NUDT22 Gene (Protein Coding)

Nudix Hydrolase 22

GC11P064226
GIFtS:
34
See more...

Aliases for NUDT22 Gene

Aliases for NUDT22 Gene

  • Nudix Hydrolase 22 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 22 2 3
  • Uridine Diphosphate Glucose Pyrophosphatase NUDT22 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 22 3 4
  • UDPG Pyrophosphatase 3 4
  • Nudix Motif 22 3 4
  • UGPPase 3 4
  • EC 3.6.1.45 4
  • MGC13045 2
  • NUDT22 5

External Ids for NUDT22 Gene

Previous GeneCards Identifiers for NUDT22 Gene

  • GC11P063751
  • GC11P063993
  • GC11P060322

Summaries for NUDT22 Gene

GeneCards Summary for NUDT22 Gene

NUDT22 (Nudix Hydrolase 22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot Summary for NUDT22 Gene

  • Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose.

Additional gene information for NUDT22 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT22 Gene

Genomics for NUDT22 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NUDT22 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J064224 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.2 216 3.7 TBP ZBTB10 SP1 MNT SMAD5 ETS1 IRF2 ZFP64 MBD2 POLR2A TRPT1 DNAJC4 HSALNG0084757 NUDT22 lnc-PPP1R14B-2 SF1 TRMT112 ZFPL1 SYVN1 PLCB3
GH11J064204 Enhancer 0.9 ENCODE 12.2 -21.3 -21257 1.2 ZBTB10 DEK SMAD5 POLR2A CTCF BHLHE40 HOMEZ ARNT REST HCFC1 FERMT3 TRPT1 NUDT22 DNAJC4 ENSG00000257086 PLCB3 MACROD1 GPR137 BAD HSALNG0084753
GH11J064199 Enhancer 0.5 Ensembl 12.2 -24.9 -24940 2.4 CEBPA CEBPB ZNF362 CEBPG ZSCAN4 ZNF121 HSALNG0084753 TRPT1 TRMT112 NUDT22 DNAJC4 PLCB3 ENSG00000257086 MACROD1 GPR137 BAD
GH11J064354 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.2 +132.0 132033 6.6 TBP CEBPA NR2C1 MNT DEK IKZF1 SMAD5 IRF2 ZNF217 CTCF RPS6KA4 ENSG00000236935 PLCB3 LINC02723 TRPT1 MARK2 PPP1R14B ESRRA PRDX5 TRMT112
GH11J064194 Enhancer 0.3 Ensembl 12.3 -28.7 -28740 4.8 RBFOX2 ZNF121 MN309365 TRPT1 TRMT112 NUDT22 DNAJC4 MACROD1 PLCB3 GPR137 BAD ENSG00000257086
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT22 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDT22

Top Transcription factor binding sites by QIAGEN in the NUDT22 gene promoter:
  • AP-2alpha
  • AP-2beta
  • CP2
  • ER-alpha
  • Max1
  • NF-kappaB1
  • Pax-2
  • Pax-2a
  • RFX1
  • SEF-1 (1)

Genomic Locations for NUDT22 Gene

Latest Assembly
chr11:64,225,941-64,230,686
(GRCh38/hg38)
Size:
4,746 bases
Orientation:
Plus strand

Previous Assembly
chr11:63,993,730-63,997,488
(GRCh37/hg19 by Entrez Gene)
Size:
3,759 bases
Orientation:
Plus strand

chr11:63,993,413-63,998,158
(GRCh37/hg19 by Ensembl)
Size:
4,746 bases
Orientation:
Plus strand

Genomic View for NUDT22 Gene

Genes around NUDT22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT22 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NUDT22 Gene

Proteins for NUDT22 Gene

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  1. Antibodies for research
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  3. Assay products for research

  • Protein details for NUDT22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRQ3-NUD22_HUMAN
    Recommended name:
    Uridine diphosphate glucose pyrophosphatase NUDT22
    Protein Accession:
    Q9BRQ3
    Secondary Accessions:
    • C9JY06
    • Q71RD5

    Protein attributes for NUDT22 Gene

    Size:
    303 amino acids
    Molecular mass:
    32580 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NUDT22 Gene

    Alternative splice isoforms for NUDT22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT22 Gene

Protein Expression for NUDT22 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NUDT22 Gene

  • Ubiquitination at Lys60
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDT22 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for NUDT22 Gene

Domains & Families for NUDT22 Gene

Gene Families for NUDT22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NUDT22 Gene

