Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008] See more...

Aliases for NTSR1 Gene

Aliases for NTSR1 Gene

  • Neurotensin Receptor 1 2 3 5
  • High-Affinity Levocabastine-Insensitive Neurotensin Receptor 3 4
  • Neurotensin Receptor 1 (High Affinity) 2 3
  • Neurotensin Receptor Type 1 3 4
  • NT-R-1 3 4
  • NTR1 3 4
  • NTRH 3 4
  • NTR 2 3
  • NTSR1 5
  • NTRR 4

External Ids for NTSR1 Gene

Previous GeneCards Identifiers for NTSR1 Gene

  • GC20P061217
  • GC20P062019
  • GC20P062066
  • GC20P060810
  • GC20P061340
  • GC20P058057

Summaries for NTSR1 Gene

Entrez Gene Summary for NTSR1 Gene

  • Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTSR1 Gene

NTSR1 (Neurotensin Receptor 1) is a Protein Coding gene. Diseases associated with NTSR1 include Suprasellar Meningioma and Trigeminal Nerve Neoplasm. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled neurotensin receptor activity. An important paralog of this gene is NTSR2.

UniProtKB/Swiss-Prot Summary for NTSR1 Gene

  • G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197).

Tocris Summary for NTSR1 Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).

Gene Wiki entry for NTSR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NTSR1 Gene

Genomics for NTSR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NTSR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTSR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NTSR1

Top Transcription factor binding sites by QIAGEN in the NTSR1 gene promoter:
  • aMEF-2
  • GATA-2
  • GCNF
  • GCNF-1
  • MEF-2A
  • NF-kappaB
  • NF-kappaB1
  • POU2F1
  • POU2F1a
  • RelA

Genomic Locations for NTSR1 Gene

Latest Assembly
chr20:62,708,770-62,762,771
(GRCh38/hg38)
Size:
54,002 bases
Orientation:
Plus strand

Previous Assembly
chr20:61,340,188-61,394,123
(GRCh37/hg19 by Entrez Gene)
Size:
53,936 bases
Orientation:
Plus strand

chr20:61,340,189-61,394,123
(GRCh37/hg19 by Ensembl)
Size:
53,935 bases
Orientation:
Plus strand

Genomic View for NTSR1 Gene

Genes around NTSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTSR1 Gene

Proteins for NTSR1 Gene

  • Protein details for NTSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30989-NTR1_HUMAN
    Recommended name:
    Neurotensin receptor type 1
    Protein Accession:
    P30989
    Secondary Accessions:
    • Q9H4H1
    • Q9H4T5

    Protein attributes for NTSR1 Gene

    Size:
    418 amino acids
    Molecular mass:
    46259 Da
    Quaternary structure:
    • Interacts (palmitoylated form) with GNA11.

    Three dimensional structures from OCA and Proteopedia for NTSR1 Gene

neXtProt entry for NTSR1 Gene

Post-translational modifications for NTSR1 Gene

  • N-glycosylated.
  • Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment.
  • Glycosylation at Asn4, Asn37, and Asn41
  • Modification sites at PhosphoSitePlus

Other Protein References for NTSR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NTSR1 Gene

Domains & Families for NTSR1 Gene

Gene Families for NTSR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for NTSR1 Gene

InterPro:
Blocks:
  • Neurotensin receptor signature
  • Neurotensin type 1 receptor signature

Suggested Antigen Peptide Sequences for NTSR1 Gene

GenScript: Design optimal peptide antigens:
  • NTRH (NTR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30989

UniProtKB/Swiss-Prot:

NTR1_HUMAN :
  • The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7.
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.
Domain:
  • The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.
genes like me logo Genes that share domains with NTSR1: view

Function for NTSR1 Gene

Molecular function for NTSR1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197).
GENATLAS Biochemistry:
neurotensin receptor 1,expressed in central and peripheral nervous system,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for NTSR1 Gene

Gene Ontology (GO) - Molecular Function for NTSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS 8381365
GO:0005515 protein binding IPI 17620610
GO:0016492 G protein-coupled neurotensin receptor activity IMP 8381365
GO:0042802 identical protein binding IEA,IPI 17620610
GO:0044877 protein-containing complex binding IEA --
genes like me logo Genes that share ontologies with NTSR1: view
genes like me logo Genes that share phenotypes with NTSR1: view

