Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUDT14 Gene

Aliases for NUDT14 Gene

  • Nudix Hydrolase 14 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 14 2 3
  • Uridine Diphosphate Glucose Pyrophosphatase 2 3
  • UDPG Pyrophosphatase 3 4
  • UGPPase 3 4
  • UGPP 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 14 4
  • UDP-Sugar Diphosphatase 3
  • Nudix Motif 14 4
  • EC 3.6.1.45 4

External Ids for NUDT14 Gene

Previous GeneCards Identifiers for NUDT14 Gene

  • GC14M099630
  • GC14M103610
  • GC14M104710
  • GC14M105639
  • GC14M085831

Summaries for NUDT14 Gene

Entrez Gene Summary for NUDT14 Gene

  • The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for NUDT14 Gene

NUDT14 (Nudix Hydrolase 14) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include hydrolase activity and ADP-ribose diphosphatase activity.

UniProtKB/Swiss-Prot for NUDT14 Gene

  • Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.

Additional gene information for NUDT14 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT14 Gene

Genomics for NUDT14 Gene

GeneHancer (GH) Regulatory Elements for NUDT14 Gene

Promoters and enhancers for NUDT14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I105180 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 571.3 0.0 -34 1.1 KLF17 GTF3C2 ZNF335 GLIS2 EGR1 ZNF143 ZNF391 SMARCA5 SP3 ZFP69B NUDT14 ENSG00000257622 PIR46609 PIR42636
GH14I105165 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 18.3 +13.9 13938 3.6 PKNOX1 ATF1 ARNT SIN3A GLIS2 ZNF213 ATF7 SP3 SMARCB1 ZNF592 JAG2 NUDT14 ENSG00000257622 MIR6765
GH14I105058 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +118.1 118138 10 HDGF ATF1 PKNOX1 SMAD1 BATF KLF5 IRF4 ZNF143 ZNF207 ATF7 GPR132 AHNAK2 CDCA4 JAG2 NUDT14 CLBA1 TEDC1 PLD4 BRF1 GC14P105040
GH14I105312 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 10.6 -134.1 -134114 5.4 PKNOX1 SREBF2 ARID4B SIN3A THRB ZNF48 ZBTB40 ZNF335 ZNF766 GLIS2 BRF1 PACS2 MTA1 ENSG00000225200 ENSG00000257270 TEX22 NUDT14 JAG2 GC14M105304
GH14I105173 Enhancer 0.9 Ensembl ENCODE dbSUPER 21.6 +6.8 6848 1.6 ZNF341 KLF9 ZNF16 ZNF600 ZBTB8A NR2F2 NUDT14 MTA1 CDCA4 ENSG00000257622 JAG2 PIR46609
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUDT14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT14 gene promoter:

Genomic Locations for NUDT14 Gene

Genomic Locations for NUDT14 Gene
chr14:105,172,937-105,181,323
(GRCh38/hg38)
Size:
8,387 bases
Orientation:
Minus strand
chr14:105,639,275-105,647,660
(GRCh37/hg19)

Genomic View for NUDT14 Gene

Genes around NUDT14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT14 Gene

Proteins for NUDT14 Gene

  • Protein details for NUDT14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95848-NUD14_HUMAN
    Recommended name:
    Uridine diphosphate glucose pyrophosphatase
    Protein Accession:
    O95848
    Secondary Accessions:
    • Q86SJ8

    Protein attributes for NUDT14 Gene

    Size:
    222 amino acids
    Molecular mass:
    24118 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAD15563.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDT14 Gene

neXtProt entry for NUDT14 Gene

Post-translational modifications for NUDT14 Gene

No Post-translational modifications

Other Protein References for NUDT14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT14 Gene

Domains & Families for NUDT14 Gene

Gene Families for NUDT14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NUDT14 Gene

Graphical View of Domain Structure for InterPro Entry

O95848

UniProtKB/Swiss-Prot:

NUD14_HUMAN :
  • Belongs to the Nudix hydrolase family.
Family:
  • Belongs to the Nudix hydrolase family.
genes like me logo Genes that share domains with NUDT14: view

Function for NUDT14 Gene

Molecular function for NUDT14 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.0-9.5.;
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.

