This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012] See more...

Aliases for NUDC Gene

Aliases for NUDC Gene

  • Nuclear Distribution C, Dynein Complex Regulator 2 3 5
  • Nuclear Distribution Protein C Homolog 3 4
  • NudC Nuclear Distribution Protein 2 3
  • Nuclear Migration Protein NudC 3 4
  • Nuclear Distribution Gene C Homolog (A. Nidulans) 2
  • Nuclear Distribution C Homolog (A. Nidulans) 2
  • Nuclear Distribution Gene C Homolog 3
  • Nuclear Distribution C Homolog 3
  • NPD011 3
  • HNUDC 3
  • MNUDC 3

External Ids for NUDC Gene

Previous GeneCards Identifiers for NUDC Gene

  • GC01M028319
  • GC01P026280
  • GC01P026481
  • GC01P026852
  • GC01P027120
  • GC01P027226
  • GC01P025501

Summaries for NUDC Gene

Entrez Gene Summary for NUDC Gene

  • This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

GeneCards Summary for NUDC Gene

NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. Diseases associated with NUDC include Lissencephaly and Familial Colorectal Cancer. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by GPCR. An important paralog of this gene is NUDCD3.

UniProtKB/Swiss-Prot Summary for NUDC Gene

  • Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

Gene Wiki entry for NUDC Gene

Additional gene information for NUDC Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUDC Gene

Genomics for NUDC Gene

GeneHancer (GH) Regulatory Elements for NUDC Gene

Promoters and enhancers for NUDC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUDC on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUDC

Top Transcription factor binding sites by QIAGEN in the NUDC gene promoter:
  • AhR
  • Arnt
  • C/EBPalpha
  • CHOP-10
  • Lmo2
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for NUDC Gene

Genomic Locations for NUDC Gene
chr1:26,900,238-26,946,871
(GRCh38/hg38)
Size:
46,634 bases
Orientation:
Plus strand
chr1:27,226,729-27,273,353
(GRCh37/hg19)
Size:
46,625 bases
Orientation:
Plus strand

Genomic View for NUDC Gene

Genes around NUDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUDC Gene

Proteins for NUDC Gene

  • Protein details for NUDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y266-NUDC_HUMAN
    Recommended name:
    Nuclear migration protein nudC
    Protein Accession:
    Q9Y266
    Secondary Accessions:
    • Q5QP31
    • Q5QP35
    • Q9H0N2
    • Q9Y2B6

    Protein attributes for NUDC Gene

    Size:
    331 amino acids
    Molecular mass:
    38243 Da
    Quaternary structure:
    • Interacts with PAFAH1B1 (By similarity). Interacts with PLK1 (PubMed:12852857). Part of a complex containing PLK1, NUDC, dynein and dynactin (PubMed:12852857). Interacts with DCDC1 (PubMed:22159412).
    SequenceCaution:
    • Sequence=BAA76628.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUDC Gene

neXtProt entry for NUDC Gene

Post-translational modifications for NUDC Gene

  • Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.
  • Ubiquitination at Lys68, Lys196, Lys250, Lys275, and Lys315
  • Modification sites at PhosphoSitePlus

Other Protein References for NUDC Gene

Antibody Products

  • Abcam antibodies for NUDC

No data available for DME Specific Peptides for NUDC Gene

Domains & Families for NUDC Gene

Gene Families for NUDC Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NUDC Gene

Blocks:
  • CS domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUDC Gene

GenScript: Design optimal peptide antigens:
  • Nuclear distribution protein C homolog (NUDC_HUMAN)
  • NPD011 (Q9H2R7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y266

UniProtKB/Swiss-Prot:

NUDC_HUMAN :
  • Belongs to the nudC family.
Family:
  • Belongs to the nudC family.
genes like me logo Genes that share domains with NUDC: view

Function for NUDC Gene

Molecular function for NUDC Gene

UniProtKB/Swiss-Prot Function:
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during maturation of erythroid precursor cells.
GENATLAS Biochemistry:
nuclear distribution gene C,Aspergillus nidulans and mouse ortholog,widely expressed in fetal and adult tissues,coexpressed with LIS1 (PAFAH1B1) in the ventricular zone of developping brain,putatively involved in neuronal migration

Phenotypes From GWAS Catalog for NUDC Gene

Gene Ontology (GO) - Molecular Function for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22159412
GO:0045296 cadherin binding HDA 25468996
GO:0051082 unfolded protein binding IBA 21873635
genes like me logo Genes that share ontologies with NUDC: view
genes like me logo Genes that share phenotypes with NUDC: view

Animal Model Products

CRISPR Products

miRNA for NUDC Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUDC Gene

Localization for NUDC Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUDC Gene

Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUDC gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IDA 25468996
GO:0005829 cytosol IDA,TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NUDC: view

Pathways & Interactions for NUDC Gene

genes like me logo Genes that share pathways with NUDC: view

Pathways by source for NUDC Gene

SIGNOR curated interactions for NUDC Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NUDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA 21873635
GO:0007049 cell cycle IEA --
GO:0032502 developmental process IBA 21873635
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NUDC: view

Drugs & Compounds for NUDC Gene

(1) Drugs for NUDC Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenethyl isothiocyanate Investigational Pharma Target 14
genes like me logo Genes that share compounds with NUDC: view

Transcripts for NUDC Gene

mRNA/cDNA for NUDC Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUDC

Alternative Splicing Database (ASD) splice patterns (SP) for NUDC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5:
SP6: -
SP7: - -

Relevant External Links for NUDC Gene

GeneLoc Exon Structure for
NUDC

Expression for NUDC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUDC Gene

Protein differential expression in normal tissues from HIPED for NUDC Gene

This gene is overexpressed in Nasal epithelium (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUDC Gene



Protein tissue co-expression partners for NUDC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUDC

SOURCE GeneReport for Unigene cluster for NUDC Gene:

Hs.263812

mRNA Expression by UniProt/SwissProt for NUDC Gene:

Q9Y266-NUDC_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.

