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Aliases for NTRK2 Gene

Aliases for NTRK2 Gene

  • Neurotrophic Receptor Tyrosine Kinase 2 2 3 5
  • BDNF/NT-3 Growth Factors Receptor 2 3 4
  • Neurotrophic Tyrosine Kinase Receptor Type 2 3 4
  • Tropomyosin-Related Kinase B 3 4
  • EC 2.7.10.1 4 56
  • GP145-TrkB 3 4
  • Trk-B 3 4
  • TRKB 3 4
  • Neurotrophic Tyrosine Kinase, Receptor, Type 2 2
  • BDNF-Tropomyosine Receptor Kinase B 3
  • Tyrosine Kinase Receptor B 3
  • TrkB Tyrosine Kinase 4
  • EC 2.7.10 56
  • EIEE58 3
  • OBHD 3

External Ids for NTRK2 Gene

Previous GeneCards Identifiers for NTRK2 Gene

  • GC09P078328
  • GC09P079138
  • GC09P080839
  • GC09P082741
  • GC09P084514
  • GC09P086473
  • GC09P087283
  • GC09P057108

Summaries for NTRK2 Gene

Entrez Gene Summary for NTRK2 Gene

  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

CIViC summary for NTRK2 Gene

GeneCards Summary for NTRK2 Gene

NTRK2 (Neurotrophic Receptor Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with NTRK2 include Obesity, Hyperphagia, And Developmental Delay and Epileptic Encephalopathy, Early Infantile, 58. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is NTRK3.

UniProtKB/Swiss-Prot for NTRK2 Gene

  • Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

Tocris Summary for NTRK2 Gene

  • Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3K and PLCgamma signaling pathways. Four members of the Trk family have been identified.

Gene Wiki entry for NTRK2 Gene

Additional gene information for NTRK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTRK2 Gene

Genomics for NTRK2 Gene

GeneHancer (GH) Regulatory Elements for NTRK2 Gene

Promoters and enhancers for NTRK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J084667 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 600.7 +2.2 2243 6.2 CTCF RAD21 CREB1 GLIS2 ZBTB8A NRF1 ZNF600 ZIC2 ZNF143 ZSCAN4 GC09P084671 NTRK2 GC09P085030
GH09J084954 Enhancer 1.2 FANTOM5 Ensembl dbSUPER 8.3 +284.8 284843 3.8 CTCF MAFK SP7 CREM RAD21 CREB1 ZNF600 ZNF143 POLR2A TRIM22 NTRK2 GC09P085030 GC09P084671
GH09J084693 Enhancer 0.7 Ensembl dbSUPER 11.5 +25.9 25902 0.7 ZNF687 IKZF1 PKNOX1 NBN NTRK2 GC09P084671 GC09P085030
GH09J084712 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +43.7 43743 0.8 ZNF687 NFIB IKZF1 IKZF2 RFX1 RCOR1 EBF1 FOS ZNF217 NTRK2 GC09P084671 GC09P085030
GH09J084758 Enhancer 1.2 FANTOM5 Ensembl ENCODE 4.1 +91.1 91063 1.4 SP1 ZNF687 RELA CREM MLLT1 IKZF1 BACH1 IKZF2 TRIM22 CBFB NTRK2 GC09P084671 GC09P085030
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTRK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NTRK2 gene promoter:
  • AP-1

Genomic Locations for NTRK2 Gene

Genomic Locations for NTRK2 Gene
chr9:84,668,458-85,027,070
(GRCh38/hg38)
Size:
358,613 bases
Orientation:
Plus strand
chr9:87,283,466-87,638,505
(GRCh37/hg19)
Size:
355,040 bases
Orientation:
Plus strand

Genomic View for NTRK2 Gene

Genes around NTRK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTRK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTRK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTRK2 Gene

Proteins for NTRK2 Gene

  • Protein details for NTRK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16620-NTRK2_HUMAN
    Recommended name:
    BDNF/NT-3 growth factors receptor
    Protein Accession:
    Q16620
    Secondary Accessions:
    • B1ANZ4
    • B4DFV9
    • Q16675
    • Q59GJ1
    • Q8WXJ5
    • Q8WXJ6
    • Q8WXJ7

    Protein attributes for NTRK2 Gene

    Size:
    822 amino acids
    Molecular mass:
    91999 Da
    Quaternary structure:
    • Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor. Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway. Interacts with APPL1 (By similarity). Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (By similarity).
    Miscellaneous:
    • Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.

