Aliases for NUDT16L1 Gene
External Ids for NUDT16L1 Gene
Previous GeneCards Identifiers for NUDT16L1 Gene
GeneCards Summary for NUDT16L1 Gene
NUDT16L1 (Nudix Hydrolase 16 Like 1) is a Protein Coding gene. Among its related pathways are Proteoglycans in cancer and Syndecan-4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT16.
UniProtKB/Swiss-Prot Summary for NUDT16L1 Gene
Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299).