Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDT18 Gene

Aliases for NUDT18 Gene

  • Nudix Hydrolase 18 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 18 2 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 18 3 4
  • 7,8-Dihydro-8-Oxoguanine Phosphatase 3 4
  • 8-Oxo-DGDP Phosphatase NUDT18 3 4
  • 2-Hydroxy-DADP Phosphatase 3 4
  • MutT Human Homolog 3 2 3
  • MutT Homolog 3 3 4
  • Nudix Motif 18 3 4
  • MTH3 3 4
  • EC 3.6.1.58 4
  • EC 3.6.1 56

External Ids for NUDT18 Gene

Previous GeneCards Identifiers for NUDT18 Gene

  • GC08M022021
  • GC08M020506
  • GC08M021964

Summaries for NUDT18 Gene

Entrez Gene Summary for NUDT18 Gene

  • The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]

GeneCards Summary for NUDT18 Gene

NUDT18 (Nudix Hydrolase 18) is a Protein Coding gene. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and 8-oxo-dGDP phosphatase activity. An important paralog of this gene is NUDT17.

UniProtKB/Swiss-Prot for NUDT18 Gene

  • Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.

Additional gene information for NUDT18 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT18 Gene

Genomics for NUDT18 Gene

GeneHancer (GH) Regulatory Elements for NUDT18 Gene

Promoters and enhancers for NUDT18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J022107 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 623.4 +0.8 794 3.4 MTA3 SP1 ZFX ELF3 MNT ZNF148 NKRF POLR2A ZNF121 CEBPG NUDT18 ENSG00000253200 XPO7 CCAR2 FAM160B2 C8orf58 BMP1 ENSG00000251034 GC08M022104 GC08M022111
GH08J022111 Enhancer 0.9 ENCODE 600.7 -1.2 -1248 0.2 ELF3 POLR2A RERE TFE3 SP7 PPARG SP5 KAT8 GLIS2 HMG20B NUDT18 GC08M022111
GH08J022088 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.9 +20.7 20738 3.2 ZFX POLR2A MLLT1 GTF2F1 ZNF384 ZSCAN21 AHR TRIM24 ZNF639 IKZF1 FAM160B2 ENSG00000253200 POLR3D CCAR2 C8orf58 NUDT18 SORBS3 ENSG00000251034 DMTN GC08M022104
GH08J022097 Enhancer 0.9 Ensembl ENCODE 22.4 +14.8 14754 0.8 CTCF ELF1 RAD21 IKZF1 GLIS2 RFX1 ZNF600 REST TRIM22 DPF2 NUDT18 FAM160B2 GC08M022104
GH08J022129 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 10.7 -21.3 -21279 4.7 ZNF148 POLR2A GLIS2 ZNF600 ZIC2 ATF1 RXRB ZEB2 ZNF740 PATZ1 HR NUDT18 GC08M022111
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT18 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT18 gene promoter:
  • AhR
  • C/EBPbeta
  • E47
  • Egr-1
  • NF-kappaB1
  • Nkx2-5
  • Olf-1
  • Tal-1

Genomic Locations for NUDT18 Gene

Genomic Locations for NUDT18 Gene
chr8:22,106,872-22,110,355
(GRCh38/hg38)
Size:
3,484 bases
Orientation:
Minus strand
chr8:21,964,383-21,966,932
(GRCh37/hg19)
Size:
2,550 bases
Orientation:
Minus strand

Genomic View for NUDT18 Gene

Genes around NUDT18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT18 Gene

Proteins for NUDT18 Gene

  • Protein details for NUDT18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVK8-NUD18_HUMAN
    Recommended name:
    8-oxo-dGDP phosphatase NUDT18
    Protein Accession:
    Q6ZVK8
    Secondary Accessions:
    • Q8IZ75
    • Q9H687

    Protein attributes for NUDT18 Gene

    Size:
    323 amino acids
    Molecular mass:
    35501 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85853.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDT18 Gene

    Alternative splice isoforms for NUDT18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT18 Gene

Selected DME Specific Peptides for NUDT18 Gene

Q6ZVK8:
  • WYLPAGRME
  • QEAKREC

Post-translational modifications for NUDT18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NUDT18 Gene

Gene Families for NUDT18 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NUDT18 Gene

Suggested Antigen Peptide Sequences for NUDT18 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 18 (NUD18_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZVK8

UniProtKB/Swiss-Prot:

NUD18_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT18: view

Function for NUDT18 Gene

Molecular function for NUDT18 Gene

UniProtKB/Swiss-Prot Function:
Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate; Xref=Rhea:RHEA:32063, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:63224, ChEBI:CHEBI:63715; EC=3.6.1.58; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.7 uM for 8-Oxo-dGDP {ECO:0000269 PubMed:22556419}; KM=11.7 uM for 8-Oxo-GDP {ECO:0000269 PubMed:22556419}; Vmax=212 pmol/min/ug enzyme toward 8-Oxo-dGDP (at 30 degrees Celsius) {ECO:0000269 PubMed:22556419}; Vmax=246 pmol/min/ug enzyme toward 8-Oxo-GDP (at 30 degrees Celsius) {ECO:0000269 PubMed:22556419}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:22556419};

