This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing resu... See more...

Aliases for NTRK2 Gene

Aliases for NTRK2 Gene

  • Neurotrophic Receptor Tyrosine Kinase 2 2 3 5
  • BDNF/NT-3 Growth Factors Receptor 2 3 4
  • Neurotrophic Tyrosine Kinase Receptor Type 2 3 4
  • Tropomyosin-Related Kinase B 3 4
  • EC 2.7.10.1 4 52
  • GP145-TrkB 3 4
  • Trk-B 3 4
  • TRKB 3 4
  • Neurotrophic Tyrosine Kinase, Receptor, Type 2 2
  • BDNF-Tropomyosine Receptor Kinase B 3
  • Tyrosine Kinase Receptor B 3
  • TrkB Tyrosine Kinase 4
  • EC 2.7.10 52
  • EIEE58 3
  • OBHD 3

External Ids for NTRK2 Gene

Previous GeneCards Identifiers for NTRK2 Gene

  • GC09P078328
  • GC09P079138
  • GC09P080839
  • GC09P082741
  • GC09P084514
  • GC09P086473
  • GC09P087283
  • GC09P057108

Summaries for NTRK2 Gene

Entrez Gene Summary for NTRK2 Gene

  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

CIViC Summary for NTRK2 Gene

GeneCards Summary for NTRK2 Gene

NTRK2 (Neurotrophic Receptor Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with NTRK2 include Obesity, Hyperphagia, And Developmental Delay and Epileptic Encephalopathy, Early Infantile, 58. Among its related pathways are ERK Signaling and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is NTRK3.

UniProtKB/Swiss-Prot Summary for NTRK2 Gene

  • Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

Tocris Summary for NTRK2 Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.

Gene Wiki entry for NTRK2 Gene

Additional gene information for NTRK2 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NTRK2 Gene

Genomics for NTRK2 Gene

GeneHancer (GH) Regulatory Elements for NTRK2 Gene

Promoters and enhancers for NTRK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J084667 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +2.2 2186 6.3 ZNF217 EP300 CTCF ZIC2 ZBTB26 RAD21 EZH2 HDAC2 ZNF341 OSR2 RF00547 NTRK2 piR-43106-208
GH09J083986 Enhancer 1.2 ENCODE dbSUPER 10.7 -680.8 -680786 3.1 FOXK2 ZNF217 ZSCAN5C NCOR1 ZNF639 TCF7 FOXA1 AFF1 HES1 KLF7 NTRK2 KIF27 RMI1 ENSG00000202523
GH09J084954 Enhancer 1.1 FANTOM5 Ensembl dbSUPER 8.3 +285.5 285528 1.2 ZNF217 CTCF RAD21 TRIM22 SMC3 SIN3A YY1 KLF8 E2F6 MYC HSALNG0072321 NTRK2 piR-60140-025
GH09J084693 Enhancer 0.7 Ensembl dbSUPER 11.5 +25.8 25843 0.6 EP300 NBN IKZF1 STAT1 BHLHE40 ZNF687 EBF1 NTRK2 RF00547 piR-43106-208
GH09J084712 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +43.7 43743 0.8 RFX1 FOS STAT3 EBF1 IKZF1 RCOR1 NFIB ZNF217 ZNF687 IKZF2 NTRK2 RF00547 piR-43106-208
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTRK2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NTRK2

Top Transcription factor binding sites by QIAGEN in the NTRK2 gene promoter:
  • AP-1

Genomic Locations for NTRK2 Gene

Genomic Locations for NTRK2 Gene
chr9:84,668,458-85,027,070
(GRCh38/hg38)
Size:
358,613 bases
Orientation:
Plus strand
chr9:87,283,466-87,638,505
(GRCh37/hg19)
Size:
355,040 bases
Orientation:
Plus strand

Genomic View for NTRK2 Gene

Genes around NTRK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTRK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTRK2 Gene

Proteins for NTRK2 Gene

  • Protein details for NTRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16620-NTRK2_HUMAN
    Recommended name:
    BDNF/NT-3 growth factors receptor
    Protein Accession:
    Q16620
    Secondary Accessions:
    • B1ANZ4
    • B4DFV9
    • Q16675
    • Q59GJ1
    • Q8WXJ5
    • Q8WXJ6
    • Q8WXJ7

