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Aliases for NTPCR Gene

Aliases for NTPCR Gene

  • Nucleoside-Triphosphatase, Cancer-Related 2 3 5
  • Nucleoside Triphosphate Phosphohydrolase 3 4
  • Human Cancer-Related NTPase 2 3
  • C1orf57 3 4
  • Cancer-Related Nucleoside-Triphosphatase 3
  • Chromosome 1 Open Reading Frame 57 2
  • Nucleoside-Triphosphatase C1orf57 3
  • EC 4
  • HCR-NTPase 3
  • NTPase 4

External Ids for NTPCR Gene

Previous HGNC Symbols for NTPCR Gene

  • C1orf57

Previous GeneCards Identifiers for NTPCR Gene

  • GC01P233087

Summaries for NTPCR Gene

Entrez Gene Summary for NTPCR Gene

  • The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]

GeneCards Summary for NTPCR Gene

NTPCR (Nucleoside-Triphosphatase, Cancer-Related) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Thiamine metabolism. Gene Ontology (GO) annotations related to this gene include nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot for NTPCR Gene

  • Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

Additional gene information for NTPCR Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTPCR Gene

Genomics for NTPCR Gene

GeneHancer (GH) Regulatory Elements for NTPCR Gene

Promoters and enhancers for NTPCR Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I232949 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 598.5 +0.2 199 2.1 HDGF PKNOX1 SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF207 KLF13 NTPCR GC01M232948 RPS7P3 MAP10 GC01M232977
GH01I232937 Enhancer 1 Ensembl dbSUPER 45.8 -12.5 -12469 0.7 HDAC1 ATF1 LEF1 TEAD4 TAL1 MAX CEBPG FOSL1 CTBP1 POLR2A NTPCR RNU6-1211P LOC105373201
GH01I232923 Enhancer 0.9 Ensembl ENCODE dbSUPER 45.8 -26.3 -26322 1 PKNOX1 CBFB IKZF1 ETV6 ELF1 RUNX3 NTPCR LOC105373201
GH01I232952 Enhancer 0.9 ENCODE 41.9 +2.5 2513 1.3 HDGF PKNOX1 INSM2 KLF17 MZF1 ZNF2 RAD21 ZNF213 ZNF366 ZNF143 NTPCR MAP10 GC01M232948 GC01M232977
GH01I232962 Enhancer 0.8 Ensembl ENCODE dbSUPER 42.5 +12.6 12631 1.3 ZSCAN4 PRDM1 NTPCR MAP10 GC01M232948 GC01M232977
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NTPCR on UCSC Golden Path with GeneCards custom track

Genomic Locations for NTPCR Gene

Genomic Locations for NTPCR Gene
33,347 bases
Plus strand

Genomic View for NTPCR Gene

Genes around NTPCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTPCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTPCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTPCR Gene

Proteins for NTPCR Gene

  • Protein details for NTPCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cancer-related nucleoside-triphosphatase
    Protein Accession:

    Protein attributes for NTPCR Gene

    190 amino acids
    Molecular mass:
    20713 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NTPCR Gene

neXtProt entry for NTPCR Gene

Post-translational modifications for NTPCR Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for NTPCR Gene

No data available for DME Specific Peptides for NTPCR Gene

Domains & Families for NTPCR Gene

Gene Families for NTPCR Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NTPCR Gene

Suggested Antigen Peptide Sequences for NTPCR Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the THEP1 NTPase family.
  • Belongs to the THEP1 NTPase family.
genes like me logo Genes that share domains with NTPCR: view

Function for NTPCR Gene

Molecular function for NTPCR Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5 uM for ATP {ECO:0000269 PubMed:17291528}; KM=46 uM for ADP {ECO:0000269 PubMed:17291528}; KM=4 uM for GTP {ECO:0000269 PubMed:17291528}; KM=6 uM for CTP {ECO:0000269 PubMed:17291528}; KM=7 uM for TTP {ECO:0000269 PubMed:17291528};
UniProtKB/Swiss-Prot CatalyticActivity:
NTP + H(2)O = NDP + phosphate.
UniProtKB/Swiss-Prot Function:
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

Enzyme Numbers (IUBMB) for NTPCR Gene

Phenotypes From GWAS Catalog for NTPCR Gene

Gene Ontology (GO) - Molecular Function for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22681889
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0017111 nucleoside-triphosphatase activity IEA --
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides IEA --
genes like me logo Genes that share ontologies with NTPCR: view

