Aliases for NUGGC Gene

Aliases for NUGGC Gene

  • Nuclear GTPase, Germinal Center Associated 2 3 5
  • Speckled-Like Pattern In The Germinal Center 2 3 4
  • Nuclear GTPase SLIP-GC 3 4
  • C8orf80 3 4
  • Chromosome 8 Open Reading Frame 80 2
  • GTPase SLIP-GC 3
  • EC 3.6.1.- 4
  • HMFN0672 3
  • SLIP-GC 3

External Ids for NUGGC Gene

Previous HGNC Symbols for NUGGC Gene

  • C8orf80

Previous GeneCards Identifiers for NUGGC Gene

  • GC08M027879

Summaries for NUGGC Gene

GeneCards Summary for NUGGC Gene

NUGGC (Nuclear GTPase, Germinal Center Associated) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot Summary for NUGGC Gene

  • Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).

Additional gene information for NUGGC Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUGGC Gene

Genomics for NUGGC Gene

GeneHancer (GH) Regulatory Elements for NUGGC Gene

Promoters and enhancers for NUGGC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J028081 Enhancer 1.1 Ensembl ENCODE dbSUPER 750.6 +1.0 967 3 ZBTB6 ZNF121 SP7 PRDM1 PKNOX1 ZBTB8A PRDM10 ZNF639 ZEB2 FOXA2 NUGGC ELP3 FJ601678-117
GH08J028086 Enhancer 0.6 ENCODE dbSUPER 750.6 -1.6 -1576 0.2 CTCF RAD21 RUNX3 USF1 SMC3 NUGGC ELP3
GH08J028087 Enhancer 0.3 Ensembl dbSUPER 750.6 -1.0 -1038 0.2 NUGGC ELP3
GH08J027308 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 +773.6 773558 5 E2F8 SP1 ZBTB40 RBPJ SMARCE1 POLR2A ATF1 FOS HCFC1 MIXL1 STMN4 TRIM35 PTK2B lnc-EPHX2-5 PNMA2 ENSG00000254362 NUGGC ENSG00000253208 CHRNA2 EPHX2
GH08J027359 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +717.9 717920 13.4 SP1 ZBTB40 FOXA1 MLX RBPJ SMARCE1 NR2F1 NR2F6 MYC CC2D1A PTK2B NUGGC CLU ADRA1A EPHX2 lnc-EPHX2-4 RF00017-6906 lnc-EPHX2-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUGGC on UCSC Golden Path with GeneCards custom track

Genomic Locations for NUGGC Gene

Genomic Locations for NUGGC Gene
chr8:28,021,964-28,084,063
(GRCh38/hg38)
Size:
62,100 bases
Orientation:
Minus strand
chr8:27,879,481-27,941,388
(GRCh37/hg19)
Size:
61,908 bases
Orientation:
Minus strand

Genomic View for NUGGC Gene

Genes around NUGGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUGGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUGGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUGGC Gene

Proteins for NUGGC Gene

  • Protein details for NUGGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CJ6-SLIP_HUMAN
    Recommended name:
    Nuclear GTPase SLIP-GC
    Protein Accession:
    Q68CJ6
    Secondary Accessions:
    • Q6ZP73

    Protein attributes for NUGGC Gene

    Size:
    796 amino acids
    Molecular mass:
    91132 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85251.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD38652.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for NUGGC Gene

Post-translational modifications for NUGGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUGGC Gene

No data available for DME Specific Peptides for NUGGC Gene

Domains & Families for NUGGC Gene

Gene Families for NUGGC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUGGC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUGGC Gene

GenScript: Design optimal peptide antigens:
  • Speckled-like pattern in the germinal center (SLIP_HUMAN)
genes like me logo Genes that share domains with NUGGC: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NUGGC Gene

Function for NUGGC Gene

Molecular function for NUGGC Gene

UniProtKB/Swiss-Prot Function:
Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).

