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Aliases for NUDT9 Gene

Aliases for NUDT9 Gene

  • Nudix Hydrolase 9 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 9 2 3
  • Adenosine Diphosphoribose Pyrophosphatase 3 4
  • ADP-Ribose Phosphohydrolase 3 4
  • ADP-Ribose Diphosphatase 3 4
  • ADPR-PPase 3 4
  • NUDT10 3 4
  • Nucleoside Diphosphate Linked Moiety X-Type Motif 9 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 9 4
  • ADP-Ribose Pyrophosphatase, Mitochondrial 3
  • ADP-Ribose Pyrosphosphatase NUDT9 3
  • Nudix Motif 9 4
  • EC 3.6.1.13 4

External Ids for NUDT9 Gene

Previous GeneCards Identifiers for NUDT9 Gene

  • GC04P088501
  • GC04P088645
  • GC04P088802
  • GC04P088700
  • GC04P088343
  • GC04P084089

Summaries for NUDT9 Gene

Entrez Gene Summary for NUDT9 Gene

  • The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUDT9 Gene

NUDT9 (Nudix Hydrolase 9) is a Protein Coding gene. Diseases associated with NUDT9 include Type 1 Diabetes Mellitus 10. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ADP-sugar diphosphatase activity.

UniProtKB/Swiss-Prot for NUDT9 Gene

  • Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5-phosphate.

Gene Wiki entry for NUDT9 Gene

Additional gene information for NUDT9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT9 Gene

Genomics for NUDT9 Gene

GeneHancer (GH) Regulatory Elements for NUDT9 Gene

Promoters and enhancers for NUDT9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J087418 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661 -1.1 -1058 5.6 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 RCOR2 NBN KDM1A NUDT9 GC04M087420 HSD17B11 RPL6P13 LOC100129693
GH04J087388 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 22 -32.2 -32173 4.1 HDGF FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B HSD17B11 RPL6P13 NUDT9 LOC100419572 HSD17B13 AFF1 RN7SL681P
GH04J087374 Enhancer 1 Ensembl ENCODE 19.4 -46.8 -46751 2.3 PKNOX1 FOXA2 RAD21 GTF3C2 ZNF766 POLR3A ZNF143 FOS MIXL1 ZNF654 NUDT9 RPL6P13 LOC100419572 HSD17B11 HSD17B13 RN7SL681P ENSG00000255723
GH04J086556 Enhancer 1.1 Ensembl ENCODE 9.7 -864.4 -864351 2.8 PKNOX1 INSM2 FEZF1 BATF ZNF2 YY1 ZNF213 ZNF350 ATF7 IKZF2 PTPN13 MAPK10 RPL6P13 NUDT9 MIR4452
GH04J086957 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.1 -462.2 -462201 6.3 PKNOX1 FOXA2 ARNT SIN3A FEZF1 IRF4 YY1 ZNF766 ZNF213 JUNB AFF1 C4orf36 LOC260422 MAPK10 NUDT9 KLHL8 PIR55151 GC04P086967 TECRP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT9 gene promoter:
  • ISGF-3
  • ZID
  • deltaCREB
  • CREB
  • COMP1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for NUDT9 Gene

Genomic Locations for NUDT9 Gene
chr4:87,422,557-87,459,454
(GRCh38/hg38)
Size:
36,898 bases
Orientation:
Plus strand
chr4:88,343,734-88,380,606
(GRCh37/hg19)
Size:
36,873 bases
Orientation:
Plus strand

Genomic View for NUDT9 Gene

Genes around NUDT9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT9 Gene

Proteins for NUDT9 Gene

  • Protein details for NUDT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW91-NUDT9_HUMAN
    Recommended name:
    ADP-ribose pyrophosphatase, mitochondrial
    Protein Accession:
    Q9BW91
    Secondary Accessions:
    • Q8NBN1
    • Q8NCB9
    • Q8NG25

    Protein attributes for NUDT9 Gene

    Size:
    350 amino acids
    Molecular mass:
    39125 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer. Interacts with GLOD4.

    Three dimensional structures from OCA and Proteopedia for NUDT9 Gene

    Alternative splice isoforms for NUDT9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT9 Gene

Post-translational modifications for NUDT9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT9 Gene

No data available for DME Specific Peptides for NUDT9 Gene

Domains & Families for NUDT9 Gene

Gene Families for NUDT9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NUDT9 Gene

Suggested Antigen Peptide Sequences for NUDT9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW91

UniProtKB/Swiss-Prot:

NUDT9_HUMAN :
  • Belongs to the Nudix hydrolase family. NudF subfamily.
Family:
  • Belongs to the Nudix hydrolase family. NudF subfamily.
genes like me logo Genes that share domains with NUDT9: view

Function for NUDT9 Gene

Molecular function for NUDT9 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ADP-D-ribose + H(2)O = AMP + D-ribose 5-phosphate.
UniProtKB/Swiss-Prot Induction:
Isoform 1 is inhibited by fluoride and N-acetyl-p-benzoquinoneimine.

