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Aliases for NUCKS1 Gene

Aliases for NUCKS1 Gene

  • Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1 2 3 5
  • NUCKS 3 4
  • P1 3 4
  • Nuclear Ubiquitous Casein Kinase And Cyclin-Dependent Kinase Substrate 3
  • Nuclear Ubiquitous Casein And Cyclin-Dependent Kinase Substrate 1 3
  • Potential LAG1 Interactor 3
  • JC7 3

External Ids for NUCKS1 Gene

Previous GeneCards Identifiers for NUCKS1 Gene

  • GC01M202419
  • GC01M203948
  • GC01M176846

Summaries for NUCKS1 Gene

Entrez Gene Summary for NUCKS1 Gene

  • This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]

GeneCards Summary for NUCKS1 Gene

NUCKS1 (Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1) is a Protein Coding gene.

Gene Wiki entry for NUCKS1 Gene

Additional gene information for NUCKS1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUCKS1 Gene

Genomics for NUCKS1 Gene

GeneHancer (GH) Regulatory Elements for NUCKS1 Gene

Promoters and enhancers for NUCKS1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I205747 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE 550.8 +0.6 561 4.1 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC NUCKS1 ELK4 EIF2D PM20D1 RAB29 DSTYK LOC100420878 RPL7AP20 ENSG00000201944
GH01I205210 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 9.9 +538.8 538803 2.8 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC DSTYK MDM4 ELK4 PPP1R15B NFASC TMCC2 CNTN2 RPL13AP11 LOC100420878 LOC101929459
GH01I205120 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 9.9 +628.5 628479 2.9 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RBBP5 MDM4 PPP1R15B ELK4 TMCC2 DSTYK RPL13AP11 NFASC SNRPGP10 LOC101929459
GH01I206611 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 9.9 -861.8 -861836 2.2 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 EIF2D ELK4 MAPKAPK2 LOC100420878 RPL7AP20 NUCKS1 RASSF5 PIR41610
GH01I205629 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.2 +118.6 118611 4.6 CLOCK DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ELK4 GC01P205631 MFSD4A RAB29 RNU6-418P CDK18 NUCKS1 PM20D1 LOC100420878
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUCKS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUCKS1 gene promoter:

Genomic Locations for NUCKS1 Gene

Genomic Locations for NUCKS1 Gene
37,458 bases
Minus strand

Genomic View for NUCKS1 Gene

Genes around NUCKS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUCKS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUCKS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUCKS1 Gene

Proteins for NUCKS1 Gene

  • Protein details for NUCKS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
    Protein Accession:
    Secondary Accessions:
    • Q54AC0
    • Q5PXE7
    • Q9H1D6
    • Q9H723

    Protein attributes for NUCKS1 Gene

    243 amino acids
    Molecular mass:
    27296 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15076.1; Type=Erroneous termination; Positions=164; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=CAC20412.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NUCKS1 Gene


neXtProt entry for NUCKS1 Gene

Post-translational modifications for NUCKS1 Gene

Other Protein References for NUCKS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUCKS1 Gene

Domains & Families for NUCKS1 Gene

Gene Families for NUCKS1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NUCKS1 Gene


Suggested Antigen Peptide Sequences for NUCKS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUCKS1: view

No data available for UniProtKB/Swiss-Prot for NUCKS1 Gene

Function for NUCKS1 Gene

Phenotypes From GWAS Catalog for NUCKS1 Gene

Gene Ontology (GO) - Molecular Function for NUCKS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003682 chromatin binding IDA 26323318
GO:0003690 double-stranded DNA binding IDA 26323318
GO:0003697 single-stranded DNA binding IEA --
GO:0003723 RNA binding HDA,IDA 22681889
genes like me logo Genes that share ontologies with NUCKS1: view
genes like me logo Genes that share phenotypes with NUCKS1: view

Animal Model Products

CRISPR Products

miRNA for NUCKS1 Gene

miRTarBase miRNAs that target NUCKS1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUCKS1 Gene

Localization for NUCKS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUCKS1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUCKS1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUCKS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA,ISS --
GO:0000790 nuclear chromatin IDA 26323318
GO:0005634 nucleus IEA,IDA 11298763
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA,IEA 17604136
genes like me logo Genes that share ontologies with NUCKS1: view

