Aliases for NUAK2 Gene
External Ids for NUAK2 Gene
Previous GeneCards Identifiers for NUAK2 Gene
GeneCards Summary for NUAK2 Gene
NUAK2 (NUAK Family Kinase 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NUAK1.
UniProtKB/Swiss-Prot Summary for NUAK2 Gene
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.