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Aliases for NUDT11 Gene

Aliases for NUDT11 Gene

  • Nudix Hydrolase 11 2 3 5
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 11 2 3
  • Diadenosine 5,5-P1,P6-Hexaphosphate Hydrolase 3-Beta 3 4
  • Diadenosine Hexaphosphate Hydrolase (AMP-Forming) 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 11 3 4
  • Nudix Motif 11 3 4
  • DIPP-3-Beta 3 4
  • DIPP3-Beta 3 4
  • HDIPP3beta 3 4
  • HAps1 3 4
  • APS1 3 4
  • Diphosphoinositol Polyphosphate Phosphohydrolase 3, Beta 3
  • Diphosphoinositol Polyphosphate Phosphohydrolase 3-Beta 3
  • EC 3.6.1.52 4
  • EC 3.6.1.60 4
  • DIPP3beta 3
  • DIPP3b 3
  • DIPP3B 4
  • ASP1 3

External Ids for NUDT11 Gene

Previous GeneCards Identifiers for NUDT11 Gene

  • GC0XP049645
  • GC0XM049277
  • GC0XM049917
  • GC0XM050149
  • GC0XM051065
  • GC0XM051249
  • GC0XM051232
  • GC0XM048674

Summaries for NUDT11 Gene

Entrez Gene Summary for NUDT11 Gene

  • NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NUDT11 Gene

NUDT11 (Nudix Hydrolase 11) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and inositol diphosphate tetrakisphosphate diphosphatase activity. An important paralog of this gene is NUDT10.

UniProtKB/Swiss-Prot for NUDT11 Gene

  • Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.

Gene Wiki entry for NUDT11 Gene

Additional gene information for NUDT11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDT11 Gene

Genomics for NUDT11 Gene

GeneHancer (GH) Regulatory Elements for NUDT11 Gene

Promoters and enhancers for NUDT11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ051495 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 659.8 +0.4 406 2.4 MXI1 USF1 ZIC2 ZNF335 GLIS2 POLR2A PATZ1 SCRT2 L3MBTL2 NRF1 NUDT11 CXorf67
GH0XJ051742 Promoter/Enhancer 1.3 Ensembl ENCODE 7.4 -247.1 -247115 2.6 NFRKB ZBTB40 YY1 ZNF335 EGR1 SCRT2 BCLAF1 RUNX3 EGR2 SMARCA5 GSPT2 NUDT11 MAGED1
GH0XJ051802 Promoter/Enhancer 1.3 Ensembl ENCODE 7.4 -306.8 -306825 1.9 ATF1 MZF1 SIN3A ZBTB40 YY1 ETS1 ZNF335 GLIS2 ELK1 ZNF143 MAGED1 RNU6-504P CENPVL1 NUDT11 LOC100631242
GH0XJ051456 Enhancer 0.4 ENCODE 20.1 +40.0 39976 0.7 CTCF ZNF654 RAD21 NUDT11 CXorf67 LOC100419238
GH0XJ052015 Enhancer 0.2 ENCODE 7.4 -519.3 -519269 0.8 NUDT11 GC0XP052044 TPMTP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDT11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDT11 gene promoter:
  • Spz1
  • FOXD1
  • Bach2
  • Ik-1
  • HSF1 (long)
  • HSF1short
  • c-Myb
  • FOXD3
  • S8
  • Elk-1

Genomic Locations for NUDT11 Gene

Genomic Locations for NUDT11 Gene
chrX:51,490,011-51,496,607
(GRCh38/hg38)
Size:
6,597 bases
Orientation:
Minus strand
chrX:51,232,863-51,239,459
(GRCh37/hg19)
Size:
6,597 bases
Orientation:
Minus strand

Genomic View for NUDT11 Gene

Genes around NUDT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDT11 Gene

Proteins for NUDT11 Gene

  • Protein details for NUDT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G61-NUD11_HUMAN
    Recommended name:
    Diphosphoinositol polyphosphate phosphohydrolase 3-beta
    Protein Accession:
    Q96G61
    Secondary Accessions:
    • Q9NVN0

