NUDT22 Gene (Protein Coding)

Nudix Hydrolase 22

GC11P064226
GIFtS:
34

Aliases for NUDT22 Gene

Aliases for NUDT22 Gene

  • Nudix Hydrolase 22 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 22 2 3
  • Uridine Diphosphate Glucose Pyrophosphatase NUDT22 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 22 3 4
  • UDPG Pyrophosphatase 3 4
  • Nudix Motif 22 3 4
  • UGPPase 3 4
  • Uridine Diphosphate Glucose Pyrophosphatase 3
  • EC 3.6.1.45 4

External Ids for NUDT22 Gene

Previous GeneCards Identifiers for NUDT22 Gene

  • GC11P063751
  • GC11P063993
  • GC11P060322

Summaries for NUDT22 Gene

GeneCards Summary for NUDT22 Gene

NUDT22 (Nudix Hydrolase 22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot Summary for NUDT22 Gene

  • Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose.

Additional gene information for NUDT22 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT22 Gene

Genomics for NUDT22 Gene

GeneHancer (GH) Regulatory Elements for NUDT22 Gene

Promoters and enhancers for NUDT22 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J064224 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.2 216 3.7 SP1 ZBTB40 CTCF RBPJ POLR2A HCFC1 MYC NFYC ETV6 ELF1 TRPT1 DNAJC4 NUDT22 lnc-PPP1R14B-2 SF1 ZFPL1 SYVN1 PLCB3 TRMT112 IMMP1LP1
GH11J064204 Enhancer 0.9 ENCODE 12.2 -21.3 -21257 1.2 CTCF ZNF362 CC2D1A MAX RAD21 TEAD4 NFIB ZNF384 SP7 GMEB1 FERMT3 TRPT1 NUDT22 DNAJC4 ENSG00000257086 PLCB3 MACROD1 GPR137 BAD STIP1
GH11J064199 Enhancer 0.5 Ensembl 12.2 -24.9 -24940 2.4 ZNF362 ZNF121 CEBPG CEBPA ZSCAN4 CEBPB TRPT1 TRMT112 NUDT22 DNAJC4 ENSG00000257086 PLCB3 MACROD1 GPR137 BAD CCDC88B
GH11J064354 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.3 +132.0 132033 6.6 GTF3C2 SIN3A ZBTB40 CTCF ZBTB6 MLX RBPJ SMARCE1 POLR2A NR2F1 RPS6KA4 PLCB3 ATG2A ENSG00000236935 SF1 ZFPL1 ENSG00000257086 POLA2 SYVN1 VPS51
GH11J064194 Enhancer 0.3 Ensembl 12.3 -28.7 -28740 4.8 ZNF121 TRPT1 TRMT112 NUDT22 DNAJC4 MACROD1 PLCB3 GPR137 BAD ENSG00000257086 ENSG00000256116
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT22 gene promoter:
  • AP-2alpha
  • AP-2beta
  • CP2
  • ER-alpha
  • Max1
  • NF-kappaB1
  • Pax-2
  • Pax-2a
  • RFX1
  • SEF-1 (1)

Genomic Locations for NUDT22 Gene

Genomic Locations for NUDT22 Gene
chr11:64,225,941-64,230,686
(GRCh38/hg38)
Size:
4,746 bases
Orientation:
Plus strand
chr11:63,993,413-63,998,158
(GRCh37/hg19)
Size:
4,746 bases
Orientation:
Plus strand

Genomic View for NUDT22 Gene

Genes around NUDT22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT22 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NUDT22 Gene

Proteins for NUDT22 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NUDT22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRQ3-NUD22_HUMAN
    Recommended name:
    Uridine diphosphate glucose pyrophosphatase NUDT22
    Protein Accession:
    Q9BRQ3
    Secondary Accessions:
    • C9JY06
    • Q71RD5

    Protein attributes for NUDT22 Gene

    Size:
    303 amino acids
    Molecular mass:
    32580 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NUDT22 Gene

    Alternative splice isoforms for NUDT22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT22 Gene

Protein Expression for NUDT22 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NUDT22 Gene

  • Ubiquitination at Lys60
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDT22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT22 Gene

Domains & Families for NUDT22 Gene

Gene Families for NUDT22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT22 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDT22 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 22 (NUD22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRQ3

UniProtKB/Swiss-Prot:

