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Aliases for NUDT17 Gene

Aliases for NUDT17 Gene

  • Nudix Hydrolase 17 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 17 2
  • Nucleoside Diphosphate-Linked Moiety X Motif 17 2
  • Nudix Motif 17 4
  • EC 3.6.1.- 4

External Ids for NUDT17 Gene

Previous GeneCards Identifiers for NUDT17 Gene

  • GC01M143075
  • GC01M144297
  • GC01M145586
  • GC01M119550

Summaries for NUDT17 Gene

GeneCards Summary for NUDT17 Gene

NUDT17 (Nudix Hydrolase 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for NUDT17 Gene

  • Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Additional gene information for NUDT17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT17 Gene

Genomics for NUDT17 Gene

GeneHancer (GH) Regulatory Elements for NUDT17 Gene

Promoters and enhancers for NUDT17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I145844 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 569.7 +0.9 872 1.9 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B NUDT17 PIAS3 NBPF20 ITGA10 PEX11B POLR3C TXNIP CD160 MIR6736
GH01I146034 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 20.8 +192.6 192566 5.6 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 HFE2 GC01P146046 PIR58458 TRG-TCC2-1 TRH-GTG1-1 TRK-CTT2-1 TRE-CTC1-1 PIAS3 POLR3C NBPF20
GH01I145822 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.8 -21.1 -21081 2.6 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 POLR3C RNF115 NUDT17 NBPF20 PIAS3 GPR89A PIR40983
GH01I144994 Enhancer 1.3 Ensembl ENCODE dbSUPER 24.2 -849.3 -849304 2.7 PKNOX1 FEZF1 ZNF48 ZNF213 ZNF548 FOS YY2 ZNF662 REST KAT8 PIAS3 POLR3C NBPF20 NUDT17 PFN1P6 GPR89A LOC645166 LIX1L-AS1 ENSG00000271644 FAM72D
GH01I146226 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.8 +383.1 383051 3.3 HDGF CLOCK ARNT SIN3A FEZF1 ZNF2 ZBTB7B POLR2B ZNF213 ZNF302 ENSG00000213240 LOC105371254 NOTCH2NL PIAS3 POLR3C NBPF20 ENSG00000234225 GPR89A NUDT17 PEX11B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUDT17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT17 gene promoter:

Genomic Locations for NUDT17 Gene

Genomic Locations for NUDT17 Gene
3,969 bases
Plus strand

Genomic View for NUDT17 Gene

Genes around NUDT17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT17 Gene

Proteins for NUDT17 Gene

  • Protein details for NUDT17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 17
    Protein Accession:

    Protein attributes for NUDT17 Gene

    328 amino acids
    Molecular mass:
    35923 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NUDT17 Gene

neXtProt entry for NUDT17 Gene

Post-translational modifications for NUDT17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT17 Gene

No data available for DME Specific Peptides for NUDT17 Gene

Domains & Families for NUDT17 Gene

Gene Families for NUDT17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDT17 Gene

Suggested Antigen Peptide Sequences for NUDT17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Nudix hydrolase family.
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT17: view

Function for NUDT17 Gene

Molecular function for NUDT17 Gene

UniProtKB/Swiss-Prot Function:
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

Enzyme Numbers (IUBMB) for NUDT17 Gene

Phenotypes From GWAS Catalog for NUDT17 Gene

Gene Ontology (GO) - Molecular Function for NUDT17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT17: view

Phenotypes for NUDT17 Gene

GenomeRNAi human phenotypes for NUDT17:
genes like me logo Genes that share phenotypes with NUDT17: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT17 Gene

Localization for NUDT17 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT17 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
cytosol 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUDT17 Gene

Pathways & Interactions for NUDT17 Gene

SuperPathways for NUDT17 Gene

No Data Available

Interacting Proteins for NUDT17 Gene

Gene Ontology (GO) - Biological Process for NUDT17 Gene


No data available for Pathways by source and SIGNOR curated interactions for NUDT17 Gene

Drugs & Compounds for NUDT17 Gene

(4) Drugs for NUDT17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
Manganese Approved Nutra 37
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(2) Additional Compounds for NUDT17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
genes like me logo Genes that share compounds with NUDT17: view

Transcripts for NUDT17 Gene

Unigene Clusters for NUDT17 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 17:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT17 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: -
SP2: - -

Relevant External Links for NUDT17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUDT17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT17 Gene

Protein differential expression in normal tissues from HIPED for NUDT17 Gene

This gene is overexpressed in Adipocyte (32.0), Spleen (21.7), and Kidney (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUDT17 Gene

Protein tissue co-expression partners for NUDT17 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT17 Gene:


SOURCE GeneReport for Unigene cluster for NUDT17 Gene:

genes like me logo Genes that share expression patterns with NUDT17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT17 Gene

Orthologs for NUDT17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDT17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUDT17 33 34
  • 98.68 (n)
(Canis familiaris)
Mammalia NUDT17 33 34
  • 85.54 (n)
(Bos Taurus)
Mammalia NUDT17 33 34
  • 85.08 (n)
(Mus musculus)
Mammalia Nudt17 33 16 34
  • 81.36 (n)
(Rattus norvegicus)
Mammalia Nudt17 33
  • 80.92 (n)
(Monodelphis domestica)
Mammalia NUDT17 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt17 33
  • 55.95 (n)
(Danio rerio)
Actinopterygii nudt17 33 34
  • 52.57 (n)
Species where no ortholog for NUDT17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT17 Gene

Gene Tree for NUDT17 (if available)
Gene Tree for NUDT17 (if available)

Paralogs for NUDT17 Gene

No data available for Paralogs for NUDT17 Gene

Variants for NUDT17 Gene

Sequence variations from dbSNP and Humsavar for NUDT17 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000597933 -- 145,846,665(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1001718595 -- 145,847,361(+) G/A genic_downstream_transcript_variant, intron_variant
rs1003820509 -- 145,845,110(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1005167671 -- 145,847,066(+) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1005469989 -- 145,845,941(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT17 Gene

Variant ID Type Subtype PubMed ID
esv3572008 CNV gain 25503493
esv3587420 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv831381 CNV gain 17160897

Variation tolerance for NUDT17 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT17 Gene

Disorders for NUDT17 Gene

Additional Disease Information for NUDT17

No disorders were found for NUDT17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT17 Gene

Publications for NUDT17 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier LD … Marra M (Genome research 1996) 3 58

Products for NUDT17 Gene

Sources for NUDT17 Gene

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