NUAK2 Gene (Protein Coding)

NUAK Family Kinase 2

GC01M205302
GIFtS:
40

Aliases for NUAK2 Gene

Aliases for NUAK2 Gene

  • NUAK Family Kinase 2 2 3 5
  • SNF1/AMP Activated Protein Kinase 2 3
  • NUAK Family, SNF1-Like Kinase, 2 2 3
  • NUAK Family SNF1-Like Kinase 2 3 4
  • SNF1/AMP Kinase-Related Kinase 3 4
  • Omphalocele Kinase 2 3 4
  • EC 2.7.11.1 4 54
  • SNARK 3 4
  • EC 2.7.11 54
  • OMPHK2 4

External Ids for NUAK2 Gene

Previous GeneCards Identifiers for NUAK2 Gene

  • GC01M202003
  • GC01M203537
  • GC01M205271
  • GC01M176436

Summaries for NUAK2 Gene

GeneCards Summary for NUAK2 Gene

NUAK2 (NUAK Family Kinase 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot Summary for NUAK2 Gene

  • Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.

Gene Wiki entry for NUAK2 Gene

Additional gene information for NUAK2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUAK2 Gene

Genomics for NUAK2 Gene

GeneHancer (GH) Regulatory Elements for NUAK2 Gene

Promoters and enhancers for NUAK2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUAK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUAK2 gene promoter:
  • AhR
  • AML1a
  • AREB6
  • Arnt
  • c-Ets-1
  • ER-alpha
  • FOXO4
  • HEN1
  • HSF2
  • Nkx6-1

Genomic Locations for NUAK2 Gene

Genomic Locations for NUAK2 Gene
chr1:205,302,059-205,321,791
(GRCh38/hg38)
Size:
19,733 bases
Orientation:
Minus strand
chr1:205,271,187-205,290,883
(GRCh37/hg19)
Size:
19,697 bases
Orientation:
Minus strand

Genomic View for NUAK2 Gene

Genes around NUAK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUAK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUAK2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NUAK2 Gene

Proteins for NUAK2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NUAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H093-NUAK2_HUMAN
    Recommended name:
    NUAK family SNF1-like kinase 2
    Protein Accession:
    Q9H093

    Protein attributes for NUAK2 Gene

    Size:
    628 amino acids
    Molecular mass:
    69612 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NUAK2 Gene

Protein Expression for NUAK2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for NUAK2 Gene

Q9H093:
  • KFLQTFCGSPLYASPEIVNG
  • VKRHHHKHNL
  • ETLGKGTYGKVK
  • VAIKSIRKDKIKDE
  • HWWVNWGY
  • LYDYISER
  • PYTGPEVD
  • RDLKLEN
  • KIADFGLSN
  • FRQIVSA
  • VVHRDLK
  • RQIVSAV
  • QRESGYYSSPE
  • PGLERQHSLKKSRKENDMAQ
  • IMSSLNH
  • KLENILLD
  • DVFVSGDP
  • KPSDACGLIRWLLMVNP

Post-translational modifications for NUAK2 Gene

  • Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUAK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NUAK2 Gene

Gene Families for NUAK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for NUAK2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUAK2 Gene

GenScript: Design optimal peptide antigens:
  • SNF1/AMP kinase-related kinase (NUAK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H093

UniProtKB/Swiss-Prot:

NUAK2_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with NUAK2: view

Function for NUAK2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NUAK2 Gene

UniProtKB/Swiss-Prot Function:
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269 PubMed:14575707, ECO:0000269 PubMed:14976552};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269 PubMed:14575707, ECO:0000269 PubMed:14976552};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-208.

Enzyme Numbers (IUBMB) for NUAK2 Gene

Phenotypes From GWAS Catalog for NUAK2 Gene

Gene Ontology (GO) - Molecular Function for NUAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA,IEA 14976552
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,IEA 14976552
GO:0005515 protein binding IPI 19927127
GO:0005524 ATP binding IEA,IDA 14976552
genes like me logo Genes that share ontologies with NUAK2: view
genes like me logo Genes that share phenotypes with NUAK2: view

Animal Models for NUAK2 Gene

MGI Knock Outs for NUAK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NUAK2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUAK2

Clone Products

  • Addgene plasmids for NUAK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUAK2 Gene

Localization for NUAK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUAK2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with NUAK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUAK2 Gene

