Aliases for NUAK1 Gene

Aliases for NUAK1 Gene

  • NUAK Family Kinase 1 2 3 5
  • AMP-Activated Protein Kinase Family Member 5 2 3
  • NUAK Family, SNF1-Like Kinase, 1 2 3
  • NUAK Family SNF1-Like Kinase 1 3 4
  • AMPK-Related Protein Kinase 5 3 4
  • Omphalocele Kinase 1 3 4
  • EC 2.7.11.1 4 52
  • ARK5 3 4
  • EC 2.7.11 52
  • KIAA0537 4
  • OMPHK1 4

External Ids for NUAK1 Gene

Previous GeneCards Identifiers for NUAK1 Gene

  • GC12M104960
  • GC12M106457
  • GC12M103517

Summaries for NUAK1 Gene

GeneCards Summary for NUAK1 Gene

NUAK1 (NUAK Family Kinase 1) is a Protein Coding gene. Diseases associated with NUAK1 include Endometrial Squamous Cell Carcinoma and Omphalocele. Among its related pathways are Gene Expression and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NUAK2.

UniProtKB/Swiss-Prot Summary for NUAK1 Gene

  • Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).

Gene Wiki entry for NUAK1 Gene

Additional gene information for NUAK1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUAK1 Gene

Genomics for NUAK1 Gene

GeneHancer (GH) Regulatory Elements for NUAK1 Gene

Promoters and enhancers for NUAK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J106130 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 506.7 +3.4 3360 13 EP300 CTCF TCF12 POLR2G PHF8 JUND TEAD4 FOS ZFX ZNF639 NUAK1 POLR3B ENSG00000260329 lnc-TCP11L2-4 piR-56229-020 ENSG00000257438
GH12J105417 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +720.7 720723 4.3 CTCF ZNF10 REST RAD21 EP300 TRIM22 SMC3 ZNF585B DEK CREB1 NUAK1 C12orf75 LOC105369955 lnc-C12orf75-1
GH12J106105 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 11.4 +31.7 31722 5.3 EP300 TCF12 TEAD4 FOS ZNF639 RFX1 ZNF341 RBM25 CTCF HDAC2 NUAK1 ENSG00000257890 ENSG00000257438 lnc-TCP11L2-4
GH12J106111 Enhancer 1 ENCODE dbSUPER 11.4 +26.4 26413 4.1 FOS ZNF639 EP300 ZIC2 RFX1 OSR2 BCL11A ZBTB17 ZNF263 CEBPG NUAK1 ENSG00000257438 lnc-TCP11L2-4
GH12J105427 Enhancer 0.7 Ensembl dbSUPER 10.3 +711.7 711733 0.6 CTCF FOS ZNF664 GATA2 RAD21 JUN POLR2A NUAK1 LOC105369955 lnc-APPL2-2 LOC105369956
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUAK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUAK1

Top Transcription factor binding sites by QIAGEN in the NUAK1 gene promoter:
  • CUTL1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pax-2
  • Pax-2a
  • Pax-4a

Genomic Locations for NUAK1 Gene

Genomic Locations for NUAK1 Gene
chr12:106,063,340-106,140,033
(GRCh38/hg38)
Size:
76,694 bases
Orientation:
Minus strand
chr12:106,457,118-106,533,811
(GRCh37/hg19)
Size:
76,694 bases
Orientation:
Minus strand

Genomic View for NUAK1 Gene

Genes around NUAK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUAK1 Gene

Proteins for NUAK1 Gene

  • Protein details for NUAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60285-NUAK1_HUMAN
    Recommended name:
    NUAK family SNF1-like kinase 1
    Protein Accession:
    O60285
    Secondary Accessions:
    • A7MD39
    • Q96KA8

    Protein attributes for NUAK1 Gene

    Size:
    661 amino acids
    Molecular mass:
    74305 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interact (via GILK motif) with PPP1CB; the interaction is direct and bridges NUAK1 and PPP1R12A. Interacts with CDKN1A.
    SequenceCaution:
    • Sequence=BAA25463.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUAK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUAK1 Gene

Selected DME Specific Peptides for NUAK1 Gene

O60285:
  • FRQIVSA
  • VVHRDLK
  • KFLQTFCGSPLYASPEIVNG
  • VKRHHHKHNL
  • ETLGKGTYGKVK
  • RQIVSAV
  • VAIKSIRKDKIKDE
  • QRESGYYSSPE
  • RLSERET
  • HWWVNWGY
  • LYDYISER
  • IMSSLNH
  • KLENILLD
  • RDLKLEN
  • KIADFGLSN

Post-translational modifications for NUAK1 Gene

  • Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.
  • Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not dephosphorylated by the myosin PP1 complex when regulating its activity, due to the presence of PPP1R12A, which prevents myosin PP1 from dephosphorylating NUAK1. Phosphorylated by STK38L upon stimulation with IGF1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUAK1 Gene

Domains & Families for NUAK1 Gene

Gene Families for NUAK1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NUAK1 Gene

Suggested Antigen Peptide Sequences for NUAK1 Gene

GenScript: Design optimal peptide antigens:
  • AMPK-related protein kinase 5 (NUAK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60285

UniProtKB/Swiss-Prot:

NUAK1_HUMAN :
  • The GILK motif mediates interaction with PPP1CB.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • The GILK motif mediates interaction with PPP1CB.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with NUAK1: view

Function for NUAK1 Gene

Molecular function for NUAK1 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-211. Activated by phosphorylation at Ser-600 AKT1 during glucose starvation; the relevance of such activation in normal cells is however unsure.
UniProtKB/Swiss-Prot Induction:
Transcriptionally regulated by members of the MAF family.