Enzyme Numbers (IUBMB) for NUDT9 Gene

Phenotypes From GWAS Catalog for NUDT9 Gene

Gene Ontology (GO) - Molecular Function for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0019144 ADP-sugar diphosphatase activity NAS 11385575
GO:0043262 adenosine-diphosphatase activity IBA --
GO:0047631 ADP-ribose diphosphatase activity EXP 12948489
genes like me logo Genes that share ontologies with NUDT9: view
genes like me logo Genes that share phenotypes with NUDT9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT9

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT9 Gene

Localization for NUDT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT9 Gene

Isoform 1: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT9 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 11385575
GO:0005739 mitochondrion IBA --
GO:0005759 mitochondrial matrix TAS --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with NUDT9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NUDT9 Gene

Pathways & Interactions for NUDT9 Gene

genes like me logo Genes that share pathways with NUDT9: view

Pathways by source for NUDT9 Gene

1 KEGG pathway for NUDT9 Gene

Gene Ontology (GO) - Biological Process for NUDT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
GO:0046032 ADP catabolic process IEA --
GO:0046709 IDP catabolic process IEA --
genes like me logo Genes that share ontologies with NUDT9: view

No data available for SIGNOR curated interactions for NUDT9 Gene

Drugs & Compounds for NUDT9 Gene

(6) Drugs for NUDT9 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
Beta-D-Glucose Experimental Pharma Target 0

(4) Additional Compounds for NUDT9 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppa
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • a5'pp5RIb
  • Adenosine 5'-diphosphoribose
  • AdoPPRib
20762-30-5
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
D-Ribose 5-phosphate
  • D-Ribose 5'-phosphate
  • D-Ribose-5-P
  • Ribose 5-phosphate
  • D-Ribose 5'-phosphoric acid
  • D-Ribose 5-phosphoric acid
3615-55-2
genes like me logo Genes that share compounds with NUDT9: view

Transcripts for NUDT9 Gene

Unigene Clusters for NUDT9 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4:
SP5:
SP6: - - - -
SP7: - - - - - - - -
SP8:
SP9: - -

Relevant External Links for NUDT9 Gene

GeneLoc Exon Structure for
NUDT9
ECgene alternative splicing isoforms for
NUDT9

Expression for NUDT9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT9 Gene

Protein differential expression in normal tissues from HIPED for NUDT9 Gene

This gene is overexpressed in Testis (10.2), Adrenal (8.0), and Skin (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT9 Gene



Protein tissue co-expression partners for NUDT9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDT9 Gene:

NUDT9

SOURCE GeneReport for Unigene cluster for NUDT9 Gene:

Hs.149500

mRNA Expression by UniProt/SwissProt for NUDT9 Gene:

Q9BW91-NUDT9_HUMAN
Tissue specificity: Ubiquitously expressed but isoform 1 is the most predominant isoform.

Evidence on tissue expression from TISSUES for NUDT9 Gene

  • Nervous system(4.7)
  • Spleen(4.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with NUDT9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT9 Gene

Orthologs for NUDT9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT9 34 33
  • 99.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT9 34 33
  • 89.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT9 34 33
  • 88.66 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT9 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nudt9 16 34 33
  • 82.86 (n)
rat
(Rattus norvegicus)
Mammalia Nudt9 33
  • 82.29 (n)
chicken
(Gallus gallus)
Aves NUDT9 34 33
  • 71.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT9 34
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3444 33
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5570 33
zebrafish
(Danio rerio)
Actinopterygii nudt9 34 33
  • 58.85 (n)
OneToOne
wufu33g07 33
fruit fly
(Drosophila melanogaster)
Insecta CG4098 34 35 33
  • 53.41 (n)
OneToOne
CG18217 35
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006085 33
  • 51.52 (n)
worm
(Caenorhabditis elegans)
Secernentea ndx-6 34 33
  • 56.45 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Species where no ortholog for NUDT9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT9 Gene

ENSEMBL:
Gene Tree for NUDT9 (if available)
TreeFam:
Gene Tree for NUDT9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT9: view image

Paralogs for NUDT9 Gene

(1) SIMAP similar genes for NUDT9 Gene using alignment to 4 proteins:

  • NUDT9_HUMAN
  • D6R8Z6_HUMAN
  • D6RAW2_HUMAN
  • H7C386_HUMAN

Pseudogenes.org Pseudogenes for NUDT9 Gene

genes like me logo Genes that share paralogs with NUDT9: view

No data available for Paralogs for NUDT9 Gene

Variants for NUDT9 Gene

Sequence variations from dbSNP and Humsavar for NUDT9 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000067760 -- 87,447,545(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000177029 -- 87,433,102(+) A/G intron_variant
rs1000193807 -- 87,430,567(+) A/C intron_variant
rs1000195347 -- 87,423,676(+) G/A intron_variant
rs10002390 -- 87,425,517(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT9 Gene

Variant ID Type Subtype PubMed ID
esv3601274 CNV loss 21293372
esv3601276 CNV loss 21293372
esv3601277 CNV loss 21293372
esv3601278 CNV loss 21293372
nsv1002789 CNV loss 25217958
nsv1004518 CNV gain 25217958
nsv1011882 CNV gain 25217958

Variation tolerance for NUDT9 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT9 Gene

Disorders for NUDT9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDT9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
type 1 diabetes mellitus 10
  • diabetes mellitus, insulin-dependent, 10
- elite association - COSMIC cancer census association via MalaCards
Search NUDT9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUDT9

genes like me logo Genes that share disorders with NUDT9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT9 Gene

Publications for NUDT9 Gene

  1. NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. (PMID: 12427752) Perraud AL … Scharenberg AM (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method. (PMID: 12897971) Zhang HT … Gong Y (Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003) 3 4 22 58
  3. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (PMID: 11385575) Perraud AL … Scharenberg AM (Nature 2001) 2 3 4 58
  4. Differential expression of NUDT9 at different phases of the menstrual cycle and in different components of normal and neoplastic human endometrium. (PMID: 19574167) Chen LY … Chen M (Taiwanese journal of obstetrics & gynecology 2009) 3 22 58
  5. The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. (PMID: 16860484) Carloto A … Ribeiro JM (Biochimica et biophysica acta 2006) 3 22 58

Products for NUDT9 Gene

Sources for NUDT9 Gene

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