Aliases for NUDT17 Gene

Aliases for NUDT17 Gene

  • Nudix Hydrolase 17 2 3 5
  • Nucleoside Diphosphate-Linked Moiety X Motif 17 2 3 4
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 17 2 3
  • Nudix Motif 17 3 4
  • EC 3.6.1.- 4

External Ids for NUDT17 Gene

Previous GeneCards Identifiers for NUDT17 Gene

  • GC01M143075
  • GC01M144297
  • GC01M145586
  • GC01M119550

Summaries for NUDT17 Gene

GeneCards Summary for NUDT17 Gene

NUDT17 (Nudix Hydrolase 17) is a Protein Coding gene. Diseases associated with NUDT17 include Alpha Thalassemia-Intellectual Disability Syndrome Type 1 and Autosomal Recessive Non-Syndromic Intellectual Disability. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT18.

UniProtKB/Swiss-Prot Summary for NUDT17 Gene

  • Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Additional gene information for NUDT17 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT17 Gene

Genomics for NUDT17 Gene

GeneHancer (GH) Regulatory Elements for NUDT17 Gene

Promoters and enhancers for NUDT17 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT17 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDT17

Top Transcription factor binding sites by QIAGEN in the NUDT17 gene promoter:
  • AREB6
  • E47
  • FOXO4
  • GATA-1
  • MAZR
  • Pax-2
  • Pax-2a
  • S8
  • Sox5
  • YY1

Genomic Locations for NUDT17 Gene

Genomic Locations for NUDT17 Gene
chr1:145,844,985-145,848,954
(GRCh38/hg38)
Size:
3,970 bases
Orientation:
Plus strand
chr1:145,586,115-145,589,439
(GRCh37/hg19)
Size:
3,325 bases
Orientation:
Minus strand

Genomic View for NUDT17 Gene

Genes around NUDT17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT17 Gene

Proteins for NUDT17 Gene

  • Protein details for NUDT17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C025-NUD17_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 17
    Protein Accession:
    P0C025

    Protein attributes for NUDT17 Gene

    Size:
    328 amino acids
    Molecular mass:
    35923 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NUDT17 Gene

neXtProt entry for NUDT17 Gene

Post-translational modifications for NUDT17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT17 Gene

No data available for DME Specific Peptides for NUDT17 Gene

Domains & Families for NUDT17 Gene

Gene Families for NUDT17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT17 Gene

Blocks:
  • NUDIX hydrolase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDT17 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 17 (NUD17_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C025

UniProtKB/Swiss-Prot:

NUD17_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT17: view

Function for NUDT17 Gene

Molecular function for NUDT17 Gene

UniProtKB/Swiss-Prot Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Enzyme Numbers (IUBMB) for NUDT17 Gene

Phenotypes From GWAS Catalog for NUDT17 Gene

Gene Ontology (GO) - Molecular Function for NUDT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IBA 21873635
GO:0035529 NADH pyrophosphatase activity IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT17: view

Phenotypes for NUDT17 Gene

genes like me logo Genes that share phenotypes with NUDT17: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT17 Gene

Localization for NUDT17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT17 gene
Compartment Confidence
cytosol 4
peroxisome 3
extracellular 2
cytoskeleton 2
mitochondrion 1
nucleus 1
golgi apparatus 1
endoplasmic reticulum 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IBA 21873635
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with NUDT17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT17 Gene

Pathways & Interactions for NUDT17 Gene

PathCards logo

SuperPathways for NUDT17 Gene

No Data Available

Interacting Proteins for NUDT17 Gene

;

Gene Ontology (GO) - Biological Process for NUDT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006734 NADH metabolic process IBA 21873635
GO:0006742 NADP catabolic process IBA 21873635
GO:0019677 NAD catabolic process IBA 21873635
genes like me logo Genes that share ontologies with NUDT17: view

No data available for Pathways by source and SIGNOR curated interactions for NUDT17 Gene

Drugs & Compounds for NUDT17 Gene

(4) Drugs for NUDT17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 51
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(2) Additional Compounds for NUDT17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
dTDP
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
491-97-4
genes like me logo Genes that share compounds with NUDT17: view

Transcripts for NUDT17 Gene

mRNA/cDNA for NUDT17 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT17 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for NUDT17 Gene

GeneLoc Exon Structure for
NUDT17

Expression for NUDT17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT17 Gene

Protein differential expression in normal tissues from HIPED for NUDT17 Gene

This gene is overexpressed in Adipocyte (32.0), Spleen (21.7), and Kidney (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUDT17 Gene



Protein tissue co-expression partners for NUDT17 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDT17

SOURCE GeneReport for Unigene cluster for NUDT17 Gene:

Hs.585066
genes like me logo Genes that share expression patterns with NUDT17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT17 Gene

Orthologs for NUDT17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDT17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT17 31 30
  • 98.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT17 31 30
  • 85.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT17 31 30
  • 85.08 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt17 17 31 30
  • 81.36 (n)
rat
(Rattus norvegicus)
Mammalia Nudt17 30
  • 80.92 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDT17 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt17 30
  • 55.95 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt17 31 30
  • 52.57 (n)
OneToOne
Species where no ortholog for NUDT17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT17 Gene

ENSEMBL:
Gene Tree for NUDT17 (if available)
TreeFam:
Gene Tree for NUDT17 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT17: view image

Paralogs for NUDT17 Gene

Paralogs for NUDT17 Gene

genes like me logo Genes that share paralogs with NUDT17: view

Variants for NUDT17 Gene

Additional dbSNP identifiers (rs#s) for NUDT17 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDT17 Gene

Variant ID Type Subtype PubMed ID
esv3572008 CNV gain 25503493
esv3587420 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv831381 CNV gain 17160897

Variation tolerance for NUDT17 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDT17 Gene

Disorders for NUDT17 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUDT17 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alpha thalassemia-intellectual disability syndrome type 1
  • alpha-thalassemia/mental retardation syndrome, deletion-type
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUDT17

genes like me logo Genes that share disorders with NUDT17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT17 Gene

Publications for NUDT17 Gene

  1. Multiple Nudix family proteins possess mRNA decapping activity. (PMID: 23353937) Song MG … Kiledjian M (RNA (New York, N.Y.) 2013) 2 3 54
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for NUDT17 Gene

Sources for NUDT17 Gene