Aliases for NUBP2 Gene
External Ids for NUBP2 Gene
Previous GeneCards Identifiers for NUBP2 Gene
This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
GeneCards Summary for NUBP2 Gene
NUBP2 (Nucleotide Binding Protein 2) is a Protein Coding gene. Diseases associated with NUBP2 include Glioblastoma Proneural Subtype and Glioblastoma Mesenchymal Subtype. Among its related pathways are Cytosolic iron-sulfur cluster assembly and Metabolism. Gene Ontology (GO) annotations related to this gene include nucleotide binding and 4 iron, 4 sulfur cluster binding. An important paralog of this gene is NUBP1.
UniProtKB/Swiss-Prot Summary for NUBP2 Gene
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.