This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] See more...

Aliases for NUBP2 Gene

Aliases for NUBP2 Gene

  • Nucleotide Binding Protein 2 2 3 5
  • Nucleotide Binding Protein 2 (MinD Homolog, E. Coli) 2 3
  • Cytosolic Fe-S Cluster Assembly Factor NUBP2 3 4
  • CIAO6 2 3
  • NBP 2 3 4
  • CFD1 2 3
  • Homolog Of Yeast Cytosolic Fe-S Cluster Deficient 1 3
  • Nucleotide Binding Protein 2 (E.Coli MinD Like) 2
  • Nucleotide-Binding Protein 2 4
  • NUBP1 3
  • NUBP2 5

External Ids for NUBP2 Gene

Previous GeneCards Identifiers for NUBP2 Gene

  • GC16P001850
  • GC16P001772
  • GC16P001832

Summaries for NUBP2 Gene

Entrez Gene Summary for NUBP2 Gene

  • This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

GeneCards Summary for NUBP2 Gene

NUBP2 (Nucleotide Binding Protein 2) is a Protein Coding gene. Diseases associated with NUBP2 include Glioblastoma Mesenchymal Subtype. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. Gene Ontology (GO) annotations related to this gene include nucleotide binding and 4 iron, 4 sulfur cluster binding. An important paralog of this gene is NUBP1.

UniProtKB/Swiss-Prot Summary for NUBP2 Gene

  • Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.

Gene Wiki entry for NUBP2 Gene

Additional gene information for NUBP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUBP2 Gene

Genomics for NUBP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NUBP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUBP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUBP2

Top Transcription factor binding sites by QIAGEN in the NUBP2 gene promoter:
  • CP2
  • E47
  • Olf-1
  • Pax-4a
  • Pax-5
  • Roaz
  • Tal-1
  • USF-1
  • USF1
  • YY1

Genomic Locations for NUBP2 Gene

Genomic Locations for NUBP2 Gene
chr16:1,782,932-1,789,186
(GRCh38/hg38)
Size:
6,255 bases
Orientation:
Plus strand
chr16:1,832,902-1,839,192
(GRCh37/hg19)
Size:
6,291 bases
Orientation:
Plus strand

Genomic View for NUBP2 Gene

Genes around NUBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUBP2 Gene

Proteins for NUBP2 Gene

  • Protein details for NUBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y2-NUBP2_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NUBP2
    Protein Accession:
    Q9Y5Y2
    Secondary Accessions:
    • D3DU80
    • Q9NWB2

    Protein attributes for NUBP2 Gene

    Size:
    271 amino acids
    Molecular mass:
    28825 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Heterotetramer of 2 NUBP1 and 2 NUBP2 chains (By similarity). Interacts with KIFC1 (By similarity). Interacts with NUBP1 (PubMed:18573874).

neXtProt entry for NUBP2 Gene

Post-translational modifications for NUBP2 Gene

  • Ubiquitination at Lys45 and Lys98
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUBP2 Gene

Domains & Families for NUBP2 Gene

Gene Families for NUBP2 Gene

Protein Domains for NUBP2 Gene

Suggested Antigen Peptide Sequences for NUBP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57200, highly similar to Nucleotide-binding protein 2 (B7Z6P0_HUMAN)
  • Nucleotide-binding protein 2 (NUBP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y2

UniProtKB/Swiss-Prot:

NUBP2_HUMAN :
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Family:
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
genes like me logo Genes that share domains with NUBP2: view

Function for NUBP2 Gene

Molecular function for NUBP2 Gene

UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.
GENATLAS Biochemistry:
nucleotide-binding protein 2,ubiquitously expressed,predominantly in a adult skeletal muscle,homolog to the mrp gene of E.coli,MinD like

Phenotypes From GWAS Catalog for NUBP2 Gene

Gene Ontology (GO) - Molecular Function for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 10486206
GO:0005515 protein binding IPI 18573874
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IBA 21873635
genes like me logo Genes that share ontologies with NUBP2: view
genes like me logo Genes that share phenotypes with NUBP2: view

Animal Models for NUBP2 Gene

MGI Knock Outs for NUBP2:
  • Nubp2 Nubp2<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for NUBP2 Gene

miRTarBase miRNAs that target NUBP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUBP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUBP2 Gene

Localization for NUBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUBP2 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Enriched at the centrosomes during mitosis. Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (By similarity). Localized at centrioles and in the nucleus at interphase (By similarity). Colocalizes with nubp-1 at prometaphase (By similarity). {ECO:0000250 UniProtKB:Q9R061, ECO:0000255 HAMAP-Rule:MF_03039}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUBP2 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 4
mitochondrion 3
plasma membrane 2
extracellular 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with NUBP2: view

Pathways & Interactions for NUBP2 Gene

PathCards logo

SuperPathways for NUBP2 Gene

genes like me logo Genes that share pathways with NUBP2: view

Pathways by source for NUBP2 Gene

2 Reactome pathways for NUBP2 Gene

Gene Ontology (GO) - Biological Process for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016226 iron-sulfur cluster assembly IBA 21873635
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with NUBP2: view