Pathways & Interactions for NUCKS1 Gene

SuperPathways for NUCKS1 Gene

No Data Available

Pathways by source for NUCKS1 Gene

1 GeneTex pathway for NUCKS1 Gene

Gene Ontology (GO) - Biological Process for NUCKS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 26323318
GO:0001678 cellular glucose homeostasis IEA,ISS --
GO:0006275 regulation of DNA replication IMP 26323318
GO:0006325 chromatin organization IEA,ISS --
GO:0006357 regulation of transcription by RNA polymerase II IC --
genes like me logo Genes that share ontologies with NUCKS1: view

No data available for SIGNOR curated interactions for NUCKS1 Gene

Drugs & Compounds for NUCKS1 Gene

No Compound Related Data Available

Transcripts for NUCKS1 Gene

mRNA/cDNA for NUCKS1 Gene

Unigene Clusters for NUCKS1 Gene

Nuclear casein kinase and cyclin-dependent kinase substrate 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUCKS1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6

Relevant External Links for NUCKS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUCKS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUCKS1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUCKS1 Gene

Protein tissue co-expression partners for NUCKS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUCKS1 Gene:


SOURCE GeneReport for Unigene cluster for NUCKS1 Gene:


mRNA Expression by UniProt/SwissProt for NUCKS1 Gene:

Tissue specificity: Widely expressed, with highest levels in thyroid gland, prostate and uterus and in fetal liver, thymus and lung.

Evidence on tissue expression from TISSUES for NUCKS1 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Intestine(4.6)
  • Blood(4.4)
  • Stomach(4.3)
  • Eye(3.9)
  • Lung(3.4)
  • Skin(3.4)
  • Kidney(3)
  • Pancreas(2.9)
  • Heart(2.7)
  • Muscle(2.7)
  • Lymph node(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with NUCKS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUCKS1 Gene

Orthologs for NUCKS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUCKS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUCKS1 33 34
  • 99.73 (n)
(Canis familiaris)
Mammalia NUCKS1 33 34
  • 92.87 (n)
(Bos Taurus)
Mammalia NUCKS1 33 34
  • 92.73 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
-- 34
  • 76 (a)
(Rattus norvegicus)
Mammalia Nucks1 33
  • 90.81 (n)
(Mus musculus)
Mammalia Nucks1 33 16 34
  • 90.6 (n)
(Ornithorhynchus anatinus)
Mammalia NUCKS1 34
  • 76 (a)
(Gallus gallus)
Aves NUCKS1 33 34
  • 84.57 (n)
(Anolis carolinensis)
Reptilia NUCKS1 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nucks1 33
  • 72.15 (n)
MGC75738 33
(Danio rerio)
Actinopterygii nucks1a 33 34
  • 59.78 (n)
nucks1b 34
  • 39 (a)
Species where no ortholog for NUCKS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUCKS1 Gene

Gene Tree for NUCKS1 (if available)
Gene Tree for NUCKS1 (if available)

Paralogs for NUCKS1 Gene

(1) SIMAP similar genes for NUCKS1 Gene using alignment to 1 proteins: Pseudogenes for NUCKS1 Gene

genes like me logo Genes that share paralogs with NUCKS1: view

No data available for Paralogs for NUCKS1 Gene

Variants for NUCKS1 Gene

Sequence variations from dbSNP and Humsavar for NUCKS1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000056285 -- 205,745,013(-) C/A intron_variant
rs1000131928 -- 205,744,064(-) T/C intron_variant
rs1000205082 -- 205,724,950(-) T/C intron_variant
rs1000232199 -- 205,744,305(-) T/G intron_variant
rs1000244953 -- 205,714,059(-) A/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for NUCKS1 Gene

Variant ID Type Subtype PubMed ID
nsv1068041 CNV deletion 25765185
nsv952644 CNV duplication 24416366

Variation tolerance for NUCKS1 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUCKS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUCKS1 Gene

Disorders for NUCKS1 Gene

Additional Disease Information for NUCKS1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUCKS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUCKS1 Gene

Publications for NUCKS1 Gene

  1. Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species. (PMID: 15381070) Grundt K … Østvold AC (Biochemical and biophysical research communications 2004) 3 4 22 58
  2. Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo. (PMID: 11298763) Ostvold AC … Grundt K (European journal of biochemistry 2001) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Genetic variability at the PARK16 locus. (PMID: 20683486) Tucci A … Paisán-Ruiz C (European journal of human genetics : EJHG 2010) 3 44 58
  5. NUCKS overexpression in breast cancer. (PMID: 19664271) Drosos Y … Aleporou-Marinou V (Cancer cell international 2009) 3 22 58

Products for NUCKS1 Gene

Sources for NUCKS1 Gene

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