Aliases for NUMB Gene
External Ids for NUMB Gene
Previous HGNC Symbols for NUMB Gene
Previous GeneCards Identifiers for NUMB Gene
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for NUMB Gene
NUMB (NUMB Endocytic Adaptor Protein) is a Protein Coding gene. Diseases associated with NUMB include Melanoma, Uveal and Maxillary Sinus Adenoid Cystic Carcinoma. Among its related pathways are Signaling by GPCR and L1CAM interactions. Gene Ontology (GO) annotations related to this gene include beta-catenin binding and alpha-catenin binding. An important paralog of this gene is NUMBL.
UniProtKB/Swiss-Prot Summary for NUMB Gene
Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity).