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Aliases for NUDCD3 Gene

Aliases for NUDCD3 Gene

  • NudC Domain Containing 3 2 3 5
  • NudC Domain-Containing Protein 3 3
  • NudC-Like Protein 3
  • KIAA1068 4
  • NudCL 3

External Ids for NUDCD3 Gene

Previous GeneCards Identifiers for NUDCD3 Gene

  • GC07M044196
  • GC07M044389

Summaries for NUDCD3 Gene

Entrez Gene Summary for NUDCD3 Gene

  • The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUDCD3 Gene

NUDCD3 (NudC Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is NUDC.

Gene Wiki entry for NUDCD3 Gene

Additional gene information for NUDCD3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD3 Gene

Genomics for NUDCD3 Gene

GeneHancer (GH) Regulatory Elements for NUDCD3 Gene

Promoters and enhancers for NUDCD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J044488 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 680.7 +0.6 589 2.6 CLOCK ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D NUDCD3 DDX56 TMED4 URGCP SNORA5B SNORA5C PURB GC07M044473 GC07M044472
GH07J044460 Enhancer 1 Ensembl ENCODE 42 +29.8 29837 2.1 BATF ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM SMARCA5 CBFB ELF1 NUDCD3 POLD2 AEBP1 RPL32P18 PIR50224
GH07J044472 Enhancer 1.1 Ensembl ENCODE 30.4 +17.1 17063 2.3 PKNOX1 FOXA2 MLX ARID4B FEZF1 DMAP1 ETS1 SLC30A9 NFKBIZ PPARG GC07M044473 GC07M044472 NUDCD3 RNU6-1097P CAMK2B AEBP1 STK17A
GH07J044465 Enhancer 0.7 ENCODE 42 +21.9 21942 6.1 MXI1 PKNOX1 FOXA2 SAP130 ZBTB40 RARA ZNF205 YY1 ZNF664 SCRT2 GC07M044468 PIR31596 RPL32P18 NUDCD3 RNU6-1097P NPC1L1 CAMK2B POLD2 AEBP1
GH07J044477 Enhancer 0.9 ENCODE 30.4 +13.3 13313 0.2 PKNOX1 ATF1 ARNT ARID4B KLF17 SIN3A ZNF2 RAD21 RFX5 ZNF335 NUDCD3 GC07M044473 GC07M044472
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDCD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDCD3 gene promoter:
  • GATA-1

Genomic Locations for NUDCD3 Gene

Genomic Locations for NUDCD3 Gene
chr7:44,379,121-44,490,880
(GRCh38/hg38)
Size:
111,760 bases
Orientation:
Minus strand
chr7:44,418,720-44,530,479
(GRCh37/hg19)
Size:
111,760 bases
Orientation:
Minus strand

Genomic View for NUDCD3 Gene

Genes around NUDCD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDCD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDCD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD3 Gene

Proteins for NUDCD3 Gene

  • Protein details for NUDCD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVD9-NUDC3_HUMAN
    Recommended name:
    NudC domain-containing protein 3
    Protein Accession:
    Q8IVD9
    Secondary Accessions:
    • Q9BTI3
    • Q9H7W9
    • Q9UPT4

    Protein attributes for NUDCD3 Gene

    Size:
    361 amino acids
    Molecular mass:
    40822 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH03691.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ96892.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB14855.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDCD3 Gene

neXtProt entry for NUDCD3 Gene

Post-translational modifications for NUDCD3 Gene

  • Ubiquitination at Lys177
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDCD3 Gene

Antibody Products

  • Abcam antibodies for NUDCD3
  • Boster Bio Antibodies for NUDCD3
  • Santa Cruz Biotechnology (SCBT) Antibodies for NUDCD3

No data available for DME Specific Peptides for NUDCD3 Gene

Domains & Families for NUDCD3 Gene

Gene Families for NUDCD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDCD3 Gene

Suggested Antigen Peptide Sequences for NUDCD3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUDCD3: view

