NUDT9 Gene (Protein Coding)

Nudix Hydrolase 9

GC04P087422
GIFtS:
40
The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic act... See more...

Aliases for NUDT9 Gene

Aliases for NUDT9 Gene

  • Nudix Hydrolase 9 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 9 2 3
  • ADP-Ribose Pyrophosphatase, Mitochondrial 3 4
  • Adenosine Diphosphoribose Pyrophosphatase 3 4
  • ADP-Ribose Phosphohydrolase 3 4
  • ADP-Ribose Diphosphatase 3 4
  • ADPR-PPase 3 4
  • NUDT10 3 4
  • Nucleoside Diphosphate Linked Moiety X-Type Motif 9 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 9 4
  • ADP-Ribose Pyrosphosphatase NUDT9 3
  • Nudix Motif 9 4
  • EC 3.6.1.13 4
  • MGC3037 2
  • NUDT9 5

External Ids for NUDT9 Gene

Previous GeneCards Identifiers for NUDT9 Gene

  • GC04P088501
  • GC04P088645
  • GC04P088802
  • GC04P088700
  • GC04P088343
  • GC04P084089

Summaries for NUDT9 Gene

Entrez Gene Summary for NUDT9 Gene

  • The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUDT9 Gene

NUDT9 (Nudix Hydrolase 9) is a Protein Coding gene. Diseases associated with NUDT9 include Psoriasis 11 and Type 1 Diabetes Mellitus 10. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ADP-sugar diphosphatase activity.

UniProtKB/Swiss-Prot Summary for NUDT9 Gene

Gene Wiki entry for NUDT9 Gene

Additional gene information for NUDT9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT9 Gene

Genomics for NUDT9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NUDT9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDT9

Top Transcription factor binding sites by QIAGEN in the NUDT9 gene promoter:
  • COMP1
  • CREB
  • deltaCREB
  • ISGF-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • ZID

Genomic Locations for NUDT9 Gene

Genomic Locations for NUDT9 Gene
chr4:87,420,002-87,459,455
(GRCh38/hg38)
Size:
39,454 bases
Orientation:
Plus strand
chr4:88,343,734-88,380,606
(GRCh37/hg19)
Size:
36,873 bases
Orientation:
Plus strand

Genomic View for NUDT9 Gene

Genes around NUDT9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NUDT9 Gene

Proteins for NUDT9 Gene

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  • Protein details for NUDT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW91-NUDT9_HUMAN
    Recommended name:
    ADP-ribose pyrophosphatase, mitochondrial
    Protein Accession:
    Q9BW91
    Secondary Accessions:
    • Q8NBN1
    • Q8NCB9
    • Q8NG25

    Protein attributes for NUDT9 Gene

    Size:
    350 amino acids
    Molecular mass:
    39125 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer. Interacts with GLOD4.

    Three dimensional structures from OCA and Proteopedia for NUDT9 Gene

    Alternative splice isoforms for NUDT9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT9 Gene

Protein Expression for NUDT9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NUDT9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT9 Gene

Domains & Families for NUDT9 Gene

Gene Families for NUDT9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NUDT9 Gene

InterPro:
Blocks:
  • NUDIX hydrolase
ProtoNet:

Suggested Antigen Peptide Sequences for NUDT9 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 9 (NUDT9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BW91

UniProtKB/Swiss-Prot:

NUDT9_HUMAN :
  • Belongs to the Nudix hydrolase family. NudF subfamily.
Family:
  • Belongs to the Nudix hydrolase family. NudF subfamily.
genes like me logo Genes that share domains with NUDT9: view

Function for NUDT9 Gene

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Molecular function for NUDT9 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+); Xref=Rhea:RHEA:10412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57967, ChEBI:CHEBI:78346, ChEBI:CHEBI:456215; EC=3.6.1.13;.
UniProtKB/Swiss-Prot Induction:
[Isoform 1]: Inhibited by fluoride and N-acetyl-p-benzoquinoneimine.

Enzyme Numbers (IUBMB) for NUDT9 Gene

Phenotypes From GWAS Catalog for NUDT9 Gene

Gene Ontology (GO) - Molecular Function for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0019144 ADP-sugar diphosphatase activity NAS 11385575
GO:0043262 adenosine-diphosphatase activity IBA 21873635
GO:0047631 ADP-ribose diphosphatase activity IEA,EXP 12948489
genes like me logo Genes that share ontologies with NUDT9: view
genes like me logo Genes that share phenotypes with NUDT9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT9

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT9

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT9 Gene

Localization for NUDT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT9 Gene

[Isoform 1]: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT9 gene
Compartment Confidence
mitochondrion 5
nucleus 5
extracellular 4
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Cell Junctions (2)
  • Nuclear bodies (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0016604 nuclear body IDA --
GO:0030054 cell junction IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with NUDT9: view

Pathways & Interactions for NUDT9 Gene

genes like me logo Genes that share pathways with NUDT9: view

Pathways by source for NUDT9 Gene

2 KEGG pathways for NUDT9 Gene

Gene Ontology (GO) - Biological Process for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
GO:0046032 ADP catabolic process IEA --
GO:0046709 IDP catabolic process IEA --
genes like me logo Genes that share ontologies with NUDT9: view

No data available for SIGNOR curated interactions for NUDT9 Gene

Drugs & Compounds for NUDT9 Gene

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  1. Drug

(6) Drugs for NUDT9 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
Manganese Approved Nutra 56
Beta-D-Glucose Experimental Pharma Target 0