    Protein attributes for NUDT11 Gene

    Size:
    164 amino acids
    Molecular mass:
    18559 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for NUDT11 Gene

Post-translational modifications for NUDT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDT11 Gene

Domains & Families for NUDT11 Gene

Gene Families for NUDT11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NUDT11 Gene

Suggested Antigen Peptide Sequences for NUDT11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G61

UniProtKB/Swiss-Prot:

NUD11_HUMAN :
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
Family:
  • Belongs to the Nudix hydrolase family. DIPP subfamily.
genes like me logo Genes that share domains with NUDT11: view

Function for NUDT11 Gene

Molecular function for NUDT11 Gene

UniProtKB/Swiss-Prot Function:
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
P(1),P(6)-bis(5-adenosyl)hexaphosphate + H(2)O = adenosine 5-pentaphosphate + AMP.
UniProtKB/Swiss-Prot CatalyticActivity:
P(1),P(5)-bis(5-adenosyl)pentaphosphate + H(2)O = adenosine 5-tetraphosphate + AMP.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.053 uM for PP-InsP5 {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; KM=13 uM for Ap6A {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; KM=37 uM for Ap5A {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:12105228, ECO:0000269 PubMed:12121577};

Enzyme Numbers (IUBMB) for NUDT11 Gene

Phenotypes From GWAS Catalog for NUDT11 Gene

Gene Ontology (GO) - Molecular Function for NUDT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000298 endopolyphosphatase activity IBA --
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity IBA,ISS --
GO:0016787 hydrolase activity IEA --
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IBA --
GO:0034431 bis(5-adenosyl)-hexaphosphatase activity IBA --
genes like me logo Genes that share ontologies with NUDT11: view
genes like me logo Genes that share phenotypes with NUDT11: view

Animal Model Products

miRNA for NUDT11 Gene

miRTarBase miRNAs that target NUDT11

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDT11 Gene

Localization for NUDT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDT11 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDT11 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUDT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUDT11: view

Pathways & Interactions for NUDT11 Gene

genes like me logo Genes that share pathways with NUDT11: view

Pathways by source for NUDT11 Gene

Gene Ontology (GO) - Biological Process for NUDT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043647 inositol phosphate metabolic process TAS --
GO:0071543 diphosphoinositol polyphosphate metabolic process IBA --
GO:1901907 diadenosine pentaphosphate catabolic process IBA --
GO:1901909 diadenosine hexaphosphate catabolic process IBA --
GO:1901911 adenosine 5-(hexahydrogen pentaphosphate) catabolic process IBA --
genes like me logo Genes that share ontologies with NUDT11: view

No data available for SIGNOR curated interactions for NUDT11 Gene

Drugs & Compounds for NUDT11 Gene

(5) Drugs for NUDT11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
Magnesium Approved Nutra 0
Manganese Approved Nutra 37

(6) Additional Compounds for NUDT11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Diphosphoinositol pentakisphosphate
  • (1R,2R,3S,4S,5R,6S)-2,3,4,5,6-Pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate
  • 1D-myo-Inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
  • 1D-myo-Inositol 5-diphosphate pentakisphosphate
  • 5-PP-InsP5
  • (1R,2R,3S,4S,5R,6S)-2,3,4,5,6-Pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphoric acid
Adenosine 5'-pentaphosphate
  • 5'-O-[(S)-Hydroxy{[(R)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]oxy}phosphoryl]adenosine
  • 5'-O-[Hydroxy({hydroxy[(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)oxy]phosphoryl}oxy)phosphoryl]adenosine
  • ADENOSINE-5'-pentaphosphATE
  • Pppppa
  • Adenosine 5'-pentaphosphoric acid
Adenosine tetraphosphate
  • Adenosine 5'-tetraphosphate
  • Adenosine 5'-tetraphosphoric acid
  • Adenosine tetraphosphoric acid
  • Ap4
  • ATPP
58337-43-2
Diadenosine hexaphosphate
  • Adenosine 5'-hexaphosphate 5'-ester with adenosine
  • Adenosine-(5')-hexaphospho-(5')-adenosine
  • Ap(6)a
  • AP6a
  • AppppppA
56983-23-4
Myo-inositol hexakisphosphate
  • 1D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • 1D-myo-Inositol hexakisphosphate
  • D-myo-Inositol 1,2,3,4,5,6-hexakisphosphate
  • Inositol 1,2,3,4,5,6-hexakisphosphate
  • myo-Inositol 1,2,3,4,5,6-hexakisphosphate
83-86-3
genes like me logo Genes that share compounds with NUDT11: view

