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Aliases for NUBP2 Gene

Aliases for NUBP2 Gene

  • Nucleotide Binding Protein 2 2 3 5
  • Nucleotide Binding Protein 2 (MinD Homolog, E. Coli) 2 3
  • NBP 2 3 4
  • Homolog Of Yeast Cytosolic Fe-S Cluster Deficient 1 3
  • Nucleotide Binding Protein 2 (E.Coli MinD Like) 2
  • Cytosolic Fe-S Cluster Assembly Factor NUBP2 3
  • Nucleotide-Binding Protein 2 4
  • NUBP1 3
  • CFD1 3

External Ids for NUBP2 Gene

Previous GeneCards Identifiers for NUBP2 Gene

  • GC16P001850
  • GC16P001772
  • GC16P001832

Summaries for NUBP2 Gene

Entrez Gene Summary for NUBP2 Gene

  • This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

GeneCards Summary for NUBP2 Gene

NUBP2 (Nucleotide Binding Protein 2) is a Protein Coding gene. Diseases associated with NUBP2 include Autonomic Nervous System Neoplasm and Peripheral Nervous System Neoplasm. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. Gene Ontology (GO) annotations related to this gene include nucleotide binding and 4 iron, 4 sulfur cluster binding.

UniProtKB/Swiss-Prot for NUBP2 Gene

  • Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.

Gene Wiki entry for NUBP2 Gene

Additional gene information for NUBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUBP2 Gene

Genomics for NUBP2 Gene

GeneHancer (GH) Regulatory Elements for NUBP2 Gene

Promoters and enhancers for NUBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I001781 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.4 -380 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 E2F8 NUBP2 SPSB3 TBL3 FAHD1 EME2 CRAMP1 IFT140 AMDHD2 HAGH ENSG00000260646
GH16I001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 111.6 -472.1 -472147 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 TELO2 ENSG00000261505 E4F1 TSC2 ENSG00000260051 IFT140
GH16I002147 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 45 +372.9 372889 17.4 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 TRAF7 SNORD60 SNHG19 ENSG00000281010 GC16M002158 GC16M002156 RAB26 ENSG00000261505 ENSG00000260051 SRRM2
GH16I001271 Enhancer 1.1 ENCODE 104.6 -511.1 -511075 1.6 PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 ZNF213 ZNF302 ZNF416 KLF13 SP3 CRAMP1 WDR90 IFT140 TELO2 ENSG00000260646 TSC2 ENSG00000261505 E4F1 WDR24 ENSG00000260051
GH16I001962 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 37.5 +181.3 181321 4.1 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000255513 SNORA64 SNHG9 RPS2 GC16M001963 GC16M001965 GC16M001966 GC16P001995 GC16P002209 SNORA10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUBP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUBP2 gene promoter:

Genomic Locations for NUBP2 Gene

Genomic Locations for NUBP2 Gene
chr16:1,782,901-1,789,191
(GRCh38/hg38)
Size:
6,291 bases
Orientation:
Plus strand
chr16:1,832,902-1,839,192
(GRCh37/hg19)

Genomic View for NUBP2 Gene

Genes around NUBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUBP2 Gene

Proteins for NUBP2 Gene

  • Protein details for NUBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y2-NUBP2_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NUBP2
    Protein Accession:
    Q9Y5Y2
    Secondary Accessions:
    • D3DU80
    • Q9NWB2

    Protein attributes for NUBP2 Gene

    Size:
    271 amino acids
    Molecular mass:
    28825 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Heterotetramer of 2 NUBP1 and 2 NUBP2 chains (By similarity). Interacts with KIFC1 (By similarity). Interacts with NUBP1 (PubMed:18573874).

neXtProt entry for NUBP2 Gene

Post-translational modifications for NUBP2 Gene

  • Ubiquitination at isoforms=45 and Lys98

No data available for DME Specific Peptides for NUBP2 Gene

Domains & Families for NUBP2 Gene

Gene Families for NUBP2 Gene

Protein Domains for NUBP2 Gene

Suggested Antigen Peptide Sequences for NUBP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y2

UniProtKB/Swiss-Prot:

NUBP2_HUMAN :
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Family:
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
genes like me logo Genes that share domains with NUBP2: view

Function for NUBP2 Gene

Molecular function for NUBP2 Gene

GENATLAS Biochemistry:
nucleotide-binding protein 2,ubiquitously expressed,predominantly in a adult skeletal muscle,homolog to the mrp gene of E.coli,MinD like
UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.

