The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is... See more...

Aliases for NUDT21 Gene

Aliases for NUDT21 Gene

  • Nudix Hydrolase 21 2 3 4 5
  • Cleavage Factor Im Complex 25 KDa Subunit 2 3 4
  • Cleavage And Polyadenylation Specificity Factor 25 KDa Subunit 3 4
  • Cleavage And Polyadenylation Specific Factor 5, 25 KD Subunit 2 3
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 2 3
  • Cleavage And Polyadenylation Specificity Factor Subunit 5 3 4
  • Cleavage And Polyadenylation Specific Factor 5, 25 KDa 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 21 3 4
  • Pre-MRNA Cleavage Factor Im 68 KDa Subunit 3 4
  • CPSF 25 KDa Subunit 3 4
  • Nudix Motif 21 3 4
  • CFIM25 3 4
  • CPSF5 3 4
  • Pre-MRNA Cleavage Factor Im 25 KDa Subunit 3
  • Pre-MRNA Cleavage Factor Im, 25kD Subunit 3
  • Pre-MRNA Cleavage Factor Im (25kD) 3
  • CFIm25 4
  • CPSF25 4

External Ids for NUDT21 Gene

Previous HGNC Symbols for NUDT21 Gene

  • CPSF5

Previous GeneCards Identifiers for NUDT21 Gene

  • GC16M055021
  • GC16M056463
  • GC16M042333

Summaries for NUDT21 Gene

Entrez Gene Summary for NUDT21 Gene

  • The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUDT21 Gene

NUDT21 (Nudix Hydrolase 21) is a Protein Coding gene. Diseases associated with NUDT21 include Amebiasis. Among its related pathways are Gene Expression and Processing of Capped Intronless Pre-mRNA. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot Summary for NUDT21 Gene

  • Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085). NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085). Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262). The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA (PubMed:20479262, PubMed:21295486). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629).

Gene Wiki entry for NUDT21 Gene

Additional gene information for NUDT21 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT21 Gene

Genomics for NUDT21 Gene

GeneHancer (GH) Regulatory Elements for NUDT21 Gene

Promoters and enhancers for NUDT21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J056450 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 534.2 +0.7 698 3.8 FOXK2 ZBTB40 ZNF217 TCF12 POLR2G SP1 GTF2E2 PHF8 ZFX ZNF10 NUDT21 OGFOD1 BBS2 RSPRY1 NUP93 MT4
GH16J056930 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 40.3 -483.3 -483319 10.1 EP300 FOXK2 HNRNPK SIN3A NRF1 MYC POLR2G USF1 SP1 NCOR1 HERPUD1 RSPRY1 NUP93 NUDT21 POLR2C CCDC102A CETP SLC12A3 LOC105371286 ENSG00000261270
GH16J056604 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 -158.0 -157957 10.8 FOXK2 SIN3A NRF1 TCF12 POLR2G NCOR1 JUND FOS ZNF10 REST MT2A ENSG00000260823 NONHSAG019534.2 RSPRY1 BBS2 MT1A MT1F NUDT21 MT1G MT1H
GH16J057132 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 24 -682.1 -682120 4.6 NONO MEF2B PLRG1 IKZF1 EBF1 NR2F1 GLIS1 ZNF521 ZNF366 SPI1 LOC105371289 PSME3IP1 NUDT21 CPNE2 RSPRY1 PLLP RF00951-047
GH16J056964 Enhancer 1.2 Ensembl ENCODE 24.9 -514.2 -514202 5.6 RXRA EP300 CTCF NRF1 NCOR1 TEAD4 FOS KDM6A TCF7 ZNF623 RSPRY1 NLRC5 NUDT21 HERPUD1 LOC105371286 MT3 NUP93 PSME3IP1 BBS2 POLR2C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT21 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDT21

Top Transcription factor binding sites by QIAGEN in the NUDT21 gene promoter:
  • AML1a
  • AP-2alpha
  • AREB6
  • CP2
  • E47
  • GATA-1
  • GATA-6
  • HFH-1
  • Nkx2-5
  • STAT5A