Evidence on tissue expression from TISSUES for NUDC Gene

  • Skin(4.8)
  • Nervous system(4.8)
  • Lung(4.7)
  • Liver(4.6)
  • Eye(4.5)
  • Heart(4.4)
  • Kidney(4.4)
  • Pancreas(2.9)
  • Bone marrow(2.4)
  • Intestine(2.3)
  • Muscle(2.1)
  • Adrenal gland(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with NUDC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUDC Gene

Orthologs for NUDC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUDC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUDC 31 30
  • 98.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUDC 31 30
  • 91.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUDC 31 30
  • 90.74 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nudc 30
  • 89.02 (n)
mouse
(Mus musculus)
Mammalia Nudc 17 31 30
  • 88.62 (n)
oppossum
(Monodelphis domestica)
Mammalia NUDC 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUDC 31
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUDC 31 30
  • 75.43 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUDC 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nudc 30
  • 68.09 (n)
Str.105 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.4183 30
zebrafish
(Danio rerio)
Actinopterygii nudc 31 30
  • 78.59 (n)
OneToOne
zgc56099 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006117 30
  • 62.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta nudC 31 30
  • 58.74 (n)
OneToOne
CG9710 32
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea nud-1 31 32 30
  • 55.63 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G27890 30
  • 57.79 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11510 30
rice
(Oryza sativa)
Liliopsida Os06g0231300 30
  • 56.79 (n)
Os.14007 30
wheat
(Triticum aestivum)
Liliopsida Ta.28702 30
bread mold
(Neurospora crassa)
Ascomycetes NCU02588 30
  • 60.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5296 31
  • 54 (a)
OneToOne
Cin.4698 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC19F8.02 30
  • 51.43 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4698 30
Species where no ortholog for NUDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUDC Gene

ENSEMBL:
Gene Tree for NUDC (if available)
TreeFam:
Gene Tree for NUDC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUDC: view image

Paralogs for NUDC Gene

Paralogs for NUDC Gene

(1) SIMAP similar genes for NUDC Gene using alignment to 2 proteins:

  • NUDC_HUMAN
  • Q9H2R7_HUMAN

Pseudogenes.org Pseudogenes for NUDC Gene

genes like me logo Genes that share paralogs with NUDC: view

Variants for NUDC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUDC Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
636298 Likely Pathogenic: APC-mutation negative familial colorectal cancer 26,913,640(+) CCAACCCAA/GT FRAMESHIFT_VARIANT
636299 Likely Pathogenic: APC-mutation negative familial colorectal cancer 26,913,774(+) CAGGTGCGATG/C FRAMESHIFT_VARIANT
636300 Likely Pathogenic: APC-mutation negative familial colorectal cancer 26,913,713(+) GA/G FRAMESHIFT_VARIANT
711767 Benign: not provided 26,913,928(+) G/C MISSENSE_VARIANT
752885 Likely Benign: not provided 26,913,491(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NUDC Gene

Structural Variations from Database of Genomic Variants (DGV) for NUDC Gene

Variant ID Type Subtype PubMed ID
esv1159948 CNV insertion 17803354
nsv1000012 CNV gain 25217958
nsv1126984 CNV deletion 24896259
nsv508689 CNV deletion 20534489
nsv834524 CNV gain+loss 17160897

Variation tolerance for NUDC Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUDC Gene

Human Gene Mutation Database (HGMD)
NUDC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUDC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUDC Gene

Disorders for NUDC Gene

MalaCards: The human disease database

(6) MalaCards diseases for NUDC Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lissencephaly
familial colorectal cancer
  • colorectal cancer, familial
miller-dieker lissencephaly syndrome
  • mdls
band heterotopia
  • bh
congenital nervous system abnormality
  • congenital neurologic anomaly
- elite association - COSMIC cancer census association via MalaCards
Search NUDC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUDC

genes like me logo Genes that share disorders with NUDC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUDC Gene

Publications for NUDC Gene

  1. A role for Plk1 phosphorylation of NudC in cytokinesis. (PMID: 12852857) Zhou T … Erikson RL (Developmental cell 2003) 3 4 23 54
  2. Molecular cloning and characterization of the human NUDC gene. (PMID: 10453739) Matsumoto N … Ledbetter DH (Human genetics 1999) 3 4 23 54
  3. A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. (PMID: 10210332) Miller BA … Osmani SA (Experimental hematology 1999) 3 4 23 54
  4. Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein. (PMID: 22159412) Kaplan A … Reiner O (Journal of cell science 2011) 3 4 54
  5. Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation. (PMID: 19560457) Pang SF … Xu P (Experimental cell research 2009) 3 23 54

Products for NUDC Gene

Sources for NUDC Gene