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Aliases for NTPCR Gene

Aliases for NTPCR Gene

  • Nucleoside-Triphosphatase, Cancer-Related 2 3 5
  • Cancer-Related Nucleoside-Triphosphatase 3 4
  • Nucleoside Triphosphate Phosphohydrolase 3 4
  • Human Cancer-Related NTPase 2 3
  • C1orf57 3 4
  • Chromosome 1 Open Reading Frame 57 2
  • Nucleoside-Triphosphatase C1orf57 3
  • EC 3.6.1.15 4
  • HCR-NTPase 3
  • NTPase 4
  • THEP1 3

External Ids for NTPCR Gene

Previous HGNC Symbols for NTPCR Gene

  • C1orf57

Previous GeneCards Identifiers for NTPCR Gene

  • GC01P233087

Summaries for NTPCR Gene

Entrez Gene Summary for NTPCR Gene

  • The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]

GeneCards Summary for NTPCR Gene

NTPCR (Nucleoside-Triphosphatase, Cancer-Related) is a Protein Coding gene. Among its related pathways are Thiamine metabolism and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot for NTPCR Gene

  • Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

Additional gene information for NTPCR Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTPCR Gene

Genomics for NTPCR Gene

GeneHancer (GH) Regulatory Elements for NTPCR Gene

Promoters and enhancers for NTPCR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J232949 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 648.4 +1.2 1163 4 HDGF ZFX CTCF ZKSCAN8 ZNF148 POLR2A ZNF384 ZNF687 ZSCAN21 AHR NTPCR GC01M232948 RPS7P3 MAP10 GC01M232977
GH01J232943 Enhancer 1 Ensembl ENCODE dbSUPER 47.2 -6.6 -6635 2.2 ZNF687 IKZF1 ZNF512 DPF2 RUNX3 NR2F1 ZFHX2 ATF7 POLR2A EGR2 NTPCR ENSG00000232175
GH01J232977 Enhancer 0.9 Ensembl ENCODE dbSUPER 47.1 +28.2 28245 2 ZBTB8A ZNF629 ZXDB RCOR1 FEZF1 ZBTB6 ETV6 NTPCR MAP10 RNU6-1211P GC01M232977 GC01M232948
GH01J232934 Enhancer 0.9 Ensembl dbSUPER 44.5 -15.0 -15035 1.4 ZNF384 ATF1 HDAC1 SOX6 CTBP1 NFE2 HDAC2 MAFG MAFK NFIC NTPCR ENSG00000232175
GH01J232937 Enhancer 0.8 dbSUPER 46 -12.5 -12497 2 TRIM24 ZNF639 SMARCA4 LEF1 HDAC1 EP300 CEBPB SOX6 CTBP1 MAFK NTPCR RPS7P3 RNU6-1211P ENSG00000232175
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTPCR on UCSC Golden Path with GeneCards custom track

Genomic Locations for NTPCR Gene

Genomic Locations for NTPCR Gene
chr1:232,950,536-232,983,882
(GRCh38/hg38)
Size:
33,347 bases
Orientation:
Plus strand
chr1:233,086,351-233,119,628
(GRCh37/hg19)
Size:
33,278 bases
Orientation:
Plus strand

Genomic View for NTPCR Gene

Genes around NTPCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTPCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTPCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTPCR Gene

Proteins for NTPCR Gene

  • Protein details for NTPCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSD7-NTPCR_HUMAN
    Recommended name:
    Cancer-related nucleoside-triphosphatase
    Protein Accession:
    Q9BSD7

    Protein attributes for NTPCR Gene

    Size:
    190 amino acids
    Molecular mass:
    20713 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NTPCR Gene

neXtProt entry for NTPCR Gene

Post-translational modifications for NTPCR Gene

  • Ubiquitination at posLast=2121
  • Modification sites at PhosphoSitePlus

Other Protein References for NTPCR Gene

No data available for DME Specific Peptides for NTPCR Gene

Domains & Families for NTPCR Gene

Gene Families for NTPCR Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NTPCR Gene

Suggested Antigen Peptide Sequences for NTPCR Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside triphosphate phosphohydrolase (NTPCR_HUMAN)
  • cDNA, FLJ95865 (Q5TDE9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BSD7

UniProtKB/Swiss-Prot:

NTPCR_HUMAN :
  • Belongs to the THEP1 NTPase family.
Family:
  • Belongs to the THEP1 NTPase family.
genes like me logo Genes that share domains with NTPCR: view

Function for NTPCR Gene

Molecular function for NTPCR Gene

UniProtKB/Swiss-Prot Function:
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5 uM for ATP {ECO:0000269 PubMed:17291528}; KM=46 uM for ADP {ECO:0000269 PubMed:17291528}; KM=4 uM for GTP {ECO:0000269 PubMed:17291528}; KM=6 uM for CTP {ECO:0000269 PubMed:17291528}; KM=7 uM for TTP {ECO:0000269 PubMed:17291528};

