Aliases for NTNG2 Gene

Aliases for NTNG2 Gene

  • Netrin G2 2 3 5
  • Netrin-G2 2 3 4
  • Netrin G1 2 3
  • BA479K20.1 (Novel Protein) 3
  • BA479K20.1 3
  • Laminet 2 3
  • Laminet-2 4
  • LHLL9381 3
  • KIAA1857 4
  • Lmnt2 3
  • NTNG1 3
  • LMNT2 4

External Ids for NTNG2 Gene

Previous HGNC Symbols for NTNG2 Gene

  • NTNG1

Previous GeneCards Identifiers for NTNG2 Gene

  • GC09P130318
  • GC09P132066
  • GC09P134026
  • GC09P135037
  • GC09P104523

Summaries for NTNG2 Gene

GeneCards Summary for NTNG2 Gene

NTNG2 (Netrin G2) is a Protein Coding gene. Diseases associated with NTNG2 include Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia and Cerebellar Atrophy, Developmental Delay, And Seizures. Among its related pathways are Metabolism of proteins and Cell adhesion molecules (CAMs). An important paralog of this gene is NTNG1.

UniProtKB/Swiss-Prot Summary for NTNG2 Gene

  • Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Gene Wiki entry for NTNG2 Gene

Additional gene information for NTNG2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NTNG2 Gene

Genomics for NTNG2 Gene

GeneHancer (GH) Regulatory Elements for NTNG2 Gene

Promoters and enhancers for NTNG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J132161 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 505.3 +0.8 849 3.4 ZIC2 ZNF423 GABPA ZBTB26 EZH2 MCM3 CTBP1 ZNF341 OSR2 SIN3A NTNG2 lnc-MED27-2 SETX EEF1A1P5 KR153194-211
GH09J132006 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12 -155.9 -155851 8.4 TCF12 USF1 JUND FOS TCF7 FOXA1 RELA EP300 REST TEAD1 SETX NTNG2 NUP214 MED27 lnc-SETX-2 piR-34911-024 lnc-RAPGEF1-3
GH09J132240 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.7 +80.1 80066 3.4 NRF1 ZNF10 ZIC2 ZBTB10 CLOCK ZNF423 ZBTB26 MYC ZNF662 ZEB1 HSALNG0074922 GTF3C4 DDX31 PRRC2B GTF3C5 NTNG2 piR-48325-144
GH09J132268 Enhancer 1 Ensembl ENCODE 10.2 +108.3 108311 2.5 CTCF TCF12 RAD21 TRIM22 ZBTB26 SMC3 ZNF148 ZNF316 MAFF POLR2A TSC1 SETX TTF1 NTNG2 PRRC2B ENSG00000176868 POMT1 lnc-TTF1-1 piR-48325-144
GH09J132259 Enhancer 0.8 ENCODE 10.7 +97.7 97717 0.2 CTCF MYC POLR2G GABPA CTBP1 TRIM22 MXI1 SIN3A DEK KLF9 NTNG2 TTF1 RNU5D-2P MED27 piR-48325-144 lnc-TTF1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NTNG2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NTNG2

Top Transcription factor binding sites by QIAGEN in the NTNG2 gene promoter:
  • AREB6
  • C/EBPalpha
  • CHOP-10
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pax-4a

Genomic Locations for NTNG2 Gene

Genomic Locations for NTNG2 Gene
chr9:132,161,652-132,244,534
(GRCh38/hg38)
Size:
82,883 bases
Orientation:
Plus strand
chr9:135,037,334-135,119,921
(GRCh37/hg19)
Size:
82,588 bases
Orientation:
Plus strand

Genomic View for NTNG2 Gene

Genes around NTNG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTNG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTNG2 Gene

Proteins for NTNG2 Gene

  • Protein details for NTNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CW9-NTNG2_HUMAN
    Recommended name:
    Netrin-G2
    Protein Accession:
    Q96CW9
    Secondary Accessions:
    • Q5JUJ2
    • Q6UXY0
    • Q96JH0

    Protein attributes for NTNG2 Gene

    Size:
    530 amino acids
    Molecular mass:
    59799 Da
    Quaternary structure:
    • Interacts with LRRC4.
    SequenceCaution:
    • Sequence=BAB47486.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NTNG2 Gene

    Alternative splice isoforms for NTNG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTNG2 Gene

Post-translational modifications for NTNG2 Gene

  • N-glycosylated.
  • Glycosylation at Asn122, Asn128, Asn310, Asn395, and Asn422
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NTNG2 Gene

Domains & Families for NTNG2 Gene

Gene Families for NTNG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NTNG2 Gene

Blocks:
  • Laminin-type EGF-like domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NTNG2 Gene

GenScript: Design optimal peptide antigens:
  • Laminet-2 (NTNG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96CW9

UniProtKB/Swiss-Prot:

NTNG2_HUMAN :
  • The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.
Domain:
  • The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.
genes like me logo Genes that share domains with NTNG2: view

Function for NTNG2 Gene

Molecular function for NTNG2 Gene

UniProtKB/Swiss-Prot Function:
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Phenotypes From GWAS Catalog for NTNG2 Gene

Gene Ontology (GO) - Molecular Function for NTNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21946559
genes like me logo Genes that share ontologies with NTNG2: view
genes like me logo Genes that share phenotypes with NTNG2: view

Animal Models for NTNG2 Gene

MGI Knock Outs for NTNG2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NTNG2

miRNA for NTNG2 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTNG2 Gene

Localization for NTNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTNG2 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTNG2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Midbody ring (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NTNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with NTNG2: view

