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This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010] See more...
Aliases for NUCB1 Gene
Aliases for NUCB1 Gene
External Ids for NUCB1 Gene
- HGNC: 8043
- NCBI Entrez Gene: 4924
- Ensembl: ENSG00000104805
- OMIM®: 601323
- UniProtKB/Swiss-Prot: Q02818
Previous GeneCards Identifiers for NUCB1 Gene
- GC19P050062
- GC19P049772
- GC19P054079
- GC19P054095
- GC19P049403
- GC19P045779
Summaries for NUCB1 Gene
-
This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]
GeneCards Summary for NUCB1 Gene
NUCB1 (Nucleobindin 1) is a Protein Coding gene. Diseases associated with NUCB1 include Ataxia, Sensory, 1, Autosomal Dominant and Cone-Rod Dystrophy 10. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is NUCB2.
UniProtKB/Swiss-Prot Summary for NUCB1 Gene
-
Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity).
Additional gene information for NUCB1 Gene
- HGNC (8043)
- NCBI Entrez Gene (4924)
- Ensembl (ENSG00000104805)
- OMIM® (601323)
- UniProtKB/Swiss-Prot (Q02818)
- Open Targets Platform(ENSG00000104805)
- Search for NUCB1 at DataMed
- Search for NUCB1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUCB1 Gene
Genomics for NUCB1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NUCB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NUCB1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUCB1
- Top Transcription factor binding sites by QIAGEN in the NUCB1 gene promoter:
-
- AP-1
- AREB6
- ARP-1
- COMP1
- CUTL1
- Ik-2
- SEF-1 (1)
- STAT1
- STAT5A
Genomic Locations for NUCB1 Gene
Latest Assembly
- chr19:48,900,312-48,923,372
- (GRCh38/hg38)
- Size:
- 23,061 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:49,403,569-49,426,629
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 23,061 bases
- Orientation:
- Plus strand
- chr19:49,403,307-49,426,629
- (GRCh37/hg19 by Ensembl)
- Size:
- 23,323 bases
- Orientation:
- Plus strand
Genomic View for NUCB1 Gene
Genes around NUCB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
NUCB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NUCB1 Gene
Proteins for NUCB1 Gene
-
Protein details for NUCB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q02818-NUCB1_HUMAN
- Recommended name:
- Nucleobindin-1
- Protein Accession:
- Q02818
- B2RD64
- Q15838
- Q7Z4J7
- Q9BUR1
Protein attributes for NUCB1 Gene
- Size:
- 461 amino acids
- Molecular mass:
- 53879 Da
- Quaternary structure:
-
- Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunits GNAI1, GNAI2 and GNAI3 with higher affinity for GNAI1 and GNAI3 than for GNAI2. Preferentially interacts with inactive rather than active GNAI3. Interaction with GNAI3 is inhibited when NUCB1 binds calcium, probably due to a conformational change which renders the GBA motif inaccessible.
- Miscellaneous:
-
- Discovered as DNA-binding protein in the serum of lupus-prone mice.
Protein Expression for NUCB1 Gene
Post-translational modifications for NUCB1 Gene
- O-glycosylated.
-
Glycosylation at Thr39, Thr42, Ser44, Thr47, Tyr50, Ser93, Thr148, Thr160, Thr162, Tyr168, Ser224, Thr313, Ser320, Thr321, Ser369, Thr372, Ser378, Thr426, and Ser444
- NX_Q02818 (NX_Q02818-1)
- Modification sites at PhosphoSitePlus
Other Protein References for NUCB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences NUCB1 / Nucleobindin Antibody and NUCB1 / Nucleobindin Monoclonal Antibody
- Novus Biologicals Antibodies for NUCB1
- Invitrogen Antibodies for NUCB1 (AFLGC-NUCB1)
-
Biorbyt antibodies for NUCB1
-
Boster Bio Antibodies for NUCB1
-
Custom Antibody ServicesProSci Antibodies for NUCB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for NUCB1
- Sino Biological Antibodies for NUCB1
Protein products for research
-
OriGene Purified Proteins for NUCB1
- Search Origene for MassSpec and Protein Over-expression Lysates for NUCB1
- Origene Custom Protein Services for NUCB1
-
Abcam proteins for NUCB1
Assay products for research
- antibodies-online: Show 17 available Nucleobindin 1 Elisa Kits ranked by validation data
- Compare Top Nucleobindin 1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for NUCB1 Gene
Domains & Families for NUCB1 Gene
Gene Families for NUCB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for NUCB1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NUCB1 Gene
- GenScript: Design optimal peptide antigens:
-
- CALNUC (NUCB1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q02818UniProtKB/Swiss-Prot:
NUCB1_HUMAN :- The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition.
