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Aliases for NUDT19 Gene

Aliases for NUDT19 Gene

  • Nudix Hydrolase 19 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 19 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 19 3 4
  • Nudix Motif 19 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 19, Mitochondrial 3
  • CTC-379B2.4 3
  • EC 3.6.1.- 4
  • EC 3.6.1 56
  • RP2 3

External Ids for NUDT19 Gene

Previous GeneCards Identifiers for NUDT19 Gene

  • GC19P037876
  • GC19P033182
  • GC19P029686
  • GC19P032667
  • GC19P032856
  • GC19P032668
  • GC19P032766
  • GC19P032841

Summaries for NUDT19 Gene

GeneCards Summary for NUDT19 Gene

NUDT19 (Nudix Hydrolase 19) is a Protein Coding gene. Diseases associated with NUDT19 include Neurodegeneration With Brain Iron Accumulation 1. Among its related pathways are Peroxisome and Peroxisomal lipid metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hydrolase activity.

UniProtKB/Swiss-Prot for NUDT19 Gene

  • Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).

Additional gene information for NUDT19 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT19 Gene

Genomics for NUDT19 Gene

GeneHancer (GH) Regulatory Elements for NUDT19 Gene

Promoters and enhancers for NUDT19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J032691 Promoter/Enhancer 1.6 Ensembl ENCODE 30.3 +27.8 27802 6.7 SP1 CC2D1A ZFX NKRF MLLT1 ZNF121 CEBPG POLR2A GTF2F1 CSDE1 PIR48211 PIR51776 GPATCH1 CEP89 ZNF507 NUDT19 ENSG00000267475 SLC7A9 FAAP24 CHST8
GH19J032745 Enhancer 1.1 Ensembl ENCODE 28.9 +80.8 80805 5 ZNF473 CTCF ZSCAN21 SP7 ZNF548 PRDM1 MLLT1 RAD21 IKZF1 GLIS2 GPATCH1 CEP89 ZNF507 FAAP24 NUDT19 ENSG00000267475 PDCD5 WDR88 DPY19L3 TDRD12
GH19J032868 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 15.4 +203.6 203617 2.6 ZNF652 SP1 PPARG HNF1A ZNF384 KAT8 RXRA ZIC2 REST FOXA2 SLC7A9 NUDT19 FAAP24 ANKRD27 RGS9BP CHST8 GC19M032863 RN7SKP22
GH19J032719 Promoter 0.9 EPDnew 28.2 +53.5 53471 0.1 CTCF MNT USF1 ZNF202 HIC1 CHAMP1 ZNF143 ZBTB33 USF2 ZBTB6 TDRD12 LOC105372368 ENSG00000267567 NUDT19 GPATCH1 ZNF507 CEP89
GH19J032718 Enhancer 0.6 Ensembl 29.1 +52.3 52304 0.4 CTBP1 USF1 ZNF217 DPF2 GATA3 ELF1 RFX5 FOXA1 JUND ZFP3 ENSG00000267567 TDRD12 LOC105372368 NUDT19 ZNF507 GPATCH1 CEP89 PDCD5 GC19M032695
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT19 gene promoter:
  • AML1a
  • HNF-4alpha1
  • HNF-4alpha2
  • p300
  • Pax-3
  • Pax-4a
  • Pax-5
  • Sp1
  • Spz1

Genomic Locations for NUDT19 Gene

Genomic Locations for NUDT19 Gene
chr19:32,666,296-32,713,796
(GRCh38/hg38)
Size:
47,501 bases
Orientation:
Plus strand
chr19:33,182,867-33,204,702
(GRCh37/hg19)
Size:
21,836 bases
Orientation:
Plus strand

Genomic View for NUDT19 Gene

Genes around NUDT19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT19 Gene

Proteins for NUDT19 Gene

  • Protein details for NUDT19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MXV4-NUD19_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 19
    Protein Accession:
    A8MXV4

    Protein attributes for NUDT19 Gene

    Size:
    375 amino acids
    Molecular mass:
    42233 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT19 Gene

Selected DME Specific Peptides for NUDT19 Gene

A8MXV4:
  • GFRLLLLQR
  • LCAHLDCTPDIWALH
  • FLSKEIWL
  • GGVLDAAD
  • LLPGDELY
  • FEEAGVLLLRPR

Post-translational modifications for NUDT19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NUDT19 Gene

Gene Families for NUDT19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NUDT19 Gene

Suggested Antigen Peptide Sequences for NUDT19 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 19, mitochondrial (NUD19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8MXV4

UniProtKB/Swiss-Prot:

NUD19_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT19: view

Function for NUDT19 Gene

Molecular function for NUDT19 Gene

UniProtKB/Swiss-Prot Function:
Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).

