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Aliases for NUDT2 Gene

Aliases for NUDT2 Gene

  • Nudix Hydrolase 2 2 3 5
  • Diadenosine Tetraphosphatase 2 3 4
  • Ap4Aase 2 3 4
  • Diadenosine 5,5-P1,P4-Tetraphosphate Asymmetrical Hydrolase 3 4
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 2 2 3
  • Diadenosine 5,5-P1,P4-Tetraphosphate Pyrophosphohydrolase 2 3
  • Bis(5-Nucleosyl)-Tetraphosphatase (Asymmetrical) 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 2 3 4
  • Ap4A Hydrolase 1 2 3
  • Nudix Motif 2 3 4
  • APAH1 3 4
  • Bis(5-Nucleosyl)-Tetraphosphatase [Asymmetrical] 3
  • Ap4A Hydrolase 4
  • EC 4

External Ids for NUDT2 Gene

Previous HGNC Symbols for NUDT2 Gene

  • APAH1

Previous GeneCards Identifiers for NUDT2 Gene

  • GC09P034641
  • GC09P034499
  • GC09P034319
  • GC09P034284

Summaries for NUDT2 Gene

Entrez Gene Summary for NUDT2 Gene

  • This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

GeneCards Summary for NUDT2 Gene

NUDT2 (Nudix Hydrolase 2) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Detoxification of Reactive Oxygen Species. Gene Ontology (GO) annotations related to this gene include GTP binding and bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity.

UniProtKB/Swiss-Prot for NUDT2 Gene

  • Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.

Gene Wiki entry for NUDT2 Gene

Additional gene information for NUDT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT2 Gene

Genomics for NUDT2 Gene

GeneHancer (GH) Regulatory Elements for NUDT2 Gene

Promoters and enhancers for NUDT2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J034327 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 694.3 -0.5 -467 3.5 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 NUDT2 UBAP2 ENSG00000228352 NOL6 PIGO FAM205A C9orf131 UNC13B VCP KIF24
GH09J034373 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 49.1 +46.2 46227 4.2 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 MYORG NUDT2 KIF24 UBAP1
GH09J034378 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 45 +50.7 50684 2.5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 NUDT2 KIF24 MYORG GC09M034390 ENSG00000207032 C9orf24
GH09J034341 Enhancer 1 Ensembl ENCODE dbSUPER 50.6 +14.3 14320 5 FOXA2 NFIA RXRA ZIC2 YY1 NR2F2 OSR2 SP1 JUND ATF3 NUDT2 MYORG C9orf24 RNU2-50P DNAI1 FAM219A IMPDH1P1 DCAF12 ENSG00000230729 RPP25L
GH09J034333 Enhancer 0.9 ENCODE dbSUPER 50.6 +5.1 5055 1.4 SOX13 SAP130 ARID4B BACH1 ERF EBF1 ZNF644 RBPJ GATAD2A SOX5 NUDT2 MYORG C9orf24 CNTFR UBAP1 GC09P034356 KIF24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT2 gene promoter:
  • HFH-1
  • NF-Y
  • CBF(2)
  • GR
  • Egr-4
  • GR-beta
  • GR-alpha
  • HNF-1A
  • FOXC1
  • HNF-1

Genomic Locations for NUDT2 Gene

Genomic Locations for NUDT2 Gene
14,208 bases
Plus strand
14,206 bases
Plus strand

Genomic View for NUDT2 Gene

Genes around NUDT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT2 Gene

Proteins for NUDT2 Gene

  • Protein details for NUDT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bis(5-nucleosyl)-tetraphosphatase [asymmetrical]
    Protein Accession:
    Secondary Accessions:
    • D3DRM0
    • Q5T589

    Protein attributes for NUDT2 Gene

    147 amino acids
    Molecular mass:
    16829 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NUDT2 Gene

neXtProt entry for NUDT2 Gene

Post-translational modifications for NUDT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT2 Gene

Antibody Products

  • Abcam antibodies for NUDT2
  • Boster Bio Antibodies for NUDT2

No data available for DME Specific Peptides for NUDT2 Gene

Domains & Families for NUDT2 Gene

Gene Families for NUDT2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NUDT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Nudix hydrolase family.
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT2: view

Function for NUDT2 Gene

Molecular function for NUDT2 Gene

UniProtKB/Swiss-Prot Function:
Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.
UniProtKB/Swiss-Prot CatalyticActivity:
P(1),P(4)-bis(5-guanosyl) tetraphosphate + H(2)O = GTP + GMP.
GENATLAS Biochemistry:
nudix (nucleoside diphosphate linked moiety X)-type motif 2,hydrolase,putative mouse cleaning gene whose functions is to cleanse the cell of potentially deleterious endogenous metabolites and to modulate the accumulation of intermediates in biochemical pathways

Enzyme Numbers (IUBMB) for NUDT2 Gene

Phenotypes From GWAS Catalog for NUDT2 Gene

Gene Ontology (GO) - Molecular Function for NUDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004081 bis(5-nucleosyl)-tetraphosphatase (asymmetrical) activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
GO:0008796 bis(5-nucleosyl)-tetraphosphatase activity IEA --
GO:0008803 bis(5-nucleosyl)-tetraphosphatase (symmetrical) activity TAS 7487923
genes like me logo Genes that share ontologies with NUDT2: view
genes like me logo Genes that share phenotypes with NUDT2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT2

miRNA for NUDT2 Gene

miRTarBase miRNAs that target NUDT2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT2 Gene

Localization for NUDT2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT2 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with NUDT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT2 Gene