Enzyme Numbers (IUBMB) for NUAK1 Gene

Phenotypes From GWAS Catalog for NUAK1 Gene

Gene Ontology (GO) - Molecular Function for NUAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 21317932
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 19927127
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NUAK1: view
genes like me logo Genes that share phenotypes with NUAK1: view

Animal Models for NUAK1 Gene

MGI Knock Outs for NUAK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NUAK1

Clone Products

  • Addgene plasmids for NUAK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUAK1 Gene

Localization for NUAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUAK1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUAK1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Microtubules (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA,IBA 21317932
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IDA 21317932
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with NUAK1: view

Pathways & Interactions for NUAK1 Gene

genes like me logo Genes that share pathways with NUAK1: view

Pathways by source for NUAK1 Gene

SIGNOR curated interactions for NUAK1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NUAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 25329316
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007155 cell adhesion IEA --
GO:0016310 phosphorylation IEA --
GO:0030155 regulation of cell adhesion IDA 20354225
genes like me logo Genes that share ontologies with NUAK1: view

Drugs & Compounds for NUAK1 Gene

(5) Drugs for NUAK1 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
HTH-01-015 Pharma NUAK1 inhibitor,highly specific and selective 0
WZ4003 Pharma NUAK1/2 inhibitor, potent and selective 0

(1) Additional Compounds for NUAK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(2) ApexBio Compounds for NUAK1 Gene

Compound Action Cas Number
HTH-01-015 NUAK1 inhibitor,highly specific and selective 1613724-42-7
WZ4003 NUAK1/2 inhibitor, potent and selective 1214265-58-3
genes like me logo Genes that share compounds with NUAK1: view

Drug Products

Transcripts for NUAK1 Gene

mRNA/cDNA for NUAK1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for NUAK1

Alternative Splicing Database (ASD) splice patterns (SP) for NUAK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3:
SP4: - - -

Relevant External Links for NUAK1 Gene

GeneLoc Exon Structure for
NUAK1

Expression for NUAK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUAK1 Gene

mRNA differential expression in normal tissues according to GTEx for NUAK1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for NUAK1 Gene

This gene is overexpressed in Lung (43.1) and Liver (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUAK1 Gene



Protein tissue co-expression partners for NUAK1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUAK1

SOURCE GeneReport for Unigene cluster for NUAK1 Gene:

Hs.524692

mRNA Expression by UniProt/SwissProt for NUAK1 Gene:

O60285-NUAK1_HUMAN
Tissue specificity: Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines.

Evidence on tissue expression from TISSUES for NUAK1 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NUAK1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NUAK1 Gene

Orthologs for NUAK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUAK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUAK1 31 30
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUAK1 31 30
  • 90.23 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUAK1 31 30
  • 89.36 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nuak1 17 31 30
  • 87.37 (n)
rat
(Rattus norvegicus)
Mammalia Nuak1 30
  • 87.1 (n)
oppossum
(Monodelphis domestica)
Mammalia NUAK1 31
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUAK1 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUAK1 31 30
  • 77.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUAK1 31
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nuak1 30
  • 70.58 (n)
zebrafish
(Danio rerio)
Actinopterygii nuak1 30
  • 67.18 (n)
NUAK1 (2 of 2) 31
  • 64 (a)
OneToMany
NUAK1 (1 of 2) 31
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43143 31
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-82 31
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNF1 31
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 57 (a)
OneToMany
Species where no ortholog for NUAK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUAK1 Gene

ENSEMBL:
Gene Tree for NUAK1 (if available)
TreeFam:
Gene Tree for NUAK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUAK1: view image

Paralogs for NUAK1 Gene

genes like me logo Genes that share paralogs with NUAK1: view

Variants for NUAK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUAK1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
779952 Benign: not provided 106,067,435(-) C/T SYNONYMOUS_VARIANT
783670 Benign: not provided 106,067,337(-) C/T MISSENSE_VARIANT
784473 Benign: not provided 106,106,530(-) A/G INTRON_VARIANT
791364 Benign: not provided 106,070,838(-) G/A SYNONYMOUS_VARIANT
rs3741883 - p.Pro543Arg

Additional dbSNP identifiers (rs#s) for NUAK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUAK1 Gene

Variant ID Type Subtype PubMed ID
esv25105 CNV loss 19812545
esv2746333 CNV deletion 23290073
nsv1040534 CNV gain 25217958
nsv832509 CNV gain 17160897

Variation tolerance for NUAK1 Gene

Residual Variation Intolerance Score: 4.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.88; 87.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUAK1 Gene

Human Gene Mutation Database (HGMD)
NUAK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUAK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUAK1 Gene

Disorders for NUAK1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUAK1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endometrial squamous cell carcinoma
  • squamous cell carcinoma of endometrium
omphalocele
  • omphalocoele
- elite association - COSMIC cancer census association via MalaCards
Search NUAK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUAK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NUAK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUAK1 Gene

Publications for NUAK1 Gene

  1. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. (PMID: 19927127) Humbert N … Bernard D (The EMBO journal 2010) 3 4 23 54
  2. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. (PMID: 20354225) Zagórska A … Alessi DR (Science signaling 2010) 3 4 23 54
  3. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. (PMID: 18254724) Al-Hakim AK … Alessi DR (The Biochemical journal 2008) 3 4 23 54
  4. ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. (PMID: 16044163) Suzuki A … Esumi H (Oncogene 2005) 3 4 23 54
  5. Regulation of caspase-6 and FLIP by the AMPK family member ARK5. (PMID: 15273717) Suzuki A … Esumi H (Oncogene 2004) 3 4 23 54

Products for NUAK1 Gene

Sources for NUAK1 Gene