Enzyme Numbers (IUBMB) for NUDT18 Gene

Phenotypes From GWAS Catalog for NUDT18 Gene

Gene Ontology (GO) - Molecular Function for NUDT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 22556419
GO:0005515 protein binding IPI 16189514
GO:0016787 hydrolase activity IEA --
GO:0044715 8-oxo-dGDP phosphatase activity IDA 22556419
GO:0044716 8-oxo-GDP phosphatase activity IDA 22556419
genes like me logo Genes that share ontologies with NUDT18: view
genes like me logo Genes that share phenotypes with NUDT18: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NUDT18 - Now 50% OFF >
  • * NUDT18 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NUDT18 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT18 Gene

Localization for NUDT18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT18 gene
Compartment Confidence
cytosol 5
nucleus 4
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT18 Gene

Pathways & Interactions for NUDT18 Gene

PathCards logo

SuperPathways for NUDT18 Gene

genes like me logo Genes that share pathways with NUDT18: view

Pathways by source for NUDT18 Gene

Gene Ontology (GO) - Biological Process for NUDT18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009117 nucleotide metabolic process IEA --
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
GO:0046057 dADP catabolic process IDA 22556419
GO:0046067 dGDP catabolic process IDA 22556419
GO:0046712 GDP catabolic process IDA 22556419
genes like me logo Genes that share ontologies with NUDT18: view

No data available for SIGNOR curated interactions for NUDT18 Gene

Drugs & Compounds for NUDT18 Gene

(6) Drugs for NUDT18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 41
CDP Experimental Pharma 0

(4) Additional Compounds for NUDT18 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-oxo-dGDP
  • 2'-Deoxy-8-oxo-guanosine-5'-diphosphate
  • 8-oxo-2'-Deoxyguanosine-5'-diphosphate
  • 8-Oxodeoxyguanosine diphosphate
  • 2'-Deoxy-8-oxo-guanosine-5'-diphosphoric acid
  • 8-oxo-2'-Deoxyguanosine-5'-diphosphoric acid
8-Oxo-dGMP
  • 8-oxo-7,8-dihydro-2'-Deoxyguanosine 5'-triphosphate
  • 8OG
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
dTDP
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
491-97-4
genes like me logo Genes that share compounds with NUDT18: view

Transcripts for NUDT18 Gene

mRNA/cDNA for NUDT18 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(61) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NUDT18 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 18:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NUDT18 - Now 50% OFF >
  • * NUDT18 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NUDT18 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT18 Gene

No ASD Table

Relevant External Links for NUDT18 Gene

GeneLoc Exon Structure for
NUDT18
ECgene alternative splicing isoforms for
NUDT18

Expression for NUDT18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT18 Gene

Protein differential expression in normal tissues from HIPED for NUDT18 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.9), Spleen (11.2), Skin (6.9), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT18 Gene



Protein tissue co-expression partners for NUDT18 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT18 Gene:

NUDT18

SOURCE GeneReport for Unigene cluster for NUDT18 Gene:

Hs.745387

Evidence on tissue expression from TISSUES for NUDT18 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NUDT18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT18 Gene

Orthologs for NUDT18 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT18 34
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia NUDT18 34
  • 88.13 (n)
cow
(Bos Taurus)
Mammalia NUDT18 34
  • 85.86 (n)
rat
(Rattus norvegicus)
Mammalia Nudt18 34
  • 82.66 (n)
mouse
(Mus musculus)
Mammalia Nudt18 17 34
  • 82.46 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt18 34
  • 51.89 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt18 34
  • 54.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002403 34
  • 54.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10898 34
  • 51.49 (n)
Species where no ortholog for NUDT18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT18 Gene

ENSEMBL:
Gene Tree for NUDT18 (if available)
TreeFam:
Gene Tree for NUDT18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT18: view image

Paralogs for NUDT18 Gene

Paralogs for NUDT18 Gene

genes like me logo Genes that share paralogs with NUDT18: view

Variants for NUDT18 Gene

Sequence variations from dbSNP and Humsavar for NUDT18 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000129020 -- 22,112,310(-) C/T upstream_transcript_variant
rs1000145902 -- 22,112,103(-) G/A upstream_transcript_variant
rs1000424477 -- 22,106,909(-) C/T 3_prime_UTR_variant
rs1001306273 -- 22,109,012(-) G/A intron_variant
rs1001358117 -- 22,108,763(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT18 Gene

Variant ID Type Subtype PubMed ID
dgv12054n54 CNV loss 21841781
dgv12055n54 CNV loss 21841781
dgv450n21 CNV loss 19592680
dgv881n27 CNV loss 19166990
esv2759604 CNV loss 17122850
nsv465613 CNV loss 19166990
nsv470204 CNV loss 18288195
nsv527293 CNV loss 19592680
nsv528590 CNV loss 19592680
nsv610765 CNV loss 21841781
nsv831263 CNV loss 17160897
nsv831264 CNV gain+loss 17160897
nsv951112 CNV deletion 24416366

Variation tolerance for NUDT18 Gene

Gene Damage Index Score: 1.80; 33.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT18 Gene

Disorders for NUDT18 Gene

Additional Disease Information for NUDT18

No disorders were found for NUDT18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT18 Gene

Publications for NUDT18 Gene

  1. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. (PMID: 22556419) Takagi Y … Sekiguchi M (The Journal of biological chemistry 2012) 2 3 4 58
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  3. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N … Twizere JC (Retrovirology 2012) 3 58
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee OH … Songyang Z (Molecular & cellular proteomics : MCP 2011) 3 58
  5. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K … Vidal M (Nature methods 2009) 3 58

Products for NUDT18 Gene

Sources for NUDT18 Gene

Content
Loading form....