    Three dimensional structures from OCA and Proteopedia for NTRK2 Gene

    Alternative splice isoforms for NTRK2 Gene

neXtProt entry for NTRK2 Gene

Selected DME Specific Peptides for NTRK2 Gene

Q16620:
  • RWMPPESI
  • SKFGMKGP
  • HHWCIPF
  • HRDLATRN
  • EYHGCLQLDNPTH
  • FVHRDLATRNC
  • VKFYGVC
  • ISCVAEN
  • GVVLWEI
  • FTYGKQPW
  • LQHEHIVKFYGVC
  • EVIECITQGRVL
  • YTLIAKN
  • GDPLIMVFEYMKHGDLN
  • ELGEGAFGKVFLAEC
  • FVHRDLA
  • YICTKIHV

Post-translational modifications for NTRK2 Gene

  • Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.
  • Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).
  • Glycosylation at isoforms=4, 5, 7, 3, 6, 2178, isoforms=4, 5, 7, 3, 6, 2241, posLast=325325, isoforms=4, 5, 7, 3, 6, 2205, posLast=412412, posLast=280280, posLast=254254, isoforms=4, 5, 3, 6, 2121, isoforms=4, 5, 3, 6, 295, posLast=6767, and isoforms=4, 5, 7, 3, 6, 2338
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • NTRK2_HUMAN (1029)

Antibody Products

  • Abcam antibodies for NTRK2

Domains & Families for NTRK2 Gene

Gene Families for NTRK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for NTRK2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53976, highly similar to BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (B4DFV9_HUMAN)
  • TrkB tyrosine kinase (NTRK2_HUMAN)
  • Tyrosine-protein kinase receptor (Q548C2_HUMAN)
  • cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA (Q5VWE5_HUMAN)
  • Neurotrophin receptor tyrosine kinase type 2 (Q8WXJ4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16620

UniProtKB/Swiss-Prot:

NTRK2_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with NTRK2: view

Function for NTRK2 Gene

Molecular function for NTRK2 Gene

UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity).
GENATLAS Biochemistry:
receptor tyrosine kinase B,linking brain derived neurotrophic factor (BDNF),neurotrophin (NTF4)

Enzyme Numbers (IUBMB) for NTRK2 Gene

Phenotypes From GWAS Catalog for NTRK2 Gene

Gene Ontology (GO) - Molecular Function for NTRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA 21873635
GO:0005030 neurotrophin receptor activity IBA 21873635
genes like me logo Genes that share ontologies with NTRK2: view
genes like me logo Genes that share phenotypes with NTRK2: view

Human Phenotype Ontology for NTRK2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NTRK2 Gene

MGI Knock Outs for NTRK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NTRK2

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NTRK2 - Now 50% OFF >
  • * NTRK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NTRK2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for NTRK2

No data available for Transcription Factor Targets and HOMER Transcription for NTRK2 Gene

Localization for NTRK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTRK2 Gene

Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Note=Internalized to endosomes upon ligand-binding. {ECO:0000250 UniProtKB:P15209}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTRK2 gene
Compartment Confidence
plasma membrane 5
endosome 4
golgi apparatus 4
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NTRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome ISS --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with NTRK2: view

Pathways & Interactions for NTRK2 Gene

genes like me logo Genes that share pathways with NTRK2: view

SIGNOR curated interactions for NTRK2 Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for NTRK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis IEA --
GO:0001764 neuron migration ISS --
GO:0001934 positive regulation of protein phosphorylation TAS 19036963
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with NTRK2: view

