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Aliases for NUDT7 Gene

Aliases for NUDT7 Gene

  • Nudix Hydrolase 7 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 7 2
  • Nucleoside Diphosphate-Linked Moiety X Motif 7 4
  • Nudix Motif 7 4
  • EC 3.6.1.- 4

External Ids for NUDT7 Gene

Previous GeneCards Identifiers for NUDT7 Gene

  • GC16U990126
  • GC16P077495
  • GC16P076316
  • GC16P063512

Summaries for NUDT7 Gene

Entrez Gene Summary for NUDT7 Gene

  • The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for NUDT7 Gene

NUDT7 (Nudix Hydrolase 7) is a Protein Coding gene. Diseases associated with NUDT7 include Neurodegeneration With Brain Iron Accumulation 1. Among its related pathways are Peroxisomal lipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include receptor binding and magnesium ion binding. An important paralog of this gene is NUDT8.

UniProtKB/Swiss-Prot for NUDT7 Gene

  • Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3,5-ADP and the corresponding 4-phosphopantetheine derivative as products. CoA into 3,5-ADP and 4-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5-triphosphates, nucleoside 5-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).

Additional gene information for NUDT7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT7 Gene

Genomics for NUDT7 Gene

GeneHancer (GH) Regulatory Elements for NUDT7 Gene

Promoters and enhancers for NUDT7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I077721 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 580.4 +0.6 595 2.5 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 ZNF207 ZNF143 NUDT7 ENSG00000261707
GH16I077779 Enhancer 0.9 Ensembl ENCODE 16.2 +58.1 58065 1.1 FOXA2 JUN ZNF398 ZSCAN21 ZFHX2 JUND BCL11A GLIS1 ZNF629 PRDM10 NUDT7 VAT1L ENSG00000261707
GH16I077676 Enhancer 0.8 ENCODE 16.3 -46.6 -46563 0.2 CTCF ZNF792 RB1 KMT2B ZSCAN9 RAD21 CC2D1A ARID2 ZSCAN5C SMC3 NUDT7 VAT1L CLEC3A WWOX ENSG00000278862
GH16I077760 Enhancer 0.6 ENCODE 18.1 +38.3 38265 1.3 ESRRA CTBP1 JUND GATA3 FOS NR2F6 PRDM10 TRIM28 TCF7L2 NUDT7 ENSG00000261707 VAT1L
GH16I077764 Enhancer 0.6 ENCODE 16.2 +42.0 42024 1 NFIA RXRA MAX ZNF398 REST RAD21 YY1 JUND ATF3 HNF4A NUDT7 ENSG00000261707 VAT1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUDT7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT7 gene promoter:

Genomic Locations for NUDT7 Gene

Genomic Locations for NUDT7 Gene
chr16:77,722,492-77,742,260
(GRCh38/hg38)
Size:
19,769 bases
Orientation:
Plus strand
chr16:77,756,411-77,776,157
(GRCh37/hg19)

Genomic View for NUDT7 Gene

Genes around NUDT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT7 Gene

Proteins for NUDT7 Gene

  • Protein details for NUDT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C024-NUDT7_HUMAN
    Recommended name:
    Peroxisomal coenzyme A diphosphatase NUDT7
    Protein Accession:
    P0C024
    Secondary Accessions:
    • B4DLE5
    • H3BUB8

    Protein attributes for NUDT7 Gene

    Size:
    238 amino acids
    Molecular mass:
    26942 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NUDT7 Gene

    Alternative splice isoforms for NUDT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT7 Gene

Post-translational modifications for NUDT7 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NUDT7 Gene

Domains & Families for NUDT7 Gene

Gene Families for NUDT7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT7 Gene

Graphical View of Domain Structure for InterPro Entry

P0C024

UniProtKB/Swiss-Prot:

NUDT7_HUMAN :
  • Belongs to the Nudix hydrolase family. PCD1 subfamily.
Family:
  • Belongs to the Nudix hydrolase family. PCD1 subfamily.
genes like me logo Genes that share domains with NUDT7: view

Function for NUDT7 Gene

Molecular function for NUDT7 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by fluoride.
UniProtKB/Swiss-Prot Function:
Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3,5-ADP and the corresponding 4-phosphopantetheine derivative as products. CoA into 3,5-ADP and 4-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5-triphosphates, nucleoside 5-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).

