Aliases for NUDT14 Gene
External Ids for NUDT14 Gene
Previous GeneCards Identifiers for NUDT14 Gene
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
GeneCards Summary for NUDT14 Gene
NUDT14 (Nudix Hydrolase 14) is a Protein Coding gene. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ADP-ribose diphosphatase activity. An important paralog of this gene is NUDT5.
UniProtKB/Swiss-Prot for NUDT14 Gene
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.