Aliases for NUDT18 Gene
External Ids for NUDT18 Gene
Previous GeneCards Identifiers for NUDT18 Gene
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
GeneCards Summary for NUDT18 Gene
NUDT18 (Nudix Hydrolase 18) is a Protein Coding gene. Diseases associated with NUDT18 include Atrial Septal Defect 3 and Lung Papillary Adenocarcinoma. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and 8-oxo-dGDP phosphatase activity. An important paralog of this gene is NUDT17.
UniProtKB/Swiss-Prot Summary for NUDT18 Gene
Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.