Aliases for NUDT8 Gene

Aliases for NUDT8 Gene

  • Nudix Hydrolase 8 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 8 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 8 3 4
  • Nudix Motif 8 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 8, Mitochondrial 3
  • EC 3.6.1.- 4
  • FLJ41567 2
  • NUDT8 5

External Ids for NUDT8 Gene

Previous GeneCards Identifiers for NUDT8 Gene

  • GC11U990247
  • GC11M067645
  • GC11M067170
  • GC11M067151
  • GC11M067395
  • GC11M063724
  • GC11M067627

Summaries for NUDT8 Gene

GeneCards Summary for NUDT8 Gene

NUDT8 (Nudix Hydrolase 8) is a Protein Coding gene. Diseases associated with NUDT8 include Endosteal Hyperostosis, Autosomal Dominant. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot Summary for NUDT8 Gene

  • Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT8 Gene

Genomics for NUDT8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NUDT8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDT8

Top Transcription factor binding sites by QIAGEN in the NUDT8 gene promoter:
  • COMP1
  • CREB
  • E47
  • GATA-1
  • HEN1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for NUDT8 Gene

Latest Assembly
chr11:67,621,421-67,629,937
(GRCh38/hg38)
Size:
8,517 bases
Orientation:
Minus strand

Previous Assembly
chr11:67,395,409-67,397,408
(GRCh37/hg19 by Entrez Gene)
Size:
2,000 bases
Orientation:
Minus strand

chr11:67,395,409-67,397,401
(GRCh37/hg19 by Ensembl)
Size:
1,993 bases
Orientation:
Minus strand

Genomic View for NUDT8 Gene

Genes around NUDT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT8 Gene

Proteins for NUDT8 Gene

  • Protein details for NUDT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV74-NUDT8_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 8
    Protein Accession:
    Q8WV74
    Secondary Accessions:
    • Q6ZW59

    Protein attributes for NUDT8 Gene

    Size:
    236 amino acids
    Molecular mass:
    25370 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NUDT8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT8 Gene

Post-translational modifications for NUDT8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT8 Gene

No data available for DME Specific Peptides for NUDT8 Gene

Domains & Families for NUDT8 Gene

Gene Families for NUDT8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT8 Gene

InterPro:
Blocks:
  • NUDIX hydrolase

Suggested Antigen Peptide Sequences for NUDT8 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 8, mitochondrial (NUDT8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WV74

UniProtKB/Swiss-Prot:

NUDT8_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT8: view

Function for NUDT8 Gene

Molecular function for NUDT8 Gene

UniProtKB/Swiss-Prot Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Enzyme Numbers (IUBMB) for NUDT8 Gene

Phenotypes From GWAS Catalog for NUDT8 Gene

Gene Ontology (GO) - Molecular Function for NUDT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT8: view
genes like me logo Genes that share phenotypes with NUDT8: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT8

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT8 Gene

Localization for NUDT8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT8 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
plasma membrane 0
extracellular 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUDT8 Gene

Pathways & Interactions for NUDT8 Gene

PathCards logo

SuperPathways for NUDT8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDT8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDT8 Gene

Drugs & Compounds for NUDT8 Gene

(4) Drugs for NUDT8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 65
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(2) Additional Compounds for NUDT8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
dTDP
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
491-97-4
genes like me logo Genes that share compounds with NUDT8: view

Transcripts for NUDT8 Gene

mRNA/cDNA for NUDT8 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT8

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1: -
SP2: -
SP3:

Relevant External Links for NUDT8 Gene

GeneLoc Exon Structure for
NUDT8

Expression for NUDT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT8 Gene

mRNA differential expression in normal tissues according to GTEx for NUDT8 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7) and Heart - Atrial Appendage (x4.8).

Protein differential expression in normal tissues from HIPED for NUDT8 Gene

This gene is overexpressed in Heart (15.7), Gallbladder (15.3), Kidney (11.3), Salivary gland (8.7), and Liver (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT8 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDT8

SOURCE GeneReport for Unigene cluster for NUDT8 Gene:

Hs.433329

Evidence on tissue expression from TISSUES for NUDT8 Gene

  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with NUDT8: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT8 Gene

Orthologs for NUDT8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NUDT8 29 30
  • 99.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NUDT8 29 30
  • 87.09 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NUDT8 29 30
  • 85.55 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nudt8 29
  • 82.27 (n)
Mouse
(Mus musculus)
Mammalia Nudt8 29 16 30
  • 81.94 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NUDT8 30
  • 39 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NUDT8 29 30
  • 65.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NUDT8 30
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100487518 29
  • 52.08 (n)
Zebrafish
(Danio rerio)
Actinopterygii nudt8 29 30
  • 57.73 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG11095 29 30
  • 50.59 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000942 29
  • 48.54 (n)
Worm
(Caenorhabditis elegans)
Secernentea ndx-3 29 30
  • 45.57 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6580 30
  • 26 (a)
OneToOne
Species where no ortholog for NUDT8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NUDT8 Gene

ENSEMBL:
Gene Tree for NUDT8 (if available)
TreeFam:
Gene Tree for NUDT8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT8: view image
Alliance of Genome Resources:
Additional Orthologs for NUDT8

Paralogs for NUDT8 Gene

No data available for Paralogs for NUDT8 Gene

Variants for NUDT8 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NUDT8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NUDT8 Gene

Variant ID Type Subtype PubMed ID
dgv1214n100 CNV gain 25217958
dgv154n27 CNV loss 19166990
dgv1981n54 CNV gain 21841781
dgv1982n54 CNV loss 21841781
esv2422195 CNV duplication 17116639
nsv1070046 CNV deletion 25765185
nsv1143690 CNV deletion 24896259
nsv468606 CNV gain 19166990
nsv468609 CNV loss 19166990
nsv469963 CNV loss 18288195
nsv555272 CNV loss 21841781
nsv555273 CNV loss 21841781
nsv951023 CNV deletion 24416366

Variation tolerance for NUDT8 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT8
Leiden Open Variation Database (LOVD)
NUDT8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDT8 Gene

Disorders for NUDT8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDT8 Gene - From: COP

Disorder Aliases PubMed IDs
endosteal hyperostosis, autosomal dominant
  • hyperostosis corticalis generalisata, benign form of worth, with torus palatinus
- elite association - COSMIC cancer census association via MalaCards
Search NUDT8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUDT8

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NUDT8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT8 Gene

Publications for NUDT8 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. (PMID: 11415433) Gasmi L … McLennan AG (The Biochemical journal 2001) 2 3
  5. A High-Density Human Mitochondrial Proximity Interaction Network. (PMID: 32877691) Antonicka H … Shoubridge EA (Cell metabolism 2020) 3

Products for NUDT8 Gene

Sources for NUDT8 Gene