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NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]
NUBP1 (Nucleotide Binding Protein 1) is a Protein Coding gene. Diseases associated with NUBP1 include Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. Gene Ontology (GO) annotations related to this gene include nucleotide binding and iron-sulfur cluster binding. An important paralog of this gene is NUBP2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | TAS | 7926816 |
GO:0005515 | protein binding | IPI | 18573874 |
GO:0005524 | ATP binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO:0051536 | iron-sulfur cluster binding | IBA,IDA | 18573874 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005814 | centriole | IEA | -- |
GO:0005815 | microtubule organizing center | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytosolic iron-sulfur cluster assembly | ||
2 | Metabolism |
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001558 | regulation of cell growth | IMP | 18573874 |
GO:0006879 | cellular iron ion homeostasis | IMP | 18573874 |
GO:0010826 | negative regulation of centrosome duplication | IEA | -- |
GO:0016226 | iron-sulfur cluster assembly | IBA,IMP | 18573874 |
GO:0030030 | cell projection organization | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NUBP1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NUBP1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NUBP1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NUBP1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nubp1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nubp1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NUBP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NUBP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NUBP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nubp1 30 |
|
||
Str.1794 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16060 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nubp1 30 31 |
|
OneToOne | |
Dr.29399 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | NUBP1_ANOGA 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17904 30 31 32 |
|
OneToOne | |
CG4858 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | F10G8.6 30 32 |
|
||
nubp-1 31 |
|
OneToOne | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFL060W 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E18987g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NBP35 30 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | NBP35 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0601100 30 |
|
||
Os.373 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.2749 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.14507 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.2864 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU08825 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC637.08 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1878 30 |
|
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2233531 | - | p.Pro39Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1297n106 | CNV | deletion | 24896259 |
dgv330e201 | CNV | deletion | 23290073 |
dgv331e201 | CNV | deletion | 23290073 |
esv2713967 | CNV | deletion | 23290073 |
esv2713968 | CNV | deletion | 23290073 |
esv2713969 | CNV | deletion | 23290073 |
esv988489 | CNV | deletion | 20482838 |
nsv1040428 | CNV | gain | 25217958 |
nsv1070327 | CNV | deletion | 25765185 |
nsv833140 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 6 |
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