Aliases for NUDT19 Gene

Aliases for NUDT19 Gene

  • Nudix Hydrolase 19 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 19 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 19 3 4
  • Nudix Motif 19 3 4
  • RP2 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 19, Mitochondrial 3
  • CTC-379B2.4 3
  • EC 3.6.1.- 4
  • EC 3.6.1 51
  • NUDT19 5

External Ids for NUDT19 Gene

Previous GeneCards Identifiers for NUDT19 Gene

  • GC19P037876
  • GC19P033182
  • GC19P029686
  • GC19P032667
  • GC19P032856
  • GC19P032880
  • GC19P032789
  • GC19P032876
  • GC19P032668
  • GC19P032766
  • GC19P032841

Summaries for NUDT19 Gene

GeneCards Summary for NUDT19 Gene

NUDT19 (Nudix Hydrolase 19) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisome. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and hydrolase activity.

UniProtKB/Swiss-Prot Summary for NUDT19 Gene

  • Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).

Additional gene information for NUDT19 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT19 Gene

Genomics for NUDT19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NUDT19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDT19

Top Transcription factor binding sites by QIAGEN in the NUDT19 gene promoter:
  • AML1a
  • HNF-4alpha1
  • HNF-4alpha2
  • p300
  • Pax-3
  • Pax-4a
  • Pax-5
  • Sp1
  • Spz1

Genomic Locations for NUDT19 Gene

Genomic Locations for NUDT19 Gene
chr19:32,691,363-32,713,796
(GRCh38/hg38)
Size:
22,434 bases
Orientation:
Plus strand
chr19:33,182,867-33,204,702
(GRCh37/hg19)
Size:
21,836 bases
Orientation:
Plus strand

Genomic View for NUDT19 Gene

Genes around NUDT19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT19 Gene

Proteins for NUDT19 Gene

  • Protein details for NUDT19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MXV4-NUD19_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 19
    Protein Accession:
    A8MXV4

    Protein attributes for NUDT19 Gene

    Size:
    375 amino acids
    Molecular mass:
    42233 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT19 Gene

Selected DME Specific Peptides for NUDT19 Gene

A8MXV4:
  • GFRLLLLQR
  • LCAHLDCTPDIWALH
  • FLSKEIWL
  • GGVLDAAD
  • LLPGDELY
  • FEEAGVLLLRPR

Post-translational modifications for NUDT19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NUDT19 Gene

Gene Families for NUDT19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT19 Gene

Suggested Antigen Peptide Sequences for NUDT19 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 19, mitochondrial (NUD19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A8MXV4

UniProtKB/Swiss-Prot:

NUD19_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT19: view

Function for NUDT19 Gene

Molecular function for NUDT19 Gene

UniProtKB/Swiss-Prot Function:
Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).

Enzyme Numbers (IUBMB) for NUDT19 Gene

Phenotypes From GWAS Catalog for NUDT19 Gene

Gene Ontology (GO) - Molecular Function for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0047617 acyl-CoA hydrolase activity TAS --
genes like me logo Genes that share ontologies with NUDT19: view
genes like me logo Genes that share phenotypes with NUDT19: view

Animal Models for NUDT19 Gene

MGI Knock Outs for NUDT19:
  • Nudt19 Nudt19<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT19

CRISPR Products

miRNA for NUDT19 Gene

miRTarBase miRNAs that target NUDT19

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT19

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUDT19 Gene

Localization for NUDT19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT19 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT19 gene
Compartment Confidence
peroxisome 4
cytosol 4
mitochondrion 3
nucleus 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoli (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome IEA --
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT19: view

Pathways & Interactions for NUDT19 Gene

genes like me logo Genes that share pathways with NUDT19: view

Pathways by source for NUDT19 Gene

Gene Ontology (GO) - Biological Process for NUDT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006625 protein targeting to peroxisome TAS --
GO:0008150 biological_process ND --
GO:0009062 fatty acid catabolic process TAS --
genes like me logo Genes that share ontologies with NUDT19: view

