This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pitu... See more...

Aliases for NUDT6 Gene

Aliases for NUDT6 Gene

  • Nudix Hydrolase 6 2 3 5
  • FGF2AS 2 3 4
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 6 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 6 3 4
  • Antisense Basic Fibroblast Growth Factor 3 4
  • FGF-AS 2 3
  • Nudix Motif 6 4
  • Protein GFG 4
  • EC 3.6.1.- 4
  • ASFGF2 3
  • GFG-1 3
  • NUDT6 5
  • Gfg-1 2
  • GFG1 3
  • Gfg 2

External Ids for NUDT6 Gene

Previous GeneCards Identifiers for NUDT6 Gene

  • GC04M124726
  • GC04M124093
  • GC04M124207
  • GC04M124272
  • GC04M124171
  • GC04M123814
  • GC04M119540

Summaries for NUDT6 Gene

Entrez Gene Summary for NUDT6 Gene

  • This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUDT6 Gene

NUDT6 (Nudix Hydrolase 6) is a Protein Coding gene. Diseases associated with NUDT6 include Gingival Overgrowth and Prostatic Adenoma. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include hydrolase activity and growth factor activity.

UniProtKB/Swiss-Prot Summary for NUDT6 Gene

Gene Wiki entry for NUDT6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT6 Gene

Genomics for NUDT6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NUDT6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDT6

Top Transcription factor binding sites by QIAGEN in the NUDT6 gene promoter:
  • AP-1
  • ATF
  • STAT3

Genomic Locations for NUDT6 Gene

Latest Assembly
chr4:122,888,697-122,922,968
(GRCh38/hg38)
Size:
34,272 bases
Orientation:
Minus strand

Previous Assembly
chr4:123,813,732-123,844,123
(GRCh37/hg19 by Entrez Gene)
Size:
30,392 bases
Orientation:
Minus strand

chr4:123,809,852-123,844,123
(GRCh37/hg19 by Ensembl)
Size:
34,272 bases
Orientation:
Minus strand

Genomic View for NUDT6 Gene

Genes around NUDT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT6 Gene

Proteins for NUDT6 Gene

  • Protein details for NUDT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53370-NUDT6_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 6
    Protein Accession:
    P53370
    Secondary Accessions:
    • A8K756
    • O95097
    • Q9UQD9

    Protein attributes for NUDT6 Gene

    Size:
    316 amino acids
    Molecular mass:
    35679 Da
    Quaternary structure:
    • Monomer and homodimer.
    Miscellaneous:
    • This protein is coded from a FGF2 (BFGF) gene antisense transcript.

    Three dimensional structures from OCA and Proteopedia for NUDT6 Gene

    Alternative splice isoforms for NUDT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT6 Gene

Post-translational modifications for NUDT6 Gene

  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDT6 Gene

No data available for DME Specific Peptides for NUDT6 Gene

Domains & Families for NUDT6 Gene

Gene Families for NUDT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT6 Gene

InterPro:
Blocks:
  • NUDIX hydrolase
  • Anti-sense to fibroblast growth factor protein GFG signature

Suggested Antigen Peptide Sequences for NUDT6 Gene

GenScript: Design optimal peptide antigens:
  • Protein GFG (NUDT6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53370

UniProtKB/Swiss-Prot:

NUDT6_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT6: view

Function for NUDT6 Gene

Molecular function for NUDT6 Gene

UniProtKB/Swiss-Prot Function:
May contribute to the regulation of cell proliferation.
GENATLAS Biochemistry:
nudix (nucleoside diphosphate linked moiety X)-type motif 6,hydrolase,antisense transcript of FGF2,coexpressed with FGF2 in many tissues,and potentially regulator of FGF2 expression,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways

Enzyme Numbers (IUBMB) for NUDT6 Gene

Phenotypes From GWAS Catalog for NUDT6 Gene

Gene Ontology (GO) - Molecular Function for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0035529 NADH pyrophosphatase activity IBA 21873635
GO:0047631 ADP-ribose diphosphatase activity IBA 21873635
GO:0051287 NAD binding IBA 21873635
genes like me logo Genes that share ontologies with NUDT6: view
genes like me logo Genes that share phenotypes with NUDT6: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT6

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT6 Gene

Localization for NUDT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT6 Gene

Cytoplasm. Nucleus. Mitochondrion. Note=Subcellular location may vary between isoforms.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT6 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytoskeleton 2
plasma membrane 1
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 11266510
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with NUDT6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NUDT6 Gene

