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Aliases for NUGGC Gene

Aliases for NUGGC Gene

  • Nuclear GTPase, Germinal Center Associated 2 3 5
  • Speckled-Like Pattern In The Germinal Center 2 3 4
  • C8orf80 3 4
  • Chromosome 8 Open Reading Frame 80 2
  • Nuclear GTPase SLIP-GC 3
  • GTPase SLIP-GC 3
  • EC 3.6.1.- 4
  • HMFN0672 3
  • SLIP-GC 3

External Ids for NUGGC Gene

Previous HGNC Symbols for NUGGC Gene

  • C8orf80

Previous GeneCards Identifiers for NUGGC Gene

  • GC08M027879

Summaries for NUGGC Gene

GeneCards Summary for NUGGC Gene

NUGGC (Nuclear GTPase, Germinal Center Associated) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for NUGGC Gene

  • Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).

Additional gene information for NUGGC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUGGC Gene

Genomics for NUGGC Gene

GeneHancer (GH) Regulatory Elements for NUGGC Gene

Promoters and enhancers for NUGGC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I028081 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.1 1136 2.7 PKNOX1 FOXA2 INSM2 FEZF1 ZNF2 YY1 ZNF335 ZNF121 ZNF213 ZNF366 NUGGC ELP3 SCARA5
GH08I028086 Enhancer 0.7 ENCODE dbSUPER 550.8 -1.6 -1576 0.2 CTCF USF1 SMC3 RUNX3 RAD21 NUGGC ELP3
GH08I028346 Enhancer 1.2 Ensembl ENCODE dbSUPER 9.8 -266.1 -266073 7.9 HDGF PKNOX1 ZBTB7B ZNF121 HSF1 ZNF143 FOS IKZF2 ZNF362 SMARCC1 FZD3 FBXO16 EXTL3 NUGGC PNOC PIR39512 PIR48760 ZNF395
GH08I028061 Enhancer 0.8 ENCODE 11.4 +22.8 22824 0.2 PKNOX1 ARID4B SIN3A ZNF2 RAD21 ZNF143 RUNX3 MIXL1 ZNF654 USF2 NUGGC PNOC SCARA5
GH08I027855 Enhancer 0.8 ENCODE dbSUPER 10.2 +227.6 227604 1.3 CTCF REST RAD21 RFX5 CHAMP1 GTF3C2 ZNF512 SMC3 ZNF580 CCDC25 SCARA5 NUGGC LOC100130612 MIR4287
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUGGC on UCSC Golden Path with GeneCards custom track

Genomic Locations for NUGGC Gene

Genomic Locations for NUGGC Gene
chr8:28,021,964-28,084,063
(GRCh38/hg38)
Size:
62,100 bases
Orientation:
Minus strand
chr8:27,879,481-27,941,388
(GRCh37/hg19)

Genomic View for NUGGC Gene

Genes around NUGGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUGGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUGGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUGGC Gene

Proteins for NUGGC Gene

  • Protein details for NUGGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CJ6-SLIP_HUMAN
    Recommended name:
    Nuclear GTPase SLIP-GC
    Protein Accession:
    Q68CJ6
    Secondary Accessions:
    • Q6ZP73

    Protein attributes for NUGGC Gene

    Size:
    796 amino acids
    Molecular mass:
    91132 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85251.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD38652.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for NUGGC Gene

Post-translational modifications for NUGGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUGGC Gene

No data available for DME Specific Peptides for NUGGC Gene

Domains & Families for NUGGC Gene

Gene Families for NUGGC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUGGC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUGGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUGGC: view

No data available for UniProtKB/Swiss-Prot for NUGGC Gene

Function for NUGGC Gene

Molecular function for NUGGC Gene

UniProtKB/Swiss-Prot Function:
Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity).

Enzyme Numbers (IUBMB) for NUGGC Gene

Phenotypes From GWAS Catalog for NUGGC Gene

Gene Ontology (GO) - Molecular Function for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 19734146
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUGGC: view
genes like me logo Genes that share phenotypes with NUGGC: view

Animal Models for NUGGC Gene

MGI Knock Outs for NUGGC:

Animal Model Products

CRISPR Products

miRNA for NUGGC Gene

miRTarBase miRNAs that target NUGGC

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUGGC Gene

Localization for NUGGC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUGGC Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUGGC gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016607 nuclear speck IEA --
GO:0043601 colocalizes_with nuclear replisome IDA 19734146
genes like me logo Genes that share ontologies with NUGGC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NUGGC Gene