No data available for SIGNOR curated interactions for NUBP2 Gene

Drugs & Compounds for NUBP2 Gene

No Compound Related Data Available

Transcripts for NUBP2 Gene

mRNA/cDNA for NUBP2 Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUBP2

Alternative Splicing Database (ASD) splice patterns (SP) for NUBP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - - -
SP14: - - - - - - -
SP15: - - - - - -

ExUns: 10a · 10b · 10c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for NUBP2 Gene

GeneLoc Exon Structure for
NUBP2

Expression for NUBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUBP2 Gene

Protein differential expression in normal tissues from HIPED for NUBP2 Gene

This gene is overexpressed in Bone (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUBP2 Gene



Protein tissue co-expression partners for NUBP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUBP2

SOURCE GeneReport for Unigene cluster for NUBP2 Gene:

Hs.256549

mRNA Expression by UniProt/SwissProt for NUBP2 Gene:

Q9Y5Y2-NUBP2_HUMAN
Tissue specificity: Widely expressed with highest expression in skeletal muscle.

Evidence on tissue expression from TISSUES for NUBP2 Gene

  • Nervous system(4.8)
  • Skin(2.7)
  • Muscle(2.5)
  • Kidney(2.5)
  • Blood(2.4)
  • Liver(2.4)
  • Lung(2.2)
  • Heart(2.2)
  • Spleen(2.2)
  • Intestine(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with NUBP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUBP2 Gene

Orthologs for NUBP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUBP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NUBP2 30 31
  • 99.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NUBP2 30 31
  • 87.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NUBP2 30 31
  • 84.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nubp2 30
  • 82.21 (n)
Mouse
(Mus musculus)
Mammalia Nubp2 30 17 31
  • 81.72 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NUBP2 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NUBP2 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NUBP2 30 31
  • 77.82 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nubp2 30
  • 71.16 (n)
Str.3565 30
Zebrafish
(Danio rerio)
Actinopterygii nubp2 30 31
  • 67.82 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NUBP2_ANOGA 30
  • 61 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG4858 30 31 32
  • 57.18 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADL006W 30
  • 57.41 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFD1 30 31 33
  • 52.46 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13970g 30
  • 50.7 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01084 30
  • 59.36 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC806.02c 30
  • 53.33 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToOne
Species where no ortholog for NUBP2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NUBP2 Gene

ENSEMBL:
Gene Tree for NUBP2 (if available)
TreeFam:
Gene Tree for NUBP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUBP2: view image

Paralogs for NUBP2 Gene

Paralogs for NUBP2 Gene

(2) SIMAP similar genes for NUBP2 Gene using alignment to 10 proteins:

  • NUBP2_HUMAN
  • B2RDN3_HUMAN
  • B7Z6P0_HUMAN
  • H3BMW1_HUMAN
  • H3BNF0_HUMAN
  • H3BNS4_HUMAN
  • H3BQE5_HUMAN
  • H3BQR2_HUMAN
  • H3BRE1_HUMAN
  • H3BRK5_HUMAN
genes like me logo Genes that share paralogs with NUBP2: view

Variants for NUBP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUBP2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
775365 Benign: not provided 1,787,990(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
789827 Benign: not provided 1,788,149(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
807348 Uncertain Significance: not provided 1,786,955(+) G/A MISSENSE_VARIANT,INTRON_VARIANT
807349 Uncertain Significance: not provided 1,788,168(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs34028164 - p.Thr266Met

Additional dbSNP identifiers (rs#s) for NUBP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUBP2 Gene

Variant ID Type Subtype PubMed ID
dgv4856n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1042986 CNV loss 25217958
nsv1051692 CNV loss 25217958
nsv1160328 CNV deletion 26073780
nsv457335 CNV loss 19166990
nsv457336 CNV loss 19166990
nsv471069 CNV loss 18288195
nsv517196 CNV gain+loss 19592680
nsv518641 CNV loss 19592680
nsv571169 CNV loss 21841781
nsv571170 CNV loss 21841781
nsv571171 CNV gain+loss 21841781
nsv571172 CNV loss 21841781
nsv827500 CNV gain 20364138
nsv952900 CNV deletion 24416366

Variation tolerance for NUBP2 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUBP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUBP2 Gene

Disorders for NUBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
glioblastoma mesenchymal subtype
- elite association - COSMIC cancer census association via MalaCards
Search NUBP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUBP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NUBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUBP2 Gene

Publications for NUBP2 Gene

  1. Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome 17, and Nubp1, mapped to chromosome 16--establish a new gene family of nucleotide-binding proteins in eukaryotes. (PMID: 10486206) Nakashima H … Ko MS (Genomics 1999) 2 3 4 23
  2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PMID: 21216879) Kaplan RC … Wallaschofski H (Human molecular genetics 2011) 3 41
  3. Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins. (PMID: 19263241) Okuno T … Kogure K (Molecular biology reports 2010) 3 23
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 41

Products for NUBP2 Gene

  • Signalway Proteins for NUBP2

Sources for NUBP2 Gene