Enzyme Numbers (IUBMB) for NUDT14 Gene

Gene Ontology (GO) - Molecular Function for NUDT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12620389
GO:0008768 UDP-sugar diphosphatase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with NUDT14: view
genes like me logo Genes that share phenotypes with NUDT14: view

Animal Models for NUDT14 Gene

MGI Knock Outs for NUDT14:

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NUDT14 Gene

Localization for NUDT14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT14 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with NUDT14: view

Pathways & Interactions for NUDT14 Gene

genes like me logo Genes that share pathways with NUDT14: view

Gene Ontology (GO) - Biological Process for NUDT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with NUDT14: view

No data available for SIGNOR curated interactions for NUDT14 Gene

Drugs & Compounds for NUDT14 Gene

(5) Drugs for NUDT14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Magnesium Approved Nutra 0
Glucose 1-phosphate Experimental Pharma 0
Uridine diphosphate glucose Experimental Pharma 0
Uridine monophosphate Experimental Pharma 0

(1) Additional Compounds for NUDT14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-glucose
  • GDP-alpha-D-Glucose
  • GDP-alpha-delta-Glucose
  • GDPG
  • Guanosine 5-pyrophosphate
  • Guanosine diphosphoglucose
5750-57-2
genes like me logo Genes that share compounds with NUDT14: view

Transcripts for NUDT14 Gene

mRNA/cDNA for NUDT14 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT14 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1:
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for NUDT14 Gene

GeneLoc Exon Structure for
NUDT14
ECgene alternative splicing isoforms for
NUDT14

Expression for NUDT14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT14 Gene

Protein differential expression in normal tissues from HIPED for NUDT14 Gene

This gene is overexpressed in Oral epithelium (8.2), Brain (6.1), and Tonsil (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDT14 Gene



NURSA nuclear receptor signaling pathways regulating expression of NUDT14 Gene:

NUDT14

SOURCE GeneReport for Unigene cluster for NUDT14 Gene:

Hs.526432

Evidence on tissue expression from TISSUES for NUDT14 Gene

  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with NUDT14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT14 Gene

Orthologs for NUDT14 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT14 33 34
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia NUDT14 33 34
  • 86.19 (n)
dog
(Canis familiaris)
Mammalia LOC612707 33
  • 85.66 (n)
NUDT14 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudt14 33
  • 82.43 (n)
mouse
(Mus musculus)
Mammalia Nudt14 33 16 34
  • 82.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NUDT14 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT14 33 34
  • 59.82 (n)
lizard
(Anolis carolinensis)
Reptilia NUDT14 34
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nudt14 33 34
  • 62.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42813 33 34
  • 58.51 (n)
CG42814 34
  • 33 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004158 33
  • 52.75 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C50F4.16 33
  • 42.51 (n)
C50F4.16 34
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToOne
Species where no ortholog for NUDT14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NUDT14 Gene

ENSEMBL:
Gene Tree for NUDT14 (if available)
TreeFam:
Gene Tree for NUDT14 (if available)

Paralogs for NUDT14 Gene

No data available for Paralogs for NUDT14 Gene

Variants for NUDT14 Gene

Sequence variations from dbSNP and Humsavar for NUDT14 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000114505 -- 105,178,666(-) T/G intron_variant
rs1000389644 -- 105,182,984(-) A/G upstream_transcript_variant
rs1000737353 -- 105,176,839(-) C/T intron_variant
rs1000762877 -- 105,173,426(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000858220 -- 105,180,933(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT14 Gene

Variant ID Type Subtype PubMed ID
nsv952279 CNV deletion 24416366
nsv9175 CNV gain 18304495
nsv817646 CNV loss 17921354
nsv566177 CNV gain 21841781
nsv566156 CNV loss 21841781
nsv566150 CNV loss 21841781
nsv517055 CNV gain+loss 19592680
nsv470679 CNV loss 18288195
nsv456458 CNV loss 19166990
nsv1112655 CNV deletion 24896259
nsv1070246 CNV deletion 25765185
nsv1054574 CNV loss 25217958
nsv1052190 CNV gain 25217958
esv2760014 CNV loss 17122850
dgv3982n54 CNV loss 21841781
dgv3977n54 CNV loss 21841781
dgv267n27 CNV loss 19166990

Variation tolerance for NUDT14 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT14 Gene

Disorders for NUDT14 Gene

Additional Disease Information for NUDT14

No disorders were found for NUDT14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT14 Gene

Publications for NUDT14 Gene

  1. Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose. (PMID: 12429023) Yagi T … Pozueta-Romero J (The Biochemical journal 2003) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  4. Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication. (PMID: 26781650) Wang G … Ruan Q (Molecular medicine reports 2016) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for NUDT14 Gene

Sources for NUDT14 Gene

Content
Loading form....