UniProtKB/Swiss-Prot for NUMB Gene
- Membrane. Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 4 |
| cytosol | 4 |
| endosome | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| endoplasmic reticulum | 1 |
- Cell Junctions (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005769 | early endosome | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005905 | clathrin-coated pit | IEA | -- |
Pathways & Interactions for NUMB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Notch Signaling Pathway (WikiPathways) | ||
| 2 | Signaling by Hedgehog | ||
| 3 | Developmental Biology |
.51
|
|
| 4 | Signaling by NOTCH1 | ||
| 5 | Neuroscience | ||
Pathways by source for NUMB Gene
1 Sino Biological pathway for NUMB Gene
4 BioSystems pathways for NUMB Gene
12 Reactome pathways for NUMB Gene
1 KEGG pathway for NUMB Gene
1 R&D Systems pathway for NUMB Gene
1 Qiagen pathway for NUMB Gene
- Molecular Mechanisms of Cancer
2 Cell Signaling Technology pathways for NUMB Gene
1 GeneTex pathway for NUMB Gene
Interacting Proteins for NUMB Gene
Selected Interacting proteins:
P49757-NUMB_HUMAN
ENSP00000451300
for NUMB Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NUMB
SIGNOR curated interactions for NUMB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007405 | neuroblast proliferation | IEA | -- |
| GO:0007409 | axonogenesis | IEA | -- |
| GO:0021670 | lateral ventricle development | ISS | -- |
Transcripts for NUMB Gene
mRNA/cDNA for NUMB Gene
- 5 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 28 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000355058 3342 nts (view in UCSC)
- ENST00000356296 3453 nts (view in UCSC)
- ENST00000359560 3309 nts (view in UCSC)
- ENST00000535282 3198 nts (view in UCSC)
- ENST00000544991 2757 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NUMB - Select products 50% OFF >
- * NUMB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NUMB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUMB
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUMB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUMB
- Browse OriGene Inhibitory RNA Products For NUMB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUMB
Clone Products
- Applied Biological Materials (abm): Clones for NUMB - Select products 50% OFF >
- * NUMB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MR225927L4
- MR230616
- MR230770
- RC209744
- RC209744L3
- RC209744L4
- RC216230
- RC216230L1
- RC216230L2
- RC216230L3
- RC216230L4
- RC220960
- RC220960L1
- RC220960L2
- RC220960L3
- RC220960L4
- RC221018
- RC221018L3
- RC221018L4
- RG209744
- RG216230
- RG220960
- RG221018
- RR207545
- RR207545L3
- RR207545L4
- MR209237L3V
- MR209237L4V
- MR225820L3V
- MR225820L4V
- MR225927L3V
- MR225927L4V
- RC209744L3V
- RC209744L4V
- RC216230L1V
- RC216230L2V
- RC216230L3V
- RC216230L4V
- RC220960L1V
- RC220960L2V
- RC220960L3V
- RC220960L4V
- RC221018L3V
- RC221018L4V
- RR207545L3V
- RR207545L4V
- MG209237
- MG225820
- MG225927
- MR209237
- MR209237L4
- MR225820
- MR209237L3
- MR225820L3
- MR225820L4
- MR225927
- MR225927L3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for NUMB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUMB
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 14a | · | 14b | · | 14c | · | 14d | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | · | 17c | · | 17d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | ||||||||||||||
| SP14: | |||||||||||||||||||||
| SP15: | |||||||||||||||||||||
| SP16: |
Relevant External Links for NUMB Gene
- GeneLoc Exon Structure for
- NUMB
Expression for NUMB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Intestine (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for NUMB Gene
This gene is overexpressed in Whole Blood (x6.1).
