Aliases for NUDCD2 Gene

Aliases for NUDCD2 Gene

  • NudC Domain Containing 2 2 3 5
  • NudC Domain-Containing Protein 2 3 4
  • NudCL2 2 3
  • NudC-Like Protein 2 3
  • DKFZp686E10109 2
  • NUDCD2 5

External Ids for NUDCD2 Gene

Previous GeneCards Identifiers for NUDCD2 Gene

  • GC05M162800
  • GC05M157980
  • GC05M162880

Summaries for NUDCD2 Gene

GeneCards Summary for NUDCD2 Gene

NUDCD2 (NudC Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is NUDC.

UniProtKB/Swiss-Prot Summary for NUDCD2 Gene

  • May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.

Gene Wiki entry for NUDCD2 Gene

Additional gene information for NUDCD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDCD2 Gene

Genomics for NUDCD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NUDCD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J163457 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 608.5 -0.5 -523 6 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 TFE3 RFX1 LEF1 NUDCD2 HMMR lnc-GABRB2-6 CCNG1 MAT2B HMMR-AS1
GH05J163436 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 17.9 +21.8 21826 4.3 BRCA1 ARHGAP35 SP1 CREB1 GATAD2A PRDM10 ZNF629 REST IKZF1 ZNF692 CCNG1 ENSG00000254186 LOC105377700 lnc-CCNG1-1 NUDCD2 HMMR HMMR-AS1 MN298233
GH05J163434 Enhancer 1 Ensembl ENCODE 11.8 +25.4 25401 1 LEF1 IKZF1 MTA2 ZNF24 HDAC1 SOX6 MCM7 MTA3 CTBP1 FOXK2 HMMR NUDCD2 HMMR-AS1 CCNG1 ENSG00000254186 LOC105377700 piR-42694-131
GH05J163502 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.7 -46.4 -46393 8.7 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 REST ZNF629 TFE3 MAT2B HMMR CCNG1 NUDCD2 MN298678-071
GH05J163499 Enhancer 0.4 Ensembl 11.7 -39.0 -38999 0.2 CTBP1 FOSL1 IKZF1 TEAD4 HMMR NUDCD2 CCNG1 MAT2B HMMR-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDCD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDCD2

Top Transcription factor binding sites by QIAGEN in the NUDCD2 gene promoter:
  • ATF-2
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CREB
  • deltaCREB
  • GR
  • GR-alpha

Genomic Locations for NUDCD2 Gene

Genomic Locations for NUDCD2 Gene
chr5:163,446,526-163,460,102
(GRCh38/hg38)
Size:
13,577 bases
Orientation:
Minus strand
chr5:162,873,532-162,887,146
(GRCh37/hg19)
Size:
13,615 bases
Orientation:
Minus strand

Genomic View for NUDCD2 Gene

Genes around NUDCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD2 Gene

Proteins for NUDCD2 Gene

  • Protein details for NUDCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVJ2-NUDC2_HUMAN
    Recommended name:
    NudC domain-containing protein 2
    Protein Accession:
    Q8WVJ2
    Secondary Accessions:
    • B2R4V0

    Protein attributes for NUDCD2 Gene

    Size:
    157 amino acids
    Molecular mass:
    17676 Da
    Quaternary structure:
    • Interacts with LIS1.

neXtProt entry for NUDCD2 Gene

Post-translational modifications for NUDCD2 Gene

  • Ubiquitination at Lys65, Lys129, and Lys147
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NUDC2_HUMAN (1583)

Other Protein References for NUDCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUDCD2 Gene

Domains & Families for NUDCD2 Gene

Gene Families for NUDCD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDCD2 Gene

Suggested Antigen Peptide Sequences for NUDCD2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92225 (B2R4V0_HUMAN)
  • NudC domain-containing protein 2 (NUDC2_HUMAN)
genes like me logo Genes that share domains with NUDCD2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NUDCD2 Gene

Function for NUDCD2 Gene

Molecular function for NUDCD2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.

Gene Ontology (GO) - Molecular Function for NUDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20133715
GO:0051082 unfolded protein binding IBA 21873635
genes like me logo Genes that share ontologies with NUDCD2: view

Phenotypes for NUDCD2 Gene

genes like me logo Genes that share phenotypes with NUDCD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDCD2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD2 Gene

Localization for NUDCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDCD2 Gene

Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with centrosomes in interphase and to spindle poles and kinetochores during mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDCD2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (3)
  • Mitotic spindle (3)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000922 spindle pole IEA --
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with NUDCD2: view

Pathways & Interactions for NUDCD2 Gene

PathCards logo

SuperPathways for NUDCD2 Gene

No Data Available

SIGNOR curated interactions for NUDCD2 Gene

Activates:

Gene Ontology (GO) - Biological Process for NUDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA 21873635
GO:0032502 developmental process IBA 21873635
genes like me logo Genes that share ontologies with NUDCD2: view

No data available for Pathways by source for NUDCD2 Gene

Drugs & Compounds for NUDCD2 Gene

No Compound Related Data Available

Transcripts for NUDCD2 Gene

mRNA/cDNA for NUDCD2 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDCD2

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1: - -
SP2: -
SP3:

Relevant External Links for NUDCD2 Gene

GeneLoc Exon Structure for
NUDCD2

Expression for NUDCD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDCD2 Gene

Protein differential expression in normal tissues from HIPED for NUDCD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDCD2 Gene



Protein tissue co-expression partners for NUDCD2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDCD2

SOURCE GeneReport for Unigene cluster for NUDCD2 Gene:

Hs.140443

Evidence on tissue expression from TISSUES for NUDCD2 Gene

  • Liver(4.3)
  • Kidney(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with NUDCD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDCD2 Gene

Orthologs for NUDCD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUDCD2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NUDCD2 30 31
  • 99.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NUDCD2 30 31
  • 95.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NUDCD2 30 31
  • 94.69 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nudcd2 30 17 31
  • 90.23 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NUDCD2 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nudcd2 30
  • 87.9 (n)
Oppossum
(Monodelphis domestica)
Mammalia NUDCD2 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NUDCD2 30 31
  • 81.1 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NUDCD2 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nudcd2 30
  • 70.28 (n)
Str.7314 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.33196 30
Zebrafish
(Danio rerio)
Actinopterygii nudcd2 30 31
  • 69 (n)
OneToOne
Species where no ortholog for NUDCD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NUDCD2 Gene

ENSEMBL:
Gene Tree for NUDCD2 (if available)
TreeFam:
Gene Tree for NUDCD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDCD2: view image

Paralogs for NUDCD2 Gene

Paralogs for NUDCD2 Gene

genes like me logo Genes that share paralogs with NUDCD2: view

Variants for NUDCD2 Gene

Additional dbSNP identifiers (rs#s) for NUDCD2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDCD2 Gene

Variant ID Type Subtype PubMed ID
esv3607453 CNV gain 21293372
nsv1017056 CNV gain 25217958
nsv1018494 CNV gain 25217958
nsv1029437 CNV gain 25217958
nsv830538 CNV gain+loss 17160897

Variation tolerance for NUDCD2 Gene

Residual Variation Intolerance Score: 43.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDCD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDCD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDCD2 Gene

Disorders for NUDCD2 Gene

No disorders were found for NUDCD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDCD2 Gene

Publications for NUDCD2 Gene

  1. NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. (PMID: 20133715) Yang Y … Zhou T (Proceedings of the National Academy of Sciences of the United States of America 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for NUDCD2 Gene

Sources for NUDCD2 Gene