Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NTS Gene

Aliases for NTS Gene

  • Neurotensin 2 3 5
  • Pro-Neurotensin/Neuromedin 2 3
  • Neurotensin/Neuromedin N 3
  • Neuromedin N 2
  • NMN-125 3
  • NT/N 3
  • NTS1 3
  • NN 3
  • NT 3

External Ids for NTS Gene

Previous GeneCards Identifiers for NTS Gene

  • GC12P086784
  • GC12P086201
  • GC12P084770
  • GC12P083324

Summaries for NTS Gene

Entrez Gene Summary for NTS Gene

  • This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]

GeneCards Summary for NTS Gene

NTS (Neurotensin) is a Protein Coding gene. Diseases associated with NTS include Duodenogastric Reflux and Dumping Syndrome. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include neuropeptide hormone activity.

UniProtKB/Swiss-Prot for NTS Gene

  • Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

Tocris Summary for NTS Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).

Gene Wiki entry for NTS Gene

Additional gene information for NTS Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTS Gene

Genomics for NTS Gene

GeneHancer (GH) Regulatory Elements for NTS Gene

Promoters and enhancers for NTS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J085873 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 650.7 +0.0 41 0.9 ZBTB21 ZSCAN4 MZF1 POLR2A ZNF366 ZBTB48 PATZ1 PRDM10 ATF7 ZNF600 NTS MGAT4C ENSG00000258178
GH12J085947 Enhancer 0.5 ENCODE 12.3 +74.4 74389 2.5 SP1 NANOG POU5F1 ETS1 MGAT4C NTS ENSG00000258178
GH12J085867 Enhancer 0.6 ENCODE 0.4 -7.0 -6967 0.1 CTCF PKNOX1 ZNF654 TRIM22 ZNF2 RAD21 SMC3 ZNF143 FOXP2 ZBTB12 RASSF9 NTS
GH12J085843 Enhancer 0.4 ENCODE 0.3 -30.2 -30173 0.9 ZNF680 HNF4A GABPA MGAT4C RASSF9 NTS
GH12J085951 Enhancer 0.5 ENCODE 0.2 +77.8 77762 0.2 CTCF GATA3 ZNF654 SMC3 RAD21 RFX5 ENSG00000258178 NTS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NTS gene promoter:
  • CREB
  • deltaCREB
  • MyoD
  • FOXD1
  • LHX3b
  • Lhx3a
  • Nkx2-5
  • Bach2

Genomic Locations for NTS Gene

Genomic Locations for NTS Gene
8,698 bases
Plus strand
8,698 bases
Plus strand

Genomic View for NTS Gene

Genes around NTS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTS Gene

Proteins for NTS Gene

  • Protein details for NTS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neurotensin/neuromedin N
    Protein Accession:

    Protein attributes for NTS Gene

    170 amino acids
    Molecular mass:
    19795 Da
    Quaternary structure:
    • Interacts with NTSR1. Interacts with SORT1.

    Three dimensional structures from OCA and Proteopedia for NTS Gene

neXtProt entry for NTS Gene

Post-translational modifications for NTS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NTS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NTS Gene

Domains & Families for NTS Gene

Gene Families for NTS Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NTS Gene

Suggested Antigen Peptide Sequences for NTS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the neurotensin family.
  • Belongs to the neurotensin family.
genes like me logo Genes that share domains with NTS: view

Function for NTS Gene

Molecular function for NTS Gene

UniProtKB/Swiss-Prot Function:
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
GENATLAS Biochemistry:
neurotensin,19.7kDa,tridecapeptide expressed in various brain regions,modulating dopaminergic neuronal activity,and released from the N cells of small intestine,responsible for regulatory and trophic effets,including gut motility

Phenotypes From GWAS Catalog for NTS Gene

Gene Ontology (GO) - Molecular Function for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005184 neuropeptide hormone activity IBA --
GO:0005515 protein binding IPI 17620610
genes like me logo Genes that share ontologies with NTS: view
genes like me logo Genes that share phenotypes with NTS: view

Animal Models for NTS Gene

MGI Knock Outs for NTS:
  • Nts Nts<tm1Dob>

Animal Model Products

miRNA for NTS Gene

miRTarBase miRNAs that target NTS

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTS Gene

Localization for NTS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTS Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTS gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043679 axon terminus IBA --
genes like me logo Genes that share ontologies with NTS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NTS Gene

Pathways & Interactions for NTS Gene

genes like me logo Genes that share pathways with NTS: view

SIGNOR curated interactions for NTS Gene


Gene Ontology (GO) - Biological Process for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8954810
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0050880 regulation of blood vessel size IEA --
genes like me logo Genes that share ontologies with NTS: view