This gene is overexpressed in Monocytes (13.7), Peripheral blood mononuclear cells (12.4), and Lung (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUMB Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUMB
SOURCE GeneReport for Unigene cluster for NUMB Gene:
Hs.525443Evidence on tissue expression from TISSUES for NUMB Gene
- Nervous system(4.9)
- Liver(4.5)
- Lung(3.2)
- Skin(3)
- Intestine(2.9)
- Muscle(2.8)
- Kidney(2.8)
- Blood(2.7)
- Thyroid gland(2.7)
- Heart(2.7)
- Bone marrow(2.5)
- Lymph node(2.4)
- Spleen(2.3)
- Stomach(2.3)
- Pancreas(2.3)
- Eye(2.1)
- Adrenal gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for NUMB
-
OriGene qPCR primer pairs and template standards for NUMB
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUMB Gene
Orthologs for NUMB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NUMB 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NUMB 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NUMB 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | NUMB 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Numb 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Numb 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | NUMB 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NUMB 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | numb 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | numb 30 31 |
|
ManyToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | numb 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | num-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9113 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4612 30 |
|
- Species where no ortholog for NUMB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for NUMB Gene
- ENSEMBL:
- Gene Tree for NUMB (if available)
- TreeFam:
- Gene Tree for NUMB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NUMB: view image
Paralogs for NUMB Gene
Paralogs for NUMB Gene
(1) SIMAP similar genes for NUMB Gene using alignment to 6 proteins:
- NUMB_HUMAN
- G3V3M5_HUMAN
- G3V3R1_HUMAN
- G3V3Z8_HUMAN
- G3V433_HUMAN
- G3V4S6_HUMAN
Variants for NUMB Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUMB Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 768662 | Benign: not provided | 73,282,366(-) | G/A | SYNONYMOUS_VARIANT | |
| 768663 | Benign: not provided | 73,292,839(-) | A/G | SYNONYMOUS_VARIANT | |
| 769401 | Benign: not provided | 73,276,659(-) | A/G | SYNONYMOUS_VARIANT | |
| rs17182272 | - | p.Val387Ile | |||
| rs17781919 | - | p.Gly595Asp |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1933n100 | CNV | gain | 25217958 |
| dgv1934n100 | CNV | loss | 25217958 |
| esv1057343 | CNV | insertion | 17803354 |
| esv2651254 | CNV | insertion | 19546169 |
| esv2659371 | CNV | deletion | 23128226 |
| esv2671759 | CNV | deletion | 23128226 |
| esv3551763 | CNV | deletion | 23714750 |
| esv3634902 | CNV | gain | 21293372 |
| esv3634903 | CNV | loss | 21293372 |
| esv3634905 | CNV | gain | 21293372 |
| esv3634906 | CNV | loss | 21293372 |
| esv3634907 | CNV | loss | 21293372 |
| esv3892561 | CNV | gain | 25118596 |
| nsv1035460 | CNV | gain | 25217958 |
| nsv1042100 | CNV | loss | 25217958 |
| nsv1113660 | CNV | deletion | 24896259 |
| nsv1125358 | OTHER | inversion | 24896259 |
| nsv477096 | CNV | novel sequence insertion | 20440878 |
| nsv513411 | CNV | insertion | 21212237 |
| nsv513412 | CNV | insertion | 21212237 |
| nsv826974 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
7.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.47;
43.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NUMB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUMB Gene
Disorders for NUMB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma, uveal |
|
|
| maxillary sinus adenoid cystic carcinoma |
|
|
| retinitis pigmentosa 42 |
|
|
| tactile agnosia |
|
|
| pericoronitis |
|
|
Search NUMB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NUMB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NUMB Gene
Publications for NUMB Gene
- Numb is an endocytic protein. (PMID: 11121447) Santolini E … Di Fiore PP (The Journal of cell biology 2000) 2 3 23
- Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. (PMID: 9303539) Salcini AE … Di Fiore PP (Genes & development 1997) 3 4 23
- Characterization and role of NUMB in the human extravillous trophopblast. (PMID: 21486681) Haider M … Gruslin A (Placenta 2011) 3 4
- Impaired expression of Notch signaling genes in aged human skeletal muscle. (PMID: 17301032) Carey KA … Cameron-Smith D (The journals of gerontology. Series A, Biological sciences and medical sciences 2007) 3 23
- Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PMID: 17903303) O'Donnell CJ … Demissie S (BMC medical genetics 2007) 3 41
ExternalLinks
Products for NUMB Gene
- Custom Antibody ServicesOriGene Antibodies for NUMB
- AP05298PU-N
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- CF501518
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- TA302758
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- TA802143
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- TA802157
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- TA802160
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- TA802161
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- TA802174
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- TA802221S
- TA802316
- TA802316S
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- RG209744
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- RC216230L1V
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- RC216230L4V
- RC220960L1V
- RC220960L2V
- RC220960L3V
- RC220960L4V
- RC221018L3V
- RC221018L4V
- RR207545L3V
- RR207545L4V
- MG209237
- MG225820
- MG225927
- MR209237
- MR209237L4
- MR225820
- MR209237L3
- MR225820L3
- MR225820L4
- MR225927
- MR225927L3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- High-throughput Antibody Production Service
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- Browse Primary Antibodies
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- Browse Secondary Antibodies
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- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for NUMB
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for NUMB (AFLGC-Numb)
- VectorBuilder Custom and pre-made DNA vectors for NUMB (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NUMB (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NUMB (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NUMB CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NUMB
- Addgene plasmids for NUMB
- antibodies-online: Show 69 available NUMB Antibodies ranked by validation data
- Compare Top NUMB Antibodies
- antibodies-online: Show 3 available NUMB Elisa Kits ranked by validation data
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- antibodies-online: Show 11 available NUMB Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for NUMB
- Search Santa Cruz Biotechnology (SCBT) for NUMB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NUMB
- Custom Antibody ServicesProSci Antibodies for NUMB
- Search for NUMB Proteins at ProSci
- Horizon Cell Lines for NUMB