NUD22_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT22: view

Function for NUDT22 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NUDT22 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.; EC=3.6.1.45; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=16.5 uM for UDP-glucose {ECO:0000269 PubMed:29413322}; KM=51.4 uM for UDP-galactose {ECO:0000269 PubMed:29413322}; Note=kcat is 0.69 sec(-1) for UDP-glucose. kcat is 0.55 sec(-1) for UDP-galactose. {ECO:0000269 PubMed:29413322};

Enzyme Numbers (IUBMB) for NUDT22 Gene

Phenotypes From GWAS Catalog for NUDT22 Gene

Gene Ontology (GO) - Molecular Function for NUDT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008768 UDP-sugar diphosphatase activity IDA,IEA 29413322
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IMP 29413322
GO:0052751 GDP-mannose hydrolase activity IBA 21873635
genes like me logo Genes that share ontologies with NUDT22: view
genes like me logo Genes that share phenotypes with NUDT22: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT22

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT22 Gene

Localization for NUDT22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT22 gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NUDT22: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT22 Gene

Pathways & Interactions for NUDT22 Gene

PathCards logo

SuperPathways for NUDT22 Gene

No Data Available

Interacting Proteins for NUDT22 Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q9BRQ3-NUD22_HUMAN ENSP00000279206 for NUDT22 Gene via UniProtKB STRING IID

GPS-Prot Interaction Network for NUDT22

Gene Ontology (GO) - Biological Process for NUDT22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDT22 Gene

Drugs & Compounds for NUDT22 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NUDT22 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NUDT22 Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(242) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - - - - -
SP6: - -

Relevant External Links for NUDT22 Gene

GeneLoc Exon Structure for
NUDT22
ECgene alternative splicing isoforms for
NUDT22

Expression for NUDT22 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT22 Gene

mRNA expression in normal human tissues for NUDT22 Gene
mRNA expression by GTEx for NUDT22 GenemRNA expression by BioGPS for NUDT22 Gene

Protein differential expression in normal tissues from HIPED for NUDT22 Gene

This gene is overexpressed in Fetal gut (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT22 Gene



Protein tissue co-expression partners for NUDT22 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT22 Gene:

NUDT22

SOURCE GeneReport for Unigene cluster for NUDT22 Gene:

Hs.656074
genes like me logo Genes that share expression patterns with NUDT22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT22 Gene

Orthologs for NUDT22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NUDT22 33 32
  • 99.45 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia NUDT22 33 32
  • 87.93 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia NUDT22 33 32
  • 86.51 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Nudt22 32
  • 86.22 (n)
mouse
(Mus musculus)
 Mammalia Nudt22 17 33 32
  • 85.63 (n)
oppossum
(Monodelphis domestica)
 Mammalia NUDT22 33
  • 71 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NUDT22 33
  • 59 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia nudt22 32
  • 55.16 (n)
Str.502 32
African clawed frog
(Xenopus laevis)
 Amphibia P17F11 32
zebrafish
(Danio rerio)
 Actinopterygii nudt22 33 32
  • 58.3 (n)
 OneToOne
wufb64h05 32
thale cress
(Arabidopsis thaliana)
 eudicotyledons NUDT9 32
  • 43.66 (n)
rice
(Oryza sativa)
 Liliopsida Os05g0117500 32
  • 43.36 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 38 (a)
 OneToOne
Species where no ortholog for NUDT22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT22 Gene

ENSEMBL:
Gene Tree for NUDT22 (if available)
TreeFam:
Gene Tree for NUDT22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT22: view image

Paralogs for NUDT22 Gene

No data available for Paralogs for NUDT22 Gene

Variants for NUDT22 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for NUDT22 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000136739 -- 64,228,904(+) A/G intron_variant
rs1000299009 -- 64,228,632(+) T/C/G intron_variant
rs1000445974 -- 64,226,339(+) G/A 5_prime_UTR_variant, intron_variant
rs1000774539 -- 64,226,560(+) A/C/G 5_prime_UTR_variant, intron_variant
rs1002629045 -- 64,230,473(+) G/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT22 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv992196 CNV deletion 20482838
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for NUDT22 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT22 Gene

Disorders for NUDT22 Gene

Additional Disease Information for NUDT22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUDT22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT22 Gene

Publications for NUDT22 Gene

  1. Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold. (PMID: 29413322) Carter M … Stenmark P (Structure (London, England : 1993) 2018) 2 3 4 56
  2. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E … Faraone SV (Journal of the American Academy of Child and Adolescent Psychiatry 2011) 3 43 56
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

ExternalLinks

View latest publications for NUDT22 gene in Mastermind

Products for NUDT22 Gene

Sources for NUDT22 Gene