NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008] See more...

Aliases for NUBP1 Gene

Aliases for NUBP1 Gene

  • Nucleotide Binding Protein 1 2 3 5
  • Nucleotide Binding Protein 1 (MinD Homolog, E. Coli) 2 3
  • Nucleotide Binding Protein 1 (E.Coli MinD Like) 2 3
  • Cytosolic Fe-S Cluster Assembly Factor NUBP1 3 4
  • CIAO5 2 3
  • NBP35 2 3
  • NBP 1 3 4
  • NBP1 3 4
  • NBP 3 4
  • Nucleotide Binding Protein (E.Coli MinD Like) 3
  • Nucleotide-Binding Protein 1 4
  • NUBP1 5

External Ids for NUBP1 Gene

Previous HGNC Symbols for NUBP1 Gene

  • NBP1

Previous GeneCards Identifiers for NUBP1 Gene

  • GC16P010631
  • GC16P010988
  • GC16P010804
  • GC16P010745
  • GC16P010837
  • GC16P010756

Summaries for NUBP1 Gene

Entrez Gene Summary for NUBP1 Gene

  • NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NUBP1 Gene

NUBP1 (Nucleotide Binding Protein 1) is a Protein Coding gene. Diseases associated with NUBP1 include Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. Gene Ontology (GO) annotations related to this gene include nucleotide binding and iron-sulfur cluster binding. An important paralog of this gene is NUBP2.

UniProtKB/Swiss-Prot Summary for NUBP1 Gene

  • Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity).

Additional gene information for NUBP1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUBP1 Gene

Genomics for NUBP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NUBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUBP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUBP1

Top Transcription factor binding sites by QIAGEN in the NUBP1 gene promoter:
  • AML1a
  • C/EBPbeta
  • Egr-2
  • Egr-3
  • En-1
  • GATA-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT5A

Genomic Locations for NUBP1 Gene

Genomic Locations for NUBP1 Gene
chr16:10,743,164-10,769,351
(GRCh38/hg38)
Size:
26,188 bases
Orientation:
Plus strand
chr16:10,837,643-10,863,208
(GRCh37/hg19)
Size:
25,566 bases
Orientation:
Plus strand

Genomic View for NUBP1 Gene

Genes around NUBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUBP1 Gene

Proteins for NUBP1 Gene

  • Protein details for NUBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53384-NUBP1_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NUBP1
    Protein Accession:
    P53384
    Secondary Accessions:
    • Q32M30
    • Q498A9
    • Q53FS7

    Protein attributes for NUBP1 Gene

    Size:
    320 amino acids
    Molecular mass:
    34534 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Heterotetramer of 2 NUBP1 and 2 NUBP2 chains (By similarity). Interacts with KIFC1 (By similarity). Interacts with NUBP2 (PubMed:18573874). Interacts with the BBS/CCT complex subunit CCT1 (By similarity).

    Alternative splice isoforms for NUBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUBP1 Gene

Post-translational modifications for NUBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUBP1 Gene

Domains & Families for NUBP1 Gene

Gene Families for NUBP1 Gene

Protein Domains for NUBP1 Gene

Suggested Antigen Peptide Sequences for NUBP1 Gene

GenScript: Design optimal peptide antigens:
  • Nucleotide-binding protein 1 (NUBP1_HUMAN)
  • C447E6.1 (Nucleotide binding protein 1 (E.coli MinD like) ) (Q2YS46_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P53384

UniProtKB/Swiss-Prot:

NUBP1_HUMAN :
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
Family:
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
genes like me logo Genes that share domains with NUBP1: view

Function for NUBP1 Gene

Molecular function for NUBP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity).
GENATLAS Biochemistry:
nucleotide binding protein 1,homolog to the mrp gene of E. coli,MinD-like

Phenotypes From GWAS Catalog for NUBP1 Gene

Gene Ontology (GO) - Molecular Function for NUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 7926816
GO:0005515 protein binding IPI 18573874
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IBA,IDA 18573874
genes like me logo Genes that share ontologies with NUBP1: view
genes like me logo Genes that share phenotypes with NUBP1: view

Animal Models for NUBP1 Gene

MGI Knock Outs for NUBP1:
  • Nubp1 Nubp1<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUBP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUBP1 Gene

Localization for NUBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUBP1 Gene

Cytoplasm. Nucleus. Cell projection. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with nubp-2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non-motile cilia. Localization is independent of NUBP2 and KIFC1. {ECO:0000250 UniProtKB:Q9R060}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUBP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 4
nucleus 4
mitochondrion 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with NUBP1: view

