Aliases for NTSR1 Gene
External Ids for NTSR1 Gene
Previous GeneCards Identifiers for NTSR1 Gene
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]
GeneCards Summary for NTSR1 Gene
NTSR1 (Neurotensin Receptor 1) is a Protein Coding gene. Diseases associated with NTSR1 include Pancreatic Ductal Carcinoma and Paralytic Poliomyelitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled neurotensin receptor activity. An important paralog of this gene is NTSR2.
UniProtKB/Swiss-Prot Summary for NTSR1 Gene
G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197).
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).