Drugs & Compounds for NTRK2 Gene

(59) Drugs for NTRK2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tyrosine Approved, Investigational Nutra 903
Amitriptyline Approved Pharma Antagonist, Target, agonist 118
Esketamine Approved, Investigational Pharma Target 56
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Larotrectinib Approved, Investigational Pharma Target, inhibitor 0

(23) Additional Compounds for NTRK2 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
AG 879
148741-30-4
LM11A 31 dihydrochloride
1243259-19-9

(4) Tocris Compounds for NTRK2 Gene

Compound Action Cas Number
AG 879 TrkA inhibitor 148741-30-4
BDNF (human) Activates TrkB and p75 receptors 218441-99-7
LM11A 31 dihydrochloride Nonpeptide p75NTR ligand; neuroprotective 1243259-19-9
TLQP 21 VGF-derived peptide 869988-94-3

(8) ApexBio Compounds for NTRK2 Gene

Compound Action Cas Number
7,8-Dihydroxyflavone 38183-03-8
ANA 12 TrkB receptor antagonist 219766-25-3
BDNF (human) 218441-99-7
Cyclotraxin B 1203586-72-4
GNF-5837 Pan-Trk inhibitor 1033769-28-6
GW441756 TrkA inhibitor,potent and selective 504433-23-2
LM 22A4 37988-18-4
NTR 368 197230-90-3
genes like me logo Genes that share compounds with NTRK2: view

Transcripts for NTRK2 Gene

Unigene Clusters for NTRK2 Gene

Neurotrophic tyrosine kinase, receptor, type 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for NTRK2 - Now 50% OFF >
  • * NTRK2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NTRK2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for NTRK2

Alternative Splicing Database (ASD) splice patterns (SP) for NTRK2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:
SP9: -
SP10:

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NTRK2 Gene

GeneLoc Exon Structure for
NTRK2
ECgene alternative splicing isoforms for
NTRK2

Expression for NTRK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTRK2 Gene

mRNA differential expression in normal tissues according to GTEx for NTRK2 Gene

This gene is overexpressed in Brain - Amygdala (x6.6), Brain - Caudate (basal ganglia) (x5.2), Brain - Nucleus accumbens (basal ganglia) (x4.9), and Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for NTRK2 Gene

This gene is overexpressed in Frontal cortex (33.1) and Cerebrospinal fluid (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTRK2 Gene



Protein tissue co-expression partners for NTRK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NTRK2 Gene:

NTRK2

SOURCE GeneReport for Unigene cluster for NTRK2 Gene:

Hs.494312

mRNA Expression by UniProt/SwissProt for NTRK2 Gene:

Q16620-NTRK2_HUMAN
Tissue specificity: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.

Evidence on tissue expression from TISSUES for NTRK2 Gene

  • Nervous system(5)
  • Bone marrow(4.2)
  • Eye(3)
  • Adrenal gland(2.4)
  • Muscle(2.2)
  • Lung(2.1)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NTRK2 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • head
genes like me logo Genes that share expression patterns with NTRK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NTRK2 Gene

Orthologs for NTRK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTRK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTRK2 35 34
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NTRK2 35 34
  • 92.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NTRK2 35 34
  • 91.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ntrk2 17 35 34
  • 87.62 (n)
rat
(Rattus norvegicus)
Mammalia Ntrk2 34
  • 87.54 (n)
oppossum
(Monodelphis domestica)
Mammalia NTRK2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTRK2 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTRK2 35 34
  • 76.98 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTRK2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntrk2 34
  • 68.01 (n)
Str.17749 34
African clawed frog
(Xenopus laevis)
Amphibia trkb-B-prov 34
zebrafish
(Danio rerio)
Actinopterygii ntrk2b 35 34
  • 64.79 (n)
OneToMany
ntrk2a 35
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trk-1 35
  • 22 (a)
OneToMany
Species where no ortholog for NTRK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTRK2 Gene

ENSEMBL:
Gene Tree for NTRK2 (if available)
TreeFam:
Gene Tree for NTRK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NTRK2: view image

Paralogs for NTRK2 Gene

(4) SIMAP similar genes for NTRK2 Gene using alignment to 5 proteins:

