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Aliases for NUDT4B Gene

Aliases for NUDT4B Gene

  • Nudix Hydrolase 4B 2 3 4 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 4 Pseudogene 1 2 3
  • Diphosphoinositol Polyphosphate Phosphohydrolase NUDT4B 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 4B 3 4
  • Nudix Motif 4B 3 4
  • DIPP-2B 3 4
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 4 3
  • Nudix Hydrolase 4 Pseudogene 1 2
  • EC 3.6.1.52 4
  • NUDT4P1 3

External Ids for NUDT4B Gene

Previous HGNC Symbols for NUDT4B Gene

  • NUDT4P1

Summaries for NUDT4B Gene

GeneCards Summary for NUDT4B Gene

NUDT4B (Nudix Hydrolase 4B) is a Protein Coding gene. An important paralog of this gene is NUDT4.

UniProtKB/Swiss-Prot for NUDT4B Gene

  • Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

Additional gene information for NUDT4B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT4B Gene

Genomics for NUDT4B Gene

GeneHancer (GH) Regulatory Elements for NUDT4B Gene

Promoters and enhancers for NUDT4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J148748 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 600.7 +0.4 401 2 MTA3 GTF2F1 CSDE1 ZSCAN21 SP7 PRDM1 MZF1 IKZF1 RNF2 ZBTB8A NUDT4B GC01P148750
GH01J148743 Enhancer 0.8 ENCODE dbSUPER 0.7 -4.2 -4233 1.5 MAFK SMARCA4 ZNF341 ZNF316 MGA FOXK2 MAFG ARNT MNT DPF2 RNU6-1171P NUDT4B
GH01J148740 Enhancer 0.2 dbSUPER 0.4 -7.8 -7750 1.1 RNU6-1171P NUDT4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT4B on UCSC Golden Path with GeneCards custom track

Genomic Locations for NUDT4B Gene

Genomic Locations for NUDT4B Gene
chr1:148,748,600-148,752,401
(GRCh38/hg38)
Size:
3,802 bases
Orientation:
Plus strand
chr1:145,136,118-145,139,902
(GRCh37/hg19)
Size:
3,785 bases
Orientation:
Minus strand

Genomic View for NUDT4B Gene

Genes around NUDT4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT4B Gene

Proteins for NUDT4B Gene

  • Protein details for NUDT4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A024RBG1-NUD4B_HUMAN
    Recommended name:
    Diphosphoinositol polyphosphate phosphohydrolase NUDT4B
    Protein Accession:
    A0A024RBG1

    Protein attributes for NUDT4B Gene

    Size:
    181 amino acids
    Molecular mass:
    20434 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT4B Gene

Post-translational modifications for NUDT4B Gene

No Post-translational modifications

Other Protein References for NUDT4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT4B Gene

Domains & Families for NUDT4B Gene

Gene Families for NUDT4B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT4B Gene

Graphical View of Domain Structure for InterPro Entry

A0A024RBG1

UniProtKB/Swiss-Prot:

NUD4B_HUMAN :
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
Family:
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
genes like me logo Genes that share domains with NUDT4B: view

No data available for Suggested Antigen Peptide Sequences for NUDT4B Gene

Function for NUDT4B Gene

Molecular function for NUDT4B Gene

UniProtKB/Swiss-Prot Function:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.; EC=3.6.1.52; Evidence=. ;.

Enzyme Numbers (IUBMB) for NUDT4B Gene

Gene Ontology (GO) - Molecular Function for NUDT4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity IEA --
genes like me logo Genes that share ontologies with NUDT4B: view
genes like me logo Genes that share phenotypes with NUDT4B: view

Animal Model Products

CRISPR Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT4B Gene

Localization for NUDT4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT4B Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUDT4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NUDT4B: view

No data available for Subcellular locations from COMPARTMENTS for NUDT4B Gene

Pathways & Interactions for NUDT4B Gene

PathCards logo

SuperPathways for NUDT4B Gene

No Data Available

Interacting Proteins for NUDT4B Gene

Gene Ontology (GO) - Biological Process for NUDT4B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDT4B Gene

Drugs & Compounds for NUDT4B Gene

No Compound Related Data Available

Transcripts for NUDT4B Gene

mRNA/cDNA for NUDT4B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(224) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT4B Gene

No ASD Table

Relevant External Links for NUDT4B Gene

GeneLoc Exon Structure for
NUDT4B
ECgene alternative splicing isoforms for
NUDT4B

Expression for NUDT4B Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT4B Gene:

NUDT4B
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT4B Gene

Orthologs for NUDT4B Gene

Evolution for NUDT4B Gene

ENSEMBL:
Gene Tree for NUDT4B (if available)
TreeFam:
Gene Tree for NUDT4B (if available)

No data available for Orthologs for NUDT4B Gene

Paralogs for NUDT4B Gene

Paralogs for NUDT4B Gene

genes like me logo Genes that share paralogs with NUDT4B: view

Variants for NUDT4B Gene

Sequence variations from dbSNP and Humsavar for NUDT4B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs112714472 -- 148,749,091(+) A/T coding_sequence_variant, missense_variant
rs112945491 -- 148,748,672(+) G/C upstream_transcript_variant
rs11484529 -- 148,747,971(+) C/T upstream_transcript_variant
rs11487273 -- 148,751,758(+) T/G 3_prime_UTR_variant
rs1158870262 -- 148,752,043(+) TTTTTTTTTTTTTTTTTT/TTTTTTTTTTTTTTT/TTTTTTTTTTTTTTTT/TTTTTTTTTTTTTTTTT/TTTTTTTTTTTTTTTTTTT/TTTTTTTTTTTTTTTTTTTT/TTTTTTTTTTTTTTTTTTTTT 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT4B Gene

Variant ID Type Subtype PubMed ID
dgv17n16 CNV deletion 17901297
dgv324n100 CNV gain 25217958
dgv325n100 CNV gain 25217958
dgv327n100 CNV gain 25217958
dgv328n100 CNV gain 25217958
dgv66e199 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1005230 CNV gain 25217958
nsv1008368 CNV gain 25217958
nsv1132304 CNV duplication 24896259
nsv498687 CNV loss 21111241
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv946254 CNV duplication 23825009
nsv946255 CNV duplication 23825009
nsv946256 CNV duplication 23825009
nsv946952 CNV duplication 23825009

Additional Variant Information for NUDT4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NUDT4B Gene

Disorders for NUDT4B Gene

No disorders were found for NUDT4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT4B Gene

Publications for NUDT4B Gene

  1. Genetic rationale for microheterogeneity of human diphosphoinositol polyphosphate phosphohydrolase type 2. (PMID: 11376937) Caffrey JJ … Shears SB (Gene 2001) 2 3 58
  2. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey ML … Hieter P (Genetics 2015) 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y … Sugano S (Genome research 2004) 3 58

Products for NUDT4B Gene

Sources for NUDT4B Gene

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