- Belongs to the nucleobindin family.
- Domain:
-
- The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition.
- The GBA (G-alpha binding and activating) motif mediates binding to the alpha subunits of guanine nucleotide-binding proteins (G proteins).
- Family:
-
- Belongs to the nucleobindin family.
Function for NUCB1 Gene
Molecular function for NUCB1 Gene
- UniProtKB/Swiss-Prot Function:
- Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity).
- GENATLAS Biochemistry:
- nucleobindin,55kDa,ubiquitously expressed,homolog of a secreted protein promoting production of DNA-specific antibodies in lupus-prone MRL/lpr mouse
Phenotypes From GWAS Catalog for NUCB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001965 | G-protein alpha-subunit binding | ISS | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005085 | guanyl-nucleotide exchange factor activity | ISS | -- |
| GO:0005509 | calcium ion binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 24136289 |
Phenotypes for NUCB1 Gene
- MGI mutant phenotypes for NUCB1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NUCB1:
Animal Models for research
-
Taconic Biosciences Mouse Models for NUCB1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NUCB1 - Starting at $85 >
- * NUCB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NUCB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUCB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUCB1
miRNA for NUCB1 Gene
- miRTarBase miRNAs that target NUCB1
-
- hsa-miR-30a-5p (MIRT005205)
- hsa-miR-193b-3p (MIRT016302)
- hsa-miR-335-5p (MIRT016838)
- hsa-miR-484 (MIRT042089)
- hsa-miR-92a-3p (MIRT048994)
- hsa-miR-4762-3p (MIRT453766)
- hsa-miR-1303 (MIRT453767)
- hsa-miR-744-3p (MIRT453768)
- hsa-miR-4303 (MIRT453769)
- hsa-miR-4423-5p (MIRT453770)
- hsa-miR-6501-5p (MIRT453771)
- hsa-miR-6761-5p (MIRT453772)
- hsa-miR-4329 (MIRT453773)
- hsa-miR-4251 (MIRT453774)
- hsa-miR-4781-3p (MIRT453775)
- hsa-miR-483-5p (MIRT453776)
- hsa-miR-6131 (MIRT515274)
- hsa-miR-6848-3p (MIRT539929)
- hsa-miR-6843-3p (MIRT539930)
- hsa-miR-3663-5p (MIRT539931)
- mmu-miR-199a-5p (MIRT596161)
- hsa-miR-335-3p (MIRT644013)
- hsa-miR-30e-3p (MIRT644014)
- hsa-miR-30d-3p (MIRT644015)
- hsa-miR-30a-3p (MIRT644016)
- hsa-miR-3152-5p (MIRT644017)
- hsa-miR-3942-3p (MIRT644018)
- hsa-miR-6881-3p (MIRT644019)
- hsa-miR-6836-3p (MIRT644020)
- hsa-miR-1248 (MIRT644021)
- hsa-miR-877-3p (MIRT644022)
- hsa-miR-3614-3p (MIRT644023)
- hsa-miR-1245b-3p (MIRT736351)
- hsa-miR-1293 (MIRT737155)
- hsa-miR-3199 (MIRT741117)
- hsa-miR-363-5p (MIRT741834)
- hsa-miR-365a-5p (MIRT741964)
- hsa-miR-365b-5p (MIRT741974)
- hsa-miR-4483 (MIRT745152)
- hsa-miR-4515 (MIRT745741)
- hsa-miR-4648 (MIRT746467)
- hsa-miR-5008-5p (MIRT749450)
- hsa-miR-6089 (MIRT751959)
- hsa-miR-6730-5p (MIRT753976)
- hsa-miR-6733-3p (MIRT754091)
- hsa-miR-6745 (MIRT754461)
- hsa-miR-6748-5p (MIRT754551)
- hsa-miR-6756-5p (MIRT754806)
- hsa-miR-6766-5p (MIRT755114)
- hsa-miR-6769a-5p (MIRT755193)
- hsa-miR-6769b-5p (MIRT755240)
- hsa-miR-8052 (MIRT760015)
- hsa-miR-1273e (MIRT761855)
- hsa-miR-1537-3p (MIRT762907)
- hsa-miR-1827 (MIRT763081)
- hsa-miR-1910-3p (MIRT763316)
- hsa-miR-2467-3p (MIRT764112)
- hsa-miR-3612 (MIRT765931)
- hsa-miR-3664-3p (MIRT766476)
- hsa-miR-377-5p (MIRT767440)
- hsa-miR-4257 (MIRT768149)
- hsa-miR-4433a-3p (MIRT769021)
- hsa-miR-4459 (MIRT769309)
- hsa-miR-4499 (MIRT769764)
- hsa-miR-4523 (MIRT769994)
- hsa-miR-455-3p (MIRT770382)
- hsa-miR-4649-3p (MIRT770650)
- hsa-miR-4695-5p (MIRT771212)
- hsa-miR-4722-5p (MIRT771569)
- hsa-miR-4768-3p (MIRT772110)
- hsa-miR-510-5p (MIRT773334)
- hsa-miR-512-5p (MIRT773371)
- hsa-miR-545-5p (MIRT774026)
- hsa-miR-5690 (MIRT774998)
- hsa-miR-6086 (MIRT775571)
- hsa-miR-650 (MIRT776689)
- hsa-miR-6511a-5p (MIRT776815)
- hsa-miR-6516-5p (MIRT777176)
- hsa-miR-665 (MIRT777589)
- hsa-miR-6808-5p (MIRT779687)
- hsa-miR-6857-3p (MIRT780504)
- hsa-miR-6893-5p (MIRT781220)
- hsa-miR-873-3p (MIRT782467)
- hsa-miR-940 (MIRT782914)