Pathways & Interactions for NUDT6 Gene

PathCards logo

SuperPathways for NUDT6 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with NUDT6: view

Pathways by source for NUDT6 Gene

54 Qiagen pathways for NUDT6 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

Gene Ontology (GO) - Biological Process for NUDT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 11266510
GO:0045786 negative regulation of cell cycle IDA 11266510
genes like me logo Genes that share ontologies with NUDT6: view

No data available for SIGNOR curated interactions for NUDT6 Gene

Drugs & Compounds for NUDT6 Gene

(28) Drugs for NUDT6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(17) Additional Compounds for NUDT6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUDT6: view

Transcripts for NUDT6 Gene

mRNA/cDNA for NUDT6 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT6

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT6 Gene

No ASD Table

Relevant External Links for NUDT6 Gene

GeneLoc Exon Structure for
NUDT6

Expression for NUDT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDT6 Gene

This gene is overexpressed in Gallbladder (27.6), Liver (10.7), Kidney (10.2), and Heart (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDT6

SOURCE GeneReport for Unigene cluster for NUDT6 Gene:

Hs.558459

mRNA Expression by UniProt/SwissProt for NUDT6 Gene:

P53370-NUDT6_HUMAN
Tissue specificity: Detected in liver, kidney and esophagus (at protein level). Ubiquitous.

Evidence on tissue expression from TISSUES for NUDT6 Gene

  • Liver(4.3)
  • Muscle(4.3)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with NUDT6: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT6 Gene

Orthologs for NUDT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NUDT6 29 30
  • 99.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NUDT6 29 30
  • 90.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NUDT6 29 30
  • 86.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nudt6 29
  • 79.83 (n)
Mouse
(Mus musculus)
Mammalia Nudt6 29 16 30
  • 77.01 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NUDT6 30
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NUDT6 29 30
  • 75.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NUDT6 30
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nudt6 29
  • 69.01 (n)
Str.20390 29
Zebrafish
(Danio rerio)
Actinopterygii nudt6 29 30
  • 60.73 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG8128 29 30 31
  • 45.26 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012857 29
  • 43.21 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons NUDT8 29
  • 48.91 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0547900 29
  • 48.86 (n)
Species where no ortholog for NUDT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NUDT6 Gene

ENSEMBL:
Gene Tree for NUDT6 (if available)
TreeFam:
Gene Tree for NUDT6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT6: view image
Alliance of Genome Resources:
Additional Orthologs for NUDT6

Paralogs for NUDT6 Gene

No data available for Paralogs for NUDT6 Gene

Variants for NUDT6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDT6 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs1048201 -- p.Arg209Gln
rs12648093 -- p.Cys114Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NUDT6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NUDT6 Gene

Variant ID Type Subtype PubMed ID
esv2657447 CNV deletion 23128226
esv3602036 CNV loss 21293372
esv3894022 CNV gain 25118596

Variation tolerance for NUDT6 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.58; 82.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT6 Gene

Human Gene Mutation Database (HGMD)
NUDT6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT6
Leiden Open Variation Database (LOVD)
NUDT6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT6 Gene

Disorders for NUDT6 Gene

MalaCards: The human disease database

(6) MalaCards diseases for NUDT6 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
gingival overgrowth
  • gingival enlargement
prostatic adenoma
  • adenoma - prostate
desmoid disease, hereditary
  • desmd
cardiac valvular dysplasia, x-linked
  • cvd1
cartilage cancer
  • chondrogenic neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search NUDT6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUDT6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NUDT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT6 Gene

Publications for NUDT6 Gene

  1. Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. (PMID: 7984147) Murphy PR … Knee RS (Molecular endocrinology (Baltimore, Md.) 1994) 2 3 4 22
  2. Association study between keratinocyte-derived growth factor gene polymorphisms and susceptibility to vitiligo vulgaris in a Taiwanese population: potential involvement of stem cell factor. (PMID: 19416273) Lan CC … Yu HS (The British journal of dermatology 2009) 3 22 40
  3. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. (PMID: 11266510) Asa SL … Ezzat S (Molecular endocrinology (Baltimore, Md.) 2001) 3 4 22
  4. Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. (PMID: 10022609) Gagnon ML … Klagsbrun M (Journal of cellular biochemistry 1999) 2 3 4
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 40

Products for NUDT6 Gene

Sources for NUDT6 Gene