    Protein attributes for NTRK2 Gene

    Size:
    822 amino acids
    Molecular mass:
    91999 Da
    Quaternary structure:
    • Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor (By similarity). Interacts with SORCS2; this interaction is important for normal targeting to post-synaptic densities in response to high-frequency stimulation (By similarity). Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway (PubMed:10092678). Interacts with APPL1 (By similarity). Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (By similarity). Interacts with SORL1; this interaction facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling (By similarity).
    Miscellaneous:
    • Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.
    • [Isoform TrkB-T1]: Non-catalytic isoform.

    Three dimensional structures from OCA and Proteopedia for NTRK2 Gene

    Alternative splice isoforms for NTRK2 Gene

neXtProt entry for NTRK2 Gene

Selected DME Specific Peptides for NTRK2 Gene

Q16620:
  • RWMPPESI
  • SKFGMKGP
  • HHWCIPF
  • HRDLATRN
  • EYHGCLQLDNPTH
  • FVHRDLATRNC
  • VKFYGVC
  • ISCVAEN
  • GVVLWEI
  • FTYGKQPW
  • LQHEHIVKFYGVC
  • EVIECITQGRVL
  • YTLIAKN
  • GDPLIMVFEYMKHGDLN
  • ELGEGAFGKVFLAEC
  • FVHRDLA
  • YICTKIHV

Post-translational modifications for NTRK2 Gene

  • Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.
  • Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).
  • Glycosylation at Asn178, Asn205, Asn67, Asn241, Asn95, Asn254, Asn121, Asn280, Asn325, Asn338, and Asn412
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NTRK2_HUMAN (1029)

Antibody Products

  • Abcam antibodies for NTRK2

Domains & Families for NTRK2 Gene

Gene Families for NTRK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for NTRK2 Gene

Blocks:
  • Immunoglobulin C-2 type
  • Tyrosine protein kinase, active site
  • Cysteine-rich flanking region, C-terminal
  • Receptor tyrosine kinase, class II
  • Cysteine-rich flanking region, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NTRK2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53976, highly similar to BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (B4DFV9_HUMAN)
  • TrkB tyrosine kinase (NTRK2_HUMAN)
  • Tyrosine-protein kinase receptor (Q548C2_HUMAN)
  • cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA (Q5VWE5_HUMAN)
  • Neurotrophin receptor tyrosine kinase type 2 (Q8WXJ4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16620

UniProtKB/Swiss-Prot:

NTRK2_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with NTRK2: view

Function for NTRK2 Gene

Molecular function for NTRK2 Gene

UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255 PROSITE-ProRule:PRU10028, ECO:0000269 PubMed:15494731};.
UniProtKB/Swiss-Prot EnzymeRegulation:
The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity).
GENATLAS Biochemistry:
receptor tyrosine kinase B,linking brain derived neurotrophic factor (BDNF),neurotrophin (NTF4)

Enzyme Numbers (IUBMB) for NTRK2 Gene

Phenotypes From GWAS Catalog for NTRK2 Gene

Gene Ontology (GO) - Molecular Function for NTRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA 21873635
GO:0005030 neurotrophin receptor activity IBA 21873635
genes like me logo Genes that share ontologies with NTRK2: view
genes like me logo Genes that share phenotypes with NTRK2: view

Human Phenotype Ontology for NTRK2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NTRK2 Gene

MGI Knock Outs for NTRK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NTRK2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTRK2

Clone Products

  • Addgene plasmids for NTRK2

No data available for Transcription Factor Targets and HOMER Transcription for NTRK2 Gene

Localization for NTRK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTRK2 Gene

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Cell junction, synapse, postsynaptic density. Note=Internalized to endosomes upon ligand-binding. {ECO:0000250 UniProtKB:P15209}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTRK2 gene
Compartment Confidence
plasma membrane 5
endosome 4
cytosol 4
golgi apparatus 4
extracellular 3
cytoskeleton 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NTRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome ISS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with NTRK2: view

Pathways & Interactions for NTRK2 Gene

PathCards logo

SuperPathways for NTRK2 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
5 Apoptosis Pathway
genes like me logo Genes that share pathways with NTRK2: view

