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Aliases for NUDT13 Gene

Aliases for NUDT13 Gene

  • Nudix Hydrolase 13 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 13 2 3
  • Nudix Motif 13 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 13 3
  • Protein KiSS-16 4
  • EC 3.-.-.- 4

External Ids for NUDT13 Gene

Previous GeneCards Identifiers for NUDT13 Gene

  • GC10P073648
  • GC10M073973
  • GC10P074762
  • GC10P074214
  • GC10P074540
  • GC10P074870
  • GC10P068863

Summaries for NUDT13 Gene

GeneCards Summary for NUDT13 Gene

NUDT13 (Nudix Hydrolase 13) is a Protein Coding gene. Among its related pathways are Metabolism and Synthesis and interconversion of nucleotide di- and triphosphates. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is NUDT12.

Additional gene information for NUDT13 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT13 Gene

Genomics for NUDT13 Gene

GeneHancer (GH) Regulatory Elements for NUDT13 Gene

Promoters and enhancers for NUDT13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J073109 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 685.2 +0.7 682 2.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 IRF4 YY1 SLC30A9 NUDT13 ZSWIM8 NDST2 ZSWIM8-AS1 SEC24C DNAJB12 ECD AGAP5 CFAP70 DNAJC9
GH10J073093 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 34.3 -14.3 -14337 4.1 MLX DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 P4HA1 ECD NDST2 DNAJB12 ZSWIM8 GLUD1P3 NUDT13 DUSP8P5 SEC24C ZSWIM8-AS1
GH10J073243 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33.9 +135.9 135858 5.5 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 DNAJC9 DNAJC9-AS1 SEC24C NDST2 ZSWIM8 NUDT13 DNAJB12 GLUD1P3 ZSWIM8-AS1 ENSG00000272140
GH10J073250 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33.9 +142.0 141959 3.5 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000227540 MRPS16 DNAJB12 NDST2 ZSWIM8 SEC24C AP3M1 ECD NUDT13 ENSG00000272140
GH10J073166 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 33.5 +57.6 57629 2.4 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ECD FAM149B1 NUDT13 NDST2 ZSWIM8 DNAJB12 SEC24C ZSWIM8-AS1 AP3M1 VCL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT13 gene promoter:
  • MAZR
  • Tal-1beta
  • E47
  • HFH-1
  • CUTL1
  • RP58
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3

Genomic Locations for NUDT13 Gene

Genomic Locations for NUDT13 Gene
chr10:73,110,375-73,131,828
(GRCh38/hg38)
Size:
21,454 bases
Orientation:
Plus strand
chr10:74,870,210-74,891,586
(GRCh37/hg19)
Size:
21,377 bases
Orientation:
Plus strand

Genomic View for NUDT13 Gene

Genes around NUDT13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT13 Gene

Proteins for NUDT13 Gene

  • Protein details for NUDT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X67-NUD13_HUMAN
    Recommended name:
    Nucleoside diphosphate-linked moiety X motif 13
    Protein Accession:
    Q86X67
    Secondary Accessions:
    • B4DV90
    • O95650
    • Q5SQM4
    • Q5SQM5
    • Q5SQM6
    • Q9Y3X2

    Protein attributes for NUDT13 Gene

    Size:
    352 amino acids
    Molecular mass:
    39688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD00649.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for NUDT13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDT13 Gene

Post-translational modifications for NUDT13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUDT13 Gene

Domains & Families for NUDT13 Gene

Gene Families for NUDT13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUDT13: view

No data available for UniProtKB/Swiss-Prot for NUDT13 Gene

Function for NUDT13 Gene

Enzyme Numbers (IUBMB) for NUDT13 Gene

Phenotypes From GWAS Catalog for NUDT13 Gene

Gene Ontology (GO) - Molecular Function for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016462 pyrophosphatase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUDT13: view
genes like me logo Genes that share phenotypes with NUDT13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUDT13

miRNA for NUDT13 Gene

miRTarBase miRNAs that target NUDT13

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT13 Gene

Localization for NUDT13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT13 gene
Compartment Confidence
mitochondrion 5
nucleus 4
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with NUDT13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDT13 Gene

Pathways & Interactions for NUDT13 Gene

genes like me logo Genes that share pathways with NUDT13: view

Pathways by source for NUDT13 Gene

Gene Ontology (GO) - Biological Process for NUDT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015949 nucleobase-containing small molecule interconversion TAS --
genes like me logo Genes that share ontologies with NUDT13: view

No data available for SIGNOR curated interactions for NUDT13 Gene

Drugs & Compounds for NUDT13 Gene

No Compound Related Data Available

Transcripts for NUDT13 Gene

Unigene Clusters for NUDT13 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - -
SP3:
SP4: - - - -
SP5: -

Relevant External Links for NUDT13 Gene

GeneLoc Exon Structure for
NUDT13
ECgene alternative splicing isoforms for
NUDT13

Expression for NUDT13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT13 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUDT13 Gene:

NUDT13

SOURCE GeneReport for Unigene cluster for NUDT13 Gene:

Hs.533657

mRNA Expression by UniProt/SwissProt for NUDT13 Gene:

Q86X67-NUD13_HUMAN
Tissue specificity: Highly expressed in metastasis-suppressed chromosome 6 melanoma hybrids.

Evidence on tissue expression from TISSUES for NUDT13 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with NUDT13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT13 Gene

Orthologs for NUDT13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUDT13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT13 34 33
  • 99.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUDT13 34 33
  • 89.2 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUDT13 34 33
  • 88.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nudt13 16 34 33
  • 82.67 (n)
rat
(Rattus norvegicus)
Mammalia Nudt13 33
  • 80.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NUDT13 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDT13 34 33
  • 66.07 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDT13 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudt13 33
  • 61.34 (n)
zebrafish
(Danio rerio)
Actinopterygii nudt13 34 33
  • 58.88 (n)
OneToMany
NUDT13 (2 of 2) 34
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ndx-9 34 33
  • 47.69 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPY1 34
  • 20 (a)
OneToMany
Species where no ortholog for NUDT13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDT13 Gene

ENSEMBL:
Gene Tree for NUDT13 (if available)
TreeFam:
Gene Tree for NUDT13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT13: view image

Paralogs for NUDT13 Gene

Paralogs for NUDT13 Gene

(1) SIMAP similar genes for NUDT13 Gene using alignment to 5 proteins:

  • NUD13_HUMAN
  • B4DV90_HUMAN
  • B4E059_HUMAN
  • Q4G134_HUMAN
  • Q5SQM6_HUMAN
genes like me logo Genes that share paralogs with NUDT13: view

Variants for NUDT13 Gene

Sequence variations from dbSNP and Humsavar for NUDT13 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000134771 -- 73,110,118(+) G/A upstream_transcript_variant
rs1000240189 -- 73,116,308(+) C/T intron_variant
rs1000244191 -- 73,126,478(+) C/A intron_variant
rs1000383926 -- 73,130,717(+) G/A 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs1000384922 -- 73,111,286(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT13 Gene

Variant ID Type Subtype PubMed ID
nsv1120224 CNV tandem duplication 24896259
nsv527219 CNV loss 19592680

Variation tolerance for NUDT13 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT13 Gene

Disorders for NUDT13 Gene

Additional Disease Information for NUDT13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUDT13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT13 Gene

Publications for NUDT13 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for NUDT13 Gene

Sources for NUDT13 Gene

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