Phenotypes From GWAS Catalog for NUBP2 Gene

Gene Ontology (GO) - Molecular Function for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 10486206
GO:0005515 protein binding IPI 18573874
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with NUBP2: view
genes like me logo Genes that share phenotypes with NUBP2: view

Animal Model Products

miRNA for NUBP2 Gene

miRTarBase miRNAs that target NUBP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUBP2 Gene

Localization for NUBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUBP2 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Enriched at the centrosomes during mitosis. Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (By similarity). Localized at centrioles and in the nucleus at interphase (By similarity). Colocalizes with nubp-1 at prometaphase (By similarity). {ECO:0000250 UniProtKB:Q9R061, ECO:0000255 HAMAP-Rule:MF_03039}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUBP2 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NUBP2: view

Pathways & Interactions for NUBP2 Gene

genes like me logo Genes that share pathways with NUBP2: view

Pathways by source for NUBP2 Gene

2 Reactome pathways for NUBP2 Gene

Gene Ontology (GO) - Biological Process for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016226 iron-sulfur cluster assembly IEA --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with NUBP2: view

No data available for SIGNOR curated interactions for NUBP2 Gene

Drugs & Compounds for NUBP2 Gene

No Compound Related Data Available

Transcripts for NUBP2 Gene

Unigene Clusters for NUBP2 Gene

Nucleotide binding protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUBP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - - -
SP14: - - - - - - -
SP15: - - - - - -

ExUns: 10a · 10b · 10c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for NUBP2 Gene

GeneLoc Exon Structure for
NUBP2
ECgene alternative splicing isoforms for
NUBP2

Expression for NUBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUBP2 Gene

Protein differential expression in normal tissues from HIPED for NUBP2 Gene

This gene is overexpressed in Bone (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUBP2 Gene



Protein tissue co-expression partners for NUBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUBP2 Gene:

NUBP2

SOURCE GeneReport for Unigene cluster for NUBP2 Gene:

Hs.256549

mRNA Expression by UniProt/SwissProt for NUBP2 Gene:

Q9Y5Y2-NUBP2_HUMAN
Tissue specificity: Widely expressed with highest expression in skeletal muscle.

Evidence on tissue expression from TISSUES for NUBP2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with NUBP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUBP2 Gene

Orthologs for NUBP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUBP2 33 34
  • 99.02 (n)
cow
(Bos Taurus)
Mammalia NUBP2 33 34
  • 87.53 (n)
dog
(Canis familiaris)
Mammalia NUBP2 33 34
  • 84.81 (n)
rat
(Rattus norvegicus)
Mammalia Nubp2 33
  • 82.21 (n)
mouse
(Mus musculus)
Mammalia Nubp2 33 16 34
  • 81.72 (n)
oppossum
(Monodelphis domestica)
Mammalia NUBP2 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUBP2 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUBP2 33 34
  • 77.82 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nubp2 33
  • 71.16 (n)
Str.3565 33
zebrafish
(Danio rerio)
Actinopterygii nubp2 33 34
  • 67.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta NUBP2_ANOGA 33
  • 61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4858 35 33 34
  • 57.18 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL006W 33
  • 57.41 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFD1 33 34 36
  • 52.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13970g 33
  • 50.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01084 33
  • 59.36 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC806.02c 33
  • 53.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
OneToOne
Species where no ortholog for NUBP2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUBP2 Gene

ENSEMBL:
Gene Tree for NUBP2 (if available)
TreeFam:
Gene Tree for NUBP2 (if available)

Paralogs for NUBP2 Gene

genes like me logo Genes that share paralogs with NUBP2: view

No data available for Paralogs for NUBP2 Gene

Variants for NUBP2 Gene

Sequence variations from dbSNP and Humsavar for NUBP2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000588840 -- 1,789,289(+) T/C downstream_transcript_variant
rs1000740118 -- 1,787,956(+) G/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1001138988 -- 1,784,052(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001367563 -- 1,787,796(+) C/T coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs1001400199 -- 1,787,991(+) GGG/GGGG coding_sequence_variant, frameshift, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NUBP2 Gene

Variant ID Type Subtype PubMed ID
nsv952900 CNV deletion 24416366
nsv827500 CNV gain 20364138
nsv571172 CNV loss 21841781
nsv571171 CNV gain+loss 21841781
nsv571170 CNV loss 21841781
nsv571169 CNV loss 21841781
nsv518641 CNV loss 19592680
nsv517196 CNV gain+loss 19592680
nsv471069 CNV loss 18288195
nsv457336 CNV loss 19166990
nsv457335 CNV loss 19166990
nsv1160328 CNV deletion 26073780
nsv1051692 CNV loss 25217958
nsv1042986 CNV loss 25217958
esv2422427 CNV duplication 17116639
dgv4856n54 CNV loss 21841781

Variation tolerance for NUBP2 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUBP2 Gene

Disorders for NUBP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
autonomic nervous system neoplasm
  • tumor of autonomic nervous system
peripheral nervous system neoplasm
  • neoplasm of peripheral nerve
- elite association - COSMIC cancer census association via MalaCards
Search NUBP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUBP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NUBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUBP2 Gene

Publications for NUBP2 Gene

  1. Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes. (PMID: 10486206) Nakashima H … Ko MS (Genomics 1999) 2 3 4 22 58
  2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PMID: 21216879) Kaplan RC … Wallaschofski H (Human molecular genetics 2011) 3 44 58
  3. Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins. (PMID: 19263241) Okuno T … Kogure K (Molecular biology reports 2010) 3 22 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 44 58

Products for NUBP2 Gene

Sources for NUBP2 Gene

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