Aliases for NUDT10 Gene
- Nudix Hydrolase 10 2 3 5
- Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 10 2 3
- Diadenosine 5',5'''-P1,P6-Hexaphosphate Hydrolase 3-Alpha 3 4
- Diphosphoinositol Polyphosphate Phosphohydrolase 3-Alpha 3 4
- Diadenosine Hexaphosphate Hydrolase (AMP-Forming) 3 4
- Nucleoside Diphosphate-Linked Moiety X Motif 10 3 4
- Nudix Motif 10 3 4
- DIPP3-Alpha 3 4
External Ids for NUDT10 Gene
Previous GeneCards Identifiers for NUDT10 Gene
This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]
GeneCards Summary for NUDT10 Gene
NUDT10 (Nudix Hydrolase 10) is a Protein Coding gene. Diseases associated with NUDT10 include Autoimmune Polyendocrine Syndrome, Type Ii and Adrenal Cortical Hypofunction. Among its related pathways are Metabolism and Inositol phosphate metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and inositol diphosphate tetrakisphosphate diphosphatase activity. An important paralog of this gene is NUDT11.
UniProtKB/Swiss-Prot Summary for NUDT10 Gene
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.