Enzyme Numbers (IUBMB) for NUDT7 Gene

Phenotypes From GWAS Catalog for NUDT7 Gene

Gene Ontology (GO) - Molecular Function for NUDT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003674 molecular_function ND --
GO:0003723 RNA binding IEA --
GO:0003986 acetyl-CoA hydrolase activity ISS --
GO:0005102 receptor binding IPI 20178365
genes like me logo Genes that share ontologies with NUDT7: view
genes like me logo Genes that share phenotypes with NUDT7: view

Animal Model Products

miRNA for NUDT7 Gene

miRTarBase miRNAs that target NUDT7

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT7 Gene

Localization for NUDT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT7 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT7 gene
Compartment Confidence
peroxisome 5
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome ISS --
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with NUDT7: view

Pathways & Interactions for NUDT7 Gene

genes like me logo Genes that share pathways with NUDT7: view

Pathways by source for NUDT7 Gene

1 KEGG pathway for NUDT7 Gene

Gene Ontology (GO) - Biological Process for NUDT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009062 fatty acid catabolic process TAS --
GO:0009132 nucleoside diphosphate metabolic process IEA --
GO:0015938 coenzyme A catabolic process ISS --
GO:0046356 acetyl-CoA catabolic process ISS --
genes like me logo Genes that share ontologies with NUDT7: view

No data available for SIGNOR curated interactions for NUDT7 Gene

Drugs & Compounds for NUDT7 Gene

(6) Drugs for NUDT7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
NADH Approved Nutra 0
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(32) Additional Compounds for NUDT7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with NUDT7: view

Transcripts for NUDT7 Gene

mRNA/cDNA for NUDT7 Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT7 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for NUDT7 Gene

GeneLoc Exon Structure for
NUDT7
ECgene alternative splicing isoforms for
NUDT7

Expression for NUDT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUDT7 Gene

This gene is overexpressed in Liver (x5.0).

Protein differential expression in normal tissues from HIPED for NUDT7 Gene

This gene is overexpressed in Liver (54.3) and Adrenal (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT7 Gene



Protein tissue co-expression partners for NUDT7 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT7 Gene:

NUDT7

SOURCE GeneReport for Unigene cluster for NUDT7 Gene:

Hs.282665

mRNA Expression by UniProt/SwissProt for NUDT7 Gene:

P0C024-NUDT7_HUMAN
Tissue specificity: Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain.
genes like me logo Genes that share expression patterns with NUDT7: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT7 Gene

Orthologs for NUDT7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT7 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia NUDT7 33 34
  • 80.53 (n)
cow
(Bos Taurus)
Mammalia NUDT7 33 34
  • 76.19 (n)
mouse
(Mus musculus)
Mammalia Nudt7 33 16 34
  • 74.74 (n)
rat
(Rattus norvegicus)
Mammalia LOC102555567 33
  • 72.78 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDT7 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT7 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT7 33 34
  • 56.93 (n)
lizard
(Anolis carolinensis)
Reptilia NUDT7 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt7 33
  • 54.67 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329471 33
  • 50.32 (n)
NUDT7 34
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ndx-8 34
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PCD1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons NUDT11 33
  • 46.44 (n)
rice
(Oryza sativa)
Liliopsida Os05g0209400 33
  • 46.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToOne
Species where no ortholog for NUDT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT7 Gene

ENSEMBL:
Gene Tree for NUDT7 (if available)
TreeFam:
Gene Tree for NUDT7 (if available)

Paralogs for NUDT7 Gene

Paralogs for NUDT7 Gene

genes like me logo Genes that share paralogs with NUDT7: view

Variants for NUDT7 Gene

Sequence variations from dbSNP and Humsavar for NUDT7 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000091522 -- 77,731,307(+) G/C intron_variant
rs1000391549 -- 77,721,203(+) G/C upstream_transcript_variant
rs1000518870 -- 77,720,943(+) C/A upstream_transcript_variant
rs1000569351 -- 77,726,023(+) C/A intron_variant
rs1000637796 -- 77,725,115(+) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT7 Gene

Variant ID Type Subtype PubMed ID
nsv573129 CNV gain 21841781
nsv573128 CNV gain 21841781
nsv521833 CNV loss 19592680
nsv471098 CNV gain 18288195
nsv457543 CNV gain 19166990
nsv457542 CNV gain 19166990
nsv1062004 CNV loss 25217958
nsv1056676 CNV loss 25217958
esv3639171 CNV gain 21293372
esv2714736 CNV deletion 23290073

Variation tolerance for NUDT7 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT7 Gene

Human Gene Mutation Database (HGMD)
NUDT7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT7 Gene

Disorders for NUDT7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDT7 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
neurodegeneration with brain iron accumulation 1
  • hss
- elite association - COSMIC cancer census association via MalaCards
Search NUDT7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUDT7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NUDT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT7 Gene

Publications for NUDT7 Gene

  1. The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. (PMID: 11415433) Gasmi L … McLennan AG (The Biochemical journal 2001) 2 3 4 22 58
  2. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 44 58
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  5. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. (PMID: 20178365) Ghosh D … Berg JM (Journal of the American Chemical Society 2010) 3 58

Products for NUDT7 Gene

Sources for NUDT7 Gene

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