Enzyme Numbers (IUBMB) for NTPCR Gene

Phenotypes From GWAS Catalog for NTPCR Gene

Gene Ontology (GO) - Molecular Function for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0017111 nucleoside-triphosphatase activity IEA --
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides IEA --
genes like me logo Genes that share ontologies with NTPCR: view
genes like me logo Genes that share phenotypes with NTPCR: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTPCR

Clone Products

  • Applied Biological Materials (abm): Clones for NTPCR - Now 50% OFF >
  • * NTPCR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NTPCR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for NTPCR

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NTPCR Gene

Localization for NTPCR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTPCR gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with NTPCR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NTPCR Gene

Pathways & Interactions for NTPCR Gene

genes like me logo Genes that share pathways with NTPCR: view

Gene Ontology (GO) - Biological Process for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NTPCR: view

No data available for SIGNOR curated interactions for NTPCR Gene

Drugs & Compounds for NTPCR Gene

(3) Drugs for NTPCR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(4) Additional Compounds for NTPCR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
NTP
thiamine monophosphate
  • THIAMIN phosphATE
  • THIAMIN phosphoric acid
  • Thiamine monophosphoric acid
  • Aneurin-monophosphorsaeureester
  • Aneurine monophosphate
495-23-8
Thiamine pyrophosphate
  • Thiamin diphosphate
  • Thiamin pyrophosphate
  • Thiamine diphosphate
  • THPP
  • TPP
154-87-0
genes like me logo Genes that share compounds with NTPCR: view

Transcripts for NTPCR Gene

Unigene Clusters for NTPCR Gene

Nucleoside-triphosphatase, cancer-related:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NTPCR

Clone Products

  • Applied Biological Materials (abm): Clones for NTPCR - Now 50% OFF >
  • * NTPCR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NTPCR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
  • Addgene plasmids for NTPCR

Alternative Splicing Database (ASD) splice patterns (SP) for NTPCR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - -
SP7: - - - - - - -
SP8:
SP9: -

Relevant External Links for NTPCR Gene

GeneLoc Exon Structure for
NTPCR
ECgene alternative splicing isoforms for
NTPCR

Expression for NTPCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTPCR Gene

Protein differential expression in normal tissues from HIPED for NTPCR Gene

This gene is overexpressed in Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NTPCR Gene



Protein tissue co-expression partners for NTPCR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NTPCR Gene:

NTPCR

SOURCE GeneReport for Unigene cluster for NTPCR Gene:

Hs.642715

Evidence on tissue expression from TISSUES for NTPCR Gene

  • Nervous system(4.5)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with NTPCR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTPCR Gene

Orthologs for NTPCR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NTPCR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTPCR 35 34
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NTPCR 35 34
  • 85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NTPCR 35 34
  • 83.33 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTPCR 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntpcr 17 35 34
  • 79.72 (n)
rat
(Rattus norvegicus)
Mammalia Ntpcr 34
  • 79.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NTPCR 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTPCR 35 34
  • 71.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTPCR 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntpcr 34
  • 61.58 (n)
zebrafish
(Danio rerio)
Actinopterygii ntpcr 35 34
  • 60.69 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10581 35 34
  • 49.8 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005921 34
  • 43.65 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G66005 34
  • 48.08 (n)
Species where no ortholog for NTPCR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTPCR Gene

ENSEMBL:
Gene Tree for NTPCR (if available)
TreeFam:
Gene Tree for NTPCR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NTPCR: view image

Paralogs for NTPCR Gene

(1) SIMAP similar genes for NTPCR Gene using alignment to 2 proteins:

  • NTPCR_HUMAN
  • Q5TDF0_HUMAN

Pseudogenes.org Pseudogenes for NTPCR Gene

genes like me logo Genes that share paralogs with NTPCR: view

No data available for Paralogs for NTPCR Gene

Variants for NTPCR Gene

Sequence variations from dbSNP and Humsavar for NTPCR Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000065437 -- 232,967,791(+) G/A intron_variant
rs1000134563 -- 232,960,596(+) C/A intron_variant
rs1000142043 -- 232,965,995(+) G/A intron_variant
rs1000215964 -- 232,968,151(+) ACC/ACCACC intron_variant
rs1000219224 -- 232,960,861(+) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NTPCR Gene

Variant ID Type Subtype PubMed ID
esv2750829 CNV gain 17911159
esv3578476 CNV loss 25503493

Variation tolerance for NTPCR Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTPCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTPCR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTPCR Gene

Disorders for NTPCR Gene

Additional Disease Information for NTPCR

No disorders were found for NTPCR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTPCR Gene

Publications for NTPCR Gene

  1. NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase. (PMID: 17291528) Placzek WJ … Wüthrich K (Journal of molecular biology 2007) 2 3 4 58
  2. On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y. (PMID: 19519914) Pasdziernik M … Kaufmann M (BMC research notes 2009) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells. (PMID: 29490077) Miotto B … Defossez PA (Nucleic acids research 2018) 3 58
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 58

Products for NTPCR Gene

Sources for NTPCR Gene

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