Transcripts for NUDT11 Gene

mRNA/cDNA for NUDT11 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(68) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDT11 Gene

Nudix (nucleoside diphosphate linked moiety X)-type motif 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDT11 Gene

No ASD Table

Relevant External Links for NUDT11 Gene

GeneLoc Exon Structure for
NUDT11
ECgene alternative splicing isoforms for
NUDT11

Expression for NUDT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUDT11 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Hypothalamus (x4.7), Testis (x4.5), and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for NUDT11 Gene

This gene is overexpressed in Heart (20.4), Fetal testis (12.5), Ovary (11.8), Testis (11.6), and Fetal Brain (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDT11 Gene



Protein tissue co-expression partners for NUDT11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDT11 Gene:

NUDT11

SOURCE GeneReport for Unigene cluster for NUDT11 Gene:

Hs.200016

mRNA Expression by UniProt/SwissProt for NUDT11 Gene:

Q96G61-NUD11_HUMAN
Tissue specificity: Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart.

Evidence on tissue expression from TISSUES for NUDT11 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with NUDT11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDT11 Gene

Orthologs for NUDT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDT11 34 33
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 96 (a)
ManyToMany
-- 34
  • 96 (a)
ManyToMany
LOC491890 33
  • 93.29 (n)
mouse
(Mus musculus)
Mammalia Nudt10 34
  • 96 (a)
ManyToMany
Nudt11 16 34 33
  • 88.01 (n)
cow
(Bos Taurus)
Mammalia NUDT11 34 33
  • 94.51 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nudt11 33
  • 87.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 72 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nudt4b 34
  • 73 (a)
ManyToMany
nudt4a 34
  • 58 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Aps 34
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y92H12BL.5 34
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8787 34
  • 40 (a)
OneToMany
Species where no ortholog for NUDT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NUDT11 Gene

ENSEMBL:
Gene Tree for NUDT11 (if available)
TreeFam:
Gene Tree for NUDT11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDT11: view image

Paralogs for NUDT11 Gene

Paralogs for NUDT11 Gene

(4) SIMAP similar genes for NUDT11 Gene using alignment to 1 proteins:

  • NUD11_HUMAN
genes like me logo Genes that share paralogs with NUDT11: view

Variants for NUDT11 Gene

Sequence variations from dbSNP and Humsavar for NUDT11 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000190777 -- 51,489,777(-) G/A downstream_transcript_variant
rs1004595019 -- 51,490,549(-) T/C 3_prime_UTR_variant
rs1005114098 -- 51,491,092(-) C/T 3_prime_UTR_variant
rs1006383205 -- 51,493,181(-) T/G intron_variant
rs1008835488 -- 51,489,837(-) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDT11 Gene

Variant ID Type Subtype PubMed ID
nsv471604 CNV gain 15918152
nsv524351 CNV gain 19592680

Variation tolerance for NUDT11 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDT11 Gene

Disorders for NUDT11 Gene

Additional Disease Information for NUDT11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUDT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDT11 Gene

Publications for NUDT11 Gene

  1. An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. (PMID: 12105228) Hidaka K … Shears SB (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. (PMID: 12121577) Leslie NR … Safrany ST (BMC biochemistry 2002) 3 4 22 58
  3. Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans. (PMID: 19902474) Hooker S … Kittles RA (The Prostate 2010) 3 44 58
  4. Multiple newly identified loci associated with prostate cancer susceptibility. (PMID: 18264097) Eeles RA … Easton DF (Nature genetics 2008) 3 44 58
  5. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. (PMID: 18264098) Gudmundsson J … Stefansson K (Nature genetics 2008) 3 44 58

Products for NUDT11 Gene

Sources for NUDT11 Gene

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