NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011] See more...

Aliases for NUDT3 Gene

Aliases for NUDT3 Gene

  • Nudix Hydrolase 3 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 3 2 3
  • Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 1 3 4
  • Diphosphoinositol Polyphosphate Phosphohydrolase 1 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 3 3 4
  • Nudix Motif 3 3 4
  • DIPP-1 3 4
  • DIPP1 3 4
  • DIPP 3 4
  • EC 3.6.1.52 4
  • EC 3.6.1.- 4

External Ids for NUDT3 Gene

Previous GeneCards Identifiers for NUDT3 Gene

  • GC06M034258
  • GC06M034302
  • GC06M034363
  • GC06M033978
  • GC06M034388
  • GC06M034894
  • GC06M035232
  • GC06M035727
  • GC06M034550
  • GC06M035568
  • GC06M038945
  • GC06M039637
  • GC06M039940
  • GC06M036281
  • GC06M036655
  • GC06M037008
  • GC06M037358
  • GC06M037711
  • GC06M038060
  • GC06M038450
  • GC06M038794

Summaries for NUDT3 Gene

Entrez Gene Summary for NUDT3 Gene

  • NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]

GeneCards Summary for NUDT3 Gene

NUDT3 (Nudix Hydrolase 3) is a Protein Coding gene. Diseases associated with NUDT3 include Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly. Among its related pathways are Metabolism and Inositol phosphate metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and diphosphoinositol-polyphosphate diphosphatase activity. An important paralog of this gene is NUDT4B.

UniProtKB/Swiss-Prot Summary for NUDT3 Gene

  • Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

Gene Wiki entry for NUDT3 Gene

Additional gene information for NUDT3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT3 Gene

Genomics for NUDT3 Gene

GeneHancer (GH) Regulatory Elements for NUDT3 Gene

Promoters and enhancers for NUDT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J034390 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 510.8 +0.6 623 3.7 HNRNPK ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 MYC POLR2G GTF2E2 NUDT3 lnc-NUDT3-2 lnc-RPS10-1 lnc-PACSIN1-1 LEMD2 TAF11 PHF1 ENSG00000272374 ZNF76 RPS10
GH06J035139 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 500 -748.1 -748123 1.6 CTCF USF1 REST ZBTB25 MYC RAD21 TRIM22 ZKSCAN8 SMC3 KLF9 TCP11 piR-50444-395 NUDT3 SCUBE3 UHRF1BP1 RF00017-5460
GH06J034340 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 500.2 +51.1 51107 1.2 FOS FEZF1 MITF GATA2 JUN ZNF366 ZNF660 SP7 SCRT2 ZNF600 NUDT3 lnc-HMGA1-5 RF00017-5448 RPS10-NUDT3 RF00017-5444
GH06J034418 Promoter 0.5 EPDnew 500.3 -25.7 -25734 0.1 POLR2A RBFOX2 NUDT3 HE856042 RPS10 RPS10-NUDT3 lnc-RPS10-NUDT3-3 piR-57135-038 RF00017-5448
GH06J035258 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 14.1 -867.5 -867519 4.1 HNRNPK ZNF217 EP300 CTCF ZSCAN5C NRF1 TCF12 MYC USF1 POLR2G ZNF76 TCP11 LOC101929285 TAF11 ENSG00000272374 DEF6 RPL10A NUDT3 RPS10 ENSG00000219023
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDT3

Top Transcription factor binding sites by QIAGEN in the NUDT3 gene promoter:
  • AML1a
  • C/EBPalpha
  • Chx10
  • E47
  • FOXD3
  • Hand1
  • NF-1/L
  • Pax-4a
  • SEF-1 (1)
  • STAT5B

Genomic Locations for NUDT3 Gene

Genomic Locations for NUDT3 Gene
chr6:34,279,679-34,392,680
(GRCh38/hg38)
Size:
113,002 bases
Orientation:
Minus strand
chr6:34,247,456-34,360,457
(GRCh37/hg19)
Size:
113,002 bases
Orientation:
Minus strand