Pathways & Interactions for NUGGC Gene

SuperPathways for NUGGC Gene

No Data Available

Interacting Proteins for NUGGC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000408697%0d%0a9606.ENSP00000301838%0d%0a
Selected Interacting proteins: ENSP00000408697 for NUGGC Gene via STRING

Symbol External ID(s) Details
FADD

Gene Ontology (GO) - Biological Process for NUGGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IMP 19734146
GO:0071222 cellular response to lipopolysaccharide IDA 19734146
GO:0097752 regulation of DNA stability IMP 19734146
genes like me logo Genes that share ontologies with NUGGC: view

No data available for Pathways by source and SIGNOR curated interactions for NUGGC Gene

Drugs & Compounds for NUGGC Gene

No Compound Related Data Available

Transcripts for NUGGC Gene

mRNA/cDNA for NUGGC Gene

Unigene Clusters for NUGGC Gene

Nuclear GTPase, germinal center associated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUGGC Gene

No ASD Table

Relevant External Links for NUGGC Gene

GeneLoc Exon Structure for
NUGGC
ECgene alternative splicing isoforms for
NUGGC

Expression for NUGGC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUGGC Gene

mRNA differential expression in normal tissues according to GTEx for NUGGC Gene

This gene is overexpressed in Liver (x20.2) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for NUGGC Gene

This gene is overexpressed in Frontal cortex (21.5), Heart (17.8), Skin (17.4), and Esophagus (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUGGC Gene



Protein tissue co-expression partners for NUGGC Gene

NURSA nuclear receptor signaling pathways regulating expression of NUGGC Gene:

NUGGC

SOURCE GeneReport for Unigene cluster for NUGGC Gene:

Hs.370129

mRNA Expression by UniProt/SwissProt for NUGGC Gene:

Q68CJ6-SLIP_HUMAN
Tissue specificity: Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell.

Evidence on tissue expression from TISSUES for NUGGC Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with NUGGC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUGGC Gene

Orthologs for NUGGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUGGC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUGGC 33 34
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia NUGGC 33 34
  • 86.06 (n)
dog
(Canis familiaris)
Mammalia NUGGC 33 34
  • 86.06 (n)
rat
(Rattus norvegicus)
Mammalia Nuggc 33
  • 81.83 (n)
mouse
(Mus musculus)
Mammalia Nuggc 33 16 34
  • 81.69 (n)
oppossum
(Monodelphis domestica)
Mammalia NUGGC 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUGGC 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H8ORF80 33
  • 58.78 (n)
-- 34
  • 48 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NUGGC 34
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-85e10.1 33
  • 43.13 (n)
NUGGC (3 of 4) 34
  • 20 (a)
OneToMany
NUGGC (1 of 4) 34
  • 18 (a)
OneToMany
NUGGC (4 of 4) 34
  • 17 (a)
OneToMany
NUGGC (2 of 4) 34
  • 12 (a)
OneToMany
Species where no ortholog for NUGGC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUGGC Gene

ENSEMBL:
Gene Tree for NUGGC (if available)
TreeFam:
Gene Tree for NUGGC (if available)

Paralogs for NUGGC Gene

No data available for Paralogs for NUGGC Gene

Variants for NUGGC Gene

Sequence variations from dbSNP and Humsavar for NUGGC Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000011658 -- 28,066,348(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000057778 -- 28,056,136(-) C/A intron_variant
rs1000096130 -- 28,058,327(-) C/G intron_variant
rs1000138002 -- 28,028,833(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000173434 -- 28,067,195(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUGGC Gene

Variant ID Type Subtype PubMed ID
esv3616733 CNV loss 21293372
esv3616734 CNV loss 21293372
nsv521155 CNV loss 19592680
nsv524295 CNV loss 19592680

Variation tolerance for NUGGC Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.70; 89.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUGGC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUGGC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUGGC Gene

Disorders for NUGGC Gene

Additional Disease Information for NUGGC

No disorders were found for NUGGC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUGGC Gene

Publications for NUGGC Gene

  1. Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. (PMID: 19734146) Richter K … Diaz M (The Journal of biological chemistry 2009) 2 3 4 58
  2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S … Nakagawara A (Oncogene 2004) 3 4 58
  3. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. (PMID: 23247143) Yu B … CARDIoGRAM Consortium (Circulation. Cardiovascular genetics 2013) 3 58
  4. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. (PMID: 20877300) Perroud N … McGuffin P (The pharmacogenomics journal 2012) 3 58
  5. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. (PMID: 22833677) Richter K … Diaz M (The Journal of biological chemistry 2012) 3 58

Products for NUGGC Gene

Sources for NUGGC Gene

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