  • NTRK2_HUMAN
  • Q548C2_HUMAN
  • Q5VWE5_HUMAN
  • Q8WXJ4_HUMAN
  • Q8WXJ8_HUMAN
genes like me logo Genes that share paralogs with NTRK2: view

Variants for NTRK2 Gene

Sequence variations from dbSNP and Humsavar for NTRK2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1085308029 pathogenic, Obesity, hyperphagia, and developmental delay 84,752,019(+) G/T coding_sequence_variant, stop_gained
rs121434633 pathogenic, Obesity, hyperphagia, and developmental delay, Obesity, hyperphagia, and developmental delay (OBHD) [MIM:613886] 84,955,510(+) A/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1324578301 A lung carcinoma sample 85,020,233(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1554774973 pathogenic, Obesity, hyperphagia, and developmental delay 84,955,504(+) C/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs201362502 other, Neuroblastoma 84,727,770(+) T/A/C coding_sequence_variant, missense_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for NTRK2 Gene

Variant ID Type Subtype PubMed ID
esv1009365 CNV deletion 20482838
esv1919120 CNV deletion 18987734
esv2214442 CNV deletion 18987734
esv23418 CNV loss 19812545
esv23628 CNV loss 19812545
esv2424316 CNV deletion 19546169
esv2434739 CNV deletion 19546169
esv2533224 CNV insertion 19546169
esv2662088 CNV deletion 23128226
esv2667995 CNV deletion 23128226
esv2738670 CNV deletion 23290073
esv2738671 CNV deletion 23290073
esv2738672 CNV deletion 23290073
esv2738674 CNV deletion 23290073
esv3303293 CNV mobile element insertion 20981092
esv3337919 CNV insertion 20981092
esv3361675 CNV insertion 20981092
esv3405858 CNV insertion 20981092
esv3545028 CNV deletion 23714750
esv3620922 CNV loss 21293372
esv3620927 CNV loss 21293372
esv4028 CNV loss 18987735
esv7446 CNV loss 19470904
esv994018 CNV gain 20482838
nsv1048977 CNV gain 25217958
nsv1110825 CNV insertion 24896259
nsv1141002 CNV deletion 24896259
nsv1143228 CNV tandem duplication 24896259
nsv436717 OTHER inversion 17901297
nsv475614 CNV novel sequence insertion 20440878
nsv476741 CNV novel sequence insertion 20440878
nsv614764 CNV loss 21841781
nsv956130 CNV deletion 24416366

Variation tolerance for NTRK2 Gene

Residual Variation Intolerance Score: 6.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTRK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTRK2
Human Gene Mutation Database (HGMD)
NTRK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTRK2 Gene

Disorders for NTRK2 Gene

MalaCards: The human disease database

(29) MalaCards diseases for NTRK2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search NTRK2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NTRK2_HUMAN
  • Epileptic encephalopathy, early infantile, 58 (EIEE58) [MIM:617830]: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE58 is an autosomal dominant condition characterized by onset of refractory seizures in the first days or months of life. {ECO:0000269 PubMed:29100083}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
  • Obesity, hyperphagia, and developmental delay (OBHD) [MIM:613886]: A disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language. {ECO:0000269 PubMed:15494731, ECO:0000269 PubMed:27884935, ECO:0000269 PubMed:29100083}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for NTRK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NTRK2: view

No data available for Genatlas for NTRK2 Gene

Publications for NTRK2 Gene

  1. Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). (PMID: 7789988) Nakagawara A … Brodeur GM (Genomics 1995) 2 3 4 23 58
  2. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans. (PMID: 19844206) Dong C … Licinio J (Molecular psychiatry 2009) 3 23 45 58
  3. Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease. (PMID: 17918233) Chen Z … Go RC (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 45 58
  4. Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. (PMID: 18534558) Li MD … Elston RC (Biological psychiatry 2008) 3 23 45 58
  5. Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans. (PMID: 16713586) Beuten J … Li MD (Biological psychiatry 2007) 3 23 45 58

Products for NTRK2 Gene