InterPro:
Blocks:
  • NUDIX hydrolase
ProtoNet:

Suggested Antigen Peptide Sequences for NUDT22 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 22 (NUD22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRQ3

UniProtKB/Swiss-Prot:

NUD22_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT22: view

Function for NUDT22 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for NUDT22 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.; EC=3.6.1.45; Evidence={ECO:0000269|PubMed:29413322};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=16.5 uM for UDP-glucose {ECO:0000269|PubMed:29413322}; KM=51.4 uM for UDP-galactose {ECO:0000269|PubMed:29413322}; Note=kcat is 0.69 sec(-1) for UDP-glucose. kcat is 0.55 sec(-1) for UDP-galactose. {ECO:0000269|PubMed:29413322};

Enzyme Numbers (IUBMB) for NUDT22 Gene

Phenotypes From GWAS Catalog for NUDT22 Gene

Gene Ontology (GO) - Molecular Function for NUDT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008768 UDP-sugar diphosphatase activity IEA,IDA 29413322
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IMP 29413322
GO:0052751 GDP-mannose hydrolase activity IBA 21873635
genes like me logo Genes that share ontologies with NUDT22: view
genes like me logo Genes that share phenotypes with NUDT22: view

Animal Models for research

  • Taconic Biosciences Mouse Models for NUDT22

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT22

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT22 Gene

Localization for NUDT22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT22 gene
Compartment Confidence
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NUDT22: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT22 Gene

Pathways & Interactions for NUDT22 Gene

PathCards logo

SuperPathways for NUDT22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDT22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUDT22 Gene

Drugs & Compounds for NUDT22 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for NUDT22 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
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mRNA/cDNA for NUDT22 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT22

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT22 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - - - - -
SP6: - -

Relevant External Links for NUDT22 Gene

GeneLoc Exon Structure for
NUDT22

Expression for NUDT22 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT22 Gene

mRNA expression in normal human tissues for NUDT22 Gene
mRNA expression by BioGPS for NUDT22 GenemRNA expression by GTEx for NUDT22 Gene

Protein differential expression in normal tissues from HIPED for NUDT22 Gene

This gene is overexpressed in Fetal gut (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT22 Gene



Protein tissue co-expression partners for NUDT22 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDT22

SOURCE GeneReport for Unigene cluster for NUDT22 Gene:

Hs.656074
genes like me logo Genes that share expression patterns with NUDT22: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT22 Gene

Orthologs for NUDT22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT22 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NUDT22 30 31
  • 99.45 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NUDT22 30 31
  • 87.93 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NUDT22 30 31
  • 86.51 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nudt22 30
  • 86.22 (n)
Mouse
(Mus musculus)
 Mammalia Nudt22 30 17 31
  • 85.63 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NUDT22 31
  • 71 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NUDT22 31
  • 59 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia nudt22 30
  • 55.16 (n)
Str.502 30
African clawed frog
(Xenopus laevis)
 Amphibia P17F11 30
Zebrafish
(Danio rerio)
 Actinopterygii nudt22 30 31
  • 58.3 (n)
 OneToOne
wufb64h05 30
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons NUDT9 30
  • 43.66 (n)
Rice
(Oryza sativa)
 Liliopsida Os05g0117500 30
  • 43.36 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 38 (a)
 OneToOne
Species where no ortholog for NUDT22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NUDT22 Gene

ENSEMBL:
Gene Tree for NUDT22 (if available)
TreeFam:
Gene Tree for NUDT22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT22: view image

Paralogs for NUDT22 Gene

No data available for Paralogs for NUDT22 Gene

Variants for NUDT22 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDT22 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2286612 - p.Gly36Cys
rs34448455 - p.Thr129Arg
rs633557 - p.Leu263Pro
rs633561 - p.Gln260Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NUDT22 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NUDT22 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv992196 CNV deletion 20482838
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for NUDT22 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.15; 80.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT22

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT22 Gene

Disorders for NUDT22 Gene

Additional Disease Information for NUDT22

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for NUDT22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT22 Gene

Publications for NUDT22 Gene

  1. Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold. (PMID: 29413322) Carter M … Stenmark P (Structure (London, England : 1993) 2018) 2 3 4
  2. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E … Faraone SV (Journal of the American Academy of Child and Adolescent Psychiatry 2011) 3 41
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

ExternalLinks

View latest publications for NUDT22 gene in Mastermind

Products for NUDT22 Gene

Sources for NUDT22 Gene