- hsa-miR-143-3p (MIRT783812)
- hsa-miR-31-3p (MIRT784633)
- hsa-miR-4735-5p (MIRT786574)
- hsa-miR-4770 (MIRT786697)
- hsa-miR-4775 (MIRT786727)
- hsa-miR-590-3p (MIRT787957)
- hsa-miR-6088 (MIRT788039)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUCB1
- Browse OriGene Inhibitory RNA Products For NUCB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUCB1
Clone products for research
- Applied Biological Materials (abm): Clones for NUCB1 - Starting at $45 >
- * NUCB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NUCB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUCB1
Cell Lines for research
-
Horizon Cell Lines for NUCB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUCB1 Gene
Localization for NUCB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NUCB1 Gene
- Golgi apparatus, cis-Golgi network membrane. Peripheral membrane protein. Lumenal side. Cytoplasm. Secreted. Note=A small fraction of the protein may be cytoplasmic. {ECO:0000250 UniProtKB:Q63083}.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| extracellular | 4 |
| nucleus | 4 |
| golgi apparatus | 4 |
| cytoskeleton | 3 |
| endosome | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| lysosome | 1 |
- Golgi apparatus (3)
- Microtubules (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | TAS,HDA | 16502470 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005769 | early endosome | IEA | -- |
Pathways & Interactions for NUCB1 Gene
Interacting Proteins for NUCB1 Gene
Selected Interacting proteins:
Q02818-NUCB1_HUMAN
ENSP00000385923
for NUCB1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NUCB1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007264 | small GTPase mediated signal transduction | ISS | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
| GO:0044267 | cellular protein metabolic process | TAS | -- |
| GO:0050790 | regulation of catalytic activity | IEA | -- |
| GO:0072718 | response to cisplatin | IEA | -- |
No data available for Pathways by source for NUCB1 Gene
Drugs & Compounds for NUCB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Calcium citrate | Approved, Investigational | Pharma | Target, ligand | 0 | ||
| Calcium Phosphate | Approved | Pharma | Target, ligand | 0 | ||
| Calcium phosphate dihydrate | Approved | Pharma | Target | 0 | ||
| S,S-Propylthiocysteine | Experimental | Pharma | Target | 0 | ||
| Thymidine-3',5'-Diphosphate | Experimental | Pharma | Target | 0 |
Transcripts for NUCB1 Gene
mRNA/cDNA for NUCB1 Gene
- 1 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000405315 2406 nts (view in UCSC)
- ENST00000407032 2158 nts (view in UCSC)
- ENST00000411700 673 nts (view in UCSC)
- ENST00000424608 884 nts (view in UCSC)
- ENST00000443560 551 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NUCB1 - Starting at $85 >
- * NUCB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NUCB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUCB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUCB1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUCB1
- Browse OriGene Inhibitory RNA Products For NUCB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUCB1
Clone products for research
- Applied Biological Materials (abm): Clones for NUCB1 - Starting at $45 >
- * NUCB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for NUCB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUCB1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 13a | · | 13b |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: |
Relevant External Links for NUCB1 Gene
- GeneLoc Exon Structure for
- NUCB1
Expression for NUCB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Lavage (13.5) and Amniocyte (12.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUCB1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUCB1
SOURCE GeneReport for Unigene cluster for NUCB1 Gene:
Hs.631602mRNA Expression by UniProt/SwissProt for NUCB1 Gene:
Q02818-NUCB1_HUMAN
Tissue specificity:
Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.
