Aliases for NUF2 Gene
External Ids for NUF2 Gene
Previous HGNC Symbols for NUF2 Gene
Previous GeneCards Identifiers for NUF2 Gene
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for NUF2 Gene
NUF2 (NUF2 Component Of NDC80 Kinetochore Complex) is a Protein Coding gene. Diseases associated with NUF2 include Ovary Serous Adenocarcinoma and Cardiomyopathy, Dilated, 1A. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by GPCR. An important paralog of this gene is TMEM259.
UniProtKB/Swiss-Prot Summary for NUF2 Gene
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).