Aliases for NUDT22 Gene
Aliases for NUDT22 Gene
External Ids for NUDT22 Gene
- HGNC: 28189
- Entrez Gene: 84304
- Ensembl: ENSG00000149761
- UniProtKB: Q9BRQ3
Previous GeneCards Identifiers for NUDT22 Gene
- GC11P063751
- GC11P063993
- GC11P060322
Summaries for NUDT22 Gene
GeneCards Summary for NUDT22 Gene
NUDT22 (Nudix Hydrolase 22) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity.
Additional gene information for NUDT22 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT22 Gene
Genomics for NUDT22 Gene
GeneHancer (GH) Regulatory Elements for NUDT22 Gene
Promoters and enhancers for NUDT22 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NUDT22 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NUDT22 Gene
Genomic Locations for NUDT22 Gene
- chr11:64,225,941-64,230,686
- (GRCh38/hg38)
- Size:
- 4,746 bases
- Orientation:
- Plus strand
- chr11:63,993,413-63,998,158
- (GRCh37/hg19)
Genomic View for NUDT22 Gene
Genes around NUDT22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Ensembl
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
NUDT22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NUDT22 Gene
Proteins for NUDT22 Gene
-
Protein details for NUDT22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BRQ3-NUD22_HUMAN
- Recommended name:
- Nucleoside diphosphate-linked moiety X motif 22
- Protein Accession:
- Q9BRQ3
- C9JY06
- Q71RD5
Protein attributes for NUDT22 Gene
- Size:
- 303 amino acids
- Molecular mass:
- 32580 Da
- Quaternary structure:
- No Data Available
Protein Expression for NUDT22 Gene
Post-translational modifications for NUDT22 Gene
Other Protein References for NUDT22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NUDT22
- Novus Biologicals Antibodies for NUDT22
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-
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Protein Products
-
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Assay Products
No data available for DME Specific Peptides for NUDT22 Gene
Domains & Families for NUDT22 Gene
Gene Families for NUDT22 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for NUDT22 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NUDT22 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BRQ3UniProtKB/Swiss-Prot:
NUD22_HUMAN :- Although related to the NUDIX hydrolase family, it lacks the Nudix box and does not seem to act as a hydrolase.
- Belongs to the Nudix hydrolase family.
- Domain:
-
- Although related to the NUDIX hydrolase family, it lacks the Nudix box and does not seem to act as a hydrolase.
- Family:
-
- Belongs to the Nudix hydrolase family.
Function for NUDT22 Gene
Phenotypes From GWAS Catalog for NUDT22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for NUDT22 Gene
- GenomeRNAi human phenotypes for NUDT22:
Animal Model Products
-
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for NUDT22
- genomics-online: gRNA clones - Search results for 101 available NUDT22 gene related products
- Overview of 101 available NUDT22 gene related products
- Applied Biological Materials CRISPR for NUDT22
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUDT22
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miRNA Products
- Search ViGene Biosciences for NUDT22
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NUDT22
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- genomics-online: shRNA clones - Search results for 101 available NUDT22 gene related products
- Overview of 101 available NUDT22 gene related products
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Clone Products
-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NUDT22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NUDT22
-
ViGene Biosciences adenoviral particle packaged cDNA for NUDT22 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NUDT22 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT22 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT22 Gene
Localization for NUDT22 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| extracellular | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT22 Gene
Pathways & Interactions for NUDT22 Gene
No Data Available
Interacting Proteins for NUDT22 Gene
Selected Interacting proteins:
ENSP00000279206
Q9BRQ3-NUD22_HUMAN
for NUDT22 Gene via
STRING
UniProtKB
IID
No data available for Pathways by source and SIGNOR curated interactions for NUDT22 Gene
Transcripts for NUDT22 Gene
mRNA/cDNA for NUDT22 Gene
- (4) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (242) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NUDT22 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NUDT22
- genomics-online: gRNA clones - Search results for 101 available NUDT22 gene related products
- Overview of 101 available NUDT22 gene related products
- Applied Biological Materials CRISPR for NUDT22
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUDT22
- GenScript: Design CRISPR guide RNA sequences for NUDT22
miRNA Products
- Search ViGene Biosciences for NUDT22
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NUDT22
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- genomics-online: shRNA clones - Search results for 101 available NUDT22 gene related products
- Overview of 101 available NUDT22 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NUDT22 gene
Clone Products
-
OriGene ORF clones in human for NUDT22
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- Sino Biological Human cDNA Clone for NUDT22
- VectorBuilder custom plasmid, inducible vectors for NUDT22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NUDT22
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NUDT22
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||
| SP6: | - | - |
Expression for NUDT22 Gene
This gene is overexpressed in Fetal gut (64.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT22 Gene
NURSA nuclear receptor signaling pathways regulating expression of NUDT22 Gene:
NUDT22SOURCE GeneReport for Unigene cluster for NUDT22 Gene:
Hs.656074Primer Products
-
OriGene qPCR primer pairs for NUDT22
-
OriGene qPCR primer pairs and template standards for NUDT22
- genomics-online: primer clones - Search results for 101 available NUDT22 gene related products
- Overview of 101 available NUDT22 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT22 Gene
Orthologs for NUDT22 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NUDT22 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NUDT22 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NUDT22 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nudt22 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Nudt22 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NUDT22 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NUDT22 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nudt22 33 |
|
||
| Str.502 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | P17F11 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nudt22 33 34 |
|
||
| wufb64h05 33 |
|
||||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | NUDT9 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0117500 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for NUDT22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NUDT22 Gene
No data available for Paralogs for NUDT22 Gene
Variants for NUDT22 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000136739 | -- | 64,228,904(+) | A/G | intron_variant | |
| rs1000299009 | -- | 64,228,632(+) | T/C | intron_variant | |
| rs1000445974 | -- | 64,226,339(+) | G/A | 5_prime_UTR_variant, intron_variant | |
| rs1000774539 | -- | 64,226,560(+) | A/G | intron_variant | |
| rs1002629045 | -- | 64,230,473(+) | G/C | downstream_transcript_variant |
Residual Variation Intolerance Score:
87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.15;
80.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NUDT22 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NUDT22
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT22 Gene
Disorders for NUDT22 Gene
Additional Disease Information for NUDT22
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NUDT22 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT22 Gene
Publications for NUDT22 Gene
- Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E … Faraone SV (Journal of the American Academy of Child and Adolescent Psychiatry 2011) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for NUDT22 Gene
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- Taconic Biosciences Mouse Models for NUDT22
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- VectorBuilder custom plasmid, inducible vectors for NUDT22
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available NUDT22 related products ranked by validation data
- antibodies-online: Search results for available NUDT22 related products ranked by validation data
- antibodies-online: Search results for available NUDT22 related products ranked by validation data
- Search GeneTex for Antibodies for NUDT22
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- ViGene Biosciences adenoviral particle packaged cDNA for NUDT22 gene
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- genomics-online: cdna clones - Search results for 101 available NUDT22 gene related products
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- Overview of 101 available NUDT22 gene related products
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- Overview of 101 available NUDT22 gene related products
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- Overview of 101 available NUDT22 gene related products
Sources for NUDT22 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems