Aliases for NUDCD1 Gene

Aliases for NUDCD1 Gene

  • NudC Domain Containing 1 2 3 5
  • Chronic Myelogenous Leukemia Tumor Antigen 66 3 4
  • NudC Domain-Containing Protein 1 3 4
  • Tumor Antigen CML66 3 4
  • CML66 3 4
  • OVA66 3

External Ids for NUDCD1 Gene

Previous GeneCards Identifiers for NUDCD1 Gene

  • GC08M110323
  • GC08M105575

Summaries for NUDCD1 Gene

GeneCards Summary for NUDCD1 Gene

NUDCD1 (NudC Domain Containing 1) is a Protein Coding gene. Diseases associated with NUDCD1 include Autoimmune Atherosclerosis.

Additional gene information for NUDCD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDCD1 Gene

Genomics for NUDCD1 Gene

GeneHancer (GH) Regulatory Elements for NUDCD1 Gene

Promoters and enhancers for NUDCD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDCD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDCD1

Top Transcription factor binding sites by QIAGEN in the NUDCD1 gene promoter:
  • HOXA9
  • HOXA9B
  • ISGF-3
  • Nkx6-1
  • Sp1

Genomic Locations for NUDCD1 Gene

Genomic Locations for NUDCD1 Gene
chr8:109,240,919-109,334,121
(GRCh38/hg38)
Size:
93,203 bases
Orientation:
Minus strand
chr8:110,253,148-110,346,614
(GRCh37/hg19)
Size:
93,467 bases
Orientation:
Minus strand

Genomic View for NUDCD1 Gene

Genes around NUDCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDCD1 Gene

Proteins for NUDCD1 Gene

  • Protein details for NUDCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RS6-NUDC1_HUMAN
    Recommended name:
    NudC domain-containing protein 1
    Protein Accession:
    Q96RS6
    Secondary Accessions:
    • B4DVX6
    • Q4G130
    • Q8NDQ5
    • Q8NG18
    • Q96SI4
    • Q9BVR5

    Protein attributes for NUDCD1 Gene

    Size:
    583 amino acids
    Molecular mass:
    66756 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Isoform 1 is the dominant immunogenic isoform and is capable of eliciting a humoral response in individuals with a variety of solid tumors. Expression of isoform 1 in a wide variety of malignancies as well as the presence of an immunogenic epitope suggest that it may be a suitable target for antigen-specific immunotherapy.
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for NUDCD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUDCD1 Gene

Post-translational modifications for NUDCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUDCD1 Gene

No data available for DME Specific Peptides for NUDCD1 Gene

Domains & Families for NUDCD1 Gene

Gene Families for NUDCD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUDCD1 Gene

Suggested Antigen Peptide Sequences for NUDCD1 Gene

GenScript: Design optimal peptide antigens:
  • Tumor antigen CML66 (NUDC1_HUMAN)
genes like me logo Genes that share domains with NUDCD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NUDCD1 Gene

Function for NUDCD1 Gene

Phenotypes From GWAS Catalog for NUDCD1 Gene

Gene Ontology (GO) - Molecular Function for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
genes like me logo Genes that share ontologies with NUDCD1: view
genes like me logo Genes that share phenotypes with NUDCD1: view

Animal Model Products

CRISPR Products

miRNA for NUDCD1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDCD1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDCD1 Gene

Localization for NUDCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDCD1 Gene

[Isoform 1]: Cytoplasm. Nucleus.
[Isoform 2]: Cytoplasm.
[Isoform 3]: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDCD1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NUDCD1: view

Pathways & Interactions for NUDCD1 Gene

PathCards logo

SuperPathways for NUDCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUDCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with NUDCD1: view

No data available for Pathways by source and SIGNOR curated interactions for NUDCD1 Gene

Drugs & Compounds for NUDCD1 Gene

No Compound Related Data Available

Transcripts for NUDCD1 Gene

mRNA/cDNA for NUDCD1 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDCD1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUDCD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -

Relevant External Links for NUDCD1 Gene

GeneLoc Exon Structure for
NUDCD1

Expression for NUDCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUDCD1 Gene

This gene is overexpressed in Breast (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDCD1 Gene



Protein tissue co-expression partners for NUDCD1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDCD1

SOURCE GeneReport for Unigene cluster for NUDCD1 Gene:

Hs.380291

mRNA Expression by UniProt/SwissProt for NUDCD1 Gene:

Q96RS6-NUDC1_HUMAN
Tissue specificity: Isoform 1 is specifically expressed in leukemias and a variety of solid tumor cell lines and is also detected in testis and heart. Isoform 2 is predominantly expressed in testis and weakly expressed in tumor cells.

Evidence on tissue expression from TISSUES for NUDCD1 Gene

  • Nervous system(4.5)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with NUDCD1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDCD1 Gene

Orthologs for NUDCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUDCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDCD1 31 30
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUDCD1 31 30
  • 92.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUDCD1 31 30
  • 92.11 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nudcd1 17 31 30
  • 89.18 (n)
rat
(Rattus norvegicus)
Mammalia Nudcd1 30
  • 89.02 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDCD1 31
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDCD1 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDCD1 31 30
  • 75.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDCD1 31
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudcd1 30
  • 68.92 (n)
Str.15325 30
African clawed frog
(Xenopus laevis)
Amphibia cml66-prov 30
zebrafish
(Danio rerio)
Actinopterygii nudcd1 31 30
  • 61.27 (n)
OneToOne
wufc11c02 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000648 30
  • 42.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10347 31 30
  • 40.66 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C44E4.5 31 30
  • 42.34 (n)
OneToOne
Species where no ortholog for NUDCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUDCD1 Gene

ENSEMBL:
Gene Tree for NUDCD1 (if available)
TreeFam:
Gene Tree for NUDCD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDCD1: view image

Paralogs for NUDCD1 Gene

No data available for Paralogs for NUDCD1 Gene

Variants for NUDCD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDCD1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs11550169 - p.Asn426Ser
rs2980618 - p.Ile269Val
rs2980619 - p.Leu252Phe
rs34660136 - p.Asn394His

Additional dbSNP identifiers (rs#s) for NUDCD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDCD1 Gene

Variant ID Type Subtype PubMed ID
dgv7281n100 CNV loss 25217958
esv3618371 CNV loss 21293372
esv3618372 CNV loss 21293372
nsv515589 CNV loss 19592680
nsv6346 CNV insertion 18451855

Variation tolerance for NUDCD1 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.85; 91.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDCD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDCD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDCD1 Gene

Disorders for NUDCD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUDCD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autoimmune atherosclerosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUDCD1

genes like me logo Genes that share disorders with NUDCD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDCD1 Gene

Publications for NUDCD1 Gene

  1. CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia. (PMID: 11416219) Yang XF … Ritz J (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 54
  2. A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. (PMID: 14688378) Yan Y … Yang XF (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 54
  3. OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling. (PMID: 30833190) Song F … Wei Q (EBioMedicine 2019) 3 54
  4. The impact of NudCD1 on renal carcinoma cell proliferation, migration, and invasion. (PMID: 29461594) Wang RJ … Tang J (European review for medical and pharmacological sciences 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for NUDCD1 Gene

Sources for NUDCD1 Gene