Genomic View for NUDT3 Gene

Genes around NUDT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT3 Gene

Proteins for NUDT3 Gene

  • Protein details for NUDT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95989-NUDT3_HUMAN
    Recommended name:
    Diphosphoinositol polyphosphate phosphohydrolase 1
    Protein Accession:
    O95989
    Secondary Accessions:
    • B2R8N4

    Protein attributes for NUDT3 Gene

    Size:
    172 amino acids
    Molecular mass:
    19471 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NUDT3 Gene

neXtProt entry for NUDT3 Gene

Post-translational modifications for NUDT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT3 Gene

Domains & Families for NUDT3 Gene

Gene Families for NUDT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NUDT3 Gene

Blocks:
  • NUDIX hydrolase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDT3 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 3 (NUDT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95989

UniProtKB/Swiss-Prot:

NUDT3_HUMAN :
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
Family:
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
genes like me logo Genes that share domains with NUDT3: view

Function for NUDT3 Gene

Molecular function for NUDT3 Gene

UniProtKB/Swiss-Prot Function:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.; EC=3.6.1.52; Evidence={ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by fluoride and InsP6.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5.9 uM for Ap6A {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; KM=7.7 uM for Ap5A {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; KM=38 mM for 5-phosphoribose 1-diphosphate {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; KM=4.2 nM for PP-InsP5 {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604}; pH dependence: Optimum pH is 7-7.5. {ECO:0000269 PubMed:10419486, ECO:0000269 PubMed:12370170, ECO:0000269 PubMed:9822604};
GENATLAS Biochemistry:
nudix (nucleoside diphosphate linked moiety X)-type motif 3,hydrolase,most predominantly expressed in brain,heart,pancreas,liver,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways

Enzyme Numbers (IUBMB) for NUDT3 Gene

Phenotypes From GWAS Catalog for NUDT3 Gene

Gene Ontology (GO) - Molecular Function for NUDT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 19585659
GO:0000298 endopolyphosphatase activity IBA 21873635
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity TAS,IDA 10585413
GO:0016787 hydrolase activity IEA --
GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with NUDT3: view
genes like me logo Genes that share phenotypes with NUDT3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT3

CRISPR Products

miRNA for NUDT3 Gene

miRTarBase miRNAs that target NUDT3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT3

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT3 Gene

Localization for NUDT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT3 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUDT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT3: view

Pathways & Interactions for NUDT3 Gene

PathCards logo

SuperPathways for NUDT3 Gene

genes like me logo Genes that share pathways with NUDT3: view

Pathways by source for NUDT3 Gene

SIGNOR curated interactions for NUDT3 Gene

Activates:

Gene Ontology (GO) - Biological Process for NUDT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 10419486
GO:0015961 diadenosine polyphosphate catabolic process TAS 10419486
GO:0043647 inositol phosphate metabolic process TAS --
GO:0071543 diphosphoinositol polyphosphate metabolic process IBA 21873635
GO:0071544 diphosphoinositol polyphosphate catabolic process IDA 10585413
genes like me logo Genes that share ontologies with NUDT3: view

Drugs & Compounds for NUDT3 Gene

(4) Drugs for NUDT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Fytic acid Investigational Pharma 0

(7) Additional Compounds for NUDT3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Diphosphoinositol pentakisphosphate
  • (1R,2R,3S,4S,5R,6S)-2,3,4,5,6-Pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate
  • 1D-myo-Inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
  • 1D-myo-Inositol 5-diphosphate pentakisphosphate
  • 5-PP-InsP5
  • (1R,2R,3S,4S,5R,6S)-2,3,4,5,6-Pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphoric acid
Diadenosine hexaphosphate
  • Adenosine 5'-hexaphosphate 5'-ester with adenosine
  • Adenosine-(5')-hexaphospho-(5')-adenosine
  • Ap(6)a
  • AP6a
  • AppppppA
56983-23-4
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
genes like me logo Genes that share compounds with NUDT3: view