Pathways & Interactions for NUAK2 Gene

genes like me logo Genes that share pathways with NUAK2: view

Pathways by source for NUAK2 Gene

3 Cell Signaling Technology pathways for NUAK2 Gene

SIGNOR curated interactions for NUAK2 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NUAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA,IEA 14976552
GO:0006915 apoptotic process IEA --
GO:0016310 phosphorylation IEA --
GO:0030036 actin cytoskeleton organization IDA 14575707
GO:0035556 intracellular signal transduction IBA 21873635
genes like me logo Genes that share ontologies with NUAK2: view

Drugs & Compounds for NUAK2 Gene

Products:

  1. Drug

(4) Drugs for NUAK2 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
WZ4003 Pharma NUAK1/2 inhibitor, potent and selective 0

(1) Additional Compounds for NUAK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(1) ApexBio Compounds for NUAK2 Gene

Compound Action Cas Number
WZ4003 NUAK1/2 inhibitor, potent and selective 1214265-58-3
genes like me logo Genes that share compounds with NUAK2: view

Transcripts for NUAK2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NUAK2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(79) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUAK2

Clone Products

  • Addgene plasmids for NUAK2

Alternative Splicing Database (ASD) splice patterns (SP) for NUAK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for NUAK2 Gene

GeneLoc Exon Structure for
NUAK2
ECgene alternative splicing isoforms for
NUAK2

Expression for NUAK2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUAK2 Gene

mRNA expression in normal human tissues for NUAK2 Gene
mRNA expression by BioGPS for NUAK2 GenemRNA expression by GTEx for NUAK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUAK2 Gene

This gene is overexpressed in Whole Blood (x9.6), Esophagus - Mucosa (x5.9), Vagina (x5.2), and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for NUAK2 Gene

This gene is overexpressed in Heart (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUAK2 Gene



Protein tissue co-expression partners for NUAK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUAK2 Gene:

NUAK2

SOURCE GeneReport for Unigene cluster for NUAK2 Gene:

Hs.497512
genes like me logo Genes that share expression patterns with NUAK2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUAK2 Gene

Orthologs for NUAK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUAK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NUAK2 33 32
  • 98.83 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia NUAK2 33 32
  • 87.69 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Nuak2 17 33 32
  • 84.78 (n)
rat
(Rattus norvegicus)
 Mammalia Nuak2 32
  • 84.32 (n)
oppossum
(Monodelphis domestica)
 Mammalia NUAK2 33
  • 82 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia NUAK2 33
  • 80 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia NUAK2 33
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NUAK2 33 32
  • 70.24 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NUAK2 33
  • 62 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia nuak2 32
  • 62.16 (n)
Str.4072 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.8315 32
zebrafish
(Danio rerio)
 Actinopterygii nuak2 33 32
  • 64.28 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG43143 33
  • 11 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea unc-82 33
  • 14 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes SNF1 33
  • 23 (a)
 OneToMany
barley
(Hordeum vulgare)
 Liliopsida Hv.464 32
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 56 (a)
 OneToMany
Species where no ortholog for NUAK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUAK2 Gene

ENSEMBL:
Gene Tree for NUAK2 (if available)
TreeFam:
Gene Tree for NUAK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUAK2: view image

Paralogs for NUAK2 Gene

Paralogs for NUAK2 Gene

(10) SIMAP similar genes for NUAK2 Gene using alignment to 1 proteins:

  • NUAK2_HUMAN
genes like me logo Genes that share paralogs with NUAK2: view

Variants for NUAK2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for NUAK2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_040966 An ovarian Endometrioid carcinoma sample p.Lys503Arg
VAR_040968 A breast pleomorphic lobular carcinoma sample p.Gly541Glu
rs1000065722 -- 205,314,387(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000067557 -- 205,315,850(-) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000098269 -- 205,316,190(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUAK2 Gene

Variant ID Type Subtype PubMed ID
nsv832381 CNV gain 17160897

Variation tolerance for NUAK2 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUAK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUAK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUAK2 Gene

Disorders for NUAK2 Gene

Additional Disease Information for NUAK2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NUAK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUAK2 Gene

Publications for NUAK2 Gene

  1. Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness. (PMID: 15345718) Legembre P … Peter ME (The Journal of biological chemistry 2004) 3 4 23 56
  2. Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. (PMID: 14575707) Suzuki A … Esumi H (Biochemical and biophysical research communications 2003) 3 4 23 56
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 56
  4. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. (PMID: 19927127) Humbert N … Bernard D (The EMBO journal 2010) 3 4 56
  5. Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes. (PMID: 19652946) Rune A … Zierath JR (Diabetologia 2009) 3 23 56

ExternalLinks

View latest publications for NUAK2 gene in Mastermind

Products for NUAK2 Gene

  • Addgene plasmids for NUAK2

Sources for NUAK2 Gene