Genomic Locations for NUDT21 Gene

Genomic Locations for NUDT21 Gene
chr16:56,429,133-56,452,199
(GRCh38/hg38)
Size:
23,067 bases
Orientation:
Minus strand
chr16:56,463,045-56,486,111
(GRCh37/hg19)
Size:
23,067 bases
Orientation:
Minus strand

Genomic View for NUDT21 Gene

Genes around NUDT21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT21 Gene

Proteins for NUDT21 Gene

  • Protein details for NUDT21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43809-CPSF5_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 5
    Protein Accession:
    O43809
    Secondary Accessions:
    • Q6IB85
    • Q6NE84

    Protein attributes for NUDT21 Gene

    Size:
    227 amino acids
    Molecular mass:
    26227 Da
    Quaternary structure:
    • Homodimer (via N- and C-terminus); binds RNA as homodimer (PubMed:20695905, PubMed:18445629, PubMed:20479262). Component of the cleavage factor Im (CFIm) complex which is a heterotetramer composed of two subunits of NUDT21/CPSF5 and two subunits of CPSF6 or CPSF7 or a heterodimer of CPSF6 and CPSF7 (PubMed:9659921, PubMed:8626397, PubMed:14561889, PubMed:20695905, PubMed:23187700, PubMed:21295486). The cleavage factor Im (CFIm) complex associates with the CPSF and CSTF complexes to promote the assembly of the core mRNA 3'-processing machinery (PubMed:29276085). Interacts with CPSF6 (via the RRM domain); this interaction is direct and enhances binding to RNA (PubMed:14561889, PubMed:15169763, PubMed:17172643, PubMed:19864460, PubMed:29276085). Interacts with CPSF7 (PubMed:29276085, Ref.30). Interacts with FIP1L1; this interaction occurs in a RNA sequence-specific manner (PubMed:15937220). Interacts with PABPN1 (PubMed:15169763). Interacts (via N-terminus) with PAPOLA (via C-terminus); this interaction is direct and diminished by acetylation (PubMed:15169763, PubMed:17172643). Interacts with SNRNP70 (PubMed:14561889). Interacts with VIRMA (PubMed:29507755).

    Three dimensional structures from OCA and Proteopedia for NUDT21 Gene

neXtProt entry for NUDT21 Gene

Post-translational modifications for NUDT21 Gene

  • Acetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2.
  • Ubiquitination at Lys23, Lys29, Lys56, and Lys182
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDT21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT21 Gene

Domains & Families for NUDT21 Gene

Gene Families for NUDT21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT21 Gene

Suggested Antigen Peptide Sequences for NUDT21 Gene

GenScript: Design optimal peptide antigens:
  • Pre-mRNA cleavage factor Im 25 kDa subunit (CPSF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43809

UniProtKB/Swiss-Prot:

CPSF5_HUMAN :
  • Belongs to the Nudix hydrolase family. CPSF5 subfamily.
Family:
  • Belongs to the Nudix hydrolase family. CPSF5 subfamily.
genes like me logo Genes that share domains with NUDT21: view

Function for NUDT21 Gene

Molecular function for NUDT21 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085). NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085). Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262). The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA (PubMed:20479262, PubMed:21295486). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629).

Phenotypes From GWAS Catalog for NUDT21 Gene

Gene Ontology (GO) - Molecular Function for NUDT21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003723 contributes_to RNA binding IDA,IEA 8626397
GO:0003729 mRNA binding IEA,IDA 21295486
GO:0005515 protein binding IPI 11716503
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NUDT21: view
genes like me logo Genes that share phenotypes with NUDT21: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT21 Gene

Localization for NUDT21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT21 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles (PubMed:15169763). {ECO:0000269 PubMed:15169763, ECO:0000269 PubMed:19864460}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT21 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
mitochondrion 3
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Centriolar satellite (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19864460
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 19864460
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with NUDT21: view

Pathways & Interactions for NUDT21 Gene

genes like me logo Genes that share pathways with NUDT21: view

Pathways by source for NUDT21 Gene

Gene Ontology (GO) - Biological Process for NUDT21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IEA --
GO:0006397 mRNA processing IBA,IDA 8626397
GO:0010608 posttranscriptional regulation of gene expression ISS --
genes like me logo Genes that share ontologies with NUDT21: view