Transcripts for NUDT3 Gene

mRNA/cDNA for NUDT3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT3 Gene

No ASD Table

Relevant External Links for NUDT3 Gene

GeneLoc Exon Structure for
NUDT3

Expression for NUDT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT3 Gene

Protein differential expression in normal tissues from HIPED for NUDT3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.6) and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT3 Gene



Protein tissue co-expression partners for NUDT3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDT3

SOURCE GeneReport for Unigene cluster for NUDT3 Gene:

Hs.188882

mRNA Expression by UniProt/SwissProt for NUDT3 Gene:

O95989-NUDT3_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.

Evidence on tissue expression from TISSUES for NUDT3 Gene

  • Nervous system(4.8)
  • Lung(3.1)
genes like me logo Genes that share expression patterns with NUDT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT3 Gene

Orthologs for NUDT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS10 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT3 31 30
  • 95.74 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT3 31
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDT3 31
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT3 31 30
  • 91.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt3 17 31 30
  • 91.07 (n)
rat
(Rattus norvegicus)
Mammalia Nudt3 30
  • 88.89 (n)
chicken
(Gallus gallus)
Aves NUDT3 31 30
  • 85.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT3 31
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nudt3a 31
  • 84 (a)
OneToMany
nudt3b 31 30
  • 76.22 (n)
OneToMany
zgc55746 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7396 30
fruit fly
(Drosophila melanogaster)
Insecta CG6391 32
  • 57 (a)
Aps 31 30
  • 56.04 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009901 30
  • 55.41 (n)
worm
(Caenorhabditis elegans)
Secernentea Y92H12BL.5 31 30
  • 49.48 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8787 31
  • 38 (a)
OneToMany
Species where no ortholog for NUDT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NUDT3 Gene

ENSEMBL:
Gene Tree for NUDT3 (if available)
TreeFam:
Gene Tree for NUDT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT3: view image

Paralogs for NUDT3 Gene

Paralogs for NUDT3 Gene

(4) SIMAP similar genes for NUDT3 Gene using alignment to 1 proteins:

  • NUDT3_HUMAN
genes like me logo Genes that share paralogs with NUDT3: view

Variants for NUDT3 Gene

Additional dbSNP identifiers (rs#s) for NUDT3 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDT3 Gene

Variant ID Type Subtype PubMed ID
dgv10618n54 CNV loss 21841781
dgv10619n54 CNV loss 21841781
dgv10620n54 CNV loss 21841781
dgv10621n54 CNV loss 21841781
dgv10622n54 CNV loss 21841781
dgv10623n54 CNV loss 21841781
dgv1115e199 CNV deletion 23128226
esv2674771 CNV deletion 23128226
esv2731907 CNV deletion 23290073
esv29044 CNV loss 19812545
esv33496 CNV loss 17666407
esv3425871 CNV insertion 20981092
esv3567619 CNV deletion 23714750
esv3608655 CNV loss 21293372
esv3608656 CNV loss 21293372
esv3608657 CNV loss 21293372
nsv1034978 CNV gain 25217958
nsv473801 CNV novel sequence insertion 20440878
nsv5253 CNV insertion 18451855
nsv602863 CNV loss 21841781
nsv602886 CNV loss 21841781

Variation tolerance for NUDT3 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDT3 Gene

Disorders for NUDT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDT3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NUDT3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUDT3

genes like me logo Genes that share disorders with NUDT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT3 Gene

Publications for NUDT3 Gene

  1. A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. (PMID: 9822604) Safrany ST … Shears SB (The EMBO journal 1998) 2 3 4 23 54
  2. Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. (PMID: 12370170) Fisher DI … Cartwright JL (The Journal of biological chemistry 2002) 3 4 23 54
  3. The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein. (PMID: 10419486) Safrany ST … Shears SB (The Journal of biological chemistry 1999) 3 4 23 54
  4. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 41 54
  5. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 41 54

Products for NUDT3 Gene

Sources for NUDT3 Gene