Aliases for NUFIP2 Gene

Aliases for NUFIP2 Gene

  • Nuclear FMR1 Interacting Protein 2 2 3 5
  • 82-FIP 2 3 4
  • Nuclear Fragile X Mental Retardation Protein Interacting Protein 2 2 3
  • Nuclear Fragile X Mental Retardation-Interacting Protein 2 3 4
  • Cell Proliferation-Inducing Gene 1 Protein 3 4
  • NUFIP2, FMR1 Interacting Protein 2 2 3
  • 82 KDa FMRP-Interacting Protein 3 4
  • FMRP-Interacting Protein 2 3 4
  • KIAA1321 2 4
  • 182-FIP 2 3
  • FIP-82 2 3
  • PIG1 2 3
  • Fragile X Mental Retardation Protein 3
  • 82-KD FMRP Interacting Protein 3
  • Proliferation-Inducing Gene 1 3
  • MGC117262 2
  • NUFIP2 5

External Ids for NUFIP2 Gene

Previous GeneCards Identifiers for NUFIP2 Gene

  • GC17M024613
  • GC17M027582
  • GC17M023791
  • GC17M029256
  • GC17M029356
  • GC17M029394
  • GC17M029432
  • GC17M029709
  • GC17M029257

Summaries for NUFIP2 Gene

GeneCards Summary for NUFIP2 Gene

NUFIP2 (Nuclear FMR1 Interacting Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot Summary for NUFIP2 Gene

Gene Wiki entry for NUFIP2 Gene

Additional gene information for NUFIP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUFIP2 Gene

Genomics for NUFIP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NUFIP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J029290 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 614.4 +1.0 1022 5.1 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 REST ZNF629 TFE3 NUFIP2 lnc-CRYBA1-4 LOC101927018 SUPT6H ENSG00000264577 MYO18A NEK8 TMEM199 SARM1 ANKRD13B
GH17J028737 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 55.8 +549.9 549928 13.9 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 TFE3 TRAF4 ENSG00000265073 piR-43105-269 SUPT6H NUFIP2 ENSG00000264577 PHF12 ENSG00000265908 ENSG00000265205 TMEM199
GH17J028715 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 49.1 +571.2 571224 14.4 BRCA1 RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 ENSG00000264577 RPL23A RAB34 NEK8 SNORD42A SNORD4A SNORD4B X96641 piR-31970 TLCD1
GH17J028901 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 35.9 +391.6 391610 2.3 ARHGAP35 SP1 CREB1 GATAD2A CTCF HNRNPL ATF7 PRDM10 ZNF629 REST DHRS13 lnc-PHF12-1 SUPT6H ENSG00000264577 PHF12 NUFIP2 ENSG00000265908 SDF2 LOC101927018 RPL23A
GH17J028643 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 34.2 +648.4 648427 4.4 SP1 CREB1 CTCF HNRNPL TEAD4 PRDM10 LEF1 IKZF1 ZNF692 POLR2A KIAA0100 lnc-SUPT6H-5 piR-54674 ENSG00000264577 NUFIP2 SUPT6H LOC101927018 PROCA1 PHF12 TMEM199
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUFIP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUFIP2

Top Transcription factor binding sites by QIAGEN in the NUFIP2 gene promoter:
  • AREB6
  • CUTL1
  • FOXD1
  • FOXO1
  • FOXO1a
  • HOXA5
  • MRF-2
  • NF-kappaB
  • SEF-1 (1)
  • Sox9

Genomic Locations for NUFIP2 Gene

Genomic Locations for NUFIP2 Gene
chr17:29,255,839-29,294,148
(GRCh38/hg38)
Size:
38,310 bases
Orientation:
Minus strand
chr17:27,582,854-27,621,166
(GRCh37/hg19)
Size:
38,313 bases
Orientation:
Minus strand

Genomic View for NUFIP2 Gene

Genes around NUFIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUFIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUFIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUFIP2 Gene

Proteins for NUFIP2 Gene

  • Protein details for NUFIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z417-NUFP2_HUMAN
    Recommended name:
    Nuclear fragile X mental retardation-interacting protein 2
    Protein Accession:
    Q7Z417
    Secondary Accessions:
    • A1L3A6
    • A1L3A7
    • Q9P2M5

    Protein attributes for NUFIP2 Gene

    Size:
    695 amino acids
    Molecular mass:
    76121 Da
    Quaternary structure:
    • Interacts with FMR1 (via N-terminus). Interacts with DDX6 (PubMed:26184334).
    SequenceCaution:
    • Sequence=BAA92559.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUFIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUFIP2 Gene

Post-translational modifications for NUFIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUFIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUFIP2 Gene

Domains & Families for NUFIP2 Gene

Gene Families for NUFIP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUFIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUFIP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53811, highly similar to Nuclear fragile X mentalretardation-interacting protein 2 (A1L3A6_HUMAN)
  • cDNA FLJ75095, highly similar to Homo sapiens 82-kD FMRP Interacting Protein (182-FIP), mRNA (A1L3A7_HUMAN)
  • FMRP-interacting protein 2 (NUFP2_HUMAN)
genes like me logo Genes that share domains with NUFIP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NUFIP2 Gene

Function for NUFIP2 Gene

Molecular function for NUFIP2 Gene

UniProtKB/Swiss-Prot Function:
Binds RNA.