Enzyme Numbers (IUBMB) for NUDT19 Gene

Phenotypes From GWAS Catalog for NUDT19 Gene

Gene Ontology (GO) - Molecular Function for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 20178365
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0047617 acyl-CoA hydrolase activity TAS --
genes like me logo Genes that share ontologies with NUDT19: view

Phenotypes for NUDT19 Gene

genes like me logo Genes that share phenotypes with NUDT19: view

Animal Models for NUDT19 Gene

MGI Knock Outs for NUDT19:
  • Nudt19 Nudt19<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT19

CRISPR Products

miRNA for NUDT19 Gene

miRTarBase miRNAs that target NUDT19

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT19

Clone Products

  • Applied Biological Materials (abm): Clones for NUDT19 - Now 50% OFF >
  • * NUDT19 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NUDT19 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUDT19 Gene

Localization for NUDT19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT19 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT19 gene
Compartment Confidence
peroxisome 4
cytosol 4
mitochondrion 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoli (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome IEA --
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT19: view

Pathways & Interactions for NUDT19 Gene

genes like me logo Genes that share pathways with NUDT19: view

Pathways by source for NUDT19 Gene

Gene Ontology (GO) - Biological Process for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006625 protein targeting to peroxisome TAS --
GO:0008150 biological_process ND --
GO:0009062 fatty acid catabolic process TAS --
genes like me logo Genes that share ontologies with NUDT19: view

No data available for SIGNOR curated interactions for NUDT19 Gene

Drugs & Compounds for NUDT19 Gene

(2) Drugs for NUDT19 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 41

(4) Additional Compounds for NUDT19 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Eicosanoyl-CoA
  • Arachidinoyl-CoA
  • Arachidinoyl-coenzyme A
  • Arachidoyl coenzyme A
  • Arachidoyl-CoA
  • Arachidoyl-coenzyme A
15895-27-9
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6
Palmityl-CoA
  • Hexadecanoyl CoA
  • Hexadecanoyl coenzyme A
  • Palmitoyl CoA
  • Palmitoyl coenzyme A
  • Palmitoyl-CoA
1763-10-6
stearoyl-coa
  • Octadecanoyl-CoA
  • Octadecanoyl-coenzyme A
  • S-Octadecanoate
  • S-Octadecanoate CoA
  • S-Octadecanoate coenzyme A
362-66-3
genes like me logo Genes that share compounds with NUDT19: view

Transcripts for NUDT19 Gene

mRNA/cDNA for NUDT19 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NUDT19 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT19

Clone Products

  • Applied Biological Materials (abm): Clones for NUDT19 - Now 50% OFF >
  • * NUDT19 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NUDT19 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT19 Gene

No ASD Table

Relevant External Links for NUDT19 Gene

GeneLoc Exon Structure for
NUDT19
ECgene alternative splicing isoforms for
NUDT19

Expression for NUDT19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDT19 Gene

This gene is overexpressed in Stomach (12.1) and Adrenal (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT19 Gene



Protein tissue co-expression partners for NUDT19 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDT19 Gene:

NUDT19

SOURCE GeneReport for Unigene cluster for NUDT19 Gene:

Hs.203961
genes like me logo Genes that share expression patterns with NUDT19: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT19 Gene

Orthologs for NUDT19 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT19 35 34
  • 99.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC617221 34
  • 79.5 (n)
NUDT19 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt19 17 35 34
  • 74.64 (n)
rat
(Rattus norvegicus)
Mammalia Nudt19 34
  • 72.67 (n)
dog
(Canis familiaris)
Mammalia NUDT19 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUDT19 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT19 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT19 35 34
  • 63.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT19 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt19 34
  • 48.46 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt19 35 34
  • 52.52 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10194 35 34
  • 47.28 (n)
OneToMany
CG10195 35
  • 29 (a)
OneToMany
CG18094 35
  • 27 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009927 34
  • 44.34 (n)
worm
(Caenorhabditis elegans)
Secernentea ndx-7 35 34
  • 43.14 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for NUDT19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT19 Gene

ENSEMBL:
Gene Tree for NUDT19 (if available)
TreeFam:
Gene Tree for NUDT19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT19: view image

Paralogs for NUDT19 Gene

genes like me logo Genes that share paralogs with NUDT19: view

No data available for Paralogs for NUDT19 Gene

Variants for NUDT19 Gene

Sequence variations from dbSNP and Humsavar for NUDT19 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000124726 -- 32,707,572(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000169189 -- 32,701,569(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000222423 -- 32,699,429(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000330733 -- 32,697,126(+) A/G intron_variant
rs1000334847 -- 32,701,861(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT19 Gene

Variant ID Type Subtype PubMed ID
nsv1067189 CNV loss 25217958
nsv1127674 CNV deletion 24896259
nsv579311 CNV gain 21841781

Variation tolerance for NUDT19 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT19
Human Gene Mutation Database (HGMD)
NUDT19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT19 Gene

Disorders for NUDT19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDT19 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
neurodegeneration with brain iron accumulation 1
  • hss
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUDT19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NUDT19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT19 Gene

Publications for NUDT19 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for NUDT19 Gene

Sources for NUDT19 Gene

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