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Aliases for NUDCD1 Gene

Aliases for NUDCD1 Gene

  • NudC Domain Containing 1 2 3 5
  • Chronic Myelogenous Leukemia Tumor Antigen 66 3 4
  • Tumor Antigen CML66 3 4
  • CML66 3 4
  • NudC Domain-Containing Protein 1 3
  • OVA66 3

External Ids for NUDCD1 Gene

Previous GeneCards Identifiers for NUDCD1 Gene

  • GC08M110323
  • GC08M105575

Summaries for NUDCD1 Gene

GeneCards Summary for NUDCD1 Gene

NUDCD1 (NudC Domain Containing 1) is a Protein Coding gene.

Additional gene information for NUDCD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUDCD1 Gene

Genomics for NUDCD1 Gene

GeneHancer (GH) Regulatory Elements for NUDCD1 Gene

Promoters and enhancers for NUDCD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I109331 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565.6 +0.8 751 4.2 HDGF FOXA2 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B NUDCD1 ENY2 PKHD1L1 ENSG00000250267
GH08I109329 Promoter 0.7 EPDnew 550.8 +4.5 4467 0.1 RFX1 BMI1 NUDCD1 ENY2 ENSG00000250267
GH08I108442 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.8 +890.4 890385 3.3 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 EMC2 LOC105375704 EIF3E NUDCD1 ENY2 RSPO2 GC08M108476
GH08I109575 Enhancer 0.9 ENCODE dbSUPER 22 -241.4 -241410 0.9 SCRT1 ZNF362 SMAD1 NFIA ZNF189 NFIB ZNF491 ZNF335 GATA3 LCORL NUDCD1 EBAG9 LOC100132813 SYBU ENY2 GC08P109564
GH08I109538 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 6.4 -206.2 -206241 3.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 EBAG9 PKHD1L1 NUDCD1 MAPK6PS5 GC08P109564
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUDCD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUDCD1 gene promoter:

Genomic Locations for NUDCD1 Gene

Genomic Locations for NUDCD1 Gene
93,467 bases
Minus strand

Genomic View for NUDCD1 Gene

Genes around NUDCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD1 Gene

Proteins for NUDCD1 Gene

  • Protein details for NUDCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NudC domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DVX6
    • Q4G130
    • Q8NDQ5
    • Q8NG18
    • Q96SI4
    • Q9BVR5

    Protein attributes for NUDCD1 Gene

    583 amino acids
    Molecular mass:
    66756 Da
    Quaternary structure:
    No Data Available
    • Isoform 1 is the dominant immunogenic isoform and is capable of eliciting a humoral response in individuals with a variety of solid tumors. Expression of isoform 1 in a wide variety of malignancies as well as the presence of an immunogenic epitope suggest that it may be a suitable target for antigen-specific immunotherapy.

    Alternative splice isoforms for NUDCD1 Gene


neXtProt entry for NUDCD1 Gene

Post-translational modifications for NUDCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDCD1 Gene

Antibody Products

  • Abcam antibodies for NUDCD1
  • Santa Cruz Biotechnology (SCBT) Antibodies for NUDCD1

No data available for DME Specific Peptides for NUDCD1 Gene

Domains & Families for NUDCD1 Gene

Gene Families for NUDCD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDCD1 Gene

Suggested Antigen Peptide Sequences for NUDCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUDCD1: view

No data available for UniProtKB/Swiss-Prot for NUDCD1 Gene

Function for NUDCD1 Gene

Phenotypes From GWAS Catalog for NUDCD1 Gene

Gene Ontology (GO) - Molecular Function for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
genes like me logo Genes that share ontologies with NUDCD1: view
genes like me logo Genes that share phenotypes with NUDCD1: view

Animal Model Products

CRISPR Products

miRNA for NUDCD1 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD1 Gene

Localization for NUDCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDCD1 Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDCD1 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NUDCD1: view

Pathways & Interactions for NUDCD1 Gene

SuperPathways for NUDCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with NUDCD1: view

No data available for Pathways by source and SIGNOR curated interactions for NUDCD1 Gene

Drugs & Compounds for NUDCD1 Gene

No Compound Related Data Available

Transcripts for NUDCD1 Gene

Unigene Clusters for NUDCD1 Gene

NudC domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -

Relevant External Links for NUDCD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUDCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUDCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDCD1 Gene

This gene is overexpressed in Breast (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUDCD1 Gene

Protein tissue co-expression partners for NUDCD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUDCD1 Gene:


SOURCE GeneReport for Unigene cluster for NUDCD1 Gene:


mRNA Expression by UniProt/SwissProt for NUDCD1 Gene:

Tissue specificity: Isoform 1 is specifically expressed in leukemias and a variety of solid tumor cell lines and is also detected in testis and heart. Isoform 2 is predominantly expressed in testis and weakly expressed in tumor cells.

Evidence on tissue expression from TISSUES for NUDCD1 Gene

  • Nervous system(4.5)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with NUDCD1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDCD1 Gene

Orthologs for NUDCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDCD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUDCD1 33 34
  • 99.71 (n)
(Canis familiaris)
Mammalia NUDCD1 33 34
  • 92.91 (n)
(Bos Taurus)
Mammalia NUDCD1 33 34
  • 92.11 (n)
(Mus musculus)
Mammalia Nudcd1 33 16 34
  • 89.18 (n)
(Rattus norvegicus)
Mammalia Nudcd1 33
  • 89.02 (n)
(Monodelphis domestica)
Mammalia NUDCD1 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia NUDCD1 34
  • 81 (a)
(Gallus gallus)
Aves NUDCD1 33 34
  • 75.19 (n)
(Anolis carolinensis)
Reptilia NUDCD1 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd1 33
  • 68.92 (n)
Str.15325 33
African clawed frog
(Xenopus laevis)
Amphibia cml66-prov 33
(Danio rerio)
Actinopterygii nudcd1 33 34
  • 61.27 (n)
wufc11c02 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000648 33
  • 42.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10347 33 34
  • 40.66 (n)
(Caenorhabditis elegans)
Secernentea C44E4.5 33 34
  • 42.34 (n)
Species where no ortholog for NUDCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDCD1 Gene

Gene Tree for NUDCD1 (if available)
Gene Tree for NUDCD1 (if available)

Paralogs for NUDCD1 Gene

No data available for Paralogs for NUDCD1 Gene

Variants for NUDCD1 Gene

Sequence variations from dbSNP and Humsavar for NUDCD1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000042395 -- 109,309,448(-) A/G intron_variant
rs1000061467 -- 109,264,797(-) T/C intron_variant
rs1000086586 -- 109,320,520(-) T/C intron_variant
rs1000133580 -- 109,258,719(-) A/T intron_variant
rs1000207530 -- 109,273,953(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUDCD1 Gene

Variant ID Type Subtype PubMed ID
dgv7281n100 CNV loss 25217958
esv3618371 CNV loss 21293372
esv3618372 CNV loss 21293372
nsv515589 CNV loss 19592680
nsv6346 CNV insertion 18451855

Variation tolerance for NUDCD1 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.85; 91.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDCD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDCD1 Gene

Disorders for NUDCD1 Gene

Additional Disease Information for NUDCD1

No disorders were found for NUDCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUDCD1 Gene

Publications for NUDCD1 Gene

  1. CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia. (PMID: 11416219) Yang XF … Ritz J (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 58
  2. A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. (PMID: 14688378) Yan Y … Yang XF (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for NUDCD1 Gene

Sources for NUDCD1 Gene

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