The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high ... See more...

Aliases for NTSR2 Gene

Aliases for NTSR2 Gene

  • Neurotensin Receptor 2 2 3 5
  • Levocabastine-Sensitive Neurotensin Receptor 3 4
  • Neurotensin Receptor Type 2 3 4
  • NT-R-2 3 4
  • NTR2 3 4
  • Neurotensin Receptor, Type 2 3

External Ids for NTSR2 Gene

Previous GeneCards Identifiers for NTSR2 Gene

  • GC02M011583
  • GC02M011849
  • GC02M011820
  • GC02M011748
  • GC02M011715
  • GC02M011798

Summaries for NTSR2 Gene

Entrez Gene Summary for NTSR2 Gene

  • The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTSR2 Gene

NTSR2 (Neurotensin Receptor 2) is a Protein Coding gene. Diseases associated with NTSR2 include Conduct Disorder. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled neurotensin receptor activity. An important paralog of this gene is NTSR1.

UniProtKB/Swiss-Prot Summary for NTSR2 Gene

  • Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for NTSR2 Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).

Gene Wiki entry for NTSR2 Gene

Additional gene information for NTSR2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NTSR2 Gene

Genomics for NTSR2 Gene

GeneHancer (GH) Regulatory Elements for NTSR2 Gene

Promoters and enhancers for NTSR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTSR2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NTSR2

Top Transcription factor binding sites by QIAGEN in the NTSR2 gene promoter:
  • ATF-2
  • Brachyury
  • CRE-BP1
  • E47
  • NRSF form 1
  • NRSF form 2

Genomic Locations for NTSR2 Gene

Genomic Locations for NTSR2 Gene
chr2:11,658,178-11,670,203
(GRCh38/hg38)
Size:
12,026 bases
Orientation:
Minus strand
chr2:11,798,304-11,810,329
(GRCh37/hg19)
Size:
12,026 bases
Orientation:
Minus strand

Genomic View for NTSR2 Gene

Genes around NTSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTSR2 Gene

Proteins for NTSR2 Gene

  • Protein details for NTSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95665-NTR2_HUMAN
    Recommended name:
    Neurotensin receptor type 2
    Protein Accession:
    O95665
    Secondary Accessions:
    • Q53QQ5
    • Q57Z87
    • Q8IY58
    • Q8TBH6

    Protein attributes for NTSR2 Gene

    Size:
    410 amino acids
    Molecular mass:
    45385 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAX00924.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for NTSR2 Gene

Post-translational modifications for NTSR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NTSR2 Gene

No data available for DME Specific Peptides for NTSR2 Gene

Domains & Families for NTSR2 Gene

Gene Families for NTSR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for NTSR2 Gene

Blocks:
  • Neurotensin receptor signature
  • Neurotensin type 2 receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NTSR2 Gene

GenScript: Design optimal peptide antigens:
  • Levocabastine-sensitive neurotensin receptor (NTR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95665

UniProtKB/Swiss-Prot:

NTR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
genes like me logo Genes that share domains with NTSR2: view

Function for NTSR2 Gene

Molecular function for NTSR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Phenotypes From GWAS Catalog for NTSR2 Gene

Gene Ontology (GO) - Molecular Function for NTSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS 9851594
GO:0016492 G protein-coupled neurotensin receptor activity IEA --
genes like me logo Genes that share ontologies with NTSR2: view
genes like me logo Genes that share phenotypes with NTSR2: view

Animal Models for NTSR2 Gene

MGI Knock Outs for NTSR2:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for NTSR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NTSR2 Gene

Localization for NTSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTSR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTSR2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NTSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9851594
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NTSR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NTSR2 Gene

Pathways & Interactions for NTSR2 Gene

genes like me logo Genes that share pathways with NTSR2: view

SIGNOR curated interactions for NTSR2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NTSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 9851594
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NTSR2: view

Drugs & Compounds for NTSR2 Gene

(12) Drugs for NTSR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levocabastine Approved, Investigational Pharma Full agonist, Agonist, Target, partial antagonist, antagonist 5
Calcium Approved Nutra 7884
Meclinertant Investigational Pharma antagonist nonpeptide neurotensin antagonist 0
Neurotensin Pharma Full agonist, Agonist NTR1 activator, Endogenous neurotransmitter and endocrine modulator 0
JMV 449 Pharma Potent neurotensin receptor agonist 0