Evidence on tissue expression from TISSUES for NUCB1 Gene
- Nervous system(4.9)
- Lung(4.8)
- Blood(4.7)
- Liver(4.6)
- Kidney(4.4)
- Skin(4.1)
- Intestine(4.1)
- Spleen(3.9)
- Muscle(3.2)
- Heart(3.1)
- Stomach(2.7)
- Pancreas(2.6)
- Eye(2.6)
- Thyroid gland(2.5)
- Lymph node(2.3)
- Adrenal gland(2.2)
- Bone marrow(2.1)
Primer products for research
-
OriGene qPCR primer pairs for NUCB1
-
OriGene qPCR primer pairs and template standards for NUCB1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUCB1 Gene
Orthologs for NUCB1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NUCB1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NUCB1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NUCB1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nucb1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nucb1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | NUCB1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | NUCB1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | NUCB1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nucb1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23574 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | nucb1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | NUCB1 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | nucb-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6711 31 |
|
OneToMany |
- Species where no ortholog for NUCB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for NUCB1 Gene
- ENSEMBL:
- Gene Tree for NUCB1 (if available)
- TreeFam:
- Gene Tree for NUCB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NUCB1: view image
Paralogs for NUCB1 Gene
Variants for NUCB1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUCB1 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs200372110 | - |
p.Arg399Gln |
|||
| rs35456905 | - |
p.Met338Val |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.63;
45.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NUCB1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NUCB1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUCB1 Gene
Disorders for NUCB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ataxia, sensory, 1, autosomal dominant |
|
|
| cone-rod dystrophy 10 |
|
|
Search NUCB1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NUCB1
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for NUCB1 Gene
Publications for NUCB1 Gene
- Organization of the human gene for nucleobindin (NUC) and its chromosomal assignment to 19q13.2-q13.4. (PMID: 8661046) Miura K … Kurosawa Y (Genomics 1996) 2 3 4 23
- Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure. (PMID: 1520323) Miura K … Kanai Y (Biochemical and biophysical research communications 1992) 3 4 23
- A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site. (PMID: 19656946) Tsukumo Y … Tomida A (The Journal of biological chemistry 2009) 3 23
- Modulation of nucleobindin-1 and nucleobindin-2 by caspases. (PMID: 18154733) Valencia CA … Liu R (FEBS letters 2008) 3 23
- Nucleobindin co-localizes and associates with cyclooxygenase (COX)-2 in human neutrophils. (PMID: 18493301) Leclerc P … Pouliot M (PloS one 2008) 3 23
ExternalLinks
Products for NUCB1 Gene
- Custom Antibody ServicesOriGene Antibodies for NUCB1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NUCB1
- Search Origene for MassSpec and Protein Over-expression Lysates for NUCB1
- Origene Custom Protein Services for NUCB1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUCB1
- Browse OriGene Inhibitory RNA Products For NUCB1
- OriGene qPCR primer pairs for NUCB1
- OriGene qPCR primer pairs and template standards for NUCB1
- OriGene CRISPR knockouts for NUCB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NUCB1
- Sino Biological Human cDNA Clone for NUCB1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for NUCB1
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for NUCB1
- Novus Biologicals proteins and lysates for NUCB1
- Browse Antibodies
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- Abcam proteins for NUCB1
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- Taconic Biosciences Mouse Models for NUCB1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for NUCB1 (AFLGC-NUCB1)
- VectorBuilder Custom and pre-made DNA vectors for NUCB1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NUCB1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NUCB1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NUCB1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NUCB1
- antibodies-online: Show 17 available Nucleobindin 1 Antibodies ranked by validation data
- Compare Top Nucleobindin 1 Antibodies
- antibodies-online: Show 17 available Nucleobindin 1 Elisa Kits ranked by validation data
- Compare Top Nucleobindin 1 Elisa Kits
- Quality Products:
- antibodies-online: Show 11 available Nucleobindin 1 Proteins ranked by validation data
- Compare Top Nucleobindin 1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for NUCB1
- Search Santa Cruz Biotechnology (SCBT) for NUCB1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NUCB1
- Horizon Cell Lines for NUCB1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUCB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUCB1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NUCB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUCB1
- Boster Bio Antibodies for NUCB1
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for NUCB1
Sources for NUCB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (29) SOURCE
- (30) HomoloGene
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- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (124) Horizon
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- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167)