Pathways by source for NTRK2 Gene

3 Tocris pathways for NTRK2 Gene
58 Qiagen pathways for NTRK2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
2 Cell Signaling Technology pathways for NTRK2 Gene

SIGNOR curated interactions for NTRK2 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for NTRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001764 neuron migration ISS --
GO:0001934 positive regulation of protein phosphorylation TAS 19036963
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with NTRK2: view

Drugs & Compounds for NTRK2 Gene

(59) Drugs for NTRK2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Entrectinib Approved, Investigational Pharma Target, inhibitor Orally active inhibitor of ALK kinase 13
Tyrosine Approved, Investigational Nutra 985
Amitriptyline Approved Pharma Antagonist, Target, agonist 119
Esketamine Approved, Investigational Pharma Target 58
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0

(23) Additional Compounds for NTRK2 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
AG 879
148741-30-4
LM11A 31 dihydrochloride
1243259-19-9

(4) Tocris Compounds for NTRK2 Gene

Compound Action Cas Number
AG 879 TrkA inhibitor 148741-30-4
BDNF (human) Activates TrkB and p75 receptors 218441-99-7
LM11A 31 dihydrochloride Nonpeptide p75NTR ligand; neuroprotective 1243259-19-9
TLQP 21 VGF-derived peptide 869988-94-3

(8) ApexBio Compounds for NTRK2 Gene

Compound Action Cas Number
7,8-Dihydroxyflavone 38183-03-8
ANA 12 TrkB receptor antagonist 219766-25-3
BDNF (human) 218441-99-7
Cyclotraxin B 1203586-72-4
GNF-5837 Pan-Trk inhibitor 1033769-28-6
GW441756 TrkA inhibitor,potent and selective 504433-23-2
LM 22A4 37988-18-4
NTR 368 197230-90-3
genes like me logo Genes that share compounds with NTRK2: view

Transcripts for NTRK2 Gene

mRNA/cDNA for NTRK2 Gene

27 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTRK2

Clone Products

  • Addgene plasmids for NTRK2

Alternative Splicing Database (ASD) splice patterns (SP) for NTRK2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:
SP9: -
SP10:

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NTRK2 Gene

GeneLoc Exon Structure for
NTRK2

Expression for NTRK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NTRK2 Gene

mRNA differential expression in normal tissues according to GTEx for NTRK2 Gene

This gene is overexpressed in Brain - Amygdala (x6.6), Brain - Caudate (basal ganglia) (x5.2), Brain - Nucleus accumbens (basal ganglia) (x4.9), and Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for NTRK2 Gene

This gene is overexpressed in Frontal cortex (33.1) and Cerebrospinal fluid (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTRK2 Gene



Protein tissue co-expression partners for NTRK2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NTRK2

SOURCE GeneReport for Unigene cluster for NTRK2 Gene:

Hs.494312

mRNA Expression by UniProt/SwissProt for NTRK2 Gene:

Q16620-NTRK2_HUMAN
Tissue specificity: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.

Evidence on tissue expression from TISSUES for NTRK2 Gene

  • Nervous system(5)
  • Bone marrow(4.2)
  • Eye(3)
  • Adrenal gland(2.4)
  • Muscle(2.2)
  • Lung(2.1)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NTRK2 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • head
genes like me logo Genes that share expression patterns with NTRK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NTRK2 Gene

Orthologs for NTRK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTRK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTRK2 31 30
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NTRK2 31 30
  • 92.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NTRK2 31 30
  • 91.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ntrk2 17 31 30
  • 87.62 (n)
rat
(Rattus norvegicus)
Mammalia Ntrk2 30
  • 87.54 (n)
oppossum
(Monodelphis domestica)
Mammalia NTRK2 31
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTRK2 31
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTRK2 31 30
  • 76.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTRK2 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntrk2 30
  • 68.01 (n)
Str.17749 30
African clawed frog
(Xenopus laevis)
Amphibia trkb-B-prov 30
zebrafish
(Danio rerio)
Actinopterygii ntrk2b 31 30
  • 64.79 (n)
OneToMany
ntrk2a 31
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trk-1 31
  • 22 (a)
OneToMany
Species where no ortholog for NTRK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTRK2 Gene