Drugs & Compounds for NTS Gene

(91) Drugs for NTS Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
JMV 449 Pharma Potent neurotensin receptor agonist 0
Kinetensin (human) Pharma Neurotensin-like peptide 0
Neurotensin Pharma Full agonist, Agonist NTR1 activator, Endogenous neurotransmitter and endocrine modulator 0
Xenin 8 Pharma Neurotensin-like peptide; potentiates insulin and glucagon secretion 0

(49) Additional Compounds for NTS Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Neuromedin N (rat, mouse, porcine, canine)

(5) Tocris Compounds for NTS Gene

Compound Action Cas Number
JMV 449 Potent neurotensin receptor agonist 139026-66-7
Kinetensin (human) Neurotensin-like peptide 103131-69-7
Neuromedin N (rat, mouse, porcine, canine) Neurotensin-like peptide 92169-45-4
Neurotensin Endogenous neurotransmitter and endocrine modulator 39379-15-2
Xenin 8 Neurotensin-like peptide; potentiates insulin and glucagon secretion 117442-28-1
genes like me logo Genes that share compounds with NTS: view

Drug Products

Transcripts for NTS Gene

mRNA/cDNA for NTS Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(223) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NTS Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for NTS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTS Gene

This gene is overexpressed in Pituitary (x13.7), Brain - Hypothalamus (x10.3), Small Intestine - Terminal Ileum (x8.6), and Brain - Hippocampus (x4.1).

Protein differential expression in normal tissues from HIPED for NTS Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTS Gene

Protein tissue co-expression partners for NTS Gene

NURSA nuclear receptor signaling pathways regulating expression of NTS Gene:


SOURCE GeneReport for Unigene cluster for NTS Gene:


Evidence on tissue expression from TISSUES for NTS Gene

  • Nervous system(4.8)
  • Intestine(3.1)
  • Stomach(3)
  • Blood(2.3)
  • Adrenal gland(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with NTS: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTS Gene

Orthologs for NTS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NTS 34 33
  • 99.22 (n)
(Canis familiaris)
Mammalia NTS 34 33
  • 92.16 (n)
(Bos Taurus)
Mammalia NTS 34 33
  • 91.18 (n)
(Mus musculus)
Mammalia Nts 16 34 33
  • 83.04 (n)
(Rattus norvegicus)
Mammalia Nts 33
  • 80.47 (n)
(Ornithorhynchus anatinus)
Mammalia NTS 34
  • 79 (a)
(Monodelphis domestica)
Mammalia NTS 34
  • 64 (a)
(Gallus gallus)
Aves NTS 34 33
  • 75.81 (n)
(Anolis carolinensis)
Reptilia NTS 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nts 33
  • 71.89 (n)
(Danio rerio)
Actinopterygii nts 34
  • 30 (a)
Species where no ortholog for NTS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTS Gene

Gene Tree for NTS (if available)
Gene Tree for NTS (if available)
Evolutionary constrained regions (ECRs) for NTS: view image

Paralogs for NTS Gene

No data available for Paralogs for NTS Gene

Variants for NTS Gene

Sequence variations from dbSNP and Humsavar for NTS Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs869025243 uncertain-significance, Ductal breast carcinoma 85,878,394(+) G/A coding_sequence_variant, missense_variant
rs1000086228 -- 85,880,929(+) G/C intron_variant
rs1000168927 -- 85,880,799(+) A/G intron_variant
rs1000418544 -- 85,881,276(+) G/A intron_variant
rs1000706589 -- 85,873,878(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NTS Gene

Variant ID Type Subtype PubMed ID
dgv1539n100 CNV gain 25217958
esv1042104 CNV insertion 17803354
esv3630250 CNV loss 21293372
esv3892241 CNV gain 25118596
esv3892242 CNV loss 25118596
nsv1049179 CNV gain 25217958

Variation tolerance for NTS Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTS Gene

Disorders for NTS Gene

MalaCards: The human disease database

(26) MalaCards diseases for NTS Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
duodenogastric reflux
dumping syndrome
  • dumping syndrome
  • malignant vasoactive intestinal peptide-secreting tumor
postgastrectomy syndrome
  • postgastric surgery syndrome
oropouche fever
  • oropouche virus disease
- elite association - COSMIC cancer census association via MalaCards
Search NTS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NTS

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NTS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTS Gene

Publications for NTS Gene

  1. Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians. (PMID: 17644423) Xiong L … Rouleau GA (Sleep medicine 2008) 3 22 44 58
  2. Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. (PMID: 1436492) Bean AJ … Dobner PR (Neuroscience 1992) 3 4 22 58
  3. Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor. (PMID: 23140271) Da Costa G … Monti JP (Journal of biomolecular structure & dynamics 2013) 3 4 58
  4. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  5. Neurotensin expression and outcome of malignant pleural mesothelioma. (PMID: 19932148) Alifano M … Forgez P (Biochimie 2010) 3 22 58

Products for NTS Gene

Sources for NTS Gene

Loading form....