This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation... See more...

Aliases for NUDT15 Gene

Aliases for NUDT15 Gene

  • Nudix Hydrolase 15 2 3 4 5
  • Nucleoside Diphosphate-Linked To Another Moiety X Hydrolase 15 3 4
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 2 3
  • Nucleotide Triphosphate Diphosphatase NUDT15 3 4
  • MutT Homolog 2 3 4
  • MTH2 3 4
  • Probable 7,8-Dihydro-8-Oxoguanine Triphosphatase NUDT15 3
  • Nucleoside Diphosphate-Linked Moiety X Motif 15 4
  • Probable 8-Oxo-DGTP Diphosphatase NUDT15 3
  • 8-Oxo-DGTPase NUDT15 3
  • Nudix Motif 15 4
  • EC 3.6.1.9 4
  • NUDT15D 3

External Ids for NUDT15 Gene

Previous GeneCards Identifiers for NUDT15 Gene

  • GC13P046409
  • GC13P047509
  • GC13P048611
  • GC13P029404

Summaries for NUDT15 Gene

Entrez Gene Summary for NUDT15 Gene

  • This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]

CIViC Summary for NUDT15 Gene

GeneCards Summary for NUDT15 Gene

NUDT15 (Nudix Hydrolase 15) is a Protein Coding gene. Diseases associated with NUDT15 include Thiopurines, Poor Metabolism Of, 2 and Azathioprine Or 6-Mercatopurine Toxicity Or Dose Selection. Among its related pathways are Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity.

UniProtKB/Swiss-Prot Summary for NUDT15 Gene

  • May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956).

Additional gene information for NUDT15 Gene

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDT15 Gene

Genomics for NUDT15 Gene

GeneHancer (GH) Regulatory Elements for NUDT15 Gene

Promoters and enhancers for NUDT15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J048036 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 506.2 +1.2 1154 5 ZBTB40 ZNF217 EP300 CTCF SIN3A TCF12 NRF1 MYC POLR2G SP1 SUCLA2 NUDT15 L13714-106 MED4 PPP1R26P1 SUCLA2-AS1
GH13J048309 Enhancer 0.6 Ensembl dbSUPER 11.8 +272.4 272434 3.6 RBM25 ZNF664 ZNF214 FOS ZNF211 NUDT15 RB1 RCBTB2 lnc-LPAR6-4
GH13J048044 Enhancer 0.4 Ensembl 0.4 +6.4 6434 1.6 JUND BATF FOS JUNB ZNF121 ENSG00000276968 MED4 SUCLA2 MED4-AS1 NUDT15 piR-38716-039
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDT15

Top Transcription factor binding sites by QIAGEN in the NUDT15 gene promoter:
  • AP-1
  • c-Myb
  • E4BP4
  • Hlf
  • HTF
  • LCR-F1
  • NCX
  • p300
  • S8
  • STAT5A

Genomic Locations for NUDT15 Gene

Genomic Locations for NUDT15 Gene
chr13:48,037,567-48,047,222
(GRCh38/hg38)
Size:
9,656 bases
Orientation:
Plus strand
chr13:48,611,703-48,621,358
(GRCh37/hg19)
Size:
9,656 bases
Orientation:
Plus strand

Genomic View for NUDT15 Gene

Genes around NUDT15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT15 Gene

Proteins for NUDT15 Gene

  • Protein details for NUDT15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV35-NUD15_HUMAN
    Recommended name:
    Nucleotide triphosphate diphosphatase NUDT15
    Protein Accession:
    Q9NV35
    Secondary Accessions:
    • A2RUR6
    • Q32Q27
    • Q6P2C9

    Protein attributes for NUDT15 Gene

    Size:
    164 amino acids
    Molecular mass:
    18609 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer (PubMed:26238318). Interacts with PCNA; interaction is disrupted in response to UV irradiation (PubMed:19419956).

    Three dimensional structures from OCA and Proteopedia for NUDT15 Gene

neXtProt entry for NUDT15 Gene

Post-translational modifications for NUDT15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT15 Gene

Domains & Families for NUDT15 Gene

Gene Families for NUDT15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NUDT15 Gene

Blocks:
  • NUDIX hydrolase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDT15 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate-linked moiety X motif 15 (NUD15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NV35

UniProtKB/Swiss-Prot:

NUD15_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT15: view

Function for NUDT15 Gene

Molecular function for NUDT15 Gene

UniProtKB/Swiss-Prot Function:
May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+); Xref=Rhea:RHEA:23996, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.9; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+); Xref=Rhea:RHEA:44644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:65317; EC=3.6.1.9; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=42 uM for dGTP (at pH 7.5) {ECO:0000269 PubMed:26238318}; KM=110 uM for 8-oxo-dGTP (at pH 7.5) {ECO:0000269 PubMed:26238318}; Note=Has a 10-fold higher catalytic efficiency toward dGTP compared to 8-oxo-dGTP. {ECO:0000269 PubMed:26238318};

Enzyme Numbers (IUBMB) for NUDT15 Gene

Phenotypes From GWAS Catalog for NUDT15 Gene

Gene Ontology (GO) - Molecular Function for NUDT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004551 nucleotide diphosphatase activity IEA --
GO:0005515 protein binding IPI 19419956
GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity IDA,IEA 22556419
GO:0016787 hydrolase activity IEA --
GO:0017110 nucleoside-diphosphatase activity EXP 22556419
genes like me logo Genes that share ontologies with NUDT15: view
genes like me logo Genes that share phenotypes with NUDT15: view