ENSEMBL:
Gene Tree for NTRK2 (if available)
TreeFam:
Gene Tree for NTRK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NTRK2: view image

Paralogs for NTRK2 Gene

(4) SIMAP similar genes for NTRK2 Gene using alignment to 5 proteins:

  • NTRK2_HUMAN
  • Q548C2_HUMAN
  • Q5VWE5_HUMAN
  • Q8WXJ4_HUMAN
  • Q8WXJ8_HUMAN
genes like me logo Genes that share paralogs with NTRK2: view

Variants for NTRK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NTRK2 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
713717 Benign: not provided 84,727,733(+) C/A SYNONYMOUS_VARIANT
722021 Likely Benign: not provided 84,955,307(+) G/A SYNONYMOUS_VARIANT
728564 Likely Benign: not provided 85,021,398(+) G/A SYNONYMOUS_VARIANT
730743 Likely Benign: not provided 85,020,226(+) G/A SYNONYMOUS_VARIANT
732652 Likely Benign: not provided 84,670,934(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NTRK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NTRK2 Gene

Variant ID Type Subtype PubMed ID
esv1009365 CNV deletion 20482838
esv1919120 CNV deletion 18987734
esv2214442 CNV deletion 18987734
esv23418 CNV loss 19812545
esv23628 CNV loss 19812545
esv2424316 CNV deletion 19546169
esv2434739 CNV deletion 19546169
esv2533224 CNV insertion 19546169
esv2662088 CNV deletion 23128226
esv2667995 CNV deletion 23128226
esv2738670 CNV deletion 23290073
esv2738671 CNV deletion 23290073
esv2738672 CNV deletion 23290073
esv2738674 CNV deletion 23290073
esv3303293 CNV mobile element insertion 20981092
esv3337919 CNV insertion 20981092
esv3361675 CNV insertion 20981092
esv3405858 CNV insertion 20981092
esv3545028 CNV deletion 23714750
esv3620922 CNV loss 21293372
esv3620927 CNV loss 21293372
esv4028 CNV loss 18987735
esv7446 CNV loss 19470904
esv994018 CNV gain 20482838
nsv1048977 CNV gain 25217958
nsv1110825 CNV insertion 24896259
nsv1141002 CNV deletion 24896259
nsv1143228 CNV tandem duplication 24896259
nsv436717 OTHER inversion 17901297
nsv475614 CNV novel sequence insertion 20440878
nsv476741 CNV novel sequence insertion 20440878
nsv614764 CNV loss 21841781
nsv956130 CNV deletion 24416366

Variation tolerance for NTRK2 Gene

Residual Variation Intolerance Score: 6.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTRK2 Gene

Human Gene Mutation Database (HGMD)
NTRK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTRK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTRK2 Gene

Disorders for NTRK2 Gene

MalaCards: The human disease database

(50) MalaCards diseases for NTRK2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NTRK2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NTRK2_HUMAN
  • Epileptic encephalopathy, early infantile, 58 (EIEE58) [MIM:617830]: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE58 is an autosomal dominant condition characterized by onset of refractory seizures in the first days or months of life. {ECO:0000269 PubMed:29100083}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
  • Obesity, hyperphagia, and developmental delay (OBHD) [MIM:613886]: A disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language. {ECO:0000269 PubMed:15494731, ECO:0000269 PubMed:27884935, ECO:0000269 PubMed:29100083}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NTRK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NTRK2: view

No data available for Genatlas for NTRK2 Gene

Publications for NTRK2 Gene

  1. Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). (PMID: 7789988) Nakagawara A … Brodeur GM (Genomics 1995) 2 3 4 23 54
  2. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. (PMID: 19844206) Dong C … Licinio J (Molecular psychiatry 2009) 3 23 41 54
  3. Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. (PMID: 18534558) Li MD … Elston RC (Biological psychiatry 2008) 3 23 41 54
  4. Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease. (PMID: 17918233) Chen Z … Go RC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41 54
  5. The pharmacogenetics of lithium response depends upon clinical co-morbidity. (PMID: 17570738) Bremer T … Kelsoe JR (Molecular diagnosis & therapy 2007) 3 23 41 54

Products for NTRK2 Gene