No data available for SIGNOR curated interactions for NUDT19 Gene

Drugs & Compounds for NUDT19 Gene

(2) Drugs for NUDT19 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 56

(4) Additional Compounds for NUDT19 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Eicosanoyl-CoA
  • Arachidinoyl-CoA
  • Arachidinoyl-coenzyme A
  • Arachidoyl coenzyme A
  • Arachidoyl-CoA
  • Arachidoyl-coenzyme A
15895-27-9
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
3546-17-6
Palmityl-CoA
  • Hexadecanoyl CoA
  • Hexadecanoyl coenzyme A
  • Palmitoyl CoA
  • Palmitoyl coenzyme A
  • Palmitoyl-CoA
1763-10-6
stearoyl-coa
  • Octadecanoyl-CoA
  • Octadecanoyl-coenzyme A
  • S-Octadecanoate
  • S-Octadecanoate CoA
  • S-Octadecanoate coenzyme A
362-66-3
genes like me logo Genes that share compounds with NUDT19: view

Transcripts for NUDT19 Gene

mRNA/cDNA for NUDT19 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDT19

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT19 Gene

No ASD Table

Relevant External Links for NUDT19 Gene

GeneLoc Exon Structure for
NUDT19

Expression for NUDT19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDT19 Gene

This gene is overexpressed in Stomach (12.1) and Adrenal (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT19 Gene



Protein tissue co-expression partners for NUDT19 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDT19

SOURCE GeneReport for Unigene cluster for NUDT19 Gene:

Hs.203961
genes like me logo Genes that share expression patterns with NUDT19: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT19 Gene

Orthologs for NUDT19 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NUDT19 30 31
  • 99.01 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC617221 30
  • 79.5 (n)
NUDT19 31
  • 71 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Nudt19 30 17 31
  • 74.64 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nudt19 30
  • 72.67 (n)
Dog
(Canis familiaris)
Mammalia NUDT19 31
  • 66 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NUDT19 31
  • 55 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NUDT19 31
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NUDT19 30 31
  • 63.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NUDT19 31
  • 43 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nudt19 30
  • 48.46 (n)
Zebrafish
(Danio rerio)
Actinopterygii nudt19 30 31
  • 52.52 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG10194 30 31
  • 47.28 (n)
OneToMany
CG10195 31
  • 29 (a)
OneToMany
CG18094 31
  • 27 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009927 30
  • 44.34 (n)
Worm
(Caenorhabditis elegans)
Secernentea ndx-7 30 31
  • 43.14 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 32 (a)
OneToOne
Species where no ortholog for NUDT19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NUDT19 Gene

ENSEMBL:
Gene Tree for NUDT19 (if available)
TreeFam:
Gene Tree for NUDT19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT19: view image

Paralogs for NUDT19 Gene

genes like me logo Genes that share paralogs with NUDT19: view

No data available for Paralogs for NUDT19 Gene

Variants for NUDT19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDT19 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
768983 Benign: not provided 32,692,678(+) A/G INTRON_VARIANT
rs10413282 - p.Arg43Gln

Additional dbSNP identifiers (rs#s) for NUDT19 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDT19 Gene

Variant ID Type Subtype PubMed ID
nsv1067189 CNV loss 25217958
nsv1127674 CNV deletion 24896259
nsv579311 CNV gain 21841781

Variation tolerance for NUDT19 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT19 Gene

Human Gene Mutation Database (HGMD)
NUDT19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT19 Gene

Disorders for NUDT19 Gene

Additional Disease Information for NUDT19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for NUDT19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT19 Gene

Publications for NUDT19 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  2. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. (PMID: 31536960) Moutaoufik MT … Babu M (iScience 2019) 3
  3. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3
  4. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for NUDT19 Gene

Sources for NUDT19 Gene