Pathways & Interactions for NUBP1 Gene

PathCards logo

SuperPathways for NUBP1 Gene

genes like me logo Genes that share pathways with NUBP1: view

Pathways by source for NUBP1 Gene

2 Reactome pathways for NUBP1 Gene

Gene Ontology (GO) - Biological Process for NUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IMP 18573874
GO:0006879 cellular iron ion homeostasis IMP 18573874
GO:0010826 negative regulation of centrosome duplication IEA --
GO:0016226 iron-sulfur cluster assembly IBA,IMP 18573874
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with NUBP1: view

No data available for SIGNOR curated interactions for NUBP1 Gene

Drugs & Compounds for NUBP1 Gene

No Compound Related Data Available

Transcripts for NUBP1 Gene

mRNA/cDNA for NUBP1 Gene

6 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUBP1

Alternative Splicing Database (ASD) splice patterns (SP) for NUBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: -
SP2:
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for NUBP1 Gene

GeneLoc Exon Structure for
NUBP1

Expression for NUBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUBP1 Gene

This gene is overexpressed in Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUBP1 Gene



Protein tissue co-expression partners for NUBP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUBP1

SOURCE GeneReport for Unigene cluster for NUBP1 Gene:

Hs.81469

Evidence on tissue expression from TISSUES for NUBP1 Gene

  • Spleen(4.2)
  • Eye(4.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with NUBP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUBP1 Gene

Orthologs for NUBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUBP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NUBP1 30 31
  • 98.86 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NUBP1 30 31
  • 88.23 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NUBP1 31
  • 88 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia NUBP1 30 31
  • 86.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nubp1 30
  • 86 (n)
Mouse
(Mus musculus)
Mammalia Nubp1 30 17 31
  • 85.58 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NUBP1 31
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NUBP1 30 31
  • 74.42 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NUBP1 31
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nubp1 30
  • 74.59 (n)
Str.1794 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16060 30
Zebrafish
(Danio rerio)
Actinopterygii nubp1 30 31
  • 72.08 (n)
OneToOne
Dr.29399 30
African malaria mosquito
(Anopheles gambiae)
Insecta NUBP1_ANOGA 30
  • 61.13 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG17904 30 31 32
  • 60.93 (n)
OneToOne
CG4858 32
  • 48 (a)
Worm
(Caenorhabditis elegans)
Secernentea F10G8.6 30 32
  • 57.79 (n)
nubp-1 31
  • 52 (a)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFL060W 30
  • 58.86 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18987g 30
  • 56.44 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NBP35 30 31 33
  • 53.89 (n)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons NBP35 30
  • 60.44 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0601100 30
  • 52.6 (n)
Os.373 30
Barley
(Hordeum vulgare)
Liliopsida Hv.2749 30
Wheat
(Triticum aestivum)
Liliopsida Ta.14507 30
Corn
(Zea mays)
Liliopsida Zm.2864 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 61 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU08825 30
  • 58.17 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC637.08 30
  • 57.55 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1878 30
Species where no ortholog for NUBP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUBP1 Gene

ENSEMBL:
Gene Tree for NUBP1 (if available)
TreeFam:
Gene Tree for NUBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUBP1: view image

Paralogs for NUBP1 Gene

Paralogs for NUBP1 Gene

(2) SIMAP similar genes for NUBP1 Gene using alignment to 5 proteins:

  • NUBP1_HUMAN
  • I3L3A0_HUMAN
  • I3L518_HUMAN
  • I3L531_HUMAN
  • Q2YS46_HUMAN

Pseudogenes.org Pseudogenes for NUBP1 Gene

genes like me logo Genes that share paralogs with NUBP1: view

Variants for NUBP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUBP1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs2233531 - p.Pro39Ala

Additional dbSNP identifiers (rs#s) for NUBP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUBP1 Gene

Variant ID Type Subtype PubMed ID
dgv1297n106 CNV deletion 24896259
dgv330e201 CNV deletion 23290073
dgv331e201 CNV deletion 23290073
esv2713967 CNV deletion 23290073
esv2713968 CNV deletion 23290073
esv2713969 CNV deletion 23290073
esv988489 CNV deletion 20482838
nsv1040428 CNV gain 25217958
nsv1070327 CNV deletion 25765185
nsv833140 CNV loss 17160897

Variation tolerance for NUBP1 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUBP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUBP1 Gene

Disorders for NUBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUBP1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NUBP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUBP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NUBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUBP1 Gene

Publications for NUBP1 Gene

  1. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. (PMID: 7926816) Shahrestanifar M … Howells RD (Gene 1994) 2 3 4
  2. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 41
  3. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood HD … Lan Q (Respiratory medicine 2009) 3 41
  4. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. (PMID: 18573874) Stehling O … Lill R (Molecular and cellular biology 2008) 3 4
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood HD … Lan Q (Carcinogenesis 2008) 3 41

Products for NUBP1 Gene

Sources for NUBP1 Gene