Phenotypes From GWAS Catalog for NUFIP2 Gene

Gene Ontology (GO) - Molecular Function for NUFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 12837692
GO:0005515 protein binding IPI 12837692
genes like me logo Genes that share ontologies with NUFIP2: view
genes like me logo Genes that share phenotypes with NUFIP2: view

Animal Model Products

CRISPR Products

miRNA for NUFIP2 Gene

miRTarBase miRNAs that target NUFIP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUFIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUFIP2 Gene

Localization for NUFIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUFIP2 Gene

Nucleus. Cytoplasm. Cytoplasm, Stress granule. Note=Distribution is cell cycle-modulated, being cytoplasmic in the G2/M phase and accumulating in nucleus during the G1 phase (PubMed:12837692). {ECO:0000269 PubMed:12837692, ECO:0000269 PubMed:26184334}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUFIP2 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 12837692
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 12837692
GO:0005829 cytosol IDA --
GO:0010494 cytoplasmic stress granule IEA,IDA 26184334
genes like me logo Genes that share ontologies with NUFIP2: view

Pathways & Interactions for NUFIP2 Gene

PathCards logo

SuperPathways for NUFIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUFIP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUFIP2 Gene

Drugs & Compounds for NUFIP2 Gene

No Compound Related Data Available

Transcripts for NUFIP2 Gene

mRNA/cDNA for NUFIP2 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUFIP2

Alternative Splicing Database (ASD) splice patterns (SP) for NUFIP2 Gene

No ASD Table

Relevant External Links for NUFIP2 Gene

GeneLoc Exon Structure for
NUFIP2

Expression for NUFIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUFIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUFIP2 Gene

This gene is overexpressed in Lung (58.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUFIP2 Gene



Protein tissue co-expression partners for NUFIP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUFIP2

SOURCE GeneReport for Unigene cluster for NUFIP2 Gene:

Hs.462598

Evidence on tissue expression from TISSUES for NUFIP2 Gene

  • Nervous system(4.7)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with NUFIP2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUFIP2 Gene

Orthologs for NUFIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUFIP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NUFIP2 30 31
  • 99.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NUFIP2 30 31
  • 95.81 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NUFIP2 30 31
  • 95.55 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nufip2 30
  • 94.11 (n)
Mouse
(Mus musculus)
Mammalia Nufip2 30 17 31
  • 93.55 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NUFIP2 31
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NUFIP2 31
  • 30 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NUFIP2 30 31
  • 72.07 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NUFIP2 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nufip2 30
  • 68.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29769 30
Zebrafish
(Danio rerio)
Actinopterygii nufip2 30 31
  • 56.06 (n)
OneToOne
Species where no ortholog for NUFIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NUFIP2 Gene

ENSEMBL:
Gene Tree for NUFIP2 (if available)
TreeFam:
Gene Tree for NUFIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUFIP2: view image

Paralogs for NUFIP2 Gene

No data available for Paralogs for NUFIP2 Gene

Variants for NUFIP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUFIP2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
708556 Benign: not provided 29,286,332(-) T/C SYNONYMOUS_VARIANT
713012 Likely Benign: not provided 29,286,820(-) T/C MISSENSE_VARIANT
726560 Likely Benign: not provided 29,286,476(-) C/T SYNONYMOUS_VARIANT
734019 Likely Benign: not provided 29,287,640(-) G/A SYNONYMOUS_VARIANT
734363 Likely Benign: not provided 29,287,723(-) G/A INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NUFIP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUFIP2 Gene

Variant ID Type Subtype PubMed ID
esv2658759 CNV deletion 23128226
esv2671407 CNV deletion 23128226
esv2715796 CNV deletion 23290073
esv3554292 CNV deletion 23714750
esv3640323 CNV loss 21293372
nsv1070820 CNV deletion 25765185
nsv953873 CNV duplication 24416366

Variation tolerance for NUFIP2 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUFIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUFIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUFIP2 Gene

Disorders for NUFIP2 Gene

Additional Disease Information for NUFIP2

No disorders were found for NUFIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUFIP2 Gene

Publications for NUFIP2 Gene

  1. 82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization. (PMID: 12837692) Bardoni B … Mandel JL (Human molecular genetics 2003) 2 3 4 23
  2. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. (PMID: 26184334) Bish R … Vogel C (Biomolecules 2015) 3 4
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction. (PMID: 16407062) Ramos A … Pastore A (Structure (London, England : 1993) 2006) 2 3

Products for NUFIP2 Gene

Sources for NUFIP2 Gene