Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDT21 Gene

Aliases for NUDT21 Gene

  • Nudix Hydrolase 21 2 3 4 5
  • Cleavage Factor Im Complex 25 KDa Subunit 2 3 4
  • Cleavage And Polyadenylation Specificity Factor 25 KDa Subunit 3 4
  • Cleavage And Polyadenylation Specific Factor 5, 25 KD Subunit 2 3
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 2 3
  • Cleavage And Polyadenylation Specific Factor 5, 25 KDa 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 21 3 4
  • Pre-MRNA Cleavage Factor Im 68 KDa Subunit 3 4
  • CPSF 25 KDa Subunit 3 4
  • Nudix Motif 21 3 4
  • CFIM25 3 4
  • CPSF5 3 4
  • Cleavage And Polyadenylation Specificity Factor Subunit 5 3
  • Pre-MRNA Cleavage Factor Im 25 KDa Subunit 3
  • Pre-MRNA Cleavage Factor Im, 25kD Subunit 3
  • Pre-MRNA Cleavage Factor Im (25kD) 3
  • CFIm25 4
  • CPSF25 4

External Ids for NUDT21 Gene

Previous HGNC Symbols for NUDT21 Gene

  • CPSF5

Previous GeneCards Identifiers for NUDT21 Gene

  • GC16M055021
  • GC16M042333

Summaries for NUDT21 Gene

Entrez Gene Summary for NUDT21 Gene

  • The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUDT21 Gene

NUDT21 (Nudix Hydrolase 21) is a Protein Coding gene. Diseases associated with NUDT21 include Amebiasis. Among its related pathways are Processing of Capped Intronless Pre-mRNA and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for NUDT21 Gene

  • Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5-UGUA-3 elements localized in the 3-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085). NUDT21/CPSF5 activates indirectly the mRNA 3-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085). Binds to 5-UGUA-3 elements localized upstream of pA signals that act as enhancers of pre-mRNA 3-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262). The homodimer mediates simultaneous sequence-specific recognition of two 5-UGUA-3 elements within the pre-mRNA (PubMed:20479262, PubMed:21295486). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629).

Gene Wiki entry for NUDT21 Gene

Additional gene information for NUDT21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT21 Gene

Genomics for NUDT21 Gene

GeneHancer (GH) Regulatory Elements for NUDT21 Gene

Promoters and enhancers for NUDT21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J056450 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 684.3 +0.7 684 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B NUDT21 OGFOD1 BBS2 RSPRY1 NUP93 MT4
GH16J056930 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 40.3 -483.3 -483320 10.1 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 HERPUD1 RSPRY1 NUP93 NUDT21 POLR2C CETP SLC12A3 LOC105371286 ENSG00000261270 NLRC5
GH16J056988 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 22.1 -538.1 -538069 4.3 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF213 ZNF207 NLRC5 NUDT21 GC16M057013
GH16J057387 Enhancer 1.1 FANTOM5 ENCODE 24 -936.0 -936003 1.3 HDGF PKNOX1 STAT5A BMI1 BATF IRF4 ZNF121 ZNF366 ZNF207 ATF7 GC16M057308 NUDT21 RSPRY1 LOC105371286 CCL22 LOC101927556 CIAPIN1 POLR2C CFAP20 CCL17
GH16J057132 Enhancer 1 Ensembl ENCODE dbSUPER 24 -682.1 -682120 4.6 PKNOX1 ZNF521 NR2F1 EBF1 PLRG1 MEF2B NONO ZNF366 GLIS1 ZNF512 LOC105371289 FAM192A NUDT21 RSPRY1 CPNE2 POLR2C PLLP GC16P057096
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT21 gene promoter:
  • Nkx2-5
  • GATA-1
  • AREB6
  • AML1a
  • E47
  • CP2
  • HFH-1
  • STAT5A
  • GATA-6
  • AP-2alpha

Genomic Locations for NUDT21 Gene

Genomic Locations for NUDT21 Gene
chr16:56,429,133-56,452,199
(GRCh38/hg38)
Size:
23,067 bases
Orientation:
Minus strand
chr16:56,463,045-56,486,111
(GRCh37/hg19)
Size:
23,067 bases
Orientation:
Minus strand