(4) Additional Compounds for NUDT9 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppa
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • a5'pp5RIb
  • Adenosine 5'-diphosphoribose
  • AdoPPRib
 20762-30-5
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
D-Ribose 5-phosphate
  • D-Ribose 5'-phosphate
  • D-Ribose-5-P
  • Ribose 5-phosphate
  • D-Ribose 5'-phosphoric acid
  • D-Ribose 5-phosphoric acid
 3615-55-2
genes like me logo Genes that share compounds with NUDT9: view

Transcripts for NUDT9 Gene

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mRNA/cDNA for NUDT9 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT9

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4:
SP5:
SP6: - - - -
SP7: - - - - - - - -
SP8:
SP9: - -

Relevant External Links for NUDT9 Gene

GeneLoc Exon Structure for
NUDT9

Expression for NUDT9 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT9 Gene

mRNA expression in normal human tissues for NUDT9 Gene
mRNA expression by BioGPS for NUDT9 GenemRNA expression by GTEx for NUDT9 Gene

Protein differential expression in normal tissues from HIPED for NUDT9 Gene

This gene is overexpressed in Testis (10.2), Adrenal (8.0), and Skin (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT9 Gene



Protein tissue co-expression partners for NUDT9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDT9

SOURCE GeneReport for Unigene cluster for NUDT9 Gene:

Hs.149500

mRNA Expression by UniProt/SwissProt for NUDT9 Gene:

Q9BW91-NUDT9_HUMAN
Tissue specificity: Ubiquitously expressed but isoform 1 is the most predominant isoform.

Evidence on tissue expression from TISSUES for NUDT9 Gene

  • Nervous system(4.8)
  • Spleen(4.4)
  • Kidney(2.6)
  • Liver(2.5)
  • Heart(2.4)
  • Muscle(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with NUDT9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT9 Gene

Orthologs for NUDT9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NUDT9 30 31
  • 99.14 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NUDT9 30 31
  • 89.14 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NUDT9 30 31
  • 88.66 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia NUDT9 31
  • 87 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 85 (a)
 OneToMany
-- 31
  • 70 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Nudt9 30 17 31
  • 82.86 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nudt9 30
  • 82.29 (n)
Chicken
(Gallus gallus)
 Aves NUDT9 30 31
  • 71.1 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NUDT9 31
  • 66 (a)
 OneToOne
African clawed frog
(Xenopus laevis)
 Amphibia Xl.3444 30
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia Str.5570 30
Zebrafish
(Danio rerio)
 Actinopterygii nudt9 30 31
  • 58.85 (n)
 OneToOne
wufu33g07 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG4098 30 31 32
  • 53.41 (n)
 OneToOne
CG18217 32
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006085 30
  • 51.52 (n)
Worm
(Caenorhabditis elegans)
 Secernentea ndx-6 30 31
  • 56.45 (n)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 47 (a)
 OneToOne
Species where no ortholog for NUDT9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NUDT9 Gene

ENSEMBL:
Gene Tree for NUDT9 (if available)
TreeFam:
Gene Tree for NUDT9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT9: view image

Paralogs for NUDT9 Gene

(1) SIMAP similar genes for NUDT9 Gene using alignment to 4 proteins:

  • NUDT9_HUMAN
  • D6R8Z6_HUMAN
  • D6RAW2_HUMAN
  • H7C386_HUMAN

Pseudogenes.org Pseudogenes for NUDT9 Gene

genes like me logo Genes that share paralogs with NUDT9: view

No data available for Paralogs for NUDT9 Gene

Variants for NUDT9 Gene

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Additional dbSNP identifiers (rs#s) for NUDT9 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDT9 Gene

Variant ID Type Subtype PubMed ID
esv3601274 CNV loss 21293372
esv3601276 CNV loss 21293372
esv3601277 CNV loss 21293372
esv3601278 CNV loss 21293372
nsv1002789 CNV loss 25217958
nsv1004518 CNV gain 25217958
nsv1011882 CNV gain 25217958

Variation tolerance for NUDT9 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDT9 Gene

Disorders for NUDT9 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NUDT9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
psoriasis 11
  • pv
type 1 diabetes mellitus 10
  • diabetes mellitus, insulin-dependent, 10
arrhythmogenic right ventricular dysplasia, familial, 13
  • arvd13
reflex epilepsy
  • epilepsy, sensory-induced
body dysmorphic disorder
  • body dysmorphia
- elite association - COSMIC cancer census association via MalaCards
Search NUDT9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUDT9

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NUDT9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT9 Gene

Publications for NUDT9 Gene

  1. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. (PMID: 12427752) Perraud AL … Scharenberg AM (The Journal of biological chemistry 2003) 2 3 4 23
  2. Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method. (PMID: 12897971) Zhang HT … Gong Y (Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003) 3 4 23
  3. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (PMID: 11385575) Perraud AL … Scharenberg AM (Nature 2001) 2 3 4
  4. Differential expression of NUDT9 at different phases of the menstrual cycle and in different components of normal and neoplastic human endometrium. (PMID: 19574167) Chen LY … Chen M (Taiwanese journal of obstetrics & gynecology 2009) 3 23
  5. The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. (PMID: 16860484) Carloto A … Ribeiro JM (Biochimica et biophysica acta 2006) 3 23

ExternalLinks

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