(2) Additional Compounds for NTSR2 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR48692
Full agonist, Agonist, Antagonist
Neuromedin N (rat, mouse, porcine, canine)
92169-45-4

(5) Tocris Compounds for NTSR2 Gene

Compound Action Cas Number
JMV 449 Potent neurotensin receptor agonist 139026-66-7
Kinetensin (human) Neurotensin-like peptide 103131-69-7
Neuromedin N (rat, mouse, porcine, canine) Neurotensin-like peptide 92169-45-4
Neurotensin Endogenous neurotransmitter and endocrine modulator 39379-15-2
Xenin 8 Neurotensin-like peptide; potentiates insulin and glucagon secretion 117442-28-1

(5) ApexBio Compounds for NTSR2 Gene

Compound Action Cas Number
JMV 449 139026-66-7
Kinetensin (human) 103131-69-7
SR 142948 184162-64-9
SR 48692 nonpeptide neurotensin antagonist 146362-70-1
Xenin 8 117442-28-1
genes like me logo Genes that share compounds with NTSR2: view

Drug Products

Transcripts for NTSR2 Gene

mRNA/cDNA for NTSR2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NTSR2

Alternative Splicing Database (ASD) splice patterns (SP) for NTSR2 Gene

No ASD Table

Relevant External Links for NTSR2 Gene

GeneLoc Exon Structure for
NTSR2

Expression for NTSR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NTSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTSR2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.8), Brain - Caudate (basal ganglia) (x7.4), Brain - Putamen (basal ganglia) (x6.9), Brain - Amygdala (x6.1), and Brain - Substantia nigra (x5.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NTSR2

SOURCE GeneReport for Unigene cluster for NTSR2 Gene:

Hs.131138

mRNA Expression by UniProt/SwissProt for NTSR2 Gene:

O95665-NTR2_HUMAN
Tissue specificity: Expressed in prostate (at protein level).

Evidence on tissue expression from TISSUES for NTSR2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with NTSR2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTSR2 Gene

Orthologs for NTSR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NTSR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTSR2 31 30
  • 99.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NTSR2 31 30
  • 86.63 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NTSR2 31 30
  • 86.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntsr2 30
  • 82.55 (n)
mouse
(Mus musculus)
Mammalia Ntsr2 17 31 30
  • 82.22 (n)
Species where no ortholog for NTSR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NTSR2 Gene

ENSEMBL:
Gene Tree for NTSR2 (if available)
TreeFam:
Gene Tree for NTSR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NTSR2: view image

Paralogs for NTSR2 Gene

(1) SIMAP similar genes for NTSR2 Gene using alignment to 1 proteins:

  • NTR2_HUMAN
genes like me logo Genes that share paralogs with NTSR2: view

Variants for NTSR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NTSR2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
738625 Likely Benign: not provided 11,662,108(-) G/T MISSENSE_VARIANT
782401 Benign: not provided 11,662,020(-) C/T MISSENSE_VARIANT
rs34764121 - p.Arg282Lys
rs6432225 - p.Ala54Val

Additional dbSNP identifiers (rs#s) for NTSR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NTSR2 Gene

Variant ID Type Subtype PubMed ID
nsv469449 CNV loss 19166990
nsv580972 CNV loss 21841781

Variation tolerance for NTSR2 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTSR2 Gene

Human Gene Mutation Database (HGMD)
NTSR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTSR2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTSR2 Gene

Disorders for NTSR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NTSR2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
conduct disorder
- elite association - COSMIC cancer census association via MalaCards
Search NTSR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NTSR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NTSR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTSR2 Gene

Publications for NTSR2 Gene

  1. Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. (PMID: 9851594) Vita N … Ferrara P (European journal of pharmacology 1998) 2 3 4 54
  2. Molecular cloning of a levocabastine-sensitive neurotensin binding site. (PMID: 8647296) Chalon P … Caput D (FEBS letters 1996) 2 3 26 54
  3. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41 54
  4. Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. (PMID: 20048080) Swift SL … Maitland NJ (Cancer research 2010) 3 4 54
  5. Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors. (PMID: 19968961) Hwang JR … Seong JY (Biochemical and biophysical research communications 2010) 3 23 54

Products for NTSR2 Gene

Sources for NTSR2 Gene