Pathways & Interactions for NTNG2 Gene

genes like me logo Genes that share pathways with NTNG2: view

Gene Ontology (GO) - Biological Process for NTNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0007409 axonogenesis ISS,IEA --
GO:0009887 animal organ morphogenesis IBA 21873635
GO:0009888 tissue development IBA 21873635
genes like me logo Genes that share ontologies with NTNG2: view

No data available for SIGNOR curated interactions for NTNG2 Gene

Drugs & Compounds for NTNG2 Gene

(1) Drugs for NTNG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NTNG2: view

Transcripts for NTNG2 Gene

mRNA/cDNA for NTNG2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTNG2 Gene

No ASD Table

Relevant External Links for NTNG2 Gene

GeneLoc Exon Structure for
NTNG2

Expression for NTNG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NTNG2 Gene

mRNA differential expression in normal tissues according to GTEx for NTNG2 Gene

This gene is overexpressed in Whole Blood (x11.1), Brain - Amygdala (x5.1), Brain - Cortex (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for NTNG2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTNG2 Gene



Protein tissue co-expression partners for NTNG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NTNG2

SOURCE GeneReport for Unigene cluster for NTNG2 Gene:

Hs.163642

Evidence on tissue expression from TISSUES for NTNG2 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with NTNG2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTNG2 Gene

Orthologs for NTNG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTNG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTNG2 31 30
  • 98.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NTNG2 31 30
  • 94.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NTNG2 31 30
  • 93.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntng2 30
  • 89.08 (n)
mouse
(Mus musculus)
Mammalia Ntng2 17 31 30
  • 87.98 (n)
oppossum
(Monodelphis domestica)
Mammalia NTNG2 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTNG2 31
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTNG2 31 30
  • 81.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTNG2 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntng2 30
  • 71.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8729 30
zebrafish
(Danio rerio)
Actinopterygii ntng2a 31 30
  • 70.13 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NetA 31
  • 18 (a)
ManyToMany
NetB 31
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-6 31
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
OneToMany
Species where no ortholog for NTNG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTNG2 Gene

ENSEMBL:
Gene Tree for NTNG2 (if available)
TreeFam:
Gene Tree for NTNG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NTNG2: view image

Paralogs for NTNG2 Gene

(1) SIMAP similar genes for NTNG2 Gene using alignment to 3 proteins:

  • NTNG2_HUMAN
  • A6NMX7_HUMAN
  • Q5JUJ3_HUMAN
genes like me logo Genes that share paralogs with NTNG2: view

Variants for NTNG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NTNG2 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
690370 Pathogenic: Global developmental delay; Areflexia; Generalized hypotonia; Stereotypical hand wringing; NEURODEVELOPMENTAL DISORDER WITH BEHAVIORAL ABNORMALITIES, ABSENT SPEECH, AND HYPOTONIA 132,198,125(+) C/CT FRAMESHIFT_VARIANT
691555 Pathogenic/Likely Pathogenic: Neurodevelopmental disorder; NEURODEVELOPMENTAL DISORDER WITH BEHAVIORAL ABNORMALITIES, ABSENT SPEECH, AND HYPOTONIA 132,241,885(+) G/A MISSENSE_VARIANT
691556 Pathogenic/Likely Pathogenic: Neurodevelopmental disorder; NEURODEVELOPMENTAL DISORDER WITH BEHAVIORAL ABNORMALITIES, ABSENT SPEECH, AND HYPOTONIA 132,198,071(+) T/G MISSENSE_VARIANT
691557 Likely Pathogenic: Neurodevelopmental disorder 132,239,125(+) C/G MISSENSE_VARIANT
691558 Pathogenic/Likely Pathogenic: Neurodevelopmental disorder; NEURODEVELOPMENTAL DISORDER WITH BEHAVIORAL ABNORMALITIES, ABSENT SPEECH, AND HYPOTONIA 132,239,114(+) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for NTNG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NTNG2 Gene

Variant ID Type Subtype PubMed ID
esv1610785 CNV insertion 17803354
esv2739125 CNV deletion 23290073
esv5554 CNV gain 19470904
nsv1035219 CNV gain 25217958
nsv1041246 CNV gain 25217958
nsv1049356 CNV gain 25217958
nsv1132985 CNV insertion 24896259
nsv1161912 CNV deletion 26073780
nsv416829 CNV insertion 16902084
nsv416962 CNV insertion 16902084
nsv469904 CNV loss 18288195
nsv509328 CNV insertion 20534489
nsv519872 CNV loss 19592680
nsv527281 CNV loss 19592680
nsv528123 CNV loss 19592680
nsv528270 CNV loss 19592680
nsv615571 CNV loss 21841781
nsv615572 CNV gain 21841781
nsv6739 CNV insertion 18451855
nsv6740 CNV insertion 18451855
nsv825134 CNV gain 20364138
nsv951793 CNV deletion 24416366
nsv951794 CNV deletion 24416366

Variation tolerance for NTNG2 Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTNG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTNG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTNG2 Gene

Disorders for NTNG2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NTNG2 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Additional Disease Information for NTNG2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NTNG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTNG2 Gene

Publications for NTNG2 Gene

  1. Structural basis for cell surface patterning through NetrinG-NGL interactions. (PMID: 21946559) Seiradake E … Jones EY (The EMBO journal 2011) 3 4 54
  2. Crystal structure of the ligand binding domain of netrin G2. (PMID: 22041449) Brasch J … Shapiro L (Journal of molecular biology 2011) 3 4 54
  3. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PMID: 18204098) Hom G … Behrens TW (The New England journal of medicine 2008) 3 41 54
  4. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. (PMID: 17507910) Eastwood SL … Harrison PJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008) 3 23 54
  5. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. (PMID: 15705354) Aoki-Suzuki M … Yoshikawa T (Biological psychiatry 2005) 3 23 54

Products for NTNG2 Gene

Sources for NTNG2 Gene