Genomic View for NUDT21 Gene

Genes around NUDT21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT21 Gene

Proteins for NUDT21 Gene

  • Protein details for NUDT21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43809-CPSF5_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 5
    Protein Accession:
    O43809
    Secondary Accessions:
    • Q6IB85
    • Q6NE84

    Protein attributes for NUDT21 Gene

    Size:
    227 amino acids
    Molecular mass:
    26227 Da
    Quaternary structure:
    • Homodimer (via N- and C-terminus); binds RNA as homodimer (PubMed:20695905, PubMed:18445629, PubMed:20479262). Component of the cleavage factor Im (CFIm) complex which is an heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or an heterodimer of CPSF6 and CPSF7 (PubMed:9659921, PubMed:8626397, PubMed:14561889, PubMed:20695905, PubMed:23187700, PubMed:21295486). The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA 3-processing machinery (PubMed:29276085). Interacts with CPSF6 (via the RRM domain); this interaction is direct and enhances binding to RNA (PubMed:14561889, PubMed:15169763, PubMed:17172643, PubMed:19864460, PubMed:29276085). Interacts with CPSF7 (PubMed:29276085, Ref.29). Interacts with FIP1L1; this interaction occurs in a RNA sequence-specific manner (PubMed:15937220). Interacts with PABPN1 (PubMed:15169763). Interacts (via N-terminus) with PAPOLA (via C-terminus); this interaction is direct and diminished by acetylation (PubMed:15169763, PubMed:17172643). Interacts with SNRNP70 (PubMed:14561889).

    Three dimensional structures from OCA and Proteopedia for NUDT21 Gene

neXtProt entry for NUDT21 Gene

Post-translational modifications for NUDT21 Gene

  • Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2.
  • Ubiquitination at Lys182 and isoforms=56
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDT21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT21 Gene

Domains & Families for NUDT21 Gene

Gene Families for NUDT21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT21 Gene

Suggested Antigen Peptide Sequences for NUDT21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43809

UniProtKB/Swiss-Prot:

CPSF5_HUMAN :
  • Belongs to the Nudix hydrolase family. CPSF5 subfamily.
Family:
  • Belongs to the Nudix hydrolase family. CPSF5 subfamily.
genes like me logo Genes that share domains with NUDT21: view

Function for NUDT21 Gene

Molecular function for NUDT21 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5-UGUA-3 elements localized in the 3-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085). NUDT21/CPSF5 activates indirectly the mRNA 3-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085). Binds to 5-UGUA-3 elements localized upstream of pA signals that act as enhancers of pre-mRNA 3-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262). The homodimer mediates simultaneous sequence-specific recognition of two 5-UGUA-3 elements within the pre-mRNA (PubMed:20479262, PubMed:21295486). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629).

Phenotypes From GWAS Catalog for NUDT21 Gene

Gene Ontology (GO) - Molecular Function for NUDT21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003723 contributes_to RNA binding IDA,IEA 8626397
GO:0003729 mRNA binding IEA,IDA 21295486
GO:0005515 protein binding IPI 11716503
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUDT21: view
genes like me logo Genes that share phenotypes with NUDT21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT21 Gene

Localization for NUDT21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT21 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles (PubMed:15169763). {ECO:0000269 PubMed:15169763, ECO:0000269 PubMed:19864460}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT21 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
mitochondrion 2
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Microtubule organizing center (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19864460
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 19864460
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with NUDT21: view

Pathways & Interactions for NUDT21 Gene

genes like me logo Genes that share pathways with NUDT21: view

Pathways by source for NUDT21 Gene

Gene Ontology (GO) - Biological Process for NUDT21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IMP,IEA 20695905
GO:0006397 mRNA processing IDA,IEA 8626397
GO:0010608 posttranscriptional regulation of gene expression ISS --
genes like me logo Genes that share ontologies with NUDT21: view

No data available for SIGNOR curated interactions for NUDT21 Gene

Drugs & Compounds for NUDT21 Gene

No Compound Related Data Available

Transcripts for NUDT21 Gene

mRNA/cDNA for NUDT21 Gene

Unigene Clusters for NUDT21 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT21

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT21 Gene

No ASD Table

Relevant External Links for NUDT21 Gene

GeneLoc Exon Structure for
NUDT21
ECgene alternative splicing isoforms for
NUDT21