Enzyme Numbers (IUBMB) for NUGGC Gene

Phenotypes From GWAS Catalog for NUGGC Gene

Gene Ontology (GO) - Molecular Function for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA,IBA 19734146
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUGGC: view
genes like me logo Genes that share phenotypes with NUGGC: view

Animal Models for NUGGC Gene

MGI Knock Outs for NUGGC:

Animal Model Products

CRISPR Products

miRNA for NUGGC Gene

miRTarBase miRNAs that target NUGGC

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUGGC

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUGGC Gene

Localization for NUGGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUGGC Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUGGC gene
Compartment Confidence
nucleus 4
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with NUGGC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NUGGC Gene

Pathways & Interactions for NUGGC Gene

PathCards logo

SuperPathways for NUGGC Gene

No Data Available

Interacting Proteins for NUGGC Gene

Gene Ontology (GO) - Biological Process for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033262 regulation of nuclear cell cycle DNA replication IMP 19734146
GO:0043066 negative regulation of apoptotic process IMP 19734146
GO:0071222 cellular response to lipopolysaccharide IDA 19734146
genes like me logo Genes that share ontologies with NUGGC: view

No data available for Pathways by source and SIGNOR curated interactions for NUGGC Gene

Drugs & Compounds for NUGGC Gene

No Compound Related Data Available

Transcripts for NUGGC Gene

mRNA/cDNA for NUGGC Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUGGC

Alternative Splicing Database (ASD) splice patterns (SP) for NUGGC Gene

No ASD Table

Relevant External Links for NUGGC Gene

GeneLoc Exon Structure for
NUGGC
ECgene alternative splicing isoforms for
NUGGC

Expression for NUGGC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUGGC Gene

mRNA differential expression in normal tissues according to GTEx for NUGGC Gene

This gene is overexpressed in Liver (x20.2) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for NUGGC Gene

This gene is overexpressed in Frontal cortex (21.5), Heart (17.8), Skin (17.4), and Esophagus (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUGGC Gene



Protein tissue co-expression partners for NUGGC Gene

NURSA nuclear receptor signaling pathways regulating expression of NUGGC Gene:

NUGGC

SOURCE GeneReport for Unigene cluster for NUGGC Gene:

Hs.370129

mRNA Expression by UniProt/SwissProt for NUGGC Gene:

Q68CJ6-SLIP_HUMAN
Tissue specificity: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell.

Evidence on tissue expression from TISSUES for NUGGC Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with NUGGC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUGGC Gene

Orthologs for NUGGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUGGC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUGGC 33 32
  • 99.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUGGC 33 32
  • 86.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUGGC 33 32
  • 86.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nuggc 32
  • 81.83 (n)
mouse
(Mus musculus)
Mammalia Nuggc 17 33 32
  • 81.69 (n)
oppossum
(Monodelphis domestica)
Mammalia NUGGC 33
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUGGC 33
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H8ORF80 32
  • 58.78 (n)
-- 33
  • 48 (a)
OneToMany
-- 33
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NUGGC 33
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-85e10.1 32
  • 43.13 (n)
NUGGC (3 of 4) 33
  • 20 (a)
OneToMany
NUGGC (1 of 4) 33
  • 18 (a)
OneToMany
NUGGC (4 of 4) 33
  • 17 (a)
OneToMany
NUGGC (2 of 4) 33
  • 12 (a)
OneToMany
Species where no ortholog for NUGGC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUGGC Gene

ENSEMBL:
Gene Tree for NUGGC (if available)
TreeFam:
Gene Tree for NUGGC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUGGC: view image

Paralogs for NUGGC Gene

No data available for Paralogs for NUGGC Gene

Variants for NUGGC Gene

Sequence variations from dbSNP and Humsavar for NUGGC Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000011658 -- 28,066,348(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000057778 -- 28,056,136(-) C/A intron_variant
rs1000096130 -- 28,058,327(-) C/G intron_variant
rs1000138002 -- 28,028,833(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000173434 -- 28,067,195(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUGGC Gene

Variant ID Type Subtype PubMed ID
esv3616733 CNV loss 21293372
esv3616734 CNV loss 21293372
nsv521155 CNV loss 19592680
nsv524295 CNV loss 19592680

Variation tolerance for NUGGC Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.70; 89.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUGGC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUGGC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUGGC Gene

Disorders for NUGGC Gene

Additional Disease Information for NUGGC

No disorders were found for NUGGC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUGGC Gene

Publications for NUGGC Gene

  1. Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. (PMID: 19734146) Richter K … Diaz M (The Journal of biological chemistry 2009) 2 3 4 56
  2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S … Nakagawara A (Oncogene 2004) 3 4 56
  3. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. (PMID: 23247143) Yu B … CARDIoGRAM Consortium (Circulation. Cardiovascular genetics 2013) 3 56
  4. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. (PMID: 20877300) Perroud N … McGuffin P (The pharmacogenomics journal 2012) 3 56
  5. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. (PMID: 22833677) Richter K … Diaz M (The Journal of biological chemistry 2012) 3 56

Products for NUGGC Gene

Sources for NUGGC Gene