Pathways & Interactions for NUDT2 Gene

genes like me logo Genes that share pathways with NUDT2: view

Pathways by source for NUDT2 Gene

Interacting Proteins for NUDT2 Gene

Gene Ontology (GO) - Biological Process for NUDT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 7487923
GO:0006915 apoptotic process ISS 11937063
GO:0034599 cellular response to oxidative stress TAS --
genes like me logo Genes that share ontologies with NUDT2: view

No data available for SIGNOR curated interactions for NUDT2 Gene

Drugs & Compounds for NUDT2 Gene

(7) Drugs for NUDT2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Uridine monophosphate Experimental Pharma 0

(6) Additional Compounds for NUDT2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diadenosine tetraphosphate
  • (PpA)2
  • a(5')P4(5')a
  • AppppA
  • Bis(5'-adenylyl) diphosphate
  • P1,P4-Bis(5'-adenosyl) tetraphosphate
Diguanosine tetraphosphate
  • (PPG)2
  • Bis(5'-guanosyl) tetraphosphate
  • Bis(guanylyl) diphosphate
  • g(5')P4(5')g
  • GP4g
P1,P4-Bis(5'-uridyl) tetraphosphate
  • Diquafosol
  • P1,P4-Bis(5'-uridyl) tetrahydrogen tetraphosphate
  • P1,P4-Bis(5'-uridyl) tetraphosphoric acid
  • P1,P4-Bis(5'-uridyl) tetrahydrogen tetraphosphoric acid
  • UppppU
P1,P4-Bis(5'-xanthosyl) tetraphosphate
  • P1,P4-Bis(5'-xanthosyl) tetraphosphoric acid
xanthosine 5-triphosphate
  • O(5')-(Tetrahydroxytriphosphoryl)xanthosine
  • Triphopsphoric acid 1-xanthosin-5'-yl ester
  • Xanthosine 5'-triphosphate
  • Xanthosine triphosphate
  • Xanthosine 5-triphosphoric acid
genes like me logo Genes that share compounds with NUDT2: view

Transcripts for NUDT2 Gene

mRNA/cDNA for NUDT2 Gene

Unigene Clusters for NUDT2 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - -
SP4: - - -
SP5: - - - -

Relevant External Links for NUDT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUDT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDT2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.4) and Oral epithelium (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT2 Gene

Protein tissue co-expression partners for NUDT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT2 Gene:


SOURCE GeneReport for Unigene cluster for NUDT2 Gene:


Evidence on tissue expression from TISSUES for NUDT2 Gene

  • Liver(4.2)
  • Pancreas(4.2)
  • Spleen(4.2)
  • Nervous system(3.3)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with NUDT2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT2 Gene

Orthologs for NUDT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUDT2 34 33
  • 99.32 (n)
(Canis familiaris)
Mammalia NUDT2 34 33
  • 91.9 (n)
(Bos Taurus)
Mammalia NUDT2 34 33
  • 90.05 (n)
(Mus musculus)
Mammalia Nudt2 16 34 33
  • 89.57 (n)
(Rattus norvegicus)
Mammalia Nudt2 33
  • 88.89 (n)
(Ornithorhynchus anatinus)
Mammalia NUDT2 34
  • 66 (a)
(Monodelphis domestica)
Mammalia NUDT2 34
  • 66 (a)
(Gallus gallus)
Aves NUDT2 34 33
  • 67.59 (n)
(Anolis carolinensis)
Reptilia NUDT2 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt2 33
  • 66.67 (n)
Str.1563 33
(Danio rerio)
Actinopterygii nudt2 34 33
  • 62.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Apf 34 33
  • 57.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008495 33
  • 55.73 (n)
(Caenorhabditis elegans)
Secernentea ndx-4 34 33
  • 55.31 (n)
Species where no ortholog for NUDT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT2 Gene

Gene Tree for NUDT2 (if available)
Gene Tree for NUDT2 (if available)
Evolutionary constrained regions (ECRs) for NUDT2: view image

Paralogs for NUDT2 Gene

No data available for Paralogs for NUDT2 Gene

Variants for NUDT2 Gene

Sequence variations from dbSNP and Humsavar for NUDT2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000272276 -- 34,333,381(+) C/G intron_variant
rs1000371309 -- 34,339,791(+) C/T intron_variant
rs1000397722 -- 34,339,976(+) C/T intron_variant
rs1000409862 -- 34,332,807(+) A/C intron_variant
rs1000428766 -- 34,340,225(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT2 Gene

Variant ID Type Subtype PubMed ID
esv2738387 CNV deletion 23290073
esv2738388 CNV deletion 23290073
esv3620335 CNV gain 21293372
nsv1015595 CNV gain 25217958
nsv1016251 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv831542 CNV gain 17160897

Variation tolerance for NUDT2 Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT2 Gene

Disorders for NUDT2 Gene

Additional Disease Information for NUDT2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUDT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT2 Gene

Publications for NUDT2 Gene

  1. Structure and substrate-binding mechanism of human Ap4A hydrolase. (PMID: 15596429) Swarbrick JD … Gooley PR (The Journal of biological chemistry 2005) 3 4 22 58
  2. Chromosomal localization of the human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase (Ap4A hydrolase) gene (APAH1) to 9p13. (PMID: 9479504) McLennan AG … Ridanpää M (Genomics 1998) 2 3 22 58
  3. Human diadenosine 5',5"'-P1,P4-tetraphosphate pyrophosphohydrolase is a member of the MutT family of nucleotide pyrophosphatases. (PMID: 7487923) Thorne NM … McLennan AG (The Biochemical journal 1995) 2 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. SARS coronavirus protein 7a interacts with human Ap4A-hydrolase. (PMID: 20144233) Vasilenko N … Zakhartchouk A (Virology journal 2010) 3 22 58

Products for NUDT2 Gene

Sources for NUDT2 Gene

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