Expression for NUDT21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT21 Gene



Protein tissue co-expression partners for NUDT21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDT21 Gene:

NUDT21

SOURCE GeneReport for Unigene cluster for NUDT21 Gene:

Hs.528834

mRNA Expression by UniProt/SwissProt for NUDT21 Gene:

O43809-CPSF5_HUMAN
Tissue specificity: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for NUDT21 Gene

  • Nervous system(4.8)
  • Eye(4.2)
  • Liver(4.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with NUDT21: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT21 Gene

Orthologs for NUDT21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT21 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia NUDT21 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT21 34 33
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT21 34 33
  • 95.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT21 34 33
  • 94.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt21 16 34 33
  • 93.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT21 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt21 33
  • 92.07 (n)
chicken
(Gallus gallus)
Aves NUDT21 34 33
  • 85.32 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT21 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt21 33
  • 81.35 (n)
Str.6398 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3893 33
zebrafish
(Danio rerio)
Actinopterygii cpsf5 34 33
  • 79.15 (n)
OneToOne
zgc63966 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8490 33
fruit fly
(Drosophila melanogaster)
Insecta CG3689 34 33
  • 70.03 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007242 33
  • 67.41 (n)
worm
(Caenorhabditis elegans)
Secernentea cfim-1 34 33
  • 64.94 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G25550 33
  • 59.97 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8939 33
soybean
(Glycine max)
eudicotyledons Gma.4672 33
rice
(Oryza sativa)
Liliopsida Os04g0683100 33
  • 58.96 (n)
Os.12933 33
wheat
(Triticum aestivum)
Liliopsida Ta.7293 33
barley
(Hordeum vulgare)
Liliopsida Hv.9029 33
corn
(Zea mays)
Liliopsida Zm.4316 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4504 34
  • 76 (a)
OneToOne
Cin.13848 33
bread mold
(Neurospora crassa)
Ascomycetes NCU09014 33
  • 54.5 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13848 33
Species where no ortholog for NUDT21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUDT21 Gene

ENSEMBL:
Gene Tree for NUDT21 (if available)
TreeFam:
Gene Tree for NUDT21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT21: view image

Paralogs for NUDT21 Gene

(1) SIMAP similar genes for NUDT21 Gene using alignment to 3 proteins:

  • CPSF5_HUMAN
  • H3BND3_HUMAN
  • H3BV41_HUMAN

Pseudogenes.org Pseudogenes for NUDT21 Gene

genes like me logo Genes that share paralogs with NUDT21: view

No data available for Paralogs for NUDT21 Gene

Variants for NUDT21 Gene

Sequence variations from dbSNP and Humsavar for NUDT21 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000562495 -- 56,441,385(-) C/T intron_variant
rs1000838469 -- 56,432,980(-) G/T intron_variant
rs1001794402 -- 56,442,645(-) C/T intron_variant
rs1002322328 -- 56,447,699(-) A/C intron_variant
rs1002723474 -- 56,432,495(-) G/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT21 Gene

Variant ID Type Subtype PubMed ID
esv3638695 CNV gain 21293372
nsv833242 CNV loss 17160897
nsv833243 CNV gain 17160897
nsv978153 CNV duplication 23825009

Variation tolerance for NUDT21 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT21 Gene

Disorders for NUDT21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDT21 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amebiasis
  • amoebiasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUDT21

genes like me logo Genes that share disorders with NUDT21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT21 Gene

Publications for NUDT21 Gene

  1. Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs. (PMID: 17098938) Kubo T … Handa H (Nucleic acids research 2006) 3 4 22 58
  2. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. (PMID: 9659921) Rüegsegger U … Keller W (Molecular cell 1998) 2 3 4 58
  3. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. (PMID: 29276085) Zhu Y … Shi Y (Molecular cell 2018) 3 4 58
  4. Cleavage factor Im is a key regulator of 3' UTR length. (PMID: 23187700) Gruber AR … Zavolan M (RNA biology 2012) 3 4 58
  5. Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. (PMID: 21295486) Yang Q … Doublié S (Structure (London, England : 1993) 2011) 3 4 58

Products for NUDT21 Gene

Sources for NUDT21 Gene

Content
Loading form....