Human Phenotype Ontology for NUDT15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for NUDT15 Gene

miRTarBase miRNAs that target NUDT15

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT15 Gene

Localization for NUDT15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT15 gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 2
peroxisome 2
plasma membrane 1
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUDT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT15 Gene

Pathways & Interactions for NUDT15 Gene

genes like me logo Genes that share pathways with NUDT15: view

Pathways by source for NUDT15 Gene

Gene Ontology (GO) - Biological Process for NUDT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 19419956
GO:0000302 response to reactive oxygen species IEA --
GO:0006195 purine nucleotide catabolic process IMP 26878724
GO:0006203 dGTP catabolic process IBA,IDA 22556419
GO:0009217 purine deoxyribonucleoside triphosphate catabolic process IEA --
genes like me logo Genes that share ontologies with NUDT15: view

No data available for SIGNOR curated interactions for NUDT15 Gene

Drugs & Compounds for NUDT15 Gene

(9) Drugs for NUDT15 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azathioprine Approved Pharma 222
Mercaptopurine Approved Pharma 228
Thioguanine Approved Pharma Purine antimetabolite 89
Magnesium Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for NUDT15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
8-Oxo-dgtp
  • 2'-Deoxy-7,8-dihydro-8-oxo-guanosine 5'-(tetrahydrogen triphosphate)
  • 8-Hydroxy-2'-deoxyguanosine 5'-triphosphate
  • 8-oxo-2'-Deoxyguanosine 5'-triphosphate
  • 8-oxo-7,8-dihydro-2'-Deoxyguanosine 5'-triphosphate
  • 8-oxo-Deoxyguanosine triphosphate
139307-94-1
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
dTDP
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
491-97-4
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with NUDT15: view

Transcripts for NUDT15 Gene

mRNA/cDNA for NUDT15 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT15 Gene

No ASD Table

Relevant External Links for NUDT15 Gene

GeneLoc Exon Structure for
NUDT15

Expression for NUDT15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDT15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDT15 Gene

This gene is overexpressed in Nasal epithelium (53.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT15 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDT15

SOURCE GeneReport for Unigene cluster for NUDT15 Gene:

Hs.144407
genes like me logo Genes that share expression patterns with NUDT15: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT15 Gene

Orthologs for NUDT15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDT15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToMany
-- 31
  • 100 (a)
OneToMany
NUDT15 30
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia NUDT15 31 30
  • 90.85 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT15 31
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt15 17 31 30
  • 85.08 (n)
Gm5519 31
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nudt15 30
  • 84.85 (n)
dog
(Canis familiaris)
Mammalia NUDT15 31 30
  • 84.05 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 76 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves NUDT15 31 30
  • 64.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT15 31
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt15 30
  • 67.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398640 30
zebrafish
(Danio rerio)
Actinopterygii nudt15 31 30
  • 61.87 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4285 30
thale cress
(Arabidopsis thaliana)
eudicotyledons NUDX1 30
  • 52.82 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02895 30
  • 51.52 (n)
Species where no ortholog for NUDT15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDT15 Gene

ENSEMBL:
Gene Tree for NUDT15 (if available)
TreeFam:
Gene Tree for NUDT15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT15: view image

Paralogs for NUDT15 Gene

Pseudogenes.org Pseudogenes for NUDT15 Gene

genes like me logo Genes that share paralogs with NUDT15: view

No data available for Paralogs for NUDT15 Gene

Variants for NUDT15 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT15 Gene

NUD15_HUMAN-Q9NV35
Polymorphic NUDT15 variants define the poor metabolism of thiopurines 2 genetic locus (THPM2) [MIM:616903]. Thiopurines are used as immunosuppressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with low NUDT15 activities have an increased risk for toxic effects after receiving standard doses of thiopurine drugs.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDT15 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs116855232 Drug Response: Thiopurines, poor metabolism of, 2; azathioprine response - Dosage, Toxicity/ADR; mercaptopurine response - Dosage, Toxicity/ADR. - 48,045,719(+) C/Tp.Arg139Cys MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs147390019 Drug Response: Thiopurines, poor metabolism of, 2. - 48,045,720(+) G/Ap.Arg139His MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs186364861 Drug Response: Thiopurines, poor metabolism of, 2. - 48,037,798(+) G/Ap.Val18Ile MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs746071566 Drug Response: Thiopurines, poor metabolism of, 2 48,037,782(+) A/AGGAGTC NON_CODING_TRANSCRIPT_VARIANT,INFRAME_INSERTION

Additional dbSNP identifiers (rs#s) for NUDT15 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDT15 Gene

Variant ID Type Subtype PubMed ID
nsv832601 CNV gain 17160897

Variation tolerance for NUDT15 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT15 Gene

Human Gene Mutation Database (HGMD)
NUDT15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT15

Disorders for NUDT15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NUDT15 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUDT15

genes like me logo Genes that share disorders with NUDT15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDT15 Gene

Publications for NUDT15 Gene

  1. Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. (PMID: 19419956) Yu Y … Zhu WG (The Journal of biological chemistry 2009) 3 4 23 54
  2. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. (PMID: 26878724) Moriyama T … Yang JJ (Nature genetics 2016) 3 4 54
  3. Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. (PMID: 26238318) Carter M … Stenmark P (Nature communications 2015) 3 4 54
  4. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia. (PMID: 25108385) Yang SK … Song K (Nature genetics 2014) 3 4 54
  5. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. (PMID: 22556419) Takagi Y … Sekiguchi M (The Journal of biological chemistry 2012) 3 4 54

Products for NUDT15 Gene

Sources for NUDT15 Gene