Phenotypes for NTPCR Gene

genes like me logo Genes that share phenotypes with NTPCR: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NTPCR

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NTPCR Gene

Localization for NTPCR Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTPCR gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA,HDA 19946888
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with NTPCR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NTPCR Gene

Pathways & Interactions for NTPCR Gene

genes like me logo Genes that share pathways with NTPCR: view

Gene Ontology (GO) - Biological Process for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NTPCR: view

No data available for SIGNOR curated interactions for NTPCR Gene

Drugs & Compounds for NTPCR Gene

(3) Drugs for NTPCR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist 0

(4) Additional Compounds for NTPCR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
thiamine monophosphate
  • Aneurin-monophosphorsaeureester
  • Aneurine monophosphate
  • Monofosfotiamina
  • Monophosphoric ester of thiamine
  • Monophosphothiamine
Thiamine pyrophosphate
  • Thaimine pyrophosphate
  • Thiamin diphosphate
  • Thiamin pyrophosphate
  • Thiamin-PPi
  • Thiamine diphosphate
genes like me logo Genes that share compounds with NTPCR: view

Transcripts for NTPCR Gene

Unigene Clusters for NTPCR Gene

Nucleoside-triphosphatase, cancer-related:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NTPCR

Alternative Splicing Database (ASD) splice patterns (SP) for NTPCR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - -
SP7: - - - - - - -
SP9: -

Relevant External Links for NTPCR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTPCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTPCR Gene

Protein differential expression in normal tissues from HIPED for NTPCR Gene

This gene is overexpressed in Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NTPCR Gene

Protein tissue co-expression partners for NTPCR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NTPCR Gene:


SOURCE GeneReport for Unigene cluster for NTPCR Gene:


Evidence on tissue expression from TISSUES for NTPCR Gene

  • Nervous system(4.5)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with NTPCR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTPCR Gene

Orthologs for NTPCR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NTPCR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NTPCR 33 34
  • 100 (n)
(Canis familiaris)
Mammalia NTPCR 33 34
  • 85 (n)
(Bos Taurus)
Mammalia NTPCR 33 34
  • 83.33 (n)
(Monodelphis domestica)
Mammalia NTPCR 34
  • 82 (a)
(Mus musculus)
Mammalia Ntpcr 33 16 34
  • 79.72 (n)
(Rattus norvegicus)
Mammalia Ntpcr 33
  • 79.72 (n)
(Ornithorhynchus anatinus)
Mammalia NTPCR 34
  • 50 (a)
(Gallus gallus)
Aves NTPCR 33 34
  • 71.75 (n)
(Anolis carolinensis)
Reptilia NTPCR 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ntpcr 33
  • 61.58 (n)
(Danio rerio)
Actinopterygii ntpcr 33 34
  • 60.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10581 33 34
  • 49.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005921 33
  • 43.65 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G66005 33
  • 48.08 (n)
Species where no ortholog for NTPCR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTPCR Gene

Gene Tree for NTPCR (if available)
Gene Tree for NTPCR (if available)

Paralogs for NTPCR Gene

(1) SIMAP similar genes for NTPCR Gene using alignment to 2 proteins: Pseudogenes for NTPCR Gene

genes like me logo Genes that share paralogs with NTPCR: view

No data available for Paralogs for NTPCR Gene

Variants for NTPCR Gene

Sequence variations from dbSNP and Humsavar for NTPCR Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000065437 -- 232,967,791(+) G/A intron_variant
rs1000134563 -- 232,960,596(+) C/A intron_variant
rs1000142043 -- 232,965,995(+) G/A intron_variant
rs1000215964 -- 232,968,151(+) ACC/ACCACC intron_variant
rs1000219224 -- 232,960,861(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NTPCR Gene

Variant ID Type Subtype PubMed ID
esv2750829 CNV gain 17911159
esv3578476 CNV loss 25503493

Variation tolerance for NTPCR Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTPCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTPCR Gene

Disorders for NTPCR Gene

Additional Disease Information for NTPCR

No disorders were found for NTPCR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTPCR Gene

Publications for NTPCR Gene

  1. NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase. (PMID: 17291528) Placzek WJ … Wüthrich K (Journal of molecular biology 2007) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  4. Repression of rRNA transcription by PARIS contributes to Parkinson's disease. (PMID: 25315684) Kang H … Shin JH (Neurobiology of disease 2015) 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for NTPCR Gene

  • Addgene plasmids for NTPCR

Sources for NTPCR Gene

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