No data available for SIGNOR curated interactions for NUDT21 Gene

Drugs & Compounds for NUDT21 Gene

No Compound Related Data Available

Transcripts for NUDT21 Gene

mRNA/cDNA for NUDT21 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT21

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT21 Gene

No ASD Table

Relevant External Links for NUDT21 Gene

GeneLoc Exon Structure for
NUDT21

Expression for NUDT21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT21 Gene



Protein tissue co-expression partners for NUDT21 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDT21

SOURCE GeneReport for Unigene cluster for NUDT21 Gene:

Hs.528834

mRNA Expression by UniProt/SwissProt for NUDT21 Gene:

O43809-CPSF5_HUMAN
Tissue specificity: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for NUDT21 Gene

  • Nervous system(4.8)
  • Eye(4.2)
  • Liver(4.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with NUDT21: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT21 Gene

Orthologs for NUDT21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT21 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia NUDT21 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUDT21 31 30
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT21 31 30
  • 95.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT21 31 30
  • 94.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt21 17 31 30
  • 93.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT21 31
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt21 30
  • 92.07 (n)
chicken
(Gallus gallus)
Aves NUDT21 31 30
  • 85.32 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT21 31
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt21 30
  • 81.35 (n)
Str.6398 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.3893 30
zebrafish
(Danio rerio)
Actinopterygii cpsf5 31 30
  • 79.15 (n)
OneToOne
zgc63966 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8490 30
fruit fly
(Drosophila melanogaster)
Insecta CG3689 31 30
  • 70.03 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007242 30
  • 67.41 (n)
worm
(Caenorhabditis elegans)
Secernentea cfim-1 31 30
  • 64.94 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G25550 30
  • 59.97 (n)
soybean
(Glycine max)
eudicotyledons Gma.4672 30
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.8939 30
rice
(Oryza sativa)
Liliopsida Os04g0683100 30
  • 58.96 (n)
Os.12933 30
barley
(Hordeum vulgare)
Liliopsida Hv.9029 30
wheat
(Triticum aestivum)
Liliopsida Ta.7293 30
corn
(Zea mays)
Liliopsida Zm.4316 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4504 31
  • 76 (a)
OneToOne
Cin.13848 30
bread mold
(Neurospora crassa)
Ascomycetes NCU09014 30
  • 54.5 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13848 30
Species where no ortholog for NUDT21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUDT21 Gene

ENSEMBL:
Gene Tree for NUDT21 (if available)
TreeFam:
Gene Tree for NUDT21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT21: view image

Paralogs for NUDT21 Gene

(1) SIMAP similar genes for NUDT21 Gene using alignment to 3 proteins:

  • CPSF5_HUMAN
  • H3BND3_HUMAN
  • H3BV41_HUMAN

Pseudogenes.org Pseudogenes for NUDT21 Gene

genes like me logo Genes that share paralogs with NUDT21: view

No data available for Paralogs for NUDT21 Gene

Variants for NUDT21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDT21 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
730270 Benign: not provided 56,434,401(-) A/G SYNONYMOUS_VARIANT
736889 Benign: not provided 56,434,354(-) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NUDT21 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDT21 Gene

Variant ID Type Subtype PubMed ID
esv3638695 CNV gain 21293372
nsv833242 CNV loss 17160897
nsv833243 CNV gain 17160897
nsv978153 CNV duplication 23825009

Variation tolerance for NUDT21 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT21 Gene

Disorders for NUDT21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDT21 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amebiasis
  • amoebiasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUDT21

genes like me logo Genes that share disorders with NUDT21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT21 Gene

Publications for NUDT21 Gene

  1. Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs. (PMID: 17098938) Kubo T … Handa H (Nucleic acids research 2006) 3 4 23 54
  2. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. (PMID: 9659921) Rüegsegger U … Keller W (Molecular cell 1998) 2 3 4 54
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 4 54
  4. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. (PMID: 29276085) Zhu Y … Shi Y (Molecular cell 2018) 3 4 54
  5. Cleavage factor Im is a key regulator of 3' UTR length. (PMID: 23187700) Gruber AR … Zavolan M (RNA biology 2012) 3 4 54

Products for NUDT21 Gene

Sources for NUDT21 Gene