Animal Models for NTSR1 Gene

MGI Knock Outs for NTSR1:

Animal Models for research

  • Taconic Biosciences Mouse Models for NTSR1

miRNA for NTSR1 Gene

miRTarBase miRNAs that target NTSR1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTSR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTSR1 Gene

Localization for NTSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTSR1 Gene

Cell membrane. Multi-pass membrane protein. Membrane raft. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000269 PubMed:21725197}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTSR1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
mitochondrion 3
nucleus 3
extracellular 2
cytoskeleton 2
endosome 2
cytosol 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NTSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with NTSR1: view

Pathways & Interactions for NTSR1 Gene

genes like me logo Genes that share pathways with NTSR1: view

SIGNOR curated interactions for NTSR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NTSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0003254 regulation of membrane depolarization IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with NTSR1: view

Drugs & Compounds for NTSR1 Gene

(20) Drugs for NTSR1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Meclinertant Investigational Pharma antagonist nonpeptide neurotensin antagonist 0
contulakin-G Investigational Pharma Agonist, Full agonist 0
Neurotensin Pharma Agonist, Full agonist NTR1 activator, Endogenous neurotransmitter and endocrine modulator 0
JMV 449 Pharma Potent neurotensin receptor agonist 0
Kinetensin (human) Pharma Neurotensin-like peptide 0

(5) Additional Compounds for NTSR1 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR48692
Antagonist
JMV449
Agonist, Full agonist
Neuromedin N (rat, mouse, porcine, canine)
92169-45-4

(5) Tocris Compounds for NTSR1 Gene

Compound Action Cas Number
JMV 449 Potent neurotensin receptor agonist 139026-66-7
Kinetensin (human) Neurotensin-like peptide 103131-69-7
Neuromedin N (rat, mouse, porcine, canine) Neurotensin-like peptide 92169-45-4
Neurotensin Endogenous neurotransmitter and endocrine modulator 39379-15-2
Xenin 8 Neurotensin-like peptide; potentiates insulin and glucagon secretion 117442-28-1

(6) ApexBio Compounds for NTSR1 Gene

Compound Action Cas Number
JMV 449 139026-66-7
Kinetensin (human) 103131-69-7
Neurotensin NTR1 activator 39379-15-2
SR 142948 184162-64-9
SR 48692 nonpeptide neurotensin antagonist 146362-70-1
Xenin 8 117442-28-1
genes like me logo Genes that share compounds with NTSR1: view

Drug products for research

Transcripts for NTSR1 Gene

mRNA/cDNA for NTSR1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTSR1

Alternative Splicing Database (ASD) splice patterns (SP) for NTSR1 Gene

No ASD Table

Relevant External Links for NTSR1 Gene

GeneLoc Exon Structure for
NTSR1

Expression for NTSR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NTSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTSR1 Gene

This gene is overexpressed in Colon - Sigmoid (x24.7), Whole Blood (x6.6), and Colon - Transverse (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NTSR1

SOURCE GeneReport for Unigene cluster for NTSR1 Gene:

Hs.590869

mRNA Expression by UniProt/SwissProt for NTSR1 Gene:

P30989-NTR1_HUMAN
Tissue specificity: Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain.

Evidence on tissue expression from TISSUES for NTSR1 Gene

  • Nervous system(4.5)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with NTSR1: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTSR1 Gene

Orthologs for NTSR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTSR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NTSR1 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia NTSR1 29 30
  • 89.07 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NTSR1 29 30
  • 87.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ntsr1 29 16 30
  • 84.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ntsr1 29
  • 83.89 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia NTSR1 30
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NTSR1 30
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NTSR1 29 30
  • 73.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NTSR1 30
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101735297 29
  • 65.43 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC569344 29
  • 67.3 (n)
ntsr1 30
  • 59 (a)
OneToOne
Species where no ortholog for NTSR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NTSR1 Gene

ENSEMBL:
Gene Tree for NTSR1 (if available)
TreeFam:
Gene Tree for NTSR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NTSR1: view image
Alliance of Genome Resources:
Additional Orthologs for NTSR1