No data available for UniProtKB/Swiss-Prot for NUDCD3 Gene

Function for NUDCD3 Gene

Phenotypes From GWAS Catalog for NUDCD3 Gene

Gene Ontology (GO) - Molecular Function for NUDCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16754861
GO:0051082 unfolded protein binding IBA --
genes like me logo Genes that share ontologies with NUDCD3: view
genes like me logo Genes that share phenotypes with NUDCD3: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD3 Gene

Localization for NUDCD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDCD3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005868 cytoplasmic dynein complex IDA 25205765
genes like me logo Genes that share ontologies with NUDCD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUDCD3 Gene

Pathways & Interactions for NUDCD3 Gene

SuperPathways for NUDCD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0032502 developmental process IBA --
GO:0060271 cilium assembly IMP 25205765
GO:1905793 protein localization to pericentriolar material IMP 25205765
genes like me logo Genes that share ontologies with NUDCD3: view

No data available for Pathways by source and SIGNOR curated interactions for NUDCD3 Gene

Drugs & Compounds for NUDCD3 Gene

No Compound Related Data Available

Transcripts for NUDCD3 Gene

mRNA/cDNA for NUDCD3 Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUDCD3 Gene

NudC domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - -
SP3:

Relevant External Links for NUDCD3 Gene

GeneLoc Exon Structure for
NUDCD3
ECgene alternative splicing isoforms for
NUDCD3

Expression for NUDCD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDCD3 Gene

Protein differential expression in normal tissues from HIPED for NUDCD3 Gene

This gene is overexpressed in Testis (17.7) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDCD3 Gene



Protein tissue co-expression partners for NUDCD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDCD3 Gene:

NUDCD3

SOURCE GeneReport for Unigene cluster for NUDCD3 Gene:

Hs.488171

Evidence on tissue expression from TISSUES for NUDCD3 Gene

  • Nervous system(4.9)
  • Pancreas(4.3)
  • Muscle(2.6)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with NUDCD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDCD3 Gene

Orthologs for NUDCD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDCD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDCD3 34 33
  • 99.45 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUDCD3 34 33
  • 86.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nudcd3 16 34 33
  • 86.11 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 83 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NUDCD3 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDCD3 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDCD3 34 33
  • 73.86 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDCD3 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd3 33
  • 66.57 (n)
zebrafish
(Danio rerio)
Actinopterygii nudcd3 34 33
  • 61.28 (n)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG31251 34 33
  • 48.91 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToOne
Species where no ortholog for NUDCD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUDCD3 Gene

ENSEMBL:
Gene Tree for NUDCD3 (if available)
TreeFam:
Gene Tree for NUDCD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDCD3: view image

Paralogs for NUDCD3 Gene

Paralogs for NUDCD3 Gene

(2) SIMAP similar genes for NUDCD3 Gene using alignment to 1 proteins:

  • NUDC3_HUMAN
genes like me logo Genes that share paralogs with NUDCD3: view

Variants for NUDCD3 Gene

Sequence variations from dbSNP and Humsavar for NUDCD3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000026537 -- 44,405,539(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000051076 -- 44,450,384(-) G/A intron_variant
rs1000084565 -- 44,462,626(-) T/C intron_variant
rs1000149579 -- 44,420,876(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000180145 -- 44,420,616(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDCD3 Gene

Variant ID Type Subtype PubMed ID
esv2675906 CNV deletion 23128226
esv2734323 CNV deletion 23290073
esv33931 CNV loss 17666407
esv3613009 CNV loss 21293372
esv3613010 CNV loss 21293372
nsv526063 CNV loss 19592680
nsv606806 CNV loss 21841781
nsv830984 CNV gain 17160897
nsv981461 CNV duplication 23825009

Variation tolerance for NUDCD3 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDCD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDCD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDCD3 Gene

Disorders for NUDCD3 Gene

Additional Disease Information for NUDCD3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUDCD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDCD3 Gene

Publications for NUDCD3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. A mammalian NudC-like protein essential for dynein stability and cell viability. (PMID: 16754861) Zhou T … Erikson RL (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for NUDCD3 Gene

Sources for NUDCD3 Gene

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