Paralogs for NTSR1 Gene

(6) SIMAP similar genes for NTSR1 Gene using alignment to 1 proteins:

  • NTR1_HUMAN
genes like me logo Genes that share paralogs with NTSR1: view

Variants for NTSR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NTSR1 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs113016803 Likely Benign: not provided 62,758,339(+) G/A
NM_002531.3(NTSR1):c.990G>A (p.Ser330=)
SYNONYMOUS
rs11698783 Benign: not provided 62,709,422(+) C/Tp.Ala72Val
NM_002531.3(NTSR1):c.215C>T (p.Ala72Val)
MISSENSE
rs139953956 Benign: not provided 62,760,026(+) A/G
NM_002531.3(NTSR1):c.1016A>G (p.Tyr339Cys)
MISSENSE
rs143899545 Benign: not provided 62,760,031(+) T/C
NM_002531.3(NTSR1):c.1021T>C (p.Phe341Leu)
MISSENSE
rs1600715206 Likely Benign: not provided 62,709,549(+) C/T
NM_002531.3(NTSR1):c.342C>T (p.Leu114=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NTSR1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NTSR1 Gene

Variant ID Type Subtype PubMed ID
dgv708n67 CNV loss 20364138
dgv7657n54 CNV loss 21841781
dgv7658n54 CNV loss 21841781
dgv797e199 CNV deletion 23128226
esv1917595 CNV deletion 18987734
esv25803 CNV loss 19812545
esv2645365 CNV deletion 19546169
esv2658201 CNV deletion 23128226
esv2658283 CNV deletion 23128226
esv2676431 CNV deletion 23128226
esv2722828 CNV deletion 23290073
esv2722830 CNV deletion 23290073
esv2722831 CNV deletion 23290073
esv2722832 CNV deletion 23290073
esv2722833 CNV deletion 23290073
esv3557341 CNV deletion 23714750
esv3557342 CNV deletion 23714750
esv3568095 CNV loss 25503493
esv3568096 CNV loss 25503493
esv3646295 CNV loss 21293372
esv4782 CNV loss 18987735
esv9171 CNV loss 19470904
nsv1073080 CNV deletion 25765185
nsv1111213 CNV tandem duplication 24896259
nsv1132902 CNV insertion 24896259
nsv1136333 CNV deletion 24896259
nsv1143992 CNV deletion 24896259
nsv1152349 CNV deletion 26484159
nsv3442 CNV insertion 18451855
nsv428380 CNV loss 18775914
nsv459065 CNV gain 19166990
nsv470558 CNV loss 18288195
nsv515840 CNV loss 19592680
nsv516618 CNV loss 19592680
nsv521375 CNV loss 19592680
nsv586496 CNV gain 21841781
nsv586503 CNV gain 21841781
nsv586523 CNV loss 21841781
nsv828789 CNV loss 20364138
nsv828790 CNV loss 20364138
nsv834026 CNV loss 17160897
nsv834027 CNV loss 17160897
nsv953302 CNV deletion 24416366
nsv9823 CNV loss 18304495

Variation tolerance for NTSR1 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTSR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTSR1
Leiden Open Variation Database (LOVD)
NTSR1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTSR1 Gene

Disorders for NTSR1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NTSR1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
suprasellar meningioma
trigeminal nerve neoplasm
  • neoplasm of trigeminal nerve
neurilemmoma of the fifth cranial nerve
  • trigeminal neurilemmoma
paralytic poliomyelitis
  • poliomyelitis, paralytic
adhesions of uterus
  • band of uterus
- elite association - COSMIC cancer census association via MalaCards
Search NTSR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NTSR1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NTSR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTSR1 Gene

Publications for NTSR1 Gene

  1. Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. (PMID: 20048080) Swift SL … Maitland NJ (Cancer research 2010) 3 4 22
  2. Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor. (PMID: 23140271) Da Costa G … Monti JP (Journal of biomolecular structure & dynamics 2013) 3 4
  3. Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains. (PMID: 21725197) Heakal Y … Kester M (Cancer biology & therapy 2011) 3 4
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 40
  5. